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Antifungal and antibacterial activity of extracts produced from Diaporthe schini.

Abstract：

:The aim of this work was the production of bioactive metabolites by submerged fermentation from the fungus Diaporthe schini, followed by their extraction, separation and characterization. Different solvents (methanol, dichloromethane and hexane) were used for the extraction of metabolites from the fermentation broth and the extracts obtained were evaluated by in vitro antibacterial and antifungal activity. The separation and characterization of the extract from the hexane extraction was performed by column chromatography and GC-MS, respectively. The extracts had a great inhibitory action on the Gram-positive bacteria Staphylococcus epidermidis and Staphylococcus aureus, on the Gram-negative bacteria Enterobacter aerogenes and Klebsiella pneumoniae and on the fungus Candida krusei. The main metabolites produced were: 13-docosenamide, (Z)-; 2-hexadecene, 3,7,11,15-tetramethyl; 9-octadecenamide and 11-octadecenoic acid. Studies related to the antibacterial and antifungal activities of metabolites extracted from microorganisms are found in the literature. However, works about the identification of metabolites produced by submerged fermentation from Diaporthe schini were not found until the present moment. This work is an initial study where the conditions of the process can be optimized by looking for the production of a specific compound and can be a promising source for obtaining new drugs.

journal_name

J Biotechnol

journal_title

Journal of biotechnology

authors

Dos Reis CM,da Rosa BV,da Rosa GP,do Carmo G,Morandini LMB,Ugalde GA,Kuhn KR,Morel AF,Jahn SL,Kuhn RC

doi

10.1016/j.jbiotec.2019.01.022

subject

Has Abstract

pub_date

2019-03-20 00:00:00

pages

30-37

eissn

0168-1656

issn

1873-4863

pii

S0168-1656(19)30048-3

journal_volume

294

pub_type

杂志文章

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