Chromosome 1q21 amplification and oncogenes in hepatocellular carcinoma.

abstract：AIM:To study the effects of tanshinone IIA (TIIA) on lipopolysaccharide (LPS)-induced acute lung injury in mice and the underlying mechanisms. METHODS:Mice were injected with LPS (10 mg/kg, i.p.), then treated with TIIA (10 mg/kg, i.p.). Seven hours after LPS injection, the lungs were collected for histological study....

journal_title：Acta pharmacologica Sinica

authors： Xu M,Cao FL,Zhang YF,Shan L,Jiang XL,An XJ,Xu W,Liu XZ,Wang XY

更新日期：2015-02-01 00:00:00

abstract：AIM:To investigate the ultrastructural localization of atrial natriuretic peptide (ANP)-synthesizing cells and the relationship between ANP-synthesizing cells and microvessels in rat gastric mucosa. METHODS:Immunohistochemistry techniques and postembedding immunoelectron microscopy techniques were used to validate the...

journal_title：Acta pharmacologica Sinica

authors： Li CH,Yang ZW,Yin ZR,Jin Z,Xing DG,Piao LH,Kim YC,Xu WX

更新日期：2006-02-01 00:00:00

abstract：AIM:To determine whether mycophenolate mofetil (MMF) has beneficial effects on refractory idiopathic thrombocytopenic purpura (ITP) and the corresponding cellular mechanism. METHODS:Twenty refractory ITP patients resistant to corticosteroid and/or splenectomy and chemical therapy were given MMF 1.5-2.0 g/d orally for ...

journal_title：Acta pharmacologica Sinica

authors： Zhang WG,Ji L,Cao XM,Chen YX,He AL,Liu J,Zhao WH,Zou SP

更新日期：2005-05-01 00:00:00

abstract：AIM:To study the stereoselectivity in pharmacokinetics of the enantiomers of trans-tramadol (trans-T) and its active metabolite, trans-O-demethyltramadol (M1) in human subjects. METHODS:Trans-T hydrochloride sustained-release tablets were taken orally by 12 healthy male volunteers. After a multiple dosage schedule, th...

journal_title：Acta pharmacologica Sinica

authors： Liu HC,Liu TJ,Yang YY,Hou YN

更新日期：2001-01-01 00:00:00

abstract：AIM:To isolate the G4 and G1 molecular forms of acetylcholinesterase in rat cortex for interpreting the therapeutical effect of the AChE inhibitor drugs. METHODS:Size exclusion chromatography and ultracentrifugation were used to isolate and ascertain the G4 and G1 molecular forms of AChE. RESULTS:After size exclusion...

journal_title：Acta pharmacologica Sinica

authors： Zhao Q,Tang XC

更新日期：2002-02-01 00:00:00

abstract：AIM:To examine if steroid-like compounds found in many Chinese medicinal products conventionally used for the promotion of blood circulation may act as active components via the same molecular mechanism triggered by cardiac glycosides, such as ouabain. METHODS:The inhibitory potency of ouabain and the identified stero...

journal_title：Acta pharmacologica Sinica

authors： Chen RJ,Chung TY,Li FY,Yang WH,Jinn TR,Tzen JT

更新日期：2010-06-01 00:00:00

abstract：:A variety of Ca2+ signals, in the form of intercellular pulses and waves, have been reported to be associated with the various sequential stages of somitogenesis: from convergent extension and the formation of the paraxial mesoderm; during the patterning of the paraxial mesoderm to establish segmental units; throughou...

journal_title：Acta pharmacologica Sinica

authors： Webb SE,Miller AL

更新日期：2006-07-01 00:00:00

abstract：AIM:To study the effects of cimetidine (Cim) on the production of interferon gamma (IFN gamma) and tumor necrosis factor alpha (TNF alpha) by splenocytes in immune-derived aplastic anemic (AA) mice. METHODS:Aplastic anemic mice model was constructed first, and then the splenocytes were induced to secrete IFN gamma and...

journal_title：Acta pharmacologica Sinica

authors： Xia T,Wang QR,Xu YH

更新日期：2001-03-01 00:00:00

abstract：AIM:Oral risedronate is effective in the treatment of postmenopausal osteoporosis when administered daily, weekly, or monthly. In this 1-year, randomized, double-blind, multicenter study we compared the weekly 35-mg and daily 5-mg risedronate dosing regimens in the treatment of Chinese postmenopausal women with osteopo...

journal_title：Acta pharmacologica Sinica

authors： Gu JM,Wang L,Lin H,Chen DC,Tang H,Jin XL,Xia WB,Hu YQ,Fu WZ,He JW,Zhang H,Wang C,Yue H,Hu WW,Liu YJ,Zhang ZL

更新日期：2015-07-01 00:00:00

abstract：:Lactoferrin (Lf) is an iron-binding glycoprotein of the transferrin family, which is expressed in most biological fluids with particularly high levels in mammalian milk. Its multiple activities lie in its capacity to bind iron and to interact with the molecular and cellular components of hosts and pathogens. Lf can bi...

journal_title：Acta pharmacologica Sinica

authors： Siqueiros-Cendón T,Arévalo-Gallegos S,Iglesias-Figueroa BF,García-Montoya IA,Salazar-Martínez J,Rascón-Cruz Q

更新日期：2014-05-01 00:00:00

abstract：AIM:To investigate the effect of incorporation of an isoleucine zipper (IZ) motif into CD40 on binding activity of CD40 for the CD40 ligand (CD40L). METHODS:Prokaryotic expression vectors for 2 soluble CD40 derivatives, shCD40His and shCD40IZ containing an IZ domain, were constructed and expressed in Escherichia coli....

journal_title：Acta pharmacologica Sinica

authors： He XH,Xu LH,Liu Y

更新日期：2006-03-01 00:00:00

abstract：:Autophagy, a form of cellular self-digestion by lysosome, is associated with various disease processes including cancers, and modulating autophagy has shown promise in the treatment of various malignancies. A number of natural products display strong antitumor activity, yet their mechanisms of action remain unclear. T...

journal_title：Acta pharmacologica Sinica

authors： Jiang SL,Guan YD,Chen XS,Ge P,Wang XL,Lao YZ,Xiao SS,Zhang Y,Yang JM,Xu XJ,Cao DS,Cheng Y

更新日期：2019-07-01 00:00:00

abstract：:Oral administration of curcumin has been shown to inhibit pulmonary fibrosis (PF) despite its extremely low bioavailability. In this study, we investigated the mechanisms underlying the anti-PF effect of curcumin in focus on intestinal endocrine. In bleomycin- and SiO2-treated mice, curcumin (75, 150 mg· kg-1 per day)...

journal_title：Acta pharmacologica Sinica

authors： Miao YM,Zhang YJ,Qiao SM,Xia YF,Wei ZF,Dai Y

更新日期：2020-07-21 00:00:00

abstract：AIM:To explore the action of doxorubicin on vascular smooth muscle cells. METHODS:Isometric tension of denuded or intact thoracic aortic vessels was recorded and [Ca(2+)](i) in isolated aortic smooth muscle cells was measured by using Fluo-3. RESULTS:Doxorubicin induced phasic and tonic contractions in denuded vessel...

journal_title：Acta pharmacologica Sinica

authors： Shen B,Ye CL,Ye KH,Zhuang L,Jiang JH

更新日期：2009-11-01 00:00:00

abstract：AIM:To investigate the mitochondria-initiated apoptosis pathway involved in Carbon tetrachloride (CCl4) hepatotoxicity in vitro. METHODS:Several cytotoxicity endpoints, including WST-8 metabolism, lactate dehydrogenase leakage and morphological changes, were examined. The 5,5'-dithio-bis(2-nitrobenzoic acid) reaction ...

journal_title：Acta pharmacologica Sinica

authors： Cai Y,Gong LK,Qi XM,Li XH,Ren J

更新日期：2005-08-01 00:00:00

abstract：AIM:High mobility group box protein 1 (HMGB1) and receptor for the advanced glycation end product (RAGE) play pivotal roles in vascular inflammation and atherosclerosis. The aim of this study was to determine whether the HMGB1-RAGE axis was involved in the actions of simvastatin on vascular inflammation and atheroscler...

journal_title：Acta pharmacologica Sinica

authors： Liu M,Yu Y,Jiang H,Zhang L,Zhang PP,Yu P,Jia JG,Chen RZ,Zou YZ,Ge JB

更新日期：2013-06-01 00:00:00

abstract：AIM:To investigate the effects of deferiprone on doxorubicin-induced cardiotoxicity and determine its protection on cardiac contractility in vivo at tissue level. METHODS:Spontaneously-beating isolated atria from rats were pretreated with deferiprone for 10 min at 1.2 mmol/L or 0.3 mmol/L, respectively before co-incub...

journal_title：Acta pharmacologica Sinica

authors： Xu LJ,Jin L,Pan H,Zhang AZ,Wei G,Li PP,Lu WY

更新日期：2006-10-01 00:00:00

abstract：AIM:To investigate the effects of different muscarinic receptor (M) subtypes in the spinal cord on the scores of naloxone-precipitated morphine-withdrawal symptoms and the changes of nNOS expression in locus coeruleus (LC). METHODS:nNOS immunohistochemistry, intrathecal injection (it), and antisense oligonucleotides (...

journal_title：Acta pharmacologica Sinica

authors： Chou WB,Zeng YM,Duan SM,Zhou WH,Gu J,Yang GD

更新日期：2002-08-01 00:00:00

abstract：AIM:To investigate the role of CYP2E1 in isoniazid (INH)-induced hepatotoxicity and the influence of rifampicin (RFP) on INH-induced liver injury. METHODS:Rats were treated with INH alone (100 mg/kg, ip) or co-administered with RFP (100 mg/kg, ig) for 10 d and 21 d. Hepatotoxicity was assayed by plasma enzymes (sALT, ...

journal_title：Acta pharmacologica Sinica

authors： Yue J,Peng RX,Yang J,Kong R,Liu J

更新日期：2004-05-01 00:00:00

abstract：AIM:Filamin binding LIM protein 1, also known as migfilin, is a skeleton organization protein that binds to mitogen-inducible gene 2 at cell-extracellular matrix adhesions. The aim of this study was to investigate the role of migfilin in cisplatin-induced apoptosis in human glioma cells, to determine the functional dom...

journal_title：Acta pharmacologica Sinica

authors： Fan J,Ou YW,Wu CY,Yu CJ,Song YM,Zhan QM

更新日期：2012-10-01 00:00:00

abstract：AIM:To investigate the expression of advanced glycation end products (AGEs) and their receptor RAGE in the livers and blood vessels of rats with non-alcoholic steatohepatitis (NASH) and the effect of pentoxifylline (PTX) on liver and artery function in rats with NASH. METHODS:Sprague-Dawley rats were fed a high-fat di...

journal_title：Acta pharmacologica Sinica

authors： Wu J,Zhao MY,Zheng H,Zhang H,Jiang Y

更新日期：2010-10-01 00:00:00

abstract：:Pre-B-cell leukemia transcription factor 3 (PBX3) is a member of the PBX family and contains a highly conserved homologous domain. PBX3 is involved in the progression of gastric cancer, colorectal cancer, and prostate cancer; however, the detailed mechanism by which it promotes tumor growth remains to be elucidated. H...

journal_title：Acta pharmacologica Sinica

authors： Li WF,Herkilini A,Tang Y,Huang P,Song GB,Miyagishi M,Kasim V,Wu SR

更新日期：2021-02-01 00:00:00

abstract：AIM:To investigate the mechanism of action of a potent analgesic, (+/-)-meptazinol. METHODS:The structures of meptazinol enantiomers were compared with opioid pharmacophore and tramadol. RESULTS:Neither enantiomer of meptazinol fitted any patterns among the opioid pharmacophore and tramadol, although they did share s...

journal_title：Acta pharmacologica Sinica

authors： Li W,Hao JL,Tang Y,Chen Y,Qiu ZB

更新日期：2005-03-01 00:00:00

abstract：AIM:To study the changes and mechanisms of protein-tyrosine kinase (PTK) and protein-tyrosine phosphatase (PTP) activities in the hippocamal synaptosome following cerebral ischemia/reperfusion (I/R) in gerbil. METHODS:Transient (15 min) global ischemia was produced by bilateral carotid artery occlusion. Total PTK and ...

journal_title：Acta pharmacologica Sinica

authors： Pei L,Li Y,Yan JZ,Zhang GY,Cui ZC,Zhu ZM

更新日期：2000-08-01 00:00:00

abstract：:Brain and eye tissues are subject to a reduced version of immune surveillance, which has evolved to protect the particularly sensitive tissues from accidental bystander damage created by regular inflammatory responses. Yet, there are autoimmune diseases in both organs. This review discusses the nature of immune reacti...

journal_title：Acta pharmacologica Sinica

authors： Wekerle H,Sun DM

更新日期：2010-09-01 00:00:00

abstract：AIM:To investigate the actions of the muscarinic agonist carbachol on glutamate-induced neurotoxicity in PC12 cells, and the underlying mechanisms. METHODS:PC12 cells were treated with different concentrations of glutamate for 24 or 48 h. The cell viability was measured using MTT assay, and the expression and activati...

journal_title：Acta pharmacologica Sinica

authors： Ma K,Yang LM,Chen HZ,Lu Y

更新日期：2013-07-01 00:00:00

abstract：AIM:To investigate the protective effects of hydrogen sulfide (H2S) against inflammation, oxidative stress and apoptosis in a rat model of resuscitated hemorrhagic shock. METHODS:Hemorrhagic shock was induced in adult male SD rats by drawing blood from the femoral artery for 10 min. The mean arterial pressure was main...

journal_title：Acta pharmacologica Sinica

authors： Xu DQ,Gao C,Niu W,Li Y,Wang YX,Gao CJ,Ding Q,Yao LN,Chai W,Li ZC

更新日期：2013-12-01 00:00:00

abstract：AIM:To study the effect of new antihepatitis drug, bicyclol, on the metabolism and hepatotoxicity of aflatoxin B1 (AFB1) in rats. METHODS:Rats were given bicyclol 300 mg/kg/d ig for 3 d and then injected ip with AFB1 1.5 mg/kg. Liver damages were examined 16 h after ip AFB1. The in vitro metabolism of AFB1 by bicyclol...

journal_title：Acta pharmacologica Sinica

authors： Lu H,Li Y

更新日期：2002-10-01 00:00:00

abstract：AIM:To investigate the anticancer effect of crocetin, a major ingredient in saffron, and its underlying mechanisms. METHODS:Cervical cancer cell line HeLa, non-small cell lung cancer cell line A549 and ovarian cancer cell line SKOV3 were treated with crocetin alone or in combination with vincristine. Cell proliferatio...

journal_title：Acta pharmacologica Sinica

authors： Zhong YJ,Shi F,Zheng XL,Wang Q,Yang L,Sun H,He F,Zhang L,Lin Y,Qin Y,Liao LC,Wang X

更新日期：2011-12-01 00:00:00

abstract：:Activation of the Ca2+/calmodulin-dependent protein kinase II isoform δA (CaMKIIδA) disturbs intracellular Ca2+ homeostasis in cardiomyocytes during chronic heart failure (CHF). We hypothesized that upregulation of CaMKIIδA in cardiomyocytes might enhance Ca2+ leak from the sarcoplasmic reticulum (SR) via activation o...

journal_title：Acta pharmacologica Sinica

authors： Gui L,Guo X,Zhang Z,Xu H,Ji YW,Wang RJ,Zhu JH,Chen QH

更新日期：2018-10-01 00:00:00