Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against ischemia-reperfusion injury in rat hearts.

abstract：AIM:To establish a 96-well plate based kinase assay using a recombinant vascular endothelial growth factor (VEGF) receptor 1 kinase domain protein. METHODS:A human VEGF receptor 1 kinase domain protein was expressed in E coli, and its activity was monitored by its ability of phosphorylating the polyE4Y substrate coate...

journal_title：Acta pharmacologica Sinica

authors： Zhuang SF,Zhou CH,Qian J,Qian Z,Shibuya M,Ye QZ

更新日期：2002-02-01 00:00:00

abstract：:DJ-1 is a multifunctional protein associated with cancers and autosomal early-onset Parkinson disease. Besides the well-documented antioxidative stress activity, recent studies show that DJ-1 has deglycation enzymatic activity and anti-ferroptosis effect. It has been shown that DJ-1 forms the homodimerization, which d...

journal_title：Acta pharmacologica Sinica

authors： Jiang L,Chen XB,Wu Q,Zhu HY,Du CY,Ying MD,He QJ,Zhu H,Yang B,Cao J

更新日期：2020-10-06 00:00:00

abstract：AIM:To investigate the effect of aluminum (Al) on high voltage-dependent calcium current (I(HVA)) and its modulation by ginkgolide B (Gin B). METHODS:The whole-cell, patch-clamp technique was used to record IHVA from acutely isolated hippocampal CA1 pyramydal neurons in rats. RESULTS:Al 0.1 mmol/L (low concentration)...

journal_title：Acta pharmacologica Sinica

authors： Chen L,Liu CJ,Tang M,Li A,Hu XW,Du YM,Shen JJ,Lu YL,Heschler J

更新日期：2005-05-01 00:00:00

abstract：:Isothiocyanates are naturally occurring small molecules that are formed from glucosinolate precursors of cruciferous vegetables. Many isothiocyanates, both natural and synthetic, display anticarcinogenic activity because they reduce activation of carcinogens and increase their detoxification. Recent studies show that ...

journal_title：Acta pharmacologica Sinica

authors： Wu X,Zhou QH,Xu K

更新日期：2009-05-01 00:00:00

abstract：AIM:To determine the postshock activation patterns with both successful and failed shocks in a canine model of ventricular fibrillation, and whether piniacidil, an early after-depolarization (EAD) inhibitor, altered the defibrillation threshold (DFT) and postshock activation patterns. METHODS:In 6 beagles, a basket ca...

journal_title：Acta pharmacologica Sinica

authors： Jin Q,Zhang N,Zhou J,Lin CJ,Pang Y,Gu G,Shen WF,Wu LQ

更新日期：2012-12-01 00:00:00

abstract：:Estrogens are important endocrine hormones that control physiological functions in reproductive organs, and play a pivotal role in the generation and progression of breast cancer. Therapeutic drugs including anti-estrogen and aromatase inhibitors are used to treat patients with breast cancer. The estrogen receptors, E...

journal_title：Acta pharmacologica Sinica

authors： Ikeda K,Horie-Inoue K,Inoue S

更新日期：2015-01-01 00:00:00

abstract：AIM:To investigate the molecular mechanism and signaling pathway by which fenoterol, a beta(2)-adrenergic receptor (beta(2)-AR) agonist, produces anti-inflammatory effects. METHODS:THP-1, a monocytic cell line, was used to explore the mechanism of beta(2)-AR stimulation in LPS-induced secretion of inflammatory cytokin...

journal_title：Acta pharmacologica Sinica

authors： Wang W,Xu M,Zhang YY,He B

更新日期：2009-11-01 00:00:00

abstract：AIM:Our previous study demonstrated an siRNA-mediated, allele-specific silencing of mutant genes that cause amyotrophic lateral sclerosis. To improve siRNA design for better therapeutic use of RNA interference, we systematically tested the base-pairing mismatch strategy in the design of asymmetric siRNA. METHODS:A nat...

journal_title：Acta pharmacologica Sinica

authors： Geng CM,Ding HL

更新日期：2008-02-01 00:00:00

abstract：AIM:To study whether etodolac enantiomers have pharmacokinetic difference after oral administration. METHODS:Fourteen rats, divided into two groups randomly, were orally given S-(+)- or R-(-)-etodolac at a single dose of 20 mg/kg, respectively. Blood samples were collected before and at 5, 10, 20, 30 min and 1, 3, 6, ...

journal_title：Acta pharmacologica Sinica

authors： Shi JM,Lai SG,Xu CJ,Duan GL,Li D

更新日期：2004-08-01 00:00:00

abstract：:Type capital I, Ukrainian natural killer T cells (NKT cells), a subset of CD1d-restricted T cells with invariant Valphabeta TCR, are characterized by prompt production of large amounts of Th1 and/or Th2 cytokines upon primary stimulation through the TCR complex. The rapid release of cytokines implies that type capital...

journal_title：Acta pharmacologica Sinica

authors： Tan JQ,Xiao W,Wang L,He YL

更新日期：2010-09-01 00:00:00

abstract：AIM:Epigallocatechin-3-gallate (EGCG) is the major polyphenolic constituent in green tea. The aim of this study is to investigate the effects of EGCG on proliferation and migration of the human colon cancer SW620 cells. METHODS:Proliferation and migration of SW620 cells were induced by the protease-activated receptor ...

journal_title：Acta pharmacologica Sinica

authors： Zhou F,Zhou H,Wang T,Mu Y,Wu B,Guo DL,Zhang XM,Wu Y

更新日期：2012-01-01 00:00:00

abstract：:Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the world. Although considerable progress has been made in the diagnosis, treatment and prognosis of CVD, there is still a critical need for novel diagnostic biomarkers and new therapeutic interventions to decrease the incidence of this ...

journal_title：Acta pharmacologica Sinica

authors： Zhou SS,Jin JP,Wang JQ,Zhang ZG,Freedman JH,Zheng Y,Cai L

更新日期：2018-07-01 00:00:00

abstract：AIM:To search for novel effective P-glycoprotein (P-gp) reversal agents in the blood-brain barrier (BBB). METHODS:Using rhodamine123 (Rh123) to examine the functional activity of P-gp in cultured bovine brain capillary endothelial cells (BCEC) and screen various principles on P-gp modulation in BBB. RESULTS:All of te...

journal_title：Acta pharmacologica Sinica

authors： He L,Liu GQ

更新日期：2002-07-01 00:00:00

abstract：AIM:To study the effect of chloroquine on the expression of human clotting factor IX (hFIX) in mice. METHODS:Hydrodynamics-based naked DNA plasmid administration was performed by tail vein injection of 10 microg of pCMV- hFIX and chloroquine (0, 100, 200, and 500 micromol/L) in 2.2 mL of Ringer's solution within 6-7 s...

journal_title：Acta pharmacologica Sinica

authors： Chen HY,Zhu HZ,Lu B,Xu X,Yao JH,Shen Q,Xue JL

更新日期：2004-05-01 00:00:00

abstract：AIM:To investigate the effect of the Tob1 gene, a member of the Transducing Molecule of ErbB2/B-cell Translocation Ggene (TOB/BTG) family, by using the adenovirus-mediated expression of Tob1 on radiosensitivity in a human breast cancer cell line MDA-MB-231. METHODS:Cell survival was determined by clonogenic assay. Apo...

journal_title：Acta pharmacologica Sinica

authors： Jiao Y,Ge CM,Meng QH,Cao JP,Tong J,Fan SJ

更新日期：2007-10-01 00:00:00

abstract：AIM:To investigate whether atorvastatin can promote formation of neurites in cultured cortical neurons and the signaling mechanisms responsible for this effect. METHODS:Cultured rat cerebral cortical neurons were incubated with atorvastatin (0.05-10 μmol/L) for various lengths of time. For pharmacological experiments,...

journal_title：Acta pharmacologica Sinica

authors： Jin Y,Sui HJ,Dong Y,Ding Q,Qu WH,Yu SX,Jin YX

更新日期：2012-07-01 00:00:00

abstract：AIM:To investigate the anticancer effect of crocetin, a major ingredient in saffron, and its underlying mechanisms. METHODS:Cervical cancer cell line HeLa, non-small cell lung cancer cell line A549 and ovarian cancer cell line SKOV3 were treated with crocetin alone or in combination with vincristine. Cell proliferatio...

journal_title：Acta pharmacologica Sinica

authors： Zhong YJ,Shi F,Zheng XL,Wang Q,Yang L,Sun H,He F,Zhang L,Lin Y,Qin Y,Liao LC,Wang X

更新日期：2011-12-01 00:00:00

abstract：AIM:Recent studies have shown that constitutive activation of the nuclear factor κB (NF-κB) plays a key role in chronic inflammation and cancers. The aim of this study was to characterize lobolide, a cembrane diterpene, as a drug candidate targeting the NF-κB signaling pathway. METHODS:A HEK 293/NF-κB-Luc stable cell ...

journal_title：Acta pharmacologica Sinica

authors： Lv XF,Chen SH,Li J,Fang JP,Guo YW,Ding K

更新日期：2012-10-01 00:00:00

abstract：AIM:To investigate the expression of c-Met in peritoneal free cancer cells isolated from human gastric cancer ascites, and its relationship to peritoneal dissemination of gastric cancer. METHODS:Peritoneal free cancer cells (PFCCs) were isolated from ascites specimens of gastric cancer patients. c-Met expression in PF...

journal_title：Acta pharmacologica Sinica

authors： Wang XL,Chen XM,Fang JP,Yang CQ

更新日期：2012-04-01 00:00:00

abstract：AIM:To differentiate the electrophysiological characteristics of somatic action potentials (AP) from isolated Neo and Juv nodose sensory neurons (NSN) and those from slices of intact Juv and adult rat nodose ganglia. METHODS:For isolated cell recordings nodose ganglia from 3-8 d old Neo and 4 weeks old Juv rats were d...

journal_title：Acta pharmacologica Sinica

authors： Li BY,Schild JH

更新日期：2002-06-01 00:00:00

abstract：:With the increasing incidence of drug-induced liver disease, attempts are being made to better understand the mechanisms behind these frequently life-endangering reactions. Analgesics and anti-inflammatory drugs are a major group exhibiting hepatotoxicity. We review research relating to these reactions, focusing on ul...

journal_title：Acta pharmacologica Sinica

authors： Manov I,Motanis H,Frumin I,Iancu TC

更新日期：2006-03-01 00:00:00

abstract：AIM:Using sparse data of valproate (VPA) serum concentrations to build a population pharmacokinetic (PPK) model of VPA in Chinese children with epilepsy and to predict serum concentrations for new patients using a Bayesian approach. METHODS:Two hundred epileptic children, whose VPA serum concentrations were collected,...

journal_title：Acta pharmacologica Sinica

authors： Jiang DC,Wang L

更新日期：2004-12-01 00:00:00

abstract：AIM:The mechanism of tramadol-induced vasodilation was investigated using isolated rabbit thoracic aortic rings. METHODS:Aortic rings from 8 rabbits were placed in organ bath and precontracted with phenylephrine (10(-5) mol/L) before addition of tramadol. Relaxation responses by tramadol were evaluated in the presence...

journal_title：Acta pharmacologica Sinica

authors： Kaya T,Gursoy S,Karadas B,Sarac B,Fafali H,Soydan AS

更新日期：2003-05-01 00:00:00

abstract：AIM:Apolipoprotein E (ApoE) plays an important role in the transport and metabolism of lipids. Recent studies show that bone mass is increased in young apoE(-/-) mice. In this study we investigated the bone phenotype and metabolism in aged apoE(-/-) mice. METHODS:Femurs and tibias were collected from 18- and 72-week-o...

journal_title：Acta pharmacologica Sinica

authors： Hong W,Xu XY,Qiu ZH,Gao JJ,Wei ZY,Zhen L,Zhang XL,Ye ZB

更新日期：2015-12-01 00:00:00

abstract：AIM:To examine the effect of curcumin on oxidative DNA damage and cell apoptosis and injury caused by the reaction of methylglyoxal(MG) with amino acids. METHODS:We used DNA strand breaks to examine the effect of curcumin on oxidative DNA damage. In addition, reactive oxygen species(ROS) formation occurs in MG-treated...

journal_title：Acta pharmacologica Sinica

authors： Chan WH,Wu HJ

更新日期：2006-09-01 00:00:00

abstract：AIM:Osteopontin (OPN), a multifunctional protein, has been reported to be protoxicant in acetaminophen hepatotoxicity. In this study, the mechanisms underlying the detrimental role of OPN in acetaminophen toxicity were explored. METHODS:Male C57BL/6 (wild-type, WT) and OPN(-/-) mice were administered with acetaminophe...

journal_title：Acta pharmacologica Sinica

authors： He CY,Liang BB,Fan XY,Cao L,Chen R,Guo YJ,Zhao J

更新日期：2012-08-01 00:00:00

abstract：AIM:To investigate the immunoregulatory functions of water extracts of Hericium erinaceum (WEHE) focusing on natural killer (NK) cell-based anticancer activities. METHODS:Mouse splenocytes or purely isolated NK cells were stimulated with 1-100 mg/L WEHE for 24 h followed by co-culture with (51)Cr-labeled Yac-1 cells f...

journal_title：Acta pharmacologica Sinica

authors： Yim MH,Shin JW,Son JY,Oh SM,Han SH,Cho JH,Cho CK,Yoo HS,Lee YW,Son CG

更新日期：2007-06-01 00:00:00

abstract：AIM:To investigate whether myosin light chain kinase (MLCK) contributed to the high proliferative ability of breast cancer cells. METHODS:Soft agar colony formation on the MCF-7 and LM-MCF-7 cell lines was determined. The cell cycles of MCF-7 and LM-MCF-7 were detected using flow cytometry analysis. Western blot analy...

journal_title：Acta pharmacologica Sinica

authors： Cui WJ,Liu Y,Zhou XL,Wang FZ,Zhang XD,Ye LH

更新日期：2010-06-01 00:00:00

abstract：:Human ether-a-go-go related gene (hERG) potassium (K(+)) channels play a critical role in cardiac action potential repolarization. Mutations that reduce hERG conductance or surface expression may cause congenital long QT syndrome (LQTS). However, the channels can be inhibited by structurally diverse small molecules, r...

journal_title：Acta pharmacologica Sinica

authors： Zhou PZ,Babcock J,Liu LQ,Li M,Gao ZB

更新日期：2011-06-01 00:00:00

abstract：AIM:High mobility group box protein 1 (HMGB1) and receptor for the advanced glycation end product (RAGE) play pivotal roles in vascular inflammation and atherosclerosis. The aim of this study was to determine whether the HMGB1-RAGE axis was involved in the actions of simvastatin on vascular inflammation and atheroscler...

journal_title：Acta pharmacologica Sinica

authors： Liu M,Yu Y,Jiang H,Zhang L,Zhang PP,Yu P,Jia JG,Chen RZ,Zou YZ,Ge JB

更新日期：2013-06-01 00:00:00