Evaluation of cell-free tumour DNA and RNA in patients with breast cancer and benign breast disease.

abstract：:Recently, the development of Src/Abl (c-Src/Bcr-Abl tyrosine kinases) dual inhibitors has attracted considerable attention from the research community for treatment of malignancies. In order to explore the different structural features impacting the Src and Abl inhibitory activities of N(9)-arenethenyl purines and to ...

journal_title：Molecular bioSystems

authors： Ma S,Zeng G,Fang D,Wang J,Wu W,Xie W,Tan S,Zheng K

更新日期：2015-02-01 00:00:00

abstract：:Understanding the molecular mechanism that underlies the differentiation of neural stem cells (NSCs) is vital to develop regenerative medicines for neurological disorders. In our previous work, Rho-GDI-γ was found to be able to prompt neuronal differentiation when it was down regulated. However, it is unclear how Rho-...

journal_title：Molecular bioSystems

authors： Wang J,Hu F,Cheng H,Zhao XM,Wen T

更新日期：2012-11-01 00:00:00

abstract：:New-type oseltamivir-resistant H1N1 influenza viruses have been a major threat to human health since the 2009 flu pandemic. To resolve the drug resistance issue, we aimed to identify a new type of inhibitors against H1 from traditional Chinese medicine (TCM) by employing the world's largest TCM database () for virtual...

journal_title：Molecular bioSystems

authors： Chang SS,Huang HJ,Chen CY

更新日期：2011-12-01 00:00:00

abstract：:Plasma membrane translocation is challenging due to the barrier of the cell membrane. Contrary to the synthetic cell-penetrating materials, tailed bacteriophages use cell-puncturing protein needles to puncture the cell membranes as an initial step of the DNA injection process. Cell-puncturing protein needles are thoug...

journal_title：Molecular bioSystems

authors： Sanghamitra NJ,Inaba H,Arisaka F,Ohtan Wang D,Kanamaru S,Kitagawa S,Ueno T

更新日期：2014-10-01 00:00:00

abstract：:Rule-based modeling provides a means to represent cell signaling systems in a way that captures site-specific details of molecular interactions. For rule-based models to be more widely understood and (re)used, conventions for model visualization and annotation are needed. We have developed the concepts of an extended ...

journal_title：Molecular bioSystems

authors： Chylek LA,Hu B,Blinov ML,Emonet T,Faeder JR,Goldstein B,Gutenkunst RN,Haugh JM,Lipniacki T,Posner RG,Yang J,Hlavacek WS

更新日期：2011-10-01 00:00:00

abstract：:Extracellular electron transfer (EET) is the key feature of some bacteria, such as Geobacter sulfurreducens and Shewanella oneidensis. Via EET processes, these bacteria can grow on electrode surfaces and make current output of microbial fuel cells. c-Type cytochromes can be used as carriers to transfer electrons, whic...

journal_title：Molecular bioSystems

authors： Ding DW,Xu J,Li L,Xie JM,Sun X

更新日期：2014-12-01 00:00:00

abstract：:The significant increase in the demand for purified protein for crystallization and structural studies has made necessary the development of multi-sample methods for identifying solution conditions that affect protein stability and aggregation. Conditions that stabilize proteins can improve protein purification and cr...

journal_title：Molecular bioSystems

authors： Senisterra GA,Finerty PJ Jr

更新日期：2009-03-01 00:00:00

abstract：:Calcium (Ca(2+)) is used as a signaling molecule to regulate many cellular processes. Calcium signaling generally involves transient elevations of the concentration of free Ca(2+) in the cytosol. More pronounced and sustained elevations of intracellular Ca(2+) concentrations are observed during apoptosis (programmed c...

journal_title：Molecular bioSystems

authors： Brnjic S,Olofsson MH,Havelka AM,Linder S

更新日期：2010-05-01 00:00:00

abstract：:Major progress in the study of RNase P has resulted from crystallography of bacterial catalytic subunits and the discovery of catalytic activity in eukaryotes. Several new substrates have also been identified, primarily in bacteria but also in yeast. Our current world should be called the "RNA-protein world" rather th...

journal_title：Molecular bioSystems

authors： Altman S

更新日期：2007-09-01 00:00:00

abstract：:Protein phosphorylation is associated with most cell signaling and developmental processes in eukaryotes. Despite the vast extent of the phosphoproteome within the cell, connecting specific kinases with relevant targets remains a significant experimental frontier. The challenge of linking kinases and their substrates ...

journal_title：Molecular bioSystems

authors： Sopko R,Andrews BJ

更新日期：2008-09-01 00:00:00

abstract：:The first fluorescent labeling technology, which can induce not only an increase in the fluorescence intensity but also a shift in the fluorescence spectrum, has been developed for "ratiometric" measurements for a protein by utilizing a newly designed "field-sensitive" fluorescent probe and its corresponding unique am...

journal_title：Molecular bioSystems

authors： Soh N,Seto D,Nakano K,Imato T

更新日期：2006-02-01 00:00:00

abstract：:The emerging field of synthetic biology is generating insatiable demands for synthetic genes, which far exceed existing gene synthesis capabilities. This review discusses the current methods of chemical DNA synthesis and gene assembly, as well as the latest engineering tools, technologies and trends which could potent...

journal_title：Molecular bioSystems

authors： Tian J,Ma K,Saaem I

更新日期：2009-07-01 00:00:00

abstract：:It is well known that oligomeric/aggregated amyloid β peptides are a key player in the pathogenesis of Alzheimer's disease and that different nanoparticles influence oligomerization/aggregation processes in experiments in vitro. Our previous results demonstrated antiaggregation effects of magnetite nanoparticles in th...

journal_title：Molecular bioSystems

authors： Gažová Z,Antošová A,Krištofiková Z,Bartoš A,Ríčný J,Cechová L,Klaschka J,Rípová D

更新日期：2010-11-01 00:00:00

abstract：:Production of biofuels has been one of the promising efforts in biotechnology in the past few decades. The perspective of these efforts can be reduction of increasing demands for fossil fuels and consequently reducing environmental pollution. Nonetheless, most previous approaches did not succeed in obviating many big ...

journal_title：Molecular bioSystems

authors： Mohammadi R,Fallah-Mehrabadi J,Bidkhori G,Zahiri J,Javad Niroomand M,Masoudi-Nejad A

更新日期：2016-07-19 00:00:00

abstract：:Genetic information in genomes is ordered, arranged in such a way that it constitutes a code, the so-called cis regulatory code. The regulatory machinery of the cell, termed trans-factors, decodes and expresses this information. In this way, genomes maintain a potential repertoire of genetic programs, parts of which a...

journal_title：Molecular bioSystems

authors： Rangel-Chavez C,Galan-Vasquez E,Martinez-Antonio A

更新日期：2017-03-28 00:00:00

abstract：:In the post-genome era, one of the most important and challenging tasks is to identify the subcellular localizations of protein complexes, and further elucidate their functions in human health with applications to understand disease mechanisms, diagnosis and therapy. Although various experimental approaches have been ...

journal_title：Molecular bioSystems

authors： Li ZC,Lai YH,Chen LL,Chen C,Xie Y,Dai Z,Zou XY

更新日期：2013-04-05 00:00:00

abstract：:Recently, more and more research has shown that microRNAs (miRNAs) play critical roles in the development and progression of various diseases, but it is not easy to predict potential human miRNA-disease associations from the vast amount of biological data. Computational methods for predicting potential disease-miRNA a...

journal_title：Molecular bioSystems

authors： Chen X,Liu MX,Yan GY

更新日期：2012-10-01 00:00:00

abstract：:Secretagogin is a hexa EF-hand Ca(2+)-binding protein expressed in neuroendocrine, pancreatic endocrine and retinal cells. The protein has been noted for its expression in specific neuronal subtypes in the support of hierarchical organizing principles in the mammalian brain. Secretagogin has previously been found to i...

journal_title：Molecular bioSystems

authors： Bauer MC,O'Connell DJ,Maj M,Wagner L,Cahill DJ,Linse S

更新日期：2011-07-01 00:00:00

abstract：:The investigation of the structure and dynamics of signal transduction systems through data-based mathematical models in ordinary differential equations or other paradigms has proven to be a successful approach in recent times. Extending this concept, we here analysed the use of kinetic models based on power-law terms...

journal_title：Molecular bioSystems

authors： Vera J,Rath O,Balsa-Canto E,Banga JR,Kolch W,Wolkenhauer O

更新日期：2010-11-01 00:00:00

abstract：:A rapid and sensitive gold-nanobioprobe based immunoassay format has been presented for the detection of capsular Vi polysaccharide of Salmonella enterica serovar Typhi (surface antigen) using anti-Vi antibodies. The Vi antigen was extracted from serovar Typhi cells, under the optimised growth conditions for its over-...

journal_title：Molecular bioSystems

authors： Pandey SK,Suri CR,Chaudhry M,Tiwari RP,Rishi P

更新日期：2012-07-06 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are key signaling proteins that regulate how cells interact with their environment. Traditional signaling cascades involving GPCRs have been well described and are well established and very important clinical targets. With the development of more recent technologies, hints about the...

journal_title：Molecular bioSystems

authors： Zhang X,Eggert US

更新日期：2013-04-05 00:00:00

abstract：:Glycodendrimers, such as glycoclusters and glycopolymers, are known to be very useful molecules to probe carbohydrate-lectin interactions. Herein, new second generation glycopeptide dendrimers (G2a-f) presenting a L-lysine-based (Lys) tetraantennary scaffold, four external thiomannosyl residues and, in the case of com...

journal_title：Molecular bioSystems

authors： Euzen R,Reymond JL

更新日期：2011-02-01 00:00:00

abstract：:The size and complexity of cellular systems make building predictive models an extremely difficult task. In principle dynamical time-course data can be used to elucidate the structure of the underlying molecular mechanisms, but a central and recurring problem is that many and very different models can be fitted to exp...

journal_title：Molecular bioSystems

authors： Erguler K,Stumpf MP

更新日期：2011-05-01 00:00:00

abstract：:Microtubules (mt) are highly dynamic polymers composed of alpha- and beta-tubulin monomers that are present in all dividing and non-dividing cells. A broad variety of natural products exists that are known to interfere with the microtubule network, by either stabilizing or de-stabilizing these rope-like polymers. Amon...

journal_title：Molecular bioSystems

authors： Eirich J,Burkhart JL,Ullrich A,Rudolf GC,Vollmar A,Zahler S,Kazmaier U,Sieber SA

更新日期：2012-08-01 00:00:00

abstract：:Growth factor receptor signaling via receptor tyrosine kinases (RTKs) is one of the basic cellular communication principals found in all metazoans. Extracellular signals are transferred via membrane spanning receptors into the cytoplasm, reversible tyrosine phosphorylation being the hallmark of all RTKs. In recent yea...

journal_title：Molecular bioSystems

authors： Dengjel J,Kratchmarova I,Blagoev B

更新日期：2009-10-01 00:00:00

abstract：:Mass spectrometry (MS) has become an increasingly important technique to analyze proteins. In popular bottom-up MS-based proteomics, reduction and alkylation are routine steps to facilitate peptide identification. However, incomplete reactions and side reactions may occur, which compromise the experimental results. In...

journal_title：Molecular bioSystems

authors： Suttapitugsakul S,Xiao H,Smeekens J,Wu R

更新日期：2017-11-21 00:00:00

abstract：:Schistosomiasis is a parasitic infection that is endemic in many developing countries in the tropics and subtropics afflicting more than 207 million people primarily in rural areas. After malaria, it is the second most important parasitic infection in terms of socio-economic and public health. Investigation of the hos...

journal_title：Molecular bioSystems

authors： Balog CI,Meissner A,Göraler S,Bladergroen MR,Vennervald BJ,Mayboroda OA,Deelder AM

更新日期：2011-05-01 00:00:00

abstract：:The ectonucleotide phosphodiesterase/pyrophosphatase-1 (NPP1) is a type II transmembrane glycoprotein that regulates extracellular inorganic purine nucleotide and inorganic diphosphate levels through the hydrolysis of ATP into AMP and diphosphate. NPP1 is a promising drug target as it plays a role in several disorders...

journal_title：Molecular bioSystems

authors： Barbeau X,Mathieu P,Paquin JF,Lagüe P

更新日期：2017-05-30 00:00:00

abstract：:The selective inhibition for JAK2 over the other JAK family kinases (JAK1, JAK3 and TYK2) has shared an immense challenge due to high conservatism. In this paper, the highly JAK2 selective mechanism of the thienopyridine derivative was identified at the molecular level, based on insights into the inhibitory effects of...

journal_title：Molecular bioSystems

authors： Li JJ,Cheng P,Tu J,Zhai HL,Zhang XY

更新日期：2016-02-01 00:00:00

abstract：:The importance of microRNA (miRNA) in modulating gene expression at the post-transcriptional level is well known. Such regulation has been shown to influence the dynamics of several regulatory networks including the cell cycle. In this study we incorporated regulatory effects of intronic miRNA into an existing mathema...

journal_title：Molecular bioSystems

authors： Gokhale S,Hariharan M,Brahmachari SK,Gadgil C

更新日期：2012-08-01 00:00:00