Fragile privileges: autoimmunity in brain and eye.

abstract：AIM:Glucagon-like peptide-1 (GLP-1) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors can not only lower blood glucose levels, but also alleviate cardiac remodeling after myocardial ischemia and hypertension. In the present study, we investigated the effects of a DPP-4 inhibitor (linagliptin) and a GLP-1 activator...

journal_title：Acta pharmacologica Sinica

authors： Wang XW,Zhang FX,Yang F,Ding ZF,Agarwal N,Guo ZK,Mehta JL

更新日期：2016-09-01 00:00:00

abstract：AIM:To investigate the influence of trimetazidine, which is known to be an antioxidant and modulator of metabolism, on cardiac function and the development of diabetic cardiomyopathy in db/db mouse. METHODS:Trimetazidine was administered to db/db mice for eight weeks. Cardiac function was measured by inserting a Milla...

journal_title：Acta pharmacologica Sinica

authors： Li YJ,Wang PH,Chen C,Zou MH,Wang DW

更新日期：2010-05-01 00:00:00

abstract：AIM:To examine the anti-cancer effects of chamaejasmenin B and neochamaejasmin C, two biflavonones isolated from the root of Stellera chamaejasme L (known as the traditional Chinese herb Rui Xiang Lang Du) in vitro. METHODS:Human liver carcinoma cell lines (HepG2 and SMMC-7721), a human non-small cell lung cancer cell...

journal_title：Acta pharmacologica Sinica

authors： Zhang C,Zhou SS,Feng LY,Zhang DY,Lin NM,Zhang LH,Pan JP,Wang JB,Li J

更新日期：2013-02-01 00:00:00

abstract：:Liver fibrosis is excessive accumulation of extracellular matrix proteins that results from various chronic liver diseases. Hepatic stellate cells (HSCs) play an essential role in the pathogenesis of liver fibrosis. Danggui Buxue Tang (DBT) is a classic formula of Chinese traditional medicine. We previously showed tha...

journal_title：Acta pharmacologica Sinica

authors： Guo T,Liu ZL,Zhao Q,Zhao ZM,Liu CH

更新日期：2018-09-01 00:00:00

abstract：AIM:Adenosine monophosphate-activated protein kinase (AMPK), a vital regulator of glucose metabolism, may affect insulin secretion in beta-cells. However, the role of AMPK in beta-cell lipotoxicity remains unclear. Fenofibrate has been reported to regulate lipid homeostasis and is involved in insulin secretion in pancr...

journal_title：Acta pharmacologica Sinica

authors： Sun Y,Ren M,Gao GQ,Gong B,Xin W,Guo H,Zhang XJ,Gao L,Zhao JJ

更新日期：2008-04-01 00:00:00

abstract：AIM:To investigate possible intracellular signal molecules involved in diphenylhydantoin (DPH)-mediated apoptosis of cerebellar granule neurons (CGN) and explore possible molecular mechanisms of neurotoxicity of DPH. METHODS:Fluorescein diacetate (FDA) stain, hochest 33258 stain, and agar gel electrophoresis were used...

journal_title：Acta pharmacologica Sinica

authors： Zhao LZ,Su XW,Huang YJ,Qiu PX,Yan GM

更新日期：2003-06-01 00:00:00

abstract：AIM:To study wound healing activity of the human placental extract (HPE) in rats. METHODS:Full thickness wounds were inflicted on depilated dorsum of Charles foster rats with 8 mm Acu-punch biopsy. The HPE was applied both at topical and im routes (2.5 mL/kg). Effects were compared on the basis of physical criteria, b...

journal_title：Acta pharmacologica Sinica

authors： Biswas TK,Auddy B,Bhattacharya NP,Bhattacharya S,Mukherjee B

更新日期：2001-12-01 00:00:00

abstract：AIM:To investigate the mechanism of action of a potent analgesic, (+/-)-meptazinol. METHODS:The structures of meptazinol enantiomers were compared with opioid pharmacophore and tramadol. RESULTS:Neither enantiomer of meptazinol fitted any patterns among the opioid pharmacophore and tramadol, although they did share s...

journal_title：Acta pharmacologica Sinica

authors： Li W,Hao JL,Tang Y,Chen Y,Qiu ZB

更新日期：2005-03-01 00:00:00

abstract：AIM:To investigate the effects of chronic ethanol intake on the locomotor activity and the levels of calcium/calmodulin-dependent protein kinase IV (CaM kinase IV) in the nucleus accumbens (NAc) of rats. Simultaneously, the effects of nonselective opioid antagonist (naloxone) on the CaM kinase IV expression in the NAc ...

journal_title：Acta pharmacologica Sinica

authors： Li J,Bian WL,Xie GQ,Cui SZ,Wu ML,Li YH,Que LL,Yuan XR

更新日期：2008-06-01 00:00:00

abstract：:Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the world. Although considerable progress has been made in the diagnosis, treatment and prognosis of CVD, there is still a critical need for novel diagnostic biomarkers and new therapeutic interventions to decrease the incidence of this ...

journal_title：Acta pharmacologica Sinica

authors： Zhou SS,Jin JP,Wang JQ,Zhang ZG,Freedman JH,Zheng Y,Cai L

更新日期：2018-07-01 00:00:00

abstract：:Cancer immunotherapy has received extensive attention due to its ability to activate the innate or adaptive immune systems of patients to combat tumors. Despite a few clinical successes, further endeavors are still needed to tackle unresolved issues, including limited response rates, development of resistance, and imm...

journal_title：Acta pharmacologica Sinica

authors： Sun B,Hyun H,Li LT,Wang AZ

更新日期：2020-07-01 00:00:00

abstract：AIM:Cathepsin L is a lysosomal cysteine protease that plays important roles in cancer tumorigenesis, proliferation and chemotherapy resistance. The aim of this study was to determine how cathepsin L regulated the radiosensitivity of human glioma cells in vitro. METHODS:Human glioma U251 cells (harboring the mutant typ...

journal_title：Acta pharmacologica Sinica

authors： Zhang QQ,Wang WJ,Li J,Yang N,Chen G,Wang Z,Liang ZQ

更新日期：2015-09-01 00:00:00

abstract：AIM:Diabetic nephropathy is one of the major complications of diabetes and the major cause of end-stage renal disease. In this study we investigated the insulin deficiency (ID) induced changes in renal mesangial cells (MCs) and in the kidney of STZ-induced diabetic rats. METHODS:Cultured rat renal MCs were incubated i...

journal_title：Acta pharmacologica Sinica

authors： Kong YL,Shen Y,Ni J,Shao DC,Miao NJ,Xu JL,Zhou L,Xue H,Zhang W,Wang XX,Lu LM

更新日期：2016-02-01 00:00:00

abstract：:miRNAs have shown promise as potential biomarkers for acute myocardial infarction (AMI). However, the current used quantitative real-time PCR (qRT-PCR) allows solely for relative expression of nucleic acids and it is susceptible to day-to-day variability, which has limited the validity of using the miRNAs as biomarker...

journal_title：Acta pharmacologica Sinica

authors： Robinson S,Follo M,Haenel D,Mauler M,Stallmann D,Heger LA,Helbing T,Duerschmied D,Peter K,Bode C,Ahrens I,Hortmann M

更新日期：2018-07-01 00:00:00

abstract：AIM:To examine the effect of curcumin on oxidative DNA damage and cell apoptosis and injury caused by the reaction of methylglyoxal(MG) with amino acids. METHODS:We used DNA strand breaks to examine the effect of curcumin on oxidative DNA damage. In addition, reactive oxygen species(ROS) formation occurs in MG-treated...

journal_title：Acta pharmacologica Sinica

authors： Chan WH,Wu HJ

更新日期：2006-09-01 00:00:00

abstract：:Human enterovirus 71 (EV71) is the primary causative agent of recent large-scale outbreaks of hand, foot, and mouth disease (HFMD) in Asia. Currently, there are no drugs available for the prevention and treatment of HFMD. In this study, we compared the anti-EV71 activities of three natural compounds, rheum emodin, art...

journal_title：Acta pharmacologica Sinica

authors： Zhong T,Zhang LY,Wang ZY,Wang Y,Song FM,Zhang YH,Yu JH

更新日期：2017-03-01 00:00:00

abstract：AIM:To determine the active ingredient of Niuchangchih (Antrodia camphorata) responsible for its anti-inflammatory effects and the relevant molecular mechanisms. METHODS:Five major antcins (A, B, C, H, and K) were isolated from fruiting bodies of Niuchangchih. Structural similarity between the antcins and 2 glucocorti...

journal_title：Acta pharmacologica Sinica

authors： Chen YC,Liu YL,Li FY,Chang CI,Wang SY,Lee KY,Li SL,Chen YP,Jinn TR,Tzen JT

更新日期：2011-07-01 00:00:00

abstract：:Volatile anesthetics improve postischemic cardiac function and reduce infarction even when administered for only a brief time at the onset of reperfusion. A recent study showed that sevoflurane postconditioning (SPC) attenuated myocardial reperfusion injury, but the underlying mechanisms remain unclear. In this study,...

journal_title：Acta pharmacologica Sinica

authors： Qiao SG,Sun Y,Sun B,Wang A,Qiu J,Hong L,An JZ,Wang C,Zhang HL

更新日期：2019-01-01 00:00:00

abstract：:A variety of cardiovascular diseases is accompanied by the loss of vascular contractility. This study sought to investigate the effects of curcumin, a natural polyphenolic compound present in turmeric, on mouse vascular contractility and the underlying mechanisms. After mice were administered curcumin (100 mg·kg-1·d-1...

journal_title：Acta pharmacologica Sinica

authors： Sun SW,Tong WJ,Guo ZF,Tuo QH,Lei XY,Zhang CP,Liao DF,Chen JX

更新日期：2017-10-01 00:00:00

abstract：:Neuronal nicotinic acetylcholine receptors are important targets for alcohol reward and dependence. Alcoholism is a serious public health problem and has been identified as the third major cause of preventable mortality in the world. Worldwide, about 2 billion people consume alcohol, with 76.3 million having diagnosab...

journal_title：Acta pharmacologica Sinica

authors： Wu J,Gao M,Taylor DH

更新日期：2014-03-01 00:00:00

abstract：:Activation of the Ca2+/calmodulin-dependent protein kinase II isoform δA (CaMKIIδA) disturbs intracellular Ca2+ homeostasis in cardiomyocytes during chronic heart failure (CHF). We hypothesized that upregulation of CaMKIIδA in cardiomyocytes might enhance Ca2+ leak from the sarcoplasmic reticulum (SR) via activation o...

journal_title：Acta pharmacologica Sinica

authors： Gui L,Guo X,Zhang Z,Xu H,Ji YW,Wang RJ,Zhu JH,Chen QH

更新日期：2018-10-01 00:00:00

abstract：AIM:The changes of seizure susceptibility of transgenic mice overexpressing GABA transporter-1 (GAT-1) were studied to clarify the possible role of GABAergic transmission in epileptogenesis. METHODS:Seizures were induced by intraperitoneal administration of pentylenetetrazol (PTZ), picrotoxin (PIC), or kainic acid (KA...

journal_title：Acta pharmacologica Sinica

authors： Zhao WJ,Ma YH,Fei J,Mei ZT,Guo LH

更新日期：2003-10-01 00:00:00

abstract：AIM:To investigate the effect of peroxisome proliferator-activated receptor gamma (PPAR gamma ) activation on the growth of rat hepatic stellate cells (HSC) and transforming growth factor beta (TGF-beta)-induced connective tissue growth factor (CTGF) expression. METHODS:After being treated with various amounts of the ...

journal_title：Acta pharmacologica Sinica

authors： Sun K,Wang Q,Huang XH

更新日期：2006-06-01 00:00:00

abstract：:Abnormal growth of the intimal layer of blood vessels (neointima formation) contributes to the progression of atherosclerosis and in-stent restenosis. Recent evidence shows that the 18-kDa translocator protein (TSPO), a mitochondrial membrane protein, is involved in diverse cardiovascular diseases. In this study we in...

journal_title：Acta pharmacologica Sinica

authors： Wu LP,Gong ZF,Wang H,Zhou ZS,Zhang MM,Liu C,Ren HM,Yang J,Han Y,Zeng CY

更新日期：2020-01-01 00:00:00

abstract：AIM:To examine how the higher expression level of CYP3A4 isoenzyme influenced the cytotoxicity of the antitumor triazoloacridinone derivative C-1305 in Chinese hamster ovary (CHO) cells. METHODS:Three CHO cell lines were examined: wild-type CHO cells; CHO-HR cells with overexpression of human cytochrome P450 reductase...

journal_title：Acta pharmacologica Sinica

authors： Augustin E,Borowa-Mazgaj B,Kikulska A,Kordalewska M,Pawłowska M

更新日期：2013-01-01 00:00:00

abstract：AIM:To determine the Ca2+ source and cellular mechanisms of spontaneous Ca2+ oscillations in hippocampal astrocytes. METHODS:The cultured cells were loaded with Fluo-4 AM, the indicator of intracellular Ca2+, and the dynamic Ca2+ transients were visualized with confocal laser-scanning microscopy. RESULTS:The spontane...

journal_title：Acta pharmacologica Sinica

authors： Wang TF,Zhou C,Tang AH,Wang SQ,Chai Z

更新日期：2006-07-01 00:00:00

abstract：AIM:To investigate the signaling pathways involved in thrombin-induced connective tissue growth factor (CTGF) expression in rat vascular smooth muscle cells (VSMCs). METHODS:Experiments were preformed on primary rat aortic smooth muscle cells (RASMCs) and a rat VSMC line (A10). CTGF protein levels were measured using ...

journal_title：Acta pharmacologica Sinica

authors： Ko WC,Chen BC,Hsu MJ,Tsai CT,Hong CY,Lin CH

更新日期：2012-01-01 00:00:00

abstract：:Pulmonary fibrosis may be partially the result of deregulated tissue repair in response to chronic hypoxia. In this study we explored the effects of hypoxia on lung fibroblasts and the effects of neotuberostemonine (NTS), a natural alkaloid isolated from Stemona tuberosa, on activation of fibroblasts in vitro and in v...

journal_title：Acta pharmacologica Sinica

authors： Lv XM,Li MD,Cheng S,Liu BL,Liu K,Zhang CF,Xu XH,Zhang M

更新日期：2018-09-01 00:00:00

abstract：AIM:To study the effects of MN-9202, a new effective Ca2+ channel blocker, on platelet aggregation, 5-HT and TXB2 release, and calcium transport induced by platelet activators. METHODS:The mobilization of cytosolic-free calcium induced by thrombin in washed platelets was observed by Ca(2+)-sensitive fluorescent indica...

journal_title：Acta pharmacologica Sinica

authors： Wang LL,Mei QB,Zhao DH,Guo ZA

更新日期：2000-07-01 00:00:00

abstract：AIM:Extract of Hominis Placenta (HP) has been used in oriental medicine as an agent for improving physiological function. The present study was conducted to investigate whether HP treatment in an experimental sciatic nerve injury animal model produces growth-promoting effects on regenerating peripheral nerve fibers aft...

journal_title：Acta pharmacologica Sinica

authors： Seo TB,Han IS,Yoon JH,Seol IC,Kim YS,Jo HK,An JJ,Hong KE,Seo YB,Kim DH,Park SK,Yang DC,Namgung U

更新日期：2006-01-01 00:00:00