Antioxidant activity of qizhu tang.

abstract：AIM:to investigate the changing resistance to nondepolarizing muscle relaxants (NDMRs) during the first month after denervation. METHODS:the denervated and innervated skeletal muscle cells were examined on days 1, 4, 7, 14, 21, and 28 after denervation. Individual denervated and innervated cells were prepared from the...

journal_title：Acta pharmacologica Sinica

authors： WANG H,YANG B,HAN GW,LI ST

更新日期：2010-12-01 00:00:00

abstract：AIM:To study the synaptic mechanisms involved in the 5-hydroxytryptamine1A/7 (5-HT1A/7) receptor-mediated reflex control of cardiac vagal preganglionic neurons (CVPN). METHODS:CVPN were retrogradely labeled and identified in brain stem slices of newborn rats, and their synaptic activity was examined using whole-cell p...

journal_title：Acta pharmacologica Sinica

authors： Chen YH,Hou LL,Wang JJ

更新日期：2008-05-01 00:00:00

abstract：:Cysteine-rich peptides from the venom of cone snails (Conus) target a wide variety of different ion channels. One family of conopeptides, the alpha-conotoxins, specifically target different isoforms of nicotinic acetylcholine receptors (nAChRs) found both in the neuromuscular junction and central nervous system. This ...

journal_title：Acta pharmacologica Sinica

authors： Azam L,McIntosh JM

更新日期：2009-06-01 00:00:00

abstract：AIM:To study the effects of recombinant human macrophage colony-stimulating factor (rhM-CSF) expressed in silkworm on cytokine productions and membrane molecule expressions of monocytes. METHODS:The rhM-CSF was added to the human peripheral blood monocyte cultures and 3 d later, the culture supernatants and cells were...

journal_title：Acta pharmacologica Sinica

authors： Ji XH,Sun LH,Qin JC,Yao K,Ding RN,Li HD,Zhu DX

更新日期：2000-09-01 00:00:00

abstract：AIM:To investigate the protective effects of prostaglandin E(1) (PGE(1)) against H(2)O(2)-induced oxidative damage on human umbilical vein endothelial cells (HUVECs). METHODS:HUVECs were pretreated with PGE(1) (0.25, 0.50, and 1.00 micromol/L) for 24 h and exposed to H(2)O(2) (200 micromol/L) for 12 h, and cell viabil...

journal_title：Acta pharmacologica Sinica

authors： Fang WT,Li HJ,Zhou LS

更新日期：2010-04-01 00:00:00

abstract：:Extracellular vesicles (EVs) comprise apoptotic bodies, microvesicles and exosomes, and they perform as key regulators in cell-to-cell communication in normal as well as diseased states. EVs contain natural cargo molecules, such as miRNA, mRNA and proteins, and transfer these functional cargos to neighboring cells or ...

journal_title：Acta pharmacologica Sinica

authors： Samanta S,Rajasingh S,Drosos N,Zhou Z,Dawn B,Rajasingh J

更新日期：2018-04-01 00:00:00

abstract：:Herbal and dietary supplements (HDS)-induced liver injury has been a great concern all over the world. Polygonum multiflorum Thunb., a well-known Chinese herbal medicine, is recently drawn increasing attention because of its hepatotoxicity. According to the clinical and experimental studies, P. multiflorum-induced liv...

journal_title：Acta pharmacologica Sinica

authors： Rao T,Liu YT,Zeng XC,Li CP,Ou-Yang DS

更新日期：2021-01-01 00:00:00

abstract：AIM:In order to elucidate the molecular mechanism underlying the cardioprotection afforded by schisandrin B (Sch B), the effect of Sch B treatment on the sensitivity of mitochondria to Ca2+-stimulated permeability transition (PT) was investigated in rat hearts under normal and ischemia-reperfusion (I-R) conditions. RE...

journal_title：Acta pharmacologica Sinica

authors： Chiu PY,Leung HY,Siu AH,Poon MK,Ko KM

更新日期：2007-10-01 00:00:00

abstract：AIM:To investigate the actions of the muscarinic agonist carbachol on glutamate-induced neurotoxicity in PC12 cells, and the underlying mechanisms. METHODS:PC12 cells were treated with different concentrations of glutamate for 24 or 48 h. The cell viability was measured using MTT assay, and the expression and activati...

journal_title：Acta pharmacologica Sinica

authors： Ma K,Yang LM,Chen HZ,Lu Y

更新日期：2013-07-01 00:00:00

abstract：AIM:To investigate the ultrastructural localization of atrial natriuretic peptide (ANP)-synthesizing cells and the relationship between ANP-synthesizing cells and microvessels in rat gastric mucosa. METHODS:Immunohistochemistry techniques and postembedding immunoelectron microscopy techniques were used to validate the...

journal_title：Acta pharmacologica Sinica

authors： Li CH,Yang ZW,Yin ZR,Jin Z,Xing DG,Piao LH,Kim YC,Xu WX

更新日期：2006-02-01 00:00:00

abstract：AIM:To investigate the inhibitory effect of the natural product Leukamenin F on liver fibrosis and explore its potential underlying mechanisms. METHODS:Carbon tetrachloride (CCl(4))-treated mouse model in vivo and in hepatic stellate cells (HSC) in vitro were used. The effect on CCl(4)-induced liver fibrosis was studi...

journal_title：Acta pharmacologica Sinica

authors： Liu Q,Wang X,Zhang Y,Li CJ,Hu LH,Shen X

更新日期：2010-07-01 00:00:00

abstract：AIM:To investigate the effects of diosgenin (Dio), a naturally occurring steroid saponin, on goiter formation in a mouse model of Graves' disease (GD) and the underlying mechanisms. METHODS:Female BALB/c mice were injected with adenovirus expressing the A subunit of thyrotropin receptor to induce GD. The mice were tre...

journal_title：Acta pharmacologica Sinica

authors： Cai H,Wang Z,Zhang HQ,Wang FR,Yu CX,Zhang FX,Gao L,Zhang J,Zhao JJ

更新日期：2014-01-01 00:00:00

abstract：:Breast cancer resistance protein (BCRP) is one of ATP-binding cassette (ABC) transporters in brain microvessel endothelial cells that transport their substrates from brain to blood, thus limiting substrates to crossing into brain through blood-brain barrier. Our previous works show that bile duct ligation (BDL) impair...

journal_title：Acta pharmacologica Sinica

authors： Qin YY,Xu P,Wu T,Qian CQ,Fan YL,Gen DH,Zhu L,Kong WM,Yang HY,Xu F,Yang YT,Liu L,Liu XD

更新日期：2020-02-01 00:00:00

abstract：:Top down central nervous system (CNS) influences on the immune system and bottom up immune system influences on the CNS take part in a complex feedforward and feedback loop which may be responsible for initiating events and perpetuating circumstances in the course of neuropsychiatric as well as immune system diseases....

journal_title：Acta pharmacologica Sinica

authors： Fricchione G,Daly R,Rogers MP,Stefano GB

更新日期：2001-07-01 00:00:00

abstract：AIM:Oral risedronate is effective in the treatment of postmenopausal osteoporosis when administered daily, weekly, or monthly. In this 1-year, randomized, double-blind, multicenter study we compared the weekly 35-mg and daily 5-mg risedronate dosing regimens in the treatment of Chinese postmenopausal women with osteopo...

journal_title：Acta pharmacologica Sinica

authors： Gu JM,Wang L,Lin H,Chen DC,Tang H,Jin XL,Xia WB,Hu YQ,Fu WZ,He JW,Zhang H,Wang C,Yue H,Hu WW,Liu YJ,Zhang ZL

更新日期：2015-07-01 00:00:00

abstract：AIM:The aim of the study was to evaluate the outcome of adenovirus-mediated p27(KIP1) (Ad-p27) expression on wound healing after filtration surgery and to investigate the inhibition of cell proliferation induced by Ad-p27. METHODS:We constructed the adenovirus recombinant vector Ad-p27 and administered it to a rabbit ...

journal_title：Acta pharmacologica Sinica

authors： Yang JG,Sun NX,Cui LJ,Wang XH,Feng ZH

更新日期：2009-04-01 00:00:00

abstract：:Autophagy, a form of cellular self-digestion by lysosome, is associated with various disease processes including cancers, and modulating autophagy has shown promise in the treatment of various malignancies. A number of natural products display strong antitumor activity, yet their mechanisms of action remain unclear. T...

journal_title：Acta pharmacologica Sinica

authors： Jiang SL,Guan YD,Chen XS,Ge P,Wang XL,Lao YZ,Xiao SS,Zhang Y,Yang JM,Xu XJ,Cao DS,Cheng Y

更新日期：2019-07-01 00:00:00

abstract：:Type 2 diabetes (T2D) and Alzheimer's disease (AD) share several common pathophysiological features. Huperzine A (Hup A), a Lycopodium alkaloid extracted from the Chinese herb moss Huperzia serrata, is a specific and reversible inhibitor of acetylcholinesterase, which is clinically used for the treatment of AD. In thi...

journal_title：Acta pharmacologica Sinica

authors： Wang HY,Wu M,Diao JL,Li JB,Sun YX,Xiao XQ

更新日期：2020-02-01 00:00:00

abstract：AIM:To explore the anti-diabetic effects of berberine and its influence on insulin secretion. METHODS:Impaired glucose tolerance rats induced by iv injection of streptozotocin 30 mg/kg were treated with berberine 187.5 and 562.5 mg/kg while fed with high fat laboratory chow. After rats were treated for 4 weeks, oral g...

journal_title：Acta pharmacologica Sinica

authors： Leng SH,Lu FE,Xu LJ

更新日期：2004-04-01 00:00:00

abstract：:Kushen (Radix Sophorae Flavescentis) has a long history of use for the treatment of tumors, inflammation and other diseases in traditional Chinese medicine. Compound Kushen Injection (CKI) is a mixture of natural compounds extracted from Kushen and Baituling (Rhizoma Smilacis Glabrae). The main principles of CKI are m...

journal_title：Acta pharmacologica Sinica

authors： Wang W,You RL,Qin WJ,Hai LN,Fang MJ,Huang GH,Kang RX,Li MH,Qiao YF,Li JW,Li AP

更新日期：2015-06-01 00:00:00

abstract：AIM:Airway hyperresponsiveness is a constant feature of asthma. The aim of the present study was to investigate airway hyperreactivity mediated by contractile and dilative receptors in an ovalbumin (OVA)-induced model of rat asthma. METHODS:Asthmatic E3 rats were prepared by intraperitoneal injection with OVA/aluminum...

journal_title：Acta pharmacologica Sinica

authors： Long JW,Yang XD,Cao L,Lu SM,Cao YX

更新日期：2009-07-01 00:00:00

abstract：:A variety of Ca2+ signals, in the form of intercellular pulses and waves, have been reported to be associated with the various sequential stages of somitogenesis: from convergent extension and the formation of the paraxial mesoderm; during the patterning of the paraxial mesoderm to establish segmental units; throughou...

journal_title：Acta pharmacologica Sinica

authors： Webb SE,Miller AL

更新日期：2006-07-01 00:00:00

abstract：:Excessive and abnormal vessel growth plays a critical role in the pathogenesis of many diseases, such as cancer. Angiogenesis is one of the hallmarks of cancer growth, invasion, and metastasis. Discovery of novel antiangiogenic agents would provide new insights into the mechanisms of angiogenesis, as well as potential...

journal_title：Acta pharmacologica Sinica

authors： Liu B,Cui LS,Zhou B,Zhang LL,Liu ZH,Zhang L

更新日期：2019-11-01 00:00:00

abstract：AIM:To investigate the influence of trimetazidine, which is known to be an antioxidant and modulator of metabolism, on cardiac function and the development of diabetic cardiomyopathy in db/db mouse. METHODS:Trimetazidine was administered to db/db mice for eight weeks. Cardiac function was measured by inserting a Milla...

journal_title：Acta pharmacologica Sinica

authors： Li YJ,Wang PH,Chen C,Zou MH,Wang DW

更新日期：2010-05-01 00:00:00

abstract：:The therapeutic outcome of chemotherapy is severely limited by intrinsic or acquired drug resistance, the most common causes of chemotherapy failure. In the past few decades, advancements in nanotechnology have provided alternative strategies for combating tumor drug resistance. Drug-loaded nanoparticles (NPs) have se...

journal_title：Acta pharmacologica Sinica

authors： Liu JP,Wang TT,Wang DG,Dong AJ,Li YP,Yu HJ

更新日期：2017-01-01 00:00:00

abstract：:Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as neural apoptosis regulated convertase (NARC1), is a key modulator of cholesterol metabolism. PCSK9 increases the serum concentration of low-density lipoprotein cholesterol by escorting low-density lipoprotein receptors (LDLRs) from the membrane of he...

journal_title：Acta pharmacologica Sinica

authors： He NY,Li Q,Wu CY,Ren Z,Gao Y,Pan LH,Wang MM,Wen HY,Jiang ZS,Tang ZH,Liu LS

更新日期：2017-03-01 00:00:00

abstract：:The mechanism underlying the resistance of cancer cells to chemotherapeutic drug varies with different cancer cells. Recent evidence shows that lysosomal function is associated with drug resistance of cancer cells. Artesunate, a derivative of artemisinin, displays broad antitumor activity and direct cytotoxicity on va...

journal_title：Acta pharmacologica Sinica

authors： Li Z,Zhu YT,Xiang M,Qiu JL,Luo SQ,Lin F

更新日期：2020-07-23 00:00:00

abstract：:Autophagy is a cell self-digestion process via lysosomes that clears "cellular waste", including aberrantly modified proteins or protein aggregates and damaged organelles. Therefore, autophagy is considered a protein and organelle quality control mechanism that maintains normal cellular homeostasis. Dysfunctional auto...

journal_title：Acta pharmacologica Sinica

authors： He LQ,Lu JH,Yue ZY

更新日期：2013-05-01 00:00:00

abstract：AIM:Both endothelin ETA receptor antagonists and angiotensin AT1 receptor antagonists lower blood pressure in hypertensive patients. A dual AT1 and ETA receptor antagonist may be more efficacious antihypertensive drug. In this study we identified the mode and mechanism of binding of imidazole series of compounds as dua...

journal_title：Acta pharmacologica Sinica

authors： Singh KD,Muthusamy K

更新日期：2013-12-01 00:00:00

abstract：AIM:To investigate the effects of the cardiotonic steroid, ouabain, on cardiac differentiation of murine embyronic stem cells (mESCs). METHODS:Cardiac differentiation of murine ESCs was enhanced by standard hanging drop method in the presence of ouabain (20 μmol/L) for 7 d. The dissociated ES derived cardiomyocytes we...

journal_title：Acta pharmacologica Sinica

authors： Lee YK,Ng KM,Lai WH,Man C,Lieu DK,Lau CP,Tse HF,Siu CW

更新日期：2011-01-01 00:00:00