Abstract:
:A computer system solution for integration of a distributed bioreactor monitoring and control instrumentation on the laboratory scale is described. Bioreactors equipped with on-line analyzers for mass spectrometry, near-infrared spectroscopy, electrochemical probes and multi-array gas sensors and their respective software were networked through a real-time expert systems platform. The system allowed data transmission of more than 1800 different signals from the instrumentation, including signals from gas sensors, electrodes, spectrometer detectors, balances, flowmeters, etc., and were used for processing and carrying out a number of computational tasks such as partial least-square regression, principal component analysis, artificial neural network modelling, heuristic decision-making and adaptive control. The system was demonstrated on different cultivations/fermentations which illustrated sensor fusion control, multivariate statistical process monitoring, adaptive glucose control and adaptive multivariate control. The performance of these examples showed high operational stability and reliable function and meet typical requirements for production safety and quality.
journal_name
J Biotechnoljournal_title
Journal of biotechnologyauthors
Cimander C,Bachinger T,Mandenius CFdoi
10.1016/s0168-1656(03)00121-4subject
Has Abstractpub_date
2003-08-15 00:00:00pages
237-48issue
3eissn
0168-1656issn
1873-4863pii
S0168165603001214journal_volume
103pub_type
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