The elaboration of a critical framework for understanding cancer: the cancer stem cell hypothesis.

abstract：:In order to determine whether routine culturing for Clostridium difficile was warranted or whether culturing a selected group of patients was adequate, we conducted a prospective trial of culturing all stool specimens for C. difficile. A total of 408 specimens from 297 patients was studied. Two hundred and eighteen st...

journal_title：Pathology

authors： Bowman RA,Riley TV

更新日期：1984-07-01 00:00:00

abstract：AIM:We investigated the role of renal sympathetic innervation in the deterioration of renal haemodynamic and excretory functions during the early post-ischaemic phase of renal ischaemia/reperfusion injury. METHODS:Anaesthetised male Sprague-Dawley rats were subjected to unilateral renal ischaemia by clamping the left ...

journal_title：Pathology

authors： Salman IM,Ameer OZ,Sattar MA,Abdullah NA,Yam MF,Najim HS,Khan AH,Johns EJ

更新日期：2010-04-01 00:00:00

abstract：:One thousand sera shown to be reactive by one of two commercial enzyme linked immunosorbent assays (ELISA) for antibodies to the AIDS virus were referred to the NSW State Reference Laboratory for confirmatory assays. Each serum was retested by two commercial ELISA systems (Abbott and ENI), the ENI exclusionary H9 ELIS...

journal_title：Pathology

authors： Imrie AA,Kehrer S,Smith GW,Penny R,Cooper DA

更新日期：1986-10-01 00:00:00

abstract：:Tumour infiltrating lymphocytes in primary melanoma have been found to correlate with patient outcomes. A subpopulation of tumour infiltrating lymphocytes expresses the transcription factor forkhead box protein 3 (FOXP3). These are known as FOXP3+ T-regulatory cells (Tregs) and are thought to play an immune suppressiv...

journal_title：Pathology

authors： Leslie C,Bowyer SE,White A,Grieu-Iacopetta F,Trevenen M,Iacopetta B,Amanuel B,Millward M

更新日期：2015-10-01 00:00:00

abstract：AIMS:There are many variants of papillary carcinoma, and some of these variants have been reported to show biological behaviours differing from that of conventional papillary carcinoma. In this study, we present our experience regarding the prevalence and prognoses of these variants of papillary carcinoma. METHODS:H&E...

journal_title：Pathology

authors： Ito Y,Hirokawa M,Uruno T,Kihara M,Higashiyama T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Miyauchi A

更新日期：2008-10-01 00:00:00

abstract：AIM:Performance measures for Australian laboratories reporting cervical cytology are a set of quantifiable measures relating to the profile and accuracy of reporting. This study reviews aggregate data collected over the ten years in which participation in the performance measures has been mandatory. METHODS:Laboratori...

journal_title：Pathology

authors： Shield PW,Finnimore J,Cummings M,Wright RG

更新日期：2010-12-01 00:00:00

abstract：INTRODUCTION:Ethanol is teratogenic, interferes with folic acid and is extensively used by young women. Our objective was to determine the effects of ethanol and/or folate deficiency on mouse fetuses. METHOD:In Experiment 1, pregnant mice receiving a commercial diet were divided into three groups: control (C), low eth...

journal_title：Pathology

authors： Gutierrez CM,Ribeiro CN,de Lima GA,Yanaguita MY,Peres LC

更新日期：2007-10-01 00:00:00

abstract：:Oral cancer is a serious public health problem, with over 200,000 new cases reported annually worldwide, two-thirds of which occur in developing countries. The overall mortality rate for intra-oral cancer remains high at approximately 50%, even with modern medical services, probably due to the advanced stage of the di...

journal_title：Pathology

authors： Walker DM,Boey G,McDonald LA

更新日期：2003-10-01 00:00:00

abstract：:In the management of rheumatic diseases, peptic ulceration associated with anti-inflammatory drug therapy is a major problem and seriously limits the usefulness of these agents. In acute experiments with a guinea pig total gastric pouch preparation, gastric damage induced by the prostaglandin synthetase inhibitor indo...

journal_title：Pathology

authors： Maclaurin BP,Watts C,Palmer DG

更新日期：1985-07-01 00:00:00

abstract：:A patient with cerebral strokes had a cardiac tumour excised. Histologically, it was an infarcted myxoma with features of a Gamna body. Findings are compared with other cardiac Gamna bodies reported in the literature. Most probably represent unusual degenerative changes in a myxoma. ...

journal_title：Pathology

authors： Coard KC,Silver MD

更新日期：1984-10-01 00:00:00

abstract：AIM:Lignocaine, a topical anaesthetic agent, is generally used in variable concentrations usually between 2% and 4% on the vocal cords prior to flexible bronchoscopy and bronchoalveolar lavage (BAL) procedures. The aim of this study was to investigate whether 2% or 1% lignocaine significantly inhibits the growth of org...

journal_title：Pathology

authors： Chandan SS,Faoagali J,Wainwright CE

更新日期：2005-08-01 00:00:00

abstract：AIM:Hepcidin, a recently identified peptide, acts as a central regulator of iron metabolism. It is regarded as a factor regulating the uptake of dietary iron and its mobilisation from macrophages and hepatic stores. It is considered as a mediator of anaemia of inflammation. The aim of this study was to assess whether s...

journal_title：Pathology

authors： Jayaranee S,Sthaneshwar P,Sokkalingam S

更新日期：2009-02-01 00:00:00

abstract：:The case is reported of a woman aged 60 yrs who presented with systemic symptoms and who was found to have proteinuria of 3.5 g per day. A renal biopsy revealed numerous neoplastic cells filling many of the glomerular capillary lumina. Immunoperoxidase stains revealed that the phenotype of the malignant cells was LCA+...

journal_title：Pathology

authors： Axelsen RA,Laird PP,Horn M

更新日期：1991-07-01 00:00:00

abstract：:The pathological findings in a retrospective review of 100 consecutive intracranial stereotactic biopsies are presented. Definite diagnosis could be established in the majority (89) of cases and included 85 neoplasms (69 primary cerebral tumors, 10 non-Hodgkin's lymphomas and 6 metastases) and 4 non-neoplastic process...

journal_title：Pathology

authors： Robbins PD,Yu LL,Lee M,Stokes BA,Thomas GW,Watson P,Wong G

更新日期：1994-10-01 00:00:00

abstract：:In this review, we focus on B-cell lymphoproliferative disorders (LPDs) and lymphomas associated with Epstein-Barr virus (EBV). In some of these diseases-such as EBV-positive diffuse large B-cell lymphoma (DLBCL), not otherwise specified-virus detection is required for the diagnosis, while in others its detection is n...

journal_title：Pathology

authors： Marques-Piubelli ML,Salas YI,Pachas C,Becker-Hecker R,Vega F,Miranda RN

更新日期：2020-01-01 00:00:00

abstract：:Sclerosing adenosis (SA) of the breast if a disease associated with an increase relative risk of malignancy. The exact incidence and factors influencing malignant transformation in association with SA are not well established. Two counts of the AgNOR silver staining technique have been correlated with ploidy and proli...

journal_title：Pathology

authors： Mourad WA

更新日期：1997-08-01 00:00:00

abstract：:Murine monoclonal antibodies to human myeloid cell surface differentiation antigens were prepared using the myelomonocytic leukemia cell line RC-2A as immunogen. Using a highly sensitive colorimetric assay, antibodies were selected as myeloid-associated based on their binding to RC-2A cells, but not to cells of the au...

journal_title：Pathology

authors： Lyons AB,Cooper SJ,Cole SR,Ashman LK

更新日期：1988-04-01 00:00:00

abstract：:Paracetamol in serum was assayed by a new enzymatic method, and the results compared with a high performance liquid chromatographic method. Results by the two procedures agreed well (t = 0.05). The correlation coefficient was 0.999, and the slope and intercept by Deming analysis were 0.975 and 0.003 mmol/l respectivel...

journal_title：Pathology

authors： Slater S

更新日期：1987-01-01 00:00:00

abstract：:A case of solitary cervical intramedullary schwannoma with an extramedullary extension is reported. This case demonstrates the difficulty of radiologic diagnosis of these tumours and the necessity for pre-treatment biopsy. ...

journal_title：Pathology

authors： Garen PD,Collett MG,Harper CG

更新日期：1988-07-01 00:00:00

abstract：:The frequency of simultaneous infection with Neisseria gonorrhoeae and Chlamydia trachomatis in men and women in Eastern Sydney was examined prospectively over a 21 month period in patients from whom appropriate specimens were obtained. In men gonococcal disease (113 cases) and chlamydial infections (124 cases) occurr...

journal_title：Pathology

authors： Tapsall JW,Kinchington M

更新日期：1996-01-01 00:00:00

abstract：:Changes in the contracture and stiffness of ventricular walls during ischemia and their effect on vascular reperfusion were studied in isolated rat hearts. Global ischemia was induced by stopping the flow of oxygenated perfusate for 60 min. Contracture pressures generated against water-filled left ventricular balloons...

journal_title：Pathology

authors： Humphrey SM,Gavin JB

更新日期：1985-07-01 00:00:00

abstract：:We report here on the usefulness of the 14C-serotonin release assay for the laboratory confirmation of the clinical diagnosis of heparin-induced thrombocytopenia syndrome (HITS). Over the past 3 yrs, some 140 individual serum samples have been tested in our laboratory for heparin-associated anti-platelet activity ('he...

journal_title：Pathology

authors： Favaloro EJ,Bernal-Hoyos E,Exner T,Koutts J

更新日期：1992-07-01 00:00:00

abstract：:The causes and pathogenesis of severe childhood pneumonia in a developing country were studied in lungs removed at autopsy from 119 Bangladeshi children who presented with pneumonia and/or diarrhea. Pneumonia was observed in 93 patients. Morphologic features included acute alveolar exudate in 51% (of the 93 patients),...

journal_title：Pathology

authors： Tomashefski JF Jr,Butler T,Islam M

更新日期：1989-04-01 00:00:00

abstract：:The aim of this study was to establish the diagnostic utility of p53 immunohistochemistry in Barrett's esophagus. Three pathologists reviewed endoscopic biopsy specimens and one surgical specimen derived from 102 subjects in a prospective follow-up series. Dysplasia was graded as negative, indefinite, low grade and hi...

journal_title：Pathology

authors： Khan S,Do KA,Kuhnert P,Pillay SP,Papadimos D,Conrad R,Jass JR

更新日期：1998-05-01 00:00:00

abstract：AIM:The purpose of this study was to elucidate the clonality of fibrous dysplasia based on X-chromosome inactivation mosaicism and polymorphism in female somatic cells at the phosphoglycerate kinase (PGK) and androgen receptor (AR) loci using microdissection technology. MATERIALS AND METHODS:Nine patients with fibrous...

journal_title：Pathology

authors： Gong L,Zhang W,Su Q

更新日期：2008-06-01 00:00:00

abstract：:Thirty-one patients aged over 60 yrs and with lupus anticoagulant (LA) were reviewed for their drug intake. Twenty-three (73%) were taking cinchona alkaloids, 10 (32%) quinine for night cramps, 11 (35%) quinidine for cardiac arrhythmia and 2 (6%) were taking both. These frequencies of drugs usage differed significantl...

journal_title：Pathology

authors： Bird MR,O'Neill AI,Buchanan RR,Ibrahim KM,Des Parkin J

更新日期：1995-04-01 00:00:00

abstract：:A novel grading system based on the counting of poorly differentiated clusters (PDC) of neoplastic cells at the invasive margin and in the tumour stroma was recently introduced among the histological parameters predictive of adverse clinical outcome in colorectal cancer (CRC). The aim of this study was to correlate th...

journal_title：Pathology

authors： Barresi V,Bonetti LR,Bettelli S

更新日期：2015-10-01 00:00:00

abstract：:Appropriate investigation of a patient with suspected von Willebrand's disease (VWD) involves a clinical assessment of the patient followed by laboratory testing. A variety of laboratory assays may be performed, not necessarily restricted to an assessment of von Willebrand factor (VWF). Due to the limitations of each ...

journal_title：Pathology

authors： Favaloro EJ,Koutts J

更新日期：1997-11-01 00:00:00

abstract：:Tonsil swabs were collected from 248 children (1 through 10 yr) who presented with acute tonsillitis. A beta-hemolytic streptococcus was grown from 129 (53%) of 244 cases and as the sole pathogen from 83 (47%) of 178 cases. Beta-Hemolytic streptococci were especially common over the age of 6 yr (68% of children) relat...

journal_title：Pathology

authors： Douglas RM,Miles H,Hansman D,Fadejevs A,Moore B,Bollen MD

更新日期：1984-01-01 00:00:00

abstract：:Thirteen patients with Aeromonas species septicemia were seen at Westmead Hospital between 1983 and 1987. In 10 patients (77%) septicemia was caused by A. sobria, and in 3 (23%) by A. hydrophila, A. caviae was not isolated. Chronic underlying illness was present in 10 patients (77%), hematological malignancy being the...

journal_title：Pathology

authors： Dryden M,Munro R

更新日期：1989-04-01 00:00:00