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Propofol and arrhythmias: two sides of the coin.

Abstract：

:The hypnotic agent propofol is effective for the induction and maintenance of anesthesia. However, recent studies have shown that propofol administration is related to arrhythmias. Propofol displays both pro- and anti-arrhythmic effects in a concentration-dependent manner. Data indicate that propofol can convert supraventricular tachycardia and ventricular tachycardia and may inhibit the conduction system of the heart. The mechanism of the cardiac effects remains poorly defined and may involve ion channels, the autonomic nervous system and cardiac gap junctions. Specifically, sodium, calcium and potassium currents in cardiac cells are suppressed by clinically relevant concentrations of propofol. Propofol shortens the action potential duration (APD) but lessens the ischemia-induced decrease in the APD. Furthermore, propofol suppresses both sympathetic and parasympathetic tone and preserves gap junctions during ischemia. All of these effects cumulatively contribute to the antiarrhythmic and proarrhythmic properties of propofol.

journal_name

Acta Pharmacol Sin

journal_title

Acta pharmacologica Sinica

authors

Liu Q,Kong AL,Chen R,Qian C,Liu SW,Sun BG,Wang LX,Song LS,Hong J

doi

10.1038/aps.2011.42

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

817-23

issue

6

eissn

1671-4083

issn

1745-7254

pii

aps201142

journal_volume

32

pub_type

杂志文章,评审

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