Relationship between atrial natriuretic peptide-immunoreactive cells and microvessels in rat gastric mucosa.

abstract：AIM:To investigate the prevalence of hepatitis B virus (HBV) genotype mixtures among patients with chronic hepatitis B (CHB) in Eastern China. METHODS:A total of 4908 chronic HBV patients from Eastern China were enrolled. HBV genotypes and subgenotypes were determined using a multiplex PCR technique. Serum viral loads...

journal_title：Acta pharmacologica Sinica

authors： Zhong J,Gao YQ,Sun XH,Zhu XJ,Li M

更新日期：2012-10-01 00:00:00

abstract：AIM:Bufalin is one of the active components in the traditional Chinese medicine ChanSu that is used to treat arrhythmia, inflammation and cancer. BF211 is a bufalin derivative with stronger cytotoxic activity in cancer cells. The aim of this study was to identify the putative target proteins of BF211 and the signaling ...

journal_title：Acta pharmacologica Sinica

authors： Sun P,Feng LX,Zhang DM,Liu M,Liu W,Mi T,Wu WY,Jiang BH,Yang M,Hu LH,Guo DA,Liu X

更新日期：2016-07-01 00:00:00

abstract：AIM:Benzothiophene compounds are selective estrogen receptor modulators (SERMs), which are recently found to activate antioxidant signaling. In this study the molecular mechanisms of antioxidant signaling activation by benzothiophene compound BC-1 were investigated. METHODS:HepG2 cells were stably transfected with ant...

journal_title：Acta pharmacologica Sinica

authors： Yu BL,Mai ZX,Liu XX,Huang ZF

更新日期：2013-03-01 00:00:00

abstract：:DJ-1 is a multifunctional protein associated with cancers and autosomal early-onset Parkinson disease. Besides the well-documented antioxidative stress activity, recent studies show that DJ-1 has deglycation enzymatic activity and anti-ferroptosis effect. It has been shown that DJ-1 forms the homodimerization, which d...

journal_title：Acta pharmacologica Sinica

authors： Jiang L,Chen XB,Wu Q,Zhu HY,Du CY,Ying MD,He QJ,Zhu H,Yang B,Cao J

更新日期：2020-10-06 00:00:00

abstract：:Aspirin (ASA) is a cardioprotective drug with anti-cardiac fibrosis action in vivo. This study was aimed to clarify the anti-cardiac fibrosis action of ASA and the underlying mechanisms. Two heart injury models (injection of isoproterenol and ligation of the left anterior descending branch) were used in mice to induce...

journal_title：Acta pharmacologica Sinica

authors： Liu PP,Liu HH,Sun SH,Shi XX,Yang WC,Su GH,Zhao J

更新日期：2017-04-01 00:00:00

abstract：AIM:Based on the structural analysis to reveal the mechanism of ligand binding to beta-secretase and the specificity of each binding sub-site. METHODS:Molecular dynamics was used to simulate on the ligand free beta-secretase and ligand bound beta-secretase. The trajectories were analyzed using the essential dynamics, ...

journal_title：Acta pharmacologica Sinica

authors： Xiong B,Huang XQ,Shen LL,Shen JH,Luo XM,Shen X,Jiang HL,Chen KX

更新日期：2004-06-01 00:00:00

abstract：AIM:To determine the memory-improving properties of huperzine A in aged rats with memory impairments naturally occurring or induced by scopolamine. METHODS:Morris water maze was used to investigate the effects of huperzine A on the acquisition and memory impairments. RESULTS:During 7-day acquisition trials, aged rats...

journal_title：Acta pharmacologica Sinica

authors： Ye JW,Shang YZ,Wang ZM,Tang XC

更新日期：2000-01-01 00:00:00

abstract：:Neuronal nicotinic acetylcholine receptors are important targets for alcohol reward and dependence. Alcoholism is a serious public health problem and has been identified as the third major cause of preventable mortality in the world. Worldwide, about 2 billion people consume alcohol, with 76.3 million having diagnosab...

journal_title：Acta pharmacologica Sinica

authors： Wu J,Gao M,Taylor DH

更新日期：2014-03-01 00:00:00

abstract：AIM:To examine the role of cholinergic neurons in the nucleus raphe magnus (NRM) in noxious heat stimulation and in the effects of morphine-induced antinociception by rats. METHODS:After the cholinergic neuron selective toxin, AF64A, was microinjected into the NRM, we examined changes in the antinociceptive threshold ...

journal_title：Acta pharmacologica Sinica

authors： Abe K,Ishida K,Kato M,Shigenaga T,Taguchi K,Miyatake T

更新日期：2002-11-01 00:00:00

abstract：AIM:Genetic variation in ALOX12, which encoded human 12-lipoxygenase, was found to be associated with fat mass in young Chinese men. The objective of this study was to investigate the relationship between single nucleotide polymorphisms (SNPs) and haplotypes in the ALOX15 gene and obesity-related phenotypes in Chinese ...

journal_title：Acta pharmacologica Sinica

authors： Ke YH,Xiao WJ,He JW,Zhang H,Yu JB,Hu WW,Gu JM,Gao G,Yue H,Wang C,Hu YQ,Li M,Liu YJ,Fu WZ,Zhang ZL

更新日期：2012-02-01 00:00:00

abstract：AIM:Seipin is a protein that resides in endoplasmic reticulum, and involved in both lipid metabolic disorders and motor neuropathy. The aim of this study was to investigate the effects of mutant seipin on autophagy system and the morphology of lipid droplets in vitro. METHODS:HEK-293, H1299 and MES23.5 cells were tran...

journal_title：Acta pharmacologica Sinica

authors： Fan HD,Chen SP,Sun YX,Xu SH,Wu LJ

更新日期：2015-04-01 00:00:00

abstract：AIM:To investigate whether nimesulide could suppress tumor growth and induce apoptosis in implanted hepatoma mice and to explore the molecular mechanisms. METHODS:Male mice received nimesulide 10 mg/kg, 20 mg/kg, and 40 mg/kg ig daily for 21 d. Electron microscopy (EM), flow cytometry (FCM), DNA ladder, radioimmunoass...

journal_title：Acta pharmacologica Sinica

authors： Li XH,Li JJ,Zhang HW,Sun P,Zhang YL,Cai SH,Ren XD

更新日期：2003-10-01 00:00:00

abstract：AIM:The changes of seizure susceptibility of transgenic mice overexpressing GABA transporter-1 (GAT-1) were studied to clarify the possible role of GABAergic transmission in epileptogenesis. METHODS:Seizures were induced by intraperitoneal administration of pentylenetetrazol (PTZ), picrotoxin (PIC), or kainic acid (KA...

journal_title：Acta pharmacologica Sinica

authors： Zhao WJ,Ma YH,Fei J,Mei ZT,Guo LH

更新日期：2003-10-01 00:00:00

abstract：AIM:alpha2 nAChR subunit mRNA expression in mice is most intense in the olfactory bulbs and interpeduncular nucleus. We aimed to investigate the properties of alpha2* nAChRs in these mouse brain regions. METHODS:alpha2 nAChR subunit-null mutant mice were engineered. Pharmacological and immunoprecipitation studies were...

journal_title：Acta pharmacologica Sinica

authors： Whiteaker P,Wilking JA,Brown RW,Brennan RJ,Collins AC,Lindstrom JM,Boulter J

更新日期：2009-06-01 00:00:00

abstract：AIM:To evaluate the pharmacokinetic characteristics of L-valyl-ara-C, a peptidomimetic prodrug of ara-C. METHODS:After the synthesis of L-valyl-ara-C, the in vitro stability of L-valyl-ara-C was examined in various biological media. Plasma pharmacokinetic profiles of ara-C and L-valyl-ara-C were also evaluated in rats...

journal_title：Acta pharmacologica Sinica

authors： Cheon EP,Han HK

更新日期：2007-02-01 00:00:00

abstract：:Organ transplantation is the most effective therapy for patients with end-stage disease. Preservation solutions and techniques are crucial for donor organ quality, which is directly related to morbidity and survival after transplantation. Currently, static cold storage (SCS) is the standard method for organ preservati...

journal_title：Acta pharmacologica Sinica

authors： Jing L,Yao L,Zhao M,Peng LP,Liu M

更新日期：2018-05-01 00:00:00

abstract：:Cardiac amyloidosis (CA) comprises a heterogeneous group of medical conditions affecting the myocardium. It presents with proteinaceous infiltration with variable degrees of severity, prevalence and evolution. Despite this heterogeneity, erroneous protein folding is the common pathophysiologic process, yielding the fo...

journal_title：Acta pharmacologica Sinica

authors： Luciani M,Troncone L,Monte FD

更新日期：2018-07-01 00:00:00

abstract：AIM:To identify the genetic variants of angiotensin II type 2 receptor (AT2R) gene in a Chinese population and to determine whether the AT2R gene polymorphisms are associated with essential hypertension (EH). METHODS:The detection of single nucleotide polymorphisms (SNPs) was performed in 19 subjects by a direct DNA s...

journal_title：Acta pharmacologica Sinica

authors： Zhang Y,Zhang KX,Wang GL,Huang W,Zhu DL

更新日期：2003-11-01 00:00:00

abstract：AIM:To test the hypothesis that PI3K/Akt/eNOS signaling has a protective role in a murine model of ventilation associated lung injury (VALI) through down-regulation of p38 MAPK signaling. METHODS:Male C57BL/J6 (wild-type, WT) or eNOS knockout mice (eNOS(-/-)) were exposed to mechanical ventilation (MV) with low (LV(T)...

journal_title：Acta pharmacologica Sinica

authors： Peng XQ,Damarla M,Skirball J,Nonas S,Wang XY,Han EJ,Hasan EJ,Cao X,Boueiz A,Damico R,Tuder RM,Sciuto AM,Anderson DR,Garcia JG,Kass DA,Hassoun PM,Zhang JT

更新日期：2010-02-01 00:00:00

abstract：:As autophagy is involved in cell growth, survival, development and death, impaired autophagic flux has been linked to a variety of human pathophysiological processes, including neurodegeneration, cancer, myopathy, cardiovascular and immune-mediated disorders. There is a growing need to identify and quantify the status...

journal_title：Acta pharmacologica Sinica

authors： Zhang XJ,Chen S,Huang KX,Le WD

更新日期：2013-05-01 00:00:00

abstract：AIM:The metabolites of naproxen produced by Cunninghamella species were isolated and identified, and further to compare the similarities between microbial transformation and mammalian metabolism. METHODS:Naproxen was transformed by three strains of Cunninghammella species (Cunninghamella blakeslesna AS 3.153, Cunningh...

journal_title：Acta pharmacologica Sinica

authors： Zhong DF,Sun L,Liu L,Huang HH

更新日期：2003-05-01 00:00:00

abstract：AIM:To investigate possible intracellular signal molecules involved in diphenylhydantoin (DPH)-mediated apoptosis of cerebellar granule neurons (CGN) and explore possible molecular mechanisms of neurotoxicity of DPH. METHODS:Fluorescein diacetate (FDA) stain, hochest 33258 stain, and agar gel electrophoresis were used...

journal_title：Acta pharmacologica Sinica

authors： Zhao LZ,Su XW,Huang YJ,Qiu PX,Yan GM

更新日期：2003-06-01 00:00:00

abstract：AIM:To study the effect of adenovirus5-mediated human hepatocyte growth factor (Ad(5)-HGF) transfer on post-infarct heart failure in a swine model. METHODS:Twelve young Suzhong swine were randomly divided into 2 groups: the Ad(5)-HGF group (n=6) and the null-Ad(5) group (n=6). Four weeks after left anterior descending...

journal_title：Acta pharmacologica Sinica

authors： Wang W,Yang ZJ,Ma DC,Wang LS,Xu SL,Zhang YR,Cao KJ,Zhang FM,Ma WZ

更新日期：2006-05-01 00:00:00

abstract：AIM:Cathepsin L is a lysosomal cysteine protease that plays important roles in cancer tumorigenesis, proliferation and chemotherapy resistance. The aim of this study was to determine how cathepsin L regulated the radiosensitivity of human glioma cells in vitro. METHODS:Human glioma U251 cells (harboring the mutant typ...

journal_title：Acta pharmacologica Sinica

authors： Zhang QQ,Wang WJ,Li J,Yang N,Chen G,Wang Z,Liang ZQ

更新日期：2015-09-01 00:00:00

abstract：AIM:To determine propofol concentration in the cerebral spinal fluid (CSF) of neurosurgical patients and carry out a preliminary population pharmacodynamic study. METHODS:Twenty-seven elective neurosurgical patients (12 men and 15 women) aged 17-74 years received propofol in a bolus dose of 2 mg/kg for 5 min and an in...

journal_title：Acta pharmacologica Sinica

authors： Li YH,Wu FS,Xu JG

更新日期：2006-05-01 00:00:00

abstract：:Type capital I, Ukrainian natural killer T cells (NKT cells), a subset of CD1d-restricted T cells with invariant Valphabeta TCR, are characterized by prompt production of large amounts of Th1 and/or Th2 cytokines upon primary stimulation through the TCR complex. The rapid release of cytokines implies that type capital...

journal_title：Acta pharmacologica Sinica

authors： Tan JQ,Xiao W,Wang L,He YL

更新日期：2010-09-01 00:00:00

abstract：AIM:To investigate the effects of rapamycin on glutamate uptake in cultured rat astrocytes expressing N-terminal 552 residues of mutant huntingtin (Htt-552). METHODS:Primary astrocyte cultures were prepared from the cortex of postnatal rat pups. An astrocytes model of Huntington's disease was established using the ast...

journal_title：Acta pharmacologica Sinica

authors： Chen LL,Wu JC,Wang LH,Wang J,Qin ZH,Difiglia M,Lin F

更新日期：2012-03-01 00:00:00

abstract：AIM:To investigate the effects of co-delivering IL-6 expressing plasmid pCI-IL-6 on the immunogenicity of the anti-caries DNA vaccine pCIA-P, which encodes the surface protein antigen PAc of Streptococcus mutans. METHODS:Plasmid pCI-IL-6 was constructed by inserting the murine IL-6 gene into the pCI vector. Expression...

journal_title：Acta pharmacologica Sinica

authors： Su LK,Yu F,Li ZF,Zeng C,Xu QA,Fan MW

更新日期：2014-05-01 00:00:00

abstract：AIM:To study the effects of tanshinone IIA (TIIA) on lipopolysaccharide (LPS)-induced acute lung injury in mice and the underlying mechanisms. METHODS:Mice were injected with LPS (10 mg/kg, i.p.), then treated with TIIA (10 mg/kg, i.p.). Seven hours after LPS injection, the lungs were collected for histological study....

journal_title：Acta pharmacologica Sinica

authors： Xu M,Cao FL,Zhang YF,Shan L,Jiang XL,An XJ,Xu W,Liu XZ,Wang XY

更新日期：2015-02-01 00:00:00

abstract：:Conjugated polymer nanomaterials (CPNs), as optically and electronically active materials, hold promise for biomedical imaging and drug delivery applications. This review highlights the recent advances in the utilization of CPNs in theranostics. Specifically, CPN-based in vivo imaging techniques, including near-infrar...

journal_title：Acta pharmacologica Sinica

authors： Qian CG,Chen YL,Feng PJ,Xiao XZ,Dong M,Yu JC,Hu QY,Shen QD,Gu Z

更新日期：2017-06-01 00:00:00