Abstract:
AIMS:Serum cobalamin (cbl, vitamin B(12)) tests are routinely ordered for investigating conditions potentially amenable to cbl supplementation. This study aimed to systematically assess the evidence of diagnostic accuracy for serum cbl tests across patient subgroups. METHODS:Seven medical databases were searched (1990 to November 2009). Studies were included that compared serum cbl to a reference standard (all reference standards employed). Study quality was assessed using QUADAS. Summary estimates of test performance were determined using the bivariate model and hierarchical summary receiver operating characteristic curves (HSROC). RESULTS:Of 2878 identified studies, 54 were included. Studies rated poorly against QUADAS criteria. Positive (PLR) and negative likelihood ratios (NLR) were 2.72 [95% confidence interval (CI) 1.95, 3.81] and 0.59 (0.49, 0.72), respectively (studies employing methylmalonic acid as the referent). In studies employing a clinical reference standard, PLR was 3.33 (0.92, 12.10) and NLR 0.34 (0.13, 0.89). Test performance did not vary by clinical indication, test method or age. CONCLUSION:This review was limited by the quality of the evidence base and lack of a gold standard. From the available evidence, diagnosis of conditions amenable to cbl supplementation on the basis of serum cbl level alone cannot be considered a reliable approach to investigating suspected vitamin deficiency.
journal_name
Pathologyjournal_title
Pathologyauthors
Willis CD,Elshaug AG,Milverton JL,Watt AM,Metz MP,Hiller JE,ASTUTE Health Study Group.doi
10.1097/PAT.0b013e3283486435subject
Has Abstractpub_date
2011-08-01 00:00:00pages
472-81issue
5eissn
0031-3025issn
1465-3931journal_volume
43pub_type
杂志文章,meta分析,评审相关文献
PATHOLOGY文献大全abstract::Recently, both the World Health Organization/International Agency for Research on Cancer (WHO/IARC) and the American Joint Committee on Cancer (AJCC) have classified oropharyngeal squamous cell carcinoma (OPSCC) on the basis of HPV status. For this purpose, the WHO/IARC recommended direct molecular HPV testing. In pra...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2019.02.002
更新日期:2019-06-01 00:00:00
abstract:AIMS:p73, a homologue of p53, is known as a negative regulator of tumour progression. However, delta Np73, an isoform of p73 lacking the NH2-terminal transactivation domain plays an oncogenic role by interfering with the activity of p53 and TA (full-length transactivating isoforms) p73. In this study, we investigated t...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020600696298
更新日期:2006-06-01 00:00:00
abstract::Hypercalcemia is a common biochemical abnormality. It is usually possible to make a presumptive diagnosis of its cause by relatively simple means. In a large majority of cases this involves differentiating between primary hyperparathyroidism and malignancy-associated hypercalcemia. Clinical evaluation and parathyroid ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028609059468
更新日期:1986-04-01 00:00:00
abstract:AIMS:This study was undertaken to investigate the genetic factors underlying the development of multifocality and phenotypic diversity in multifocal papillary thyroid carcinoma (mPTC). METHODS:Loss of heterozygosity (LOH) and BRAF(V600E) mutation status were analysed in a total of 55 individual tumour foci from 18 cas...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313025.2010.508780
更新日期:2010-01-01 00:00:00
abstract::We present the clinical and postmortem findings in seven adults (four females and three males), who died with dissection of the coronary arteries. The median age was 56 years. Five of the coronary artery dissections (CADs) were spontaneous and two followed trauma: one a motor vehicle accident, the other occurred durin...
journal_title:Pathology
pub_type: 杂志文章
doi:
更新日期:2001-08-01 00:00:00
abstract:AIMS:Nuclear factor-kappa B (NF-kappaB) activation has been recognised as an important mechanism in the development of cancers. However, expression status of NF-kappaB-related proteins in oesophageal squamous cell carcinoma (ESCC) tissues is largely unknown. In this study, we analysed expressions of NF-kappaB members (...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313020903257756
更新日期:2009-01-01 00:00:00
abstract::The main controversy about nerve sheath tumors (NSTs) has been their histogenesis. A Schwann cell origin has been proposed by many investigators for both schwannomas and neurofibromas. However Erlandson and Woodruff observed that while schwannomas appeared to be composed predominantly of Schwann cells, neurofibromas c...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029400169051
更新日期:1994-01-01 00:00:00
abstract::A rapid technique suitable for routine laboratory use for determining the percentage of large platelets in the peripheral blood is described. In 50 haematologically normal subjects, megathrombocytes (platelets with a volume of 16-33 fl) constituted 3.0-16.6% (mean +/- 2 SD) of the platelet count. Of the 10 patients ex...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027609094424
更新日期:1976-01-01 00:00:00
abstract::A 36-yr-old female with a 20-yr history of fibrodysplasia ossificans progressiva (FOP) died as the result of ruptured gastric ulcers. The patient had been treated with disodium ethane-l-hydroxy-1, 1-diphosphonate (EHDP). Post mortem there was thickening of the aortic valve cusps and mitral valve leaflets as well as sh...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028309083514
更新日期:1983-07-01 00:00:00
abstract::Multiplex immunofluorescence (mIF) allows simultaneous antibody-based detection and quantification of the expression of up to six markers, plus a nuclear counterstain, on a single tissue section. Recent studies have shown the potential for mIF to advance our understanding of complex disease processes, including cancer...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2017.11.087
更新日期:2018-04-01 00:00:00
abstract::The recent upsurge in the association of congenital neurological disorders and infection by the Zika virus (ZIKV) has resulted in increased research focus on the biology of this flavivirus. Studies in animal models indicate that ZIKV can breach the placental barrier and selectively infect and deplete neuroprogenitor c...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1016/j.pathol.2017.07.008
更新日期:2017-12-01 00:00:00
abstract::The aim of this study was to establish the diagnostic utility of p53 immunohistochemistry in Barrett's esophagus. Three pathologists reviewed endoscopic biopsy specimens and one surgical specimen derived from 102 subjects in a prospective follow-up series. Dysplasia was graded as negative, indefinite, low grade and hi...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029800169076
更新日期:1998-05-01 00:00:00
abstract::The cancer stem cell hypothesis suggests that malignant tumours may arise from a limited number of specialised cells possessing the key 'stem' properties of self-renewal and the ability to produce differentiated progeny. Such cells purportedly constitute a small fraction of most tumours but have greater potential to p...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.3109/00313020903488773
更新日期:2010-02-01 00:00:00
abstract::Distinction between melanocytic naevi and melanoma occasionally poses a diagnostic challenge in ambiguous cases showing overlapping histological features. Melanomas are characterised by the presence of multiple genomic copy number variants (CNVs), while this is not a feature of naevi. We assessed the feasibility and u...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2016.11.008
更新日期:2017-04-01 00:00:00
abstract::Staining for iron showed previously overlooked intra-alveolar siderophages widely distributed in the lungs of two pairs of siblings, all of whom had hospital admissions for apparent life-threatening events (ALTEs) before dying suddenly at home. A mother and babysitter were convicted of their murder and manslaughter re...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/00313029700169554
更新日期:1997-02-01 00:00:00
abstract::Sclerosing adenosis (SA) of the breast if a disease associated with an increase relative risk of malignancy. The exact incidence and factors influencing malignant transformation in association with SA are not well established. Two counts of the AgNOR silver staining technique have been correlated with ploidy and proli...
journal_title:Pathology
pub_type: 临床试验,杂志文章
doi:10.1080/00313029700169015
更新日期:1997-08-01 00:00:00
abstract::Phospholipid preparations from the nematode Ascaris suum or cysts of Echinococcus granulosus (hydatid cysts) induced an eosinophilia when injected into the peritoneal cavity of rats. Peritoneal eosinophilia persisted throughout 21 days of daily injections of Ascaris lipid and was accompanied by blood eosinophilia, mas...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027709085252
更新日期:1977-04-01 00:00:00
abstract::Recently developed antibodies against uroplakin II and ΔNp63 (p40) show utility in diagnosing primary bladder urothelial carcinoma, although application in metastatic bladder cancer and patient outcomes has been less well defined. We evaluated these antibodies by immunostain intensity and H-score, in conjunction with ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2016.05.008
更新日期:2016-10-01 00:00:00
abstract::Three cases of nodular lymphomas with cytoplasmic inclusions were studied histologically, histochemically and immunocytochemically, and ultrastructurally. One case had Russell body-like inclusions, another had needle-like inclusions not previously reported, while the last showed cells with cytoplasmic vacuoles. Two of...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.3109/00313028209092121
更新日期:1982-10-01 00:00:00
abstract::The objective of this study was to establish a population based reference range for a commercial immunoblot assay detecting myositis specific autoantibodies (MSAs) and myositis associated autoantibodies (MAAs), and to assess the diagnostic performance of this reference range against the manufacturer's recommended rang...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2016.03.012
更新日期:2016-06-01 00:00:00
abstract:AIMS:Biochemical analysis of glucose and ketones in the vitreous humour obtained at post-mortem examination is representative of the levels in the blood prior to death. Elevated levels can be indicative of conditions including diabetic ketoacidosis, which can be a cause for unexpected death. A rapid screening test for ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0b013e3283650b93
更新日期:2013-10-01 00:00:00
abstract::Lymphoplasmacytic lymphoma (LPL) represents a distinct type of mature B-cell lymphoma with a substantial subset of cases being associated with Waldenström macroglobulinaemia (WM), defined as primarily bone marrow involvement and the presence of an IgM monoclonal paraprotein. MYD88 L265P mutation, although not specific...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1016/j.pathol.2019.09.009
更新日期:2020-01-01 00:00:00
abstract::The coexistence of a pancreatic papillary cystic tumor with hairy cell leukemia is reported. To the best of our knowledge this association has never been published. A 41-year-old man diagnosed with hairy cell leukemia developed a second malignancy that corresponded to a papillary cystic pancreatic tumor. The patient u...
journal_title:Pathology
pub_type: 杂志文章
doi:
更新日期:2000-08-01 00:00:00
abstract::The aim of the present study is to describe the histological and mutational characteristics of a series of both large and small bowel adenocarcinomas in patients with Crohn's disease from a tertiary referral centre of inflammatory bowel disease. Bowel adenocarcinoma was diagnosed in 11 (1.7%) of 660 consecutive patien...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0000000000000123
更新日期:2014-08-01 00:00:00
abstract::A histopathological examination was made of 60 stapes obtained during surgery for clinical otosclerosis. The findings, correlated with the clinical history and macroscopic appearances of the stapes, led to the following observations. The histological extent of the focus of otosclerosis agrees well with the macroscopic...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028409067908
更新日期:1984-01-01 00:00:00
abstract::Deregulation of the receptors of TNF-related apoptosis inducing ligand (TRAIL) has been reported in various cancers. In an effort to define the role of these receptors we profiled their expression in gallbladder cancer (GBC) and explored their clinical significance. Expression of TRAIL receptors' mRNA in GBC was analy...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2019.12.001
更新日期:2020-04-01 00:00:00
abstract::Eight histologically-confirmed cases of clear cell sarcoma of the kidney (CCSK) were studied for possible mutations in the p53 tumor suppressor gene by the immunohistochemical demonstration of mutant p53 proteins using a monoclonal (DO7: Dako) and a polyclonal (AB565: Chemicon) antibody to p53 protein. All cases exhib...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029600169034
更新日期:1996-08-01 00:00:00
abstract:AIMS:Clinical decision making and optimal clinical trial design based on cancer genetic information will be increasingly informed by the mutational status of multiple genes. METHODS:We performed mutation screening on 22 fresh frozen gastrointestinal stromal tumours (GISTs) using a multiplexed oncogene screening panel ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0b013e3283559c45
更新日期:2012-08-01 00:00:00
abstract::A clinicopathological analysis was made of data from 250 cases of nodular fasciitis. These benign nodules usually occurred in young and middle-aged adults in the 4th and 5th decades, most often in the forearm (27%) followed by the thigh (17%) and the upper arm (12%), and grew rather rapidly to reach a mean diameter of...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028409059097
更新日期:1984-04-01 00:00:00
abstract::An indirect haemaglutination method was developed for the immunochemical detection of myoglobin in human urine. Myoglobin was found in the urine of 84% of 44 patients with acute myocardial infarction. In contrast, it was detected in the urine of 2.7% of 147 control subjects and in none of a control group of 15 patient...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027609101494
更新日期:1976-10-01 00:00:00