Wound healing activity of human placental extracts in rats.

Abstract:

AIM:To study wound healing activity of the human placental extract (HPE) in rats. METHODS:Full thickness wounds were inflicted on depilated dorsum of Charles foster rats with 8 mm Acu-punch biopsy. The HPE was applied both at topical and im routes (2.5 mL/kg). Effects were compared on the basis of physical criteria, biochemical criteria, and histopathological study with respect to untreated control, vehicle control (1.5 % benzyl alcohol), and framycetin topical treated groups. RESULTS:Significant lowering of wound size (P<0.05), wound index (P<0.05), and number of days required for complete healing (P<0.01); significant gain in tensile strength (P<0.01); appreciable increase of tissue DNA, total protein, and collagenesis were observed in HPE treated group. CONCLUSION:Human placental extract systematically helps collagenesis leading to potent healing of wounds.

journal_name

Acta Pharmacol Sin

authors

Biswas TK,Auddy B,Bhattacharya NP,Bhattacharya S,Mukherjee B

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

1113-6

issue

12

eissn

1671-4083

issn

1745-7254

journal_volume

22

pub_type

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