Abstract：
AIM:To investigate the influence of trimetazidine, which is known to be an antioxidant and modulator of metabolism, on cardiac function and the development of diabetic cardiomyopathy in db/db mouse. METHODS:Trimetazidine was administered to db/db mice for eight weeks. Cardiac function was measured by inserting a Millar catheter into the left ventricle, and oxidative stress and AMP-activated protein kinase (AMPK) activity in the myocardium were evaluated. RESULTS:Untreated db/db mice exhibited a significant decrease in cardiac function compared to normal C57 mice. Oxidative stress and lipid deposition were markedly increased in the myocardium, concomitant with inactivation of AMPK and increased expression of peroxisome proliferator-activated receptor coactivator-1 alpha (PGC-1 alpha). Trimetazidine significantly improved systolic and diastolic function in hearts of db/db mice and led to reduced production of reactive oxygen species and deposition of fatty acid in cardiomyocytes. Trimetazidine also caused AMPK activation and reduced PGC-1 alpha expression in the hearts of db/db mice. CONCLUSION:The data suggest that trimetazidine significantly improves cardiac function in db/db mice by attenuating lipotoxicity and improving the oxidation status of the heart. Activation of AMPK and decreased expression of PGC-1 alpha were involved in this process. Furthermore, our study suggests that trimetazidine suppresses the development of diabetic cardiomyopathy, which warrants further clinical investigation.
journal_name
Acta Pharmacol Sinjournal_title
Acta pharmacologica Sinicaauthors
Li YJ,Wang PH,Chen C,Zou MH,Wang DWdoi
10.1038/aps.2010.31subject
Has Abstractpub_date
2010-05-01 00:00:00pages
560-9issue
5eissn
1671-4083issn
1745-7254pii
aps201031journal_volume
31pub_type
杂志文章abstract：AIM:To investigate the blood pressure (BP), baroreflex sensitivity (BRS), and organ damage in hybrids of spontaneously hypertensive rats and Sprague-Dawley rats. METHODS:Spontaneously hypertensive rats and Sprague-Dawley rats were crossbred, and the F1 hybrids were inbred randomly to produce an F2 generation. At the a...
journal_title：Acta pharmacologica Sinica
pub_type： 杂志文章
doi：10.1111/j.1745-7254.2005.00162.x
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abstract：AIM:To investigate the ability of an antisense RNA eukaryotic expression plasmid pcDNA3.1/survivin in down-regulating the expression level of survivin mRNA and survivin protein and reversed multidrug resistance (MDR) in adriamycin-resistant HL-60/ADR cell line. METHODS:The expression of survivin mRNA was measured by R...
journal_title：Acta pharmacologica Sinica
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abstract：AIM:Targeting the VEGF/VEGF receptor (VEGFR) pathway has proved to be an effective antiangiogenic approach for cancer treatment. Here, we identified 6-((2-((3-acetamidophenyl)amino)pyrimidin-4-yl)oxy)-N-phenyl-1-naphthamide (designated herein as DW10075) as a novel and highly selective inhibitor of VEGFRs. METHODS:In ...
journal_title：Acta pharmacologica Sinica
pub_type： 杂志文章
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abstract：:Cancer immunotherapy has received extensive attention due to its ability to activate the innate or adaptive immune systems of patients to combat tumors. Despite a few clinical successes, further endeavors are still needed to tackle unresolved issues, including limited response rates, development of resistance, and imm...
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pub_type： 杂志文章,评审
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abstract：:Esophageal cancer is one of the most common types of cancer in the world, and it demonstrates a distinct geographical distribution pattern in China. In the last decade, inducing apoptosis with traditional Chinese medicine (TCM) has become an active area in both fundamental and clinical research on cancer therapy. In t...
journal_title：Acta pharmacologica Sinica
pub_type： 杂志文章,评审
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journal_title：Acta pharmacologica Sinica
pub_type： 杂志文章,评审
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doi：10.1111/j.1745-7254.2007.00485.x
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pub_type： 杂志文章
doi：
更新日期：2002-10-01 00:00:00
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journal_title：Acta pharmacologica Sinica
pub_type： 杂志文章
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更新日期：2017-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2009-04-01 00:00:00
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journal_title：Acta pharmacologica Sinica
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2004-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-12-01 00:00:00
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doi：10.1111/j.1745-7254.2006.00389.x
更新日期：2006-07-01 00:00:00
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doi：
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pub_type： 杂志文章
doi：
更新日期：2001-08-01 00:00:00
abstract：:Pre-B-cell leukemia transcription factor 3 (PBX3) is a member of the PBX family and contains a highly conserved homologous domain. PBX3 is involved in the progression of gastric cancer, colorectal cancer, and prostate cancer; however, the detailed mechanism by which it promotes tumor growth remains to be elucidated. H...
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更新日期：2021-02-01 00:00:00
abstract：AIM:Adenosine monophosphate-activated protein kinase (AMPK), a vital regulator of glucose metabolism, may affect insulin secretion in beta-cells. However, the role of AMPK in beta-cell lipotoxicity remains unclear. Fenofibrate has been reported to regulate lipid homeostasis and is involved in insulin secretion in pancr...
journal_title：Acta pharmacologica Sinica
pub_type： 杂志文章
doi：10.1111/j.1745-7254.2008.00717.x
更新日期：2008-04-01 00:00:00
