Abstract：
AIM:To determine whether ATP-sensitive potassium channels are altered in VSMC from arotas and mesenteric arteries of obese rat, and their association with obesity-triggered increase in blood pressure. METHODS:Obesity was induced by 24 weeks of high-fat diet feeding in male Sprague-Dawley rats. Control rats were fed with standard laboratory rat chow. Blood pressure and body weight of these rats were measured every 4 weeks. At the end of 24 weeks, K(ATP) channelmediated relaxation responses in the aortas and mesenteric arteries, K(ATP) channel current, and gene expression were examined, respectively. RESULTS:Blood pressure and body weight were increased in rats fed with high-fat diet. K(ATP) channelmediated relaxation responses, currents, and K(ATP) expression in VSMC of both aortas and mesenteric arteries were inhibited in these rats. CONCLUSION:Altered ATP-sensitive potassium channels in obese rats may underscore obesity-triggered increase in blood pressure.
journal_name
Acta Pharmacol Sinjournal_title
Acta pharmacologica Sinicaauthors
Fan LH,Tian HY,Ma AQ,Hu Z,Huo JH,Cao YXdoi
10.1111/j.1745-7254.2008.00810.xsubject
Has Abstractpub_date
2008-10-01 00:00:00pages
1167-74issue
10eissn
1671-4083issn
1745-7254journal_volume
29pub_type
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