Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol.

abstract：AIM:We have shown that a combination of ligustrazine and berberine produces more effective inhibition on platelet activation and inflammatory reactions in rat acute myocardial infarction compared with either agent alone. In this study we evaluated the beneficial effects of a combination of ligustrazine and berberine in...

journal_title：Acta pharmacologica Sinica

authors： Zhang Y,Ma XJ,Guo CY,Wang MM,Kou N,Qu H,Mao HM,Shi DZ

更新日期：2016-04-01 00:00:00

abstract：AIM:Fibroblast growth factor 7 (FGF7) is involved in a number of physiological and pathological processes, including lung disease. However, relatively little is known about the effect of FGF7 gene polymorphisms on chronic obstructive pulmonary disease (COPD) susceptibility. This study aimed to investigate the associati...

journal_title：Acta pharmacologica Sinica

authors： Xu SC,Kuang JY,Liu J,Ma CL,Feng YL,Su ZG

更新日期：2012-08-01 00:00:00

abstract：AIM:To study the effect of chronic insulin treatment on insulin post-receptor signaling transduction and whether the effects of metformin are transmitted throughout the cascade of insulin signaling intermediates in a human hepatoma cell line (Hep G2). METHODS:Hep G2 cells were incubated in serum free media containing ...

journal_title：Acta pharmacologica Sinica

authors： Yuan L,Ziegler R,Hamann A

更新日期：2003-01-01 00:00:00

abstract：AIM:Previous study has shown that endometrial cancers with LKB1 inactivation are highly responsive to mTOR inhibitors. In this study we examined the effect of LKB1 gene status on mTOR inhibitor responses in non-small cell lung cancer (NSCLC) cells. METHODS:Lung cancer cell lines Calu-1, H460, H1299, H1792, and A549 we...

journal_title：Acta pharmacologica Sinica

authors： Xiao P,Sun LL,Wang J,Han RL,Ma Q,Zhong DS

更新日期：2015-09-01 00:00:00

abstract：:Lappaconitine (LA) has been widely used for postoperative and cancer pain control. LA exhibits excellent analgesic activity with a longer effective time than common local anesthetics such as tetracaine and bupivacaine. However, the mechanisms underlying the featured analgesic activity of LA remain largely unknown. Her...

journal_title：Acta pharmacologica Sinica

authors： Li YF,Zheng YM,Yu Y,Gan Y,Gao ZB

更新日期：2019-04-01 00:00:00

abstract：AIM:To investigate the protective effects of prostaglandin E(1) (PGE(1)) against H(2)O(2)-induced oxidative damage on human umbilical vein endothelial cells (HUVECs). METHODS:HUVECs were pretreated with PGE(1) (0.25, 0.50, and 1.00 micromol/L) for 24 h and exposed to H(2)O(2) (200 micromol/L) for 12 h, and cell viabil...

journal_title：Acta pharmacologica Sinica

authors： Fang WT,Li HJ,Zhou LS

更新日期：2010-04-01 00:00:00

abstract：:Esophageal cancer is one of the most common types of cancer in the world, and it demonstrates a distinct geographical distribution pattern in China. In the last decade, inducing apoptosis with traditional Chinese medicine (TCM) has become an active area in both fundamental and clinical research on cancer therapy. In t...

journal_title：Acta pharmacologica Sinica

authors： Zhang YS,Shen Q,Li J

更新日期：2016-03-01 00:00:00

abstract：AIM:To study effects of arachidonic acid (AA) and its metabolites on the hyposmotic membrane stretch-induced increase in calcium-activated potassium currents (I(KCa)) in gastric myocytes. METHODS:Membrane currents were recorded by using a conventional whole cell patch-clamp technique in gastric myocytes isolated with ...

journal_title：Acta pharmacologica Sinica

authors： Yang M,Li XL,Xu HY,Sun JB,Mei B,Zheng HF,Piao LH,Xing DG,Li ZL,Xu WX

更新日期：2005-10-01 00:00:00

abstract：:The signal transducer and activator of transcription 3 (STAT3) plays a critical role in platelet functions. This study sought to understand the effects of the STAT3 inhibitor SC99 on platelet activation and aggregation. Immunoblotting assays were applied to measure the effects of SC99 on the STAT3 signaling pathway. A...

journal_title：Acta pharmacologica Sinica

authors： Xu Z,Xu YJ,Hao YN,Ren LJ,Zhang ZB,Xu X,Cao BY,Dai KS,Zhu L,Fang Q,Kong Y,Mao XL

更新日期：2017-05-01 00:00:00

abstract：AIM:To evaluate the pharmacokinetic interactions between theophylline and antofloxacin in vivo and in vitro. METHODS:A randomized, 5-day treatment and 3-way crossover design was documented in 12 healthy subjects. The subjects were orally administered with antofloxacin (400 mg on d 1 and 200 mg on d 2 to 5), theophylli...

journal_title：Acta pharmacologica Sinica

authors： Liu L,Pan X,Liu HY,Liu XD,Yang HW,Xie L,Cheng JL,Fan HW,Xiao DW

更新日期：2011-10-01 00:00:00

abstract：AIM:To Study the interaction of macrophage colony-stimulating factor (M-CSF) and interleukin-10 (IL-10) in productions of IL-12 and IL-18 and expressions of CD14, CD23, and CD64 by human monocytes. METHODS:Purified adherent human monocytes were cultured with M-CSF or IL-10 alone, or with M-CSF+IL-10 and 2-3d later, th...

journal_title：Acta pharmacologica Sinica

authors： Ji XH,Yao T,Qin JC,Wang SK,Wang HJ,Yao K

更新日期：2004-10-01 00:00:00

abstract：AIM:To study the protein and mRNA expressions of pro-inflammatory and anti-inflammatory cytokines in the brain of rats with atherosclerosis (AS) and the effects of Ginkgo biloba extract (GbE) on expressions of cytokines. METHODS:The experimental model of AS in rats were established by intraperitioneal injection of vit...

journal_title：Acta pharmacologica Sinica

authors： Jiao YB,Rui YC,Li TJ,Yang PY,Qiu Y

更新日期：2005-07-01 00:00:00

abstract：:Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the world. Although considerable progress has been made in the diagnosis, treatment and prognosis of CVD, there is still a critical need for novel diagnostic biomarkers and new therapeutic interventions to decrease the incidence of this ...

journal_title：Acta pharmacologica Sinica

authors： Zhou SS,Jin JP,Wang JQ,Zhang ZG,Freedman JH,Zheng Y,Cai L

更新日期：2018-07-01 00:00:00

abstract：AIM:To examine the effect of curcumin on oxidative DNA damage and cell apoptosis and injury caused by the reaction of methylglyoxal(MG) with amino acids. METHODS:We used DNA strand breaks to examine the effect of curcumin on oxidative DNA damage. In addition, reactive oxygen species(ROS) formation occurs in MG-treated...

journal_title：Acta pharmacologica Sinica

authors： Chan WH,Wu HJ

更新日期：2006-09-01 00:00:00

abstract：AIM:Abrus agglutinin (AGG) from the seeds of Indian medicinal plant Abrus precatorius belongs to the class II ribosome inactivating protein family. In this study we investigated the anticancer effects of AGG against human hepatocellular carcinoma in vitro and in vivo. METHODS:Cell proliferation, DNA fragmentation, Ann...

journal_title：Acta pharmacologica Sinica

authors： Mukhopadhyay S,Panda PK,Das DN,Sinha N,Behera B,Maiti TK,Bhutia SK

更新日期：2014-06-01 00:00:00

abstract：:Tobacco use is estimated to be the largest single cause of premature death in the world. Nicotine is the major addictive substance in tobacco products. After cigarette smoking, nicotine quickly acts on its target, nicotinic acetylcholine receptors (nAChRs), which are widely distributed throughout the mammalian central...

journal_title：Acta pharmacologica Sinica

authors： Wu J

更新日期：2010-09-01 00:00:00

abstract：AIM:Breviscapine isolated from the Chinese herb Erigeron breviscapus (Vant) Hand-Mazz is widely used to treat cardiovascular and cerebrovascular diseases. The aim of this study was to improve the pharmacokinetic profiles of breviscapine using nanostructured lipid carrier based on an ionic complex formation. METHODS:Br...

journal_title：Acta pharmacologica Sinica

authors： Li M,Zheng Y,Shan FY,Zhou J,Gong T,Zhang ZR

更新日期：2013-08-01 00:00:00

abstract：AIM:To study the role of calcitonin gene-related peptide (CGRP) in nitric oxide (NO)-mediated myocardial delayed preconditioning induced by heat stress. METHODS:The isolated rat heart was perfused in a Langendorff model. Hearts for all groups were subjected to 4 h hypothermia (4 degrees C) and 40 min reperfusion (37 d...

journal_title：Acta pharmacologica Sinica

authors： Tan B,He SY,Deng HW,Li YJ

更新日期：2001-09-01 00:00:00

abstract：:As the most powerful antigen-presenting cell type, dendritic cells (DCs) can induce potent antigen-specific immune responses in vivo, hence becoming optimal cell population for vaccination purposes. DCs can be derived ex vivo in quantity and manipulated extensively to be endowed with adequate immune-stimulating capaci...

journal_title：Acta pharmacologica Sinica

authors： Gu YZ,Zhao X,Song XR

更新日期：2020-07-01 00:00:00

abstract：AIM:alpha2 nAChR subunit mRNA expression in mice is most intense in the olfactory bulbs and interpeduncular nucleus. We aimed to investigate the properties of alpha2* nAChRs in these mouse brain regions. METHODS:alpha2 nAChR subunit-null mutant mice were engineered. Pharmacological and immunoprecipitation studies were...

journal_title：Acta pharmacologica Sinica

authors： Whiteaker P,Wilking JA,Brown RW,Brennan RJ,Collins AC,Lindstrom JM,Boulter J

更新日期：2009-06-01 00:00:00

abstract：:Neuritin is a member of the neurotrophic factor family, which is activated by neural activity and neurotrophins, and promotes neurite growth and branching. It has shown to play an important role in neuronal plasticity and regeneration. It is also involved in other biological processes such as angiogenesis, tumorigenes...

journal_title：Acta pharmacologica Sinica

authors： Yao JJ,Zhao QR,Lu JM,Mei YA

更新日期：2018-09-01 00:00:00

abstract：:Terpene lactones are a class of bioactive constituents of standardized preparations of Ginkgo biloba leaf extract, extensively used as add-on therapies in patients with ischemic cardiovascular and cerebrovascular diseases. This investigation evaluated human pharmacokinetics of ginkgo terpene lactones and impact of the...

journal_title：Acta pharmacologica Sinica

authors： Liu XW,Yang JL,Niu W,Jia WW,Olaleye OE,Wen Q,Duan XN,Huang YH,Wang FQ,Du FF,Zhong CC,Li YF,Xu F,Gao Q,Li L,Li C

更新日期：2018-12-01 00:00:00

abstract：AIM:Airway hyperresponsiveness is a constant feature of asthma. The aim of the present study was to investigate airway hyperreactivity mediated by contractile and dilative receptors in an ovalbumin (OVA)-induced model of rat asthma. METHODS:Asthmatic E3 rats were prepared by intraperitoneal injection with OVA/aluminum...

journal_title：Acta pharmacologica Sinica

authors： Long JW,Yang XD,Cao L,Lu SM,Cao YX

更新日期：2009-07-01 00:00:00

abstract：AIM:To express dopamine D1 receptor in baculovirus-Sf9 cell system, and to investigate the effects of l-12-chloroscoulerine (l-CSL) on the recombinant D1 receptor (D1R). METHODS:The recombinant baculovirus, Autographa californica nuclear polyhedrosis virus bearing D1R (AcNPV- D1R) was generated, and then was used to p...

journal_title：Acta pharmacologica Sinica

authors： He Y,Jin WQ,Shen QX,Chen XJ,Jin GZ

更新日期：2003-03-01 00:00:00

abstract：:Fibronectin (FN) is a main component of extracellular matrix (ECM) in most adult tissues. Under pathological conditions, particularly inflammation, wound healing and tumors, an alternatively spliced exon extra domain A (EDA) is included in the FN protein (EDA+FN), which facilitates cellular proliferation, motility, an...

journal_title：Acta pharmacologica Sinica

authors： Wang HC,Wang P,Chen YW,Zhang Y

更新日期：2019-07-01 00:00:00

abstract：AIM:To model the three-dimensional structure and investigate the interaction mechanism of the proprotein convertase furin/kexin and their inhibitors (eglin c mutants). METHODS:The three-dimensional complex structures of furin/kexin with its inhibitors, eglin c mutants, were generated by modeller program using the newl...

journal_title：Acta pharmacologica Sinica

authors： Cai XH,Zhang Q,Ding DF

更新日期：2004-12-01 00:00:00

abstract：AIM:It is generally assumed that only unbound drugs can reach the site of action by diffusing across the membranes and exerting pharmacological effects by interacting with receptors. Recent research has shown that the percentage of free drugs may depend on the total drug concentration. The aim of the paper is to verify...

journal_title：Acta pharmacologica Sinica

authors： Kalitynski R,Dawidowicz AL,Poszytek J

更新日期：2006-12-01 00:00:00

abstract：:Aflibercept, as a soluble decoy vascular endothelial growth factor receptor, Which has been used as a first-line monotherapy for cancers. Aflibercept often causes cardiovascular toxicities including hypertension, but the mechanisms underlying aflibercept-induced hypertension remain unknown. In this study we investigat...

journal_title：Acta pharmacologica Sinica

authors： Dong ZC,Wu MM,Zhang YL,Wang QS,Liang C,Yan X,Zou LX,Chen C,Han X,Zhang B,Zhang ZR

更新日期：2020-12-10 00:00:00

abstract：AIM:To investigate the effects of rapamycin on glutamate uptake in cultured rat astrocytes expressing N-terminal 552 residues of mutant huntingtin (Htt-552). METHODS:Primary astrocyte cultures were prepared from the cortex of postnatal rat pups. An astrocytes model of Huntington's disease was established using the ast...

journal_title：Acta pharmacologica Sinica

authors： Chen LL,Wu JC,Wang LH,Wang J,Qin ZH,Difiglia M,Lin F

更新日期：2012-03-01 00:00:00

abstract：AIM:Both endothelin ETA receptor antagonists and angiotensin AT1 receptor antagonists lower blood pressure in hypertensive patients. A dual AT1 and ETA receptor antagonist may be more efficacious antihypertensive drug. In this study we identified the mode and mechanism of binding of imidazole series of compounds as dua...

journal_title：Acta pharmacologica Sinica

authors： Singh KD,Muthusamy K

更新日期：2013-12-01 00:00:00