Conjugated polymer nanomaterials for theranostics.

abstract：AIM:To present the 4 to 9 years (median: 6 years) treatment follow up of 10 HIV1-AIDS patients, 9 at AIDS and 1 at A3 stages. METHODS:We have applied from 1992 to 1994, AZT combined with 2 integrase inhibitors, acriflavine and hydroxy-methyl-ellipticine. We could shift, in 1994, to combinations of 3 drugs including tw...

journal_title：Acta pharmacologica Sinica

authors： Mathe G,Morette C,Hallard M,Pontiggia P,Blanquet D,Hage F

更新日期：2002-01-01 00:00:00

abstract：AIM:To investigate the anticancer mechanism of a methoxyflavanone derivative, WJ9708012, highlighting its role on a crosstalk between endoplasmic reticulum (ER) and mitochondrial stress. METHODS:Cell proliferation was examined using sulforhodamine B assay. Cell-cycle progression, Ca(2+) mobilization and mitochondrial ...

journal_title：Acta pharmacologica Sinica

authors： Kuo TC,Huang WJ,Guh JH

更新日期：2011-01-01 00:00:00

abstract：AIM:To investigate whether histidine can enhance the anticonvulsant efficacy of carbamazepine (CBZ) and simultaneously improve the spatial memory impairment induced by transauricular kindled seizures in Sprague-Dawley rats. METHODS:Chronic transauricular kindling was induced by repeated application of initially subcon...

journal_title：Acta pharmacologica Sinica

authors： Li Q,Jin CL,Xu LS,Zhu-Ge ZB,Yang LX,Liu LY,Chen Z

更新日期：2005-11-01 00:00:00

abstract：AIM:To examine the therapeutic effects and underlying mechanisms of DZ2002, a reversible S-adenosyl-L-homocysteine hydrolase (SAHH) inhibitor, on lupus-prone female NZB×NZW F1 (NZB/W F1) mice. METHODS:Female NZB/W F1 mice were treated orally with DZ2002 (0.5 mg·kg(-1)·d(-1)) for 11 weeks, and the proteinuria level and...

journal_title：Acta pharmacologica Sinica

authors： He SJ,Lin ZM,Wu YW,Bai BX,Yang XQ,He PL,Zhu FH,Tang W,Zuo JP

更新日期：2014-02-01 00:00:00

abstract：AIM:To investigate the effect of the Tob1 gene, a member of the Transducing Molecule of ErbB2/B-cell Translocation Ggene (TOB/BTG) family, by using the adenovirus-mediated expression of Tob1 on radiosensitivity in a human breast cancer cell line MDA-MB-231. METHODS:Cell survival was determined by clonogenic assay. Apo...

journal_title：Acta pharmacologica Sinica

authors： Jiao Y,Ge CM,Meng QH,Cao JP,Tong J,Fan SJ

更新日期：2007-10-01 00:00:00

abstract：AIM:To study the influence of angiotensin (Ang) II receptor antagonist (AT1) valsartan and angiotensin-converting enzyme (ACE) inhibitor fosinopril on the cardiac hypertrophy induced by catecholamine. METHODS:A cardiac hypertrophy model was produced by i.p. norepinephrine (NE) 1.5 mg.kg-1.d-1 x 15 d. The animals were ...

journal_title：Acta pharmacologica Sinica

authors： Xiang Y,Huang J

更新日期：2000-09-01 00:00:00

abstract：AIM:To study the effects of 3-n-butylphthalide (NBP) on the TREK-1 channel expressed in Chinese hamster ovary (CHO) cells. METHODS:Whole-cell patch-clamp recording was used to record TREK-1 channel currents. The effects of varying doses of l-NBP on TREK-1 currents were also observed. Current-clamp recordings were perf...

journal_title：Acta pharmacologica Sinica

authors： Ji XC,Zhao WH,Cao DX,Shi QQ,Wang XL

更新日期：2011-02-01 00:00:00

abstract：AIM:To investigate the anticancer effect of crocetin, a major ingredient in saffron, and its underlying mechanisms. METHODS:Cervical cancer cell line HeLa, non-small cell lung cancer cell line A549 and ovarian cancer cell line SKOV3 were treated with crocetin alone or in combination with vincristine. Cell proliferatio...

journal_title：Acta pharmacologica Sinica

authors： Zhong YJ,Shi F,Zheng XL,Wang Q,Yang L,Sun H,He F,Zhang L,Lin Y,Qin Y,Liao LC,Wang X

更新日期：2011-12-01 00:00:00

abstract：AIM:To determine the Ca2+ source and cellular mechanisms of spontaneous Ca2+ oscillations in hippocampal astrocytes. METHODS:The cultured cells were loaded with Fluo-4 AM, the indicator of intracellular Ca2+, and the dynamic Ca2+ transients were visualized with confocal laser-scanning microscopy. RESULTS:The spontane...

journal_title：Acta pharmacologica Sinica

authors： Wang TF,Zhou C,Tang AH,Wang SQ,Chai Z

更新日期：2006-07-01 00:00:00

abstract：AIM:To investigate the prevalence of hepatitis B virus (HBV) genotype mixtures among patients with chronic hepatitis B (CHB) in Eastern China. METHODS:A total of 4908 chronic HBV patients from Eastern China were enrolled. HBV genotypes and subgenotypes were determined using a multiplex PCR technique. Serum viral loads...

journal_title：Acta pharmacologica Sinica

authors： Zhong J,Gao YQ,Sun XH,Zhu XJ,Li M

更新日期：2012-10-01 00:00:00

abstract：:Cocaine is one of the most abused illicit drugs worldwide. It is well known that the dopamine (DA) transporter is its major target; but cocaine also acts on other targets including nicotinic acetylcholine receptors (nAChRs). In this study, we investigated the effects of cocaine on a special subtype of neuronal nAChR, ...

journal_title：Acta pharmacologica Sinica

authors： Ma ZG,Jiang N,Huang YB,Ma XK,Brek Eaton J,Gao M,Chang YC,Lukas RJ,Whiteaker P,Neisewander J,Wu J

更新日期：2020-02-01 00:00:00

abstract：AIM:To investigate whether IL-12p40 plays a crucial role in regulating islet allograft rejection in a streptozotocin (STZ)-induced diabetes mouse model. METHODS:C57BL/6 and IL-12p40 gene knockout mice were selected as recipient mice, to which the diabetes was induced with a treatment of STZ (150-200 mg/kg) by a single...

journal_title：Acta pharmacologica Sinica

authors： Bi EG,Shi W,Zou J,Hao ZH,Li ZH,Cai D,Zhang HQ,Sun B

更新日期：2006-08-01 00:00:00

abstract：AIM:To investigate the blood pressure (BP), baroreflex sensitivity (BRS), and organ damage in hybrids of spontaneously hypertensive rats and Sprague-Dawley rats. METHODS:Spontaneously hypertensive rats and Sprague-Dawley rats were crossbred, and the F1 hybrids were inbred randomly to produce an F2 generation. At the a...

journal_title：Acta pharmacologica Sinica

authors： Xie HH,Shen FM,Miao CY,Su DF

更新日期：2005-09-01 00:00:00

abstract：AIM:To study the synaptic mechanisms involved in the 5-hydroxytryptamine1A/7 (5-HT1A/7) receptor-mediated reflex control of cardiac vagal preganglionic neurons (CVPN). METHODS:CVPN were retrogradely labeled and identified in brain stem slices of newborn rats, and their synaptic activity was examined using whole-cell p...

journal_title：Acta pharmacologica Sinica

authors： Chen YH,Hou LL,Wang JJ

更新日期：2008-05-01 00:00:00

abstract：AIM:To study the inhibitory effect of general gambogic acids (GGA) on transplantation tumor SMMC-7721 in experimental animal model and SMMC-7721 cells in vitro. METHODS:Anti-tumor activity of GGA in the experimental transplantation tumor SMMC-7721 was evaluated by relative tumor growth ratio. Cell morphology was obser...

journal_title：Acta pharmacologica Sinica

authors： Guo QL,You QD,Wu ZQ,Yuan ST,Zhao L

更新日期：2004-06-01 00:00:00

abstract：:For follicular lymphoma (FL) with grade 1/2, the complete response (CR) rate of the first-line R-CHOP treatment was significantly low. In this study, we assessed the rationality of the administration of rituximab for FL patients with grade 1/2 based on concentration-response relationship analyses. Thus, we conducted a...

journal_title：Acta pharmacologica Sinica

authors： Liu S,Huang H,Chen RX,Wang Z,Guan YP,Peng C,Fang XJ,Chen ZJ,Guan SX,Zhu X,Ren QG,Yao YY,Huang HB,Huang M,Wang XD,Lin TY

更新日期：2020-07-31 00:00:00

abstract：:The signal transducer and activator of transcription 3 (STAT3) plays a critical role in platelet functions. This study sought to understand the effects of the STAT3 inhibitor SC99 on platelet activation and aggregation. Immunoblotting assays were applied to measure the effects of SC99 on the STAT3 signaling pathway. A...

journal_title：Acta pharmacologica Sinica

authors： Xu Z,Xu YJ,Hao YN,Ren LJ,Zhang ZB,Xu X,Cao BY,Dai KS,Zhu L,Fang Q,Kong Y,Mao XL

更新日期：2017-05-01 00:00:00

abstract：AIM:To determine propofol concentration in the cerebral spinal fluid (CSF) of neurosurgical patients and carry out a preliminary population pharmacodynamic study. METHODS:Twenty-seven elective neurosurgical patients (12 men and 15 women) aged 17-74 years received propofol in a bolus dose of 2 mg/kg for 5 min and an in...

journal_title：Acta pharmacologica Sinica

authors： Li YH,Wu FS,Xu JG

更新日期：2006-05-01 00:00:00

abstract：AIM:Aquaporins (AQPs) are the water-channels that play important roles in brain water homeostasis and in cerebral edema induced by brain injury. In this study we investigated the relationship between AQPs and a neuroprotective agent curcumin that was effective in the treatment of brain edema in mice with intracerebral ...

journal_title：Acta pharmacologica Sinica

authors： Wang BF,Cui ZW,Zhong ZH,Sun YH,Sun QF,Yang GY,Bian LG

更新日期：2015-08-01 00:00:00

abstract：AIM:To investigate the immunoregulatory functions of water extracts of Hericium erinaceum (WEHE) focusing on natural killer (NK) cell-based anticancer activities. METHODS:Mouse splenocytes or purely isolated NK cells were stimulated with 1-100 mg/L WEHE for 24 h followed by co-culture with (51)Cr-labeled Yac-1 cells f...

journal_title：Acta pharmacologica Sinica

authors： Yim MH,Shin JW,Son JY,Oh SM,Han SH,Cho JH,Cho CK,Yoo HS,Lee YW,Son CG

更新日期：2007-06-01 00:00:00

abstract：AIM:To investigate the stereoselective metabolism of propafenone (PPF) by human liver CYP3A4. METHODS:A chiral and an achiral HPLC were combined to determine the enantiomer of PPF in S9 incubates prepared from transgenic Chinese hamster CHL cells lines expressing CYP3A4. The time-dependent study was performed using in...

journal_title：Acta pharmacologica Sinica

authors： Zhou Q,Yao TW,Yu YN,Zeng S

更新日期：2001-10-01 00:00:00

abstract：AIM:To investigate the effect of a group of novel synthetic dithiolane analogs of lignans and a well characterized platelet-activating factor (PAF) receptor antagonist, L659,989 on PAF-receptor binding, IFN-gamma- and lipopolysaccharide (LPS)-induced NO production, and steady-state inducible nitric-oxide synthase (iNOS...

journal_title：Acta pharmacologica Sinica

authors： Hussaini IM,Zhang YH,Lysiak JJ,Shen TY

更新日期：2000-10-01 00:00:00

abstract：AIM:To investigate the mitochondria-initiated apoptosis pathway involved in Carbon tetrachloride (CCl4) hepatotoxicity in vitro. METHODS:Several cytotoxicity endpoints, including WST-8 metabolism, lactate dehydrogenase leakage and morphological changes, were examined. The 5,5'-dithio-bis(2-nitrobenzoic acid) reaction ...

journal_title：Acta pharmacologica Sinica

authors： Cai Y,Gong LK,Qi XM,Li XH,Ren J

更新日期：2005-08-01 00:00:00

abstract：:The revolutionary induced pluripotent stem cell (iPSC) technology provides a new path for cell replacement therapies and drug screening. Patient-specific iPSCs and subsequent differentiated cells manifesting disease phenotypes will finally position human disease pathology at the core of drug discovery. Cells used to t...

journal_title：Acta pharmacologica Sinica

authors： Zhang R,Zhang LH,Xie X

更新日期：2013-06-01 00:00:00

abstract：:Midbrain dopaminergic (DA) neurons are governed by an endogenous cholinergic system, originated in the mesopontine nuclei. Nicotine hijacks nicotinic acetylcholine receptors (nAChRs) and interferes with physiological function of the cholinergic system. In this review, we describe the anatomical organization of the cho...

journal_title：Acta pharmacologica Sinica

authors： Xiao C,Zhou CY,Jiang JH,Yin C

更新日期：2020-01-01 00:00:00

abstract：AIM:To explore the action of doxorubicin on vascular smooth muscle cells. METHODS:Isometric tension of denuded or intact thoracic aortic vessels was recorded and [Ca(2+)](i) in isolated aortic smooth muscle cells was measured by using Fluo-3. RESULTS:Doxorubicin induced phasic and tonic contractions in denuded vessel...

journal_title：Acta pharmacologica Sinica

authors： Shen B,Ye CL,Ye KH,Zhuang L,Jiang JH

更新日期：2009-11-01 00:00:00

abstract：AIM:To investigate the mechanisms underlying the isomer-selective distribution of 3-n-butylphthalide (NBP) hydroxylated metabolites, 3-hydroxy-NBP (3-OH-NBP) and 10-hydroxy-NBP (10-OH-NBP), across the blood brain barrier (BBB). METHODS:After oral administration of NBP (20 mg/kg) to rats, the pharmacokinetics of two ma...

journal_title：Acta pharmacologica Sinica

authors： Diao XX,Zhong K,Li XL,Zhong DF,Chen XY

更新日期：2015-12-01 00:00:00

abstract：AIM:To investigate the effects of the cardiotonic steroid, ouabain, on cardiac differentiation of murine embyronic stem cells (mESCs). METHODS:Cardiac differentiation of murine ESCs was enhanced by standard hanging drop method in the presence of ouabain (20 μmol/L) for 7 d. The dissociated ES derived cardiomyocytes we...

journal_title：Acta pharmacologica Sinica

authors： Lee YK,Ng KM,Lai WH,Man C,Lieu DK,Lau CP,Tse HF,Siu CW

更新日期：2011-01-01 00:00:00

abstract：AIM:Ischemia/reperfusion is an initial triggering event that leads to gut-induced acute lung injury (ALI). In this study, we investigated whether hypoxia inducible factor-1α (HIF-1α) played a role in the pathogenesis of lung injury induced by trauma and hemorrhagic shock (T/HS). METHODS:Male Wistar rats underwent lapa...

journal_title：Acta pharmacologica Sinica

authors： Jiang H,Huang Y,Xu H,Hu R,Li QF

更新日期：2012-05-01 00:00:00

abstract：:Tobacco use is estimated to be the largest single cause of premature death in the world. Nicotine is the major addictive substance in tobacco products. After cigarette smoking, nicotine quickly acts on its target, nicotinic acetylcholine receptors (nAChRs), which are widely distributed throughout the mammalian central...

journal_title：Acta pharmacologica Sinica

authors： Wu J

更新日期：2010-09-01 00:00:00