Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors.

abstract：AIM:Glucagon-like peptide-1 (GLP-1) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors can not only lower blood glucose levels, but also alleviate cardiac remodeling after myocardial ischemia and hypertension. In the present study, we investigated the effects of a DPP-4 inhibitor (linagliptin) and a GLP-1 activator...

journal_title：Acta pharmacologica Sinica

authors： Wang XW,Zhang FX,Yang F,Ding ZF,Agarwal N,Guo ZK,Mehta JL

更新日期：2016-09-01 00:00:00

abstract：AIM:To evaluate the nasal absorption enhancement of insulin by sodium deoxycholate (SDC) in combination with cyclodextrins (CD). METHODS:The concentration of glucose in blood was measured. Scanning electron microscopy technique was used to investigate the effect of enhancers on the nasal mucocilia. The effect of SDC i...

journal_title：Acta pharmacologica Sinica

authors： Zhang Y,Jiang XG,Yao J

更新日期：2001-11-01 00:00:00

abstract：AIM:Epigallocatechin-3-gallate (EGCG) is the major polyphenolic constituent in green tea. The aim of this study is to investigate the effects of EGCG on proliferation and migration of the human colon cancer SW620 cells. METHODS:Proliferation and migration of SW620 cells were induced by the protease-activated receptor ...

journal_title：Acta pharmacologica Sinica

authors： Zhou F,Zhou H,Wang T,Mu Y,Wu B,Guo DL,Zhang XM,Wu Y

更新日期：2012-01-01 00:00:00

abstract：AIM:The current therapeutic approaches have a limited effect on the dysregulated pulmonary vascular remodeling, which is characteristic of pulmonary arterial hypertension (PAH). In this study we examined whether salvianolic acid A (SAA) extracted from the traditional Chinese medicine 'Dan Shen' attenuated vascular remo...

journal_title：Acta pharmacologica Sinica

authors： Chen YC,Yuan TY,Zhang HF,Wang DS,Yan Y,Niu ZR,Lin YH,Fang LH,Du GH

更新日期：2016-06-01 00:00:00

abstract：:Type capital I, Ukrainian natural killer T cells (NKT cells), a subset of CD1d-restricted T cells with invariant Valphabeta TCR, are characterized by prompt production of large amounts of Th1 and/or Th2 cytokines upon primary stimulation through the TCR complex. The rapid release of cytokines implies that type capital...

journal_title：Acta pharmacologica Sinica

authors： Tan JQ,Xiao W,Wang L,He YL

更新日期：2010-09-01 00:00:00

abstract：AIM:To explore the action mechanism of antidepressants. METHODS:The PC12 cell proliferation was detected by flow cytometry. The proliferation of hippocampal progenitor cells and level of brain-derived neurotrophic factor (BDNF) were measured by immunohistochemistry. RESULTS:Treatment with N-methylaspartate (NMDA) 600...

journal_title：Acta pharmacologica Sinica

authors： Li YF,Zhang YZ,Liu YQ,Wang HL,Yuan L,Luo ZP

更新日期：2004-11-01 00:00:00

abstract：:Single-target drugs have not achieved satisfactory therapeutic effects for complex diseases involving multiple factors. Instead, innovations in recent drug research and development have revealed the emergence of compound drugs, such as cocktail therapies and "polypills", as the frontier in new drug development. A trad...

journal_title：Acta pharmacologica Sinica

authors： Zhang JH,Zhu Y,Fan XH,Zhang BL

更新日期：2015-06-01 00:00:00

abstract：AIM:To study the effect of new antihepatitis drug, bicyclol, on the metabolism and hepatotoxicity of aflatoxin B1 (AFB1) in rats. METHODS:Rats were given bicyclol 300 mg/kg/d ig for 3 d and then injected ip with AFB1 1.5 mg/kg. Liver damages were examined 16 h after ip AFB1. The in vitro metabolism of AFB1 by bicyclol...

journal_title：Acta pharmacologica Sinica

authors： Lu H,Li Y

更新日期：2002-10-01 00:00:00

abstract：AIM:To investigate the effect of ectogenesis unsaturated fatty acid on carbachol-induced muscarinic current (ICCh) and its mechanism. METHODS:Using the whole-cell patch-clamp technique, ICCh was recorded in single smooth muscle cell isolated from the antral circular smooth muscles of guinea-pig stomach. RESULTS:Arach...

journal_title：Acta pharmacologica Sinica

authors： Cui YF,Jin H,Guo HS,Li L,Yu YC,Xu WX

更新日期：2003-03-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is among the most lethal of human malignancies. During human multistep hepatocarcinogenesis, genomic gain represents an important mechanism in the activation of proto-oncogenes. In many circumstances, activated oncogenes hold clinical implications both as prognostic markers and targets f...

journal_title：Acta pharmacologica Sinica

authors： Chen L,Chan TH,Guan XY

更新日期：2010-09-01 00:00:00

abstract：AIM:To study the effect of chloroquine on the expression of human clotting factor IX (hFIX) in mice. METHODS:Hydrodynamics-based naked DNA plasmid administration was performed by tail vein injection of 10 microg of pCMV- hFIX and chloroquine (0, 100, 200, and 500 micromol/L) in 2.2 mL of Ringer's solution within 6-7 s...

journal_title：Acta pharmacologica Sinica

authors： Chen HY,Zhu HZ,Lu B,Xu X,Yao JH,Shen Q,Xue JL

更新日期：2004-05-01 00:00:00

abstract：AIM:The aim of the study was to evaluate the outcome of adenovirus-mediated p27(KIP1) (Ad-p27) expression on wound healing after filtration surgery and to investigate the inhibition of cell proliferation induced by Ad-p27. METHODS:We constructed the adenovirus recombinant vector Ad-p27 and administered it to a rabbit ...

journal_title：Acta pharmacologica Sinica

authors： Yang JG,Sun NX,Cui LJ,Wang XH,Feng ZH

更新日期：2009-04-01 00:00:00

abstract：:Anlotinib is a new oral tyrosine kinase inhibitor; this study was designed to characterize its pharmacokinetics and disposition. Anlotinib was evaluated in rats, tumor-bearing mice, and dogs and also assessed in vitro to characterize its pharmacokinetics and disposition and drug interaction potential. Samples were ana...

journal_title：Acta pharmacologica Sinica

authors： Zhong CC,Chen F,Yang JL,Jia WW,Li L,Cheng C,Du FF,Zhang SP,Xie CY,Zhang NT,Olaleye OE,Wang FQ,Xu F,Lou LG,Chen DY,Niu W,Li C

更新日期：2018-06-01 00:00:00

abstract：AIM:To study wound healing activity of the human placental extract (HPE) in rats. METHODS:Full thickness wounds were inflicted on depilated dorsum of Charles foster rats with 8 mm Acu-punch biopsy. The HPE was applied both at topical and im routes (2.5 mL/kg). Effects were compared on the basis of physical criteria, b...

journal_title：Acta pharmacologica Sinica

authors： Biswas TK,Auddy B,Bhattacharya NP,Bhattacharya S,Mukherjee B

更新日期：2001-12-01 00:00:00

abstract：AIM:To examine the effect of curcumin on oxidative DNA damage and cell apoptosis and injury caused by the reaction of methylglyoxal(MG) with amino acids. METHODS:We used DNA strand breaks to examine the effect of curcumin on oxidative DNA damage. In addition, reactive oxygen species(ROS) formation occurs in MG-treated...

journal_title：Acta pharmacologica Sinica

authors： Chan WH,Wu HJ

更新日期：2006-09-01 00:00:00

abstract：AIM:To investigate the protective effects of prostaglandin E(1) (PGE(1)) against H(2)O(2)-induced oxidative damage on human umbilical vein endothelial cells (HUVECs). METHODS:HUVECs were pretreated with PGE(1) (0.25, 0.50, and 1.00 micromol/L) for 24 h and exposed to H(2)O(2) (200 micromol/L) for 12 h, and cell viabil...

journal_title：Acta pharmacologica Sinica

authors： Fang WT,Li HJ,Zhou LS

更新日期：2010-04-01 00:00:00

abstract：AIM:Chinese medicine CGA formula consists of polysaccharide from Cordyceps sinensis mycelia (CS-PS), gypenosides and amygdalin, which is derived from Fuzheng Huayu (FZHY) capsule for treating liver fibrosis. In this study we attempted to confirm the therapeutic effects of CGA formula in dimethylnitrosamine (DMN)-induce...

journal_title：Acta pharmacologica Sinica

authors： Li XM,Peng JH,Sun ZL,Tian HJ,Duan XH,Liu L,Ma X,Feng Q,Liu P,Hu YY

更新日期：2016-06-01 00:00:00

abstract：AIM:To study the expressions of vascular endothelial growth factor (VEG F), angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), Tie-1, and Tie-2 in C57BL/6 mouse brain after permanent focal cerebral ischemia. METHODS:The mRNA levels of VEGF, Ang-1, Ang-2, Tie-1, and Tie-2 were measured by semiquantitative reverse transcri...

journal_title：Acta pharmacologica Sinica

authors： Wang RG,Zhu XZ

更新日期：2002-05-01 00:00:00

abstract：AIM:To investigate the effect of a group of novel synthetic dithiolane analogs of lignans and a well characterized platelet-activating factor (PAF) receptor antagonist, L659,989 on PAF-receptor binding, IFN-gamma- and lipopolysaccharide (LPS)-induced NO production, and steady-state inducible nitric-oxide synthase (iNOS...

journal_title：Acta pharmacologica Sinica

authors： Hussaini IM,Zhang YH,Lysiak JJ,Shen TY

更新日期：2000-10-01 00:00:00

abstract：:Herbal and dietary supplements (HDS)-induced liver injury has been a great concern all over the world. Polygonum multiflorum Thunb., a well-known Chinese herbal medicine, is recently drawn increasing attention because of its hepatotoxicity. According to the clinical and experimental studies, P. multiflorum-induced liv...

journal_title：Acta pharmacologica Sinica

authors： Rao T,Liu YT,Zeng XC,Li CP,Ou-Yang DS

更新日期：2021-01-01 00:00:00

abstract：:As the most powerful antigen-presenting cell type, dendritic cells (DCs) can induce potent antigen-specific immune responses in vivo, hence becoming optimal cell population for vaccination purposes. DCs can be derived ex vivo in quantity and manipulated extensively to be endowed with adequate immune-stimulating capaci...

journal_title：Acta pharmacologica Sinica

authors： Gu YZ,Zhao X,Song XR

更新日期：2020-07-01 00:00:00

abstract：:Top down central nervous system (CNS) influences on the immune system and bottom up immune system influences on the CNS take part in a complex feedforward and feedback loop which may be responsible for initiating events and perpetuating circumstances in the course of neuropsychiatric as well as immune system diseases....

journal_title：Acta pharmacologica Sinica

authors： Fricchione G,Daly R,Rogers MP,Stefano GB

更新日期：2001-07-01 00:00:00

abstract：AIM:To investigate the antidepressant-like effects of a novel 5-HT3 receptor antagonist N-(benzo[d]thiazol-2-yl)-3-methoxyquinoxalin-2-carboxamide (6z) in acute and chronic murine models of depression. METHODS:5-HT3 receptor antagonism was examined in guinea pig ileum in vitro. A tail suspension test (TST) was used as...

journal_title：Acta pharmacologica Sinica

authors： Gupta D,Radhakrishnan M,Kurhe Y,Thangaraj D,Prabhakar V,Kanade P

更新日期：2014-12-01 00:00:00

abstract：AIM:To investigate effects of CpG oligodeoxynucleotide (CpG ODN) on the mRNA expression of transcription factors GATA binding protein 3 (GATA-3) and T-box expressed in T cells (T-bet) in asthmatic mice. METHODS:An asthmatic mouse model was established and treated with CpG ODN. Total inflammatory cells and eosinophils ...

journal_title：Acta pharmacologica Sinica

authors： Wu ZQ,Xu YP,Xiang H,Shen HH

更新日期：2005-09-01 00:00:00

abstract：AIM:To investigate the protective effects of hydrogen sulfide (H2S) against inflammation, oxidative stress and apoptosis in a rat model of resuscitated hemorrhagic shock. METHODS:Hemorrhagic shock was induced in adult male SD rats by drawing blood from the femoral artery for 10 min. The mean arterial pressure was main...

journal_title：Acta pharmacologica Sinica

authors： Xu DQ,Gao C,Niu W,Li Y,Wang YX,Gao CJ,Ding Q,Yao LN,Chai W,Li ZC

更新日期：2013-12-01 00:00:00

abstract：AIM:Radiation-induced brain injury (RIBI) is the most common and severe adverse effect induced by cranial radiation therapy (CRT). In the present study, we examined the effects of the traditional Chinese medicine Shenqi Fuzheng Injection (SFI) on RIBI in mice, and explored the underlying mechanisms. METHODS:C57BL/6J m...

journal_title：Acta pharmacologica Sinica

authors： Zhang J,Tong F,Cai Q,Chen LJ,Dong JH,Wu G,Dong XR

更新日期：2015-11-01 00:00:00

abstract：AIM:Ischemia/reperfusion is an initial triggering event that leads to gut-induced acute lung injury (ALI). In this study, we investigated whether hypoxia inducible factor-1α (HIF-1α) played a role in the pathogenesis of lung injury induced by trauma and hemorrhagic shock (T/HS). METHODS:Male Wistar rats underwent lapa...

journal_title：Acta pharmacologica Sinica

authors： Jiang H,Huang Y,Xu H,Hu R,Li QF

更新日期：2012-05-01 00:00:00

abstract：AIM:To investigate the effects of 3-n-butylphthalide (NBP) on apoptosis induced by transient focal cerebral ischemia in rats, compare the action potency of s-(-)-, r-(+)- and (+/-)-NBP, and clarify the enantiomer that played a main role. METHODS:DNA fragmentation was detected by the terminal deoxynucleotidyl transfera...

journal_title：Acta pharmacologica Sinica

authors： Chang Q,Wang XL

更新日期：2003-08-01 00:00:00

abstract：:Conjugated polymer nanomaterials (CPNs), as optically and electronically active materials, hold promise for biomedical imaging and drug delivery applications. This review highlights the recent advances in the utilization of CPNs in theranostics. Specifically, CPN-based in vivo imaging techniques, including near-infrar...

journal_title：Acta pharmacologica Sinica

authors： Qian CG,Chen YL,Feng PJ,Xiao XZ,Dong M,Yu JC,Hu QY,Shen QD,Gu Z

更新日期：2017-06-01 00:00:00

abstract：AIM:To investigate the effects of onychin on the proliferation of cultured rat artery vascular smooth muscle cells (VSMCs) in the presence of 10% new-born calf serum (NCS). METHODS:Rat VSMCs were incubated with onychin 150 micromol/L or genistein 10 micromol/L in the presence of 10% NCS for 24 h. The proliferation of ...

journal_title：Acta pharmacologica Sinica

authors： Yang M,Huang HL,Zhu BY,Tuo QH,Liao DF

更新日期：2005-02-01 00:00:00