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Improved S-adenosyl-l-methionine production in Saccharomyces cerevisiae using tofu yellow serofluid.

Abstract：

:S-adenosyl-l-methionine (SAM) has been attracting increasing attention because of its significance in the pharmaceutical industry; however, the high cost of this compound limits its application. Tofu yellow serofluid exhibits high nutritional value and is not costly; therefore, it can be utilized as a substrate in the fermentation industry. In the current study, Saccharomyces cerevisiae was cultured in the tofu yellow serofluid fermentation medium for the SAM biosynthesis. The optimum tofu yellow serofluid fermentation medium contained 70 g/L of glucose, 30 % of yellow serofluid, 20 g/L of l-methionine, and 2.5 g/L of ammonium citrate. Under these conditions, the optimum feeding strategy was established. The results revealed that the dry cell weight (DCW) reached 123.1 g/L, the maximum production of SAM was 16.14 g/L, the highest SAM productivity reached 1.048 g/L/h, and SAM content was determined at 131.1 mg/g DCW. Furthermore, addition of tofu yellow serofluid reduced the average cost of SAM by 31.9 % to compare with the culture process without addition of tofu yellow serofluid. Thus, the tofu yellow serofluid fermentation medium improved the production of SAM and significantly reduced the production costs.

journal_name

J Biotechnol

journal_title

Journal of biotechnology

authors

Li G,Li H,Tan Y,Hao N,Yang X,Chen K,Ouyang P

doi

10.1016/j.jbiotec.2020.01.004

subject

Has Abstract

pub_date

2020-02-10 00:00:00

pages

100-106

eissn

0168-1656

issn

1873-4863

pii

S0168-1656(20)30004-3

journal_volume

309

pub_type

杂志文章

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