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Hypertonic and isotonic potassium solutions have different effects on vessel contractility resulting in differences in optimal resting tension in rat aorta.

Abstract：

AIM:To compare high K(+ )-induced contraction and optimal resting tension measured by two commonly used techniques of hypertonic and isotonic K(+ ) in aortas with and without adventitial fat from various age rats. METHODS:Three age groups of rats (15, 25, and 62 weeks) were used to prepare thoracic aortic rings in which adventitial fat was either removed or left intact. High K(+ ) (30 mmol/L)-induced contractions were observed under increasing resting tensions of 1.0, 1.5, 2.0, 2.5, 3.0, and 3.5 g. Optimal resting tension was the resting tension at which the aorta showed a maximal contraction. RESULTS:The contractions induced by 2 kinds of high K(+ ) were significantly different. Hypertonic and isotonic K(+ ) induced a different style of contraction, and the pattern varied with different ages. At the age of 15 weeks, isotonic K(+ )-induced contractions were greater than hypertonic K+-induced contractions. However, at the age of 62 weeks, isotonic K(+ )-induced contractions were smaller than hypertonic K(+ )-induced contractions. Optimal resting tensions measured by 2 kinds of high K(+ ) were inconsistent. Optimal resting tensions in different kinds of aortic preparations from various age rats were almost a constant of 2 g, determined by isotonic K(+ ), but a variable, determined by hypertonic K(+ ). The adventitial fat could delay the development of high K(+ )-induced contractions at different resting tensions, but had little effect on the maximal contractions. CONCLUSION:Hypertonic and isotonic K(+ ) may produce different contractions resulting in differences in optimal resting tension in rat aorta.

journal_name

Acta Pharmacol Sin

journal_title

Acta pharmacologica Sinica

authors

Guan YF,Chen RH,Wang P,Qin Y,Su DF,Miao CY

doi

10.1111/j.1745-7254.2007.00548.x

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

643-50

issue

5

eissn

1671-4083

issn

1745-7254

journal_volume

28

pub_type

杂志文章

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