A gold nanoparticles based immuno-bioprobe for detection of Vi capsular polysaccharide of Salmonella enterica serovar Typhi.

abstract：:Systematic screens for human disease genes have emerged in recent years, due to the wealth of information provided by genome sequences and large scale datasets. Here we review how integration of genomic data in yeast and human is helping to elucidate the genetic basis of mitochondrial diseases. The identification of n...

journal_title：Molecular bioSystems

authors： Perocchi F,Mancera E,Steinmetz LM

更新日期：2008-01-01 00:00:00

abstract：:Comparative analysis of the complete genome sequences from a variety of poorly studied organisms aims at predicting ecological and behavioral properties of these organisms and helping in characterizing their habitats. This task requires finding appropriate descriptors that could be correlated with the core traits of e...

journal_title：Molecular bioSystems

authors： Galperin MY,Higdon R,Kolker E

更新日期：2010-04-01 00:00:00

abstract：:Fabry disease (FD) is an X-linked lysosomal storage disorder caused by a deficiency of the lysosomal hydrolase α-galactosidase A (α-GalA) that leads to the intra-lysosomal accumulation of globotriaosylceramide (Gb3) in various organ systems. As a consequence, a multisystems disorder develops, culminating in stroke, pr...

journal_title：Molecular bioSystems

authors： Matafora V,Cuccurullo M,Beneduci A,Petrazzuolo O,Simeone A,Anastasio P,Mignani R,Feriozzi S,Pisani A,Comotti C,Bachi A,Capasso G

更新日期：2015-06-01 00:00:00

abstract：:Are protein functions continuous or discretized? Proteomics investigations are starting to address this non-trivial awesome question focusing upon determining the nature of biological molecular relationships. In the following editorial we present a number of experimental studies published in this themed Proteomics Iss...

journal_title：Molecular bioSystems

authors： Urbani A,Castagnola M,Fasano M,Bini L,Modesti A,Timperio AM,Roncada P

更新日期：2013-06-01 00:00:00

abstract：:Drug combinations have been widely applied to treat complex diseases, like cancer, HIV and cardiovascular diseases. One of the most important characteristics for drug combinations is the synergistic effects among different drugs, that is to say, the combination effects are larger than the sum of individual effects. Al...

journal_title：Molecular bioSystems

authors： Chen D,Zhang H,Lu P,Liu X,Cao H

更新日期：2016-02-01 00:00:00

abstract：:In order to elucidate the effect of flexible linker length on the catalytic efficiency of fusion proteins, two short flexible peptide linkers of various lengths were fused between Arabidopsis thaliana 4-coumaroyl-CoA ligase (4CL) and Polygonum cuspidatum stilbene synthase (STS) to generate fusion proteins 4CL-(GSG)n-S...

journal_title：Molecular bioSystems

authors： Guo H,Yang Y,Xue F,Zhang H,Huang T,Liu W,Liu H,Zhang F,Yang M,Liu C,Lu H,Zhang Y,Ma L

更新日期：2017-02-28 00:00:00

abstract：:Cervical cancer is initiated by infection with high-risk human papillomavirus (HPV). The viral E6 and E7 oncogenes are required for the initiation of cervical epithelial cell immortalization, but do not suffice to cause cervical cancer. Human oncogenes and tumor suppressor genes with altered activity in cervical carci...

journal_title：Molecular bioSystems

authors： Kravchenko-Balasha N,Klein S,Safrai M,Levitzki A

更新日期：2011-05-01 00:00:00

abstract：:Epithelial to mesenchymal transition (EMT) is a biological process that plays a crucial role in cancer metastasis. Although studies regarding the EMT mechanisms are usual in terms of gene expression and protein functions, little is known about the involvement of lipids in EMT. In this work, an untargeted lipidomic ana...

journal_title：Molecular bioSystems

authors： Dalmau N,Jaumot J,Tauler R,Bedia C

更新日期：2015-12-01 00:00:00

abstract：:Cycloserine (CS, 4-amino-3-isoxazolidone) is a cyclic amino acid mimic that is known to inhibit many essential pyridoxal 5'-phosphate (PLP)-dependent enzymes. Two CS enantiomers are known; D-cycloserine (DCS, also known as Seromycin) is a natural product that is used to treat resistant Mycobacterium tuberculosis infec...

journal_title：Molecular bioSystems

authors： Lowther J,Yard BA,Johnson KA,Carter LG,Bhat VT,Raman MC,Clarke DJ,Ramakers B,McMahon SA,Naismith JH,Campopiano DJ

更新日期：2010-09-01 00:00:00

abstract：:Disordered regions within proteins have increasingly been associated with various cellular functions. Identifying the specific roles played by disorder in these functions has proved difficult. However, the development of reliable prediction algorithms has expanded the study of disorder from a few anecdotal examples to...

journal_title：Molecular bioSystems

authors： Bellay J,Michaut M,Kim T,Han S,Colak R,Myers CL,Kim PM

更新日期：2012-01-01 00:00:00

abstract：:Normalization of array data relies on the assumption that most genes are not altered, which means that the signals for different samples should be scaled to have similar median or average values. However, accumulating evidence suggests that gene expression could be widely up-regulated in cancers. Our previous results ...

journal_title：Molecular bioSystems

authors： Wu D,Kang J,Huang Y,Li X,Wang X,Huang D,Wang Y,Li B,Hao D,Gu Q,Tang N,Li K,Guo Z,Li X,Xu J,Wang D

更新日期：2014-06-01 00:00:00

abstract：:The identification of genetic markers (e.g. genes, pathways and subnetworks) for cancer has been one of the most challenging research areas in recent years. A subset of these studies attempt to analyze genome-wide expression profiles to identify markers with high reliability and reusability across independent whole-tr...

journal_title：Molecular bioSystems

authors： Farahmand S,Goliaei S,Ansari-Pour N,Razaghi-Moghadam Z

更新日期：2016-03-01 00:00:00

abstract：:Photo-chemical deamination of cytosine using 3-cyanovinylcarbazole nucleoside (CNVK) mediated photo-cross-linking is a technique for site-directed mutagenesis. Using this technique in vivo requires the elimination of a high-temperature incubation step; instead, incubation should be carried out under physiological cond...

journal_title：Molecular bioSystems

authors： Sethi S,Ooe M,Sakamoto T,Fujimoto K

更新日期：2017-06-01 00:00:00

abstract：:The emerging field of synthetic biology is generating insatiable demands for synthetic genes, which far exceed existing gene synthesis capabilities. This review discusses the current methods of chemical DNA synthesis and gene assembly, as well as the latest engineering tools, technologies and trends which could potent...

journal_title：Molecular bioSystems

authors： Tian J,Ma K,Saaem I

更新日期：2009-07-01 00:00:00

abstract：:Endogenous thymidylate synthases, isolated from tissues or cultured cells of the same specific origin, have been reported to show differing slow-binding inhibition patterns. These were reflected by biphasic or linear dependence of the inactivation rate on time and accompanied by differing inhibition parameters. Consid...

journal_title：Molecular bioSystems

authors： Ludwiczak J,Maj P,Wilk P,Frączyk T,Ruman T,Kierdaszuk B,Jarmuła A,Rode W

更新日期：2016-04-01 00:00:00

abstract：:We demonstrate the expected preference of an immobilised oligosaccharide Man(9)(GlcNAc)(2) upon a 96-well photochemical array, for its known receptor, the cell-surface lectin Dendritic Cell-Specific ICAM3 Grabbing Nonintegrin (DC-SIGN) when compared to immobilised competing monosaccharides. ...

journal_title：Molecular bioSystems

authors： Dilly SJ,Clark AJ,Mitchell DA,Marsh A,Taylor PC

更新日期：2011-01-01 00:00:00

abstract：:The essential idea of regenerative medicine is to fix or replace tissues or organs with alive and patient-specific implants. Pluripotent stem cells are able to indefinitely self-renew and differentiate into all cell types of the body which makes them a potent substantial player in regenerative medicine. The easily acc...

journal_title：Molecular bioSystems

authors： Baranek M,Belter A,Naskręt-Barciszewska MZ,Stobiecki M,Markiewicz WT,Barciszewski J

更新日期：2017-01-31 00:00:00

abstract：:Biological networks are effective tools for studying molecular interactions. Modular structure, in which genes or proteins may tend to be associated with functional modules or protein complexes, is a remarkable feature of biological networks. Mining modular structure from biological networks enables us to focus on a s...

journal_title：Molecular bioSystems

authors： Jiao QJ,Huang Y,Shen HB

更新日期：2016-11-15 00:00:00

abstract：:The recognition and association between the Ca2+/calmodulin-activated protein kinase II-α (CaMKIIα) and the multi-PDZ domain protein 1 (MUPP1) plays an important role in the sperm acrosome reaction and human fertilization. Previously, we have demonstrated that the MUPP1 PDZ11 domain is the primary binding partner of t...

journal_title：Molecular bioSystems

authors： Zhang YL,Han ZF

更新日期：2017-09-26 00:00:00

abstract：:Abundant information about the nucleotide sequence of the human genome has become readily available and it is now necessary to develop methods for the identification of genes that are involved in important cellular, developmental and disease-related processes. Identification methods based on the activities of hammerhe...

journal_title：Molecular bioSystems

authors： Sano M,Kato Y,Taira K

更新日期：2005-05-01 00:00:00

abstract：:Human mitogen-activated protein kinase (MAPK) family members JNK and p38 are two homologous protein-serine/threonine kinases but play distinct roles in the pathological process of neurological disorders. Selective targeting of JNK over p38 has been established as a potential therapeutic approach to epilepsy and other ...

journal_title：Molecular bioSystems

authors： Zhuo ZH,Sun YZ,Jin PN,Li FY,Zhang YL,Wang HL

更新日期：2016-07-19 00:00:00

abstract：:Protein tyrosine phosphatases (PTPs) constitute a large family of enzymes that play key roles in cell signaling. Deregulation of PTP activity results in aberrant tyrosine phosphorylation, which has been linked to the etiology of several human diseases, including cancer. Since phosphate removal by the PTPs can both enh...

journal_title：Molecular bioSystems

authors： Liang F,Kumar S,Zhang ZY

更新日期：2007-05-01 00:00:00

abstract：:To faithfully execute diverse biological programs all cells need to access and distribute their genomes in a highly organized way. In the nucleus of eukaryotic cells DNA is packed with histone proteins into chromatin. The originating nucleo-protein complex is the regulatory platform for all genetic processes. Of these...

journal_title：Molecular bioSystems

authors： Nikolov M,Fischle W

更新日期：2013-02-02 00:00:00

abstract：:Synthetic studies of lipid A and LPS partial structures have been performed to investigate the relationship between structures and functions of LPS. Recent studies have suggested several pathological implications of LPS from parasitic bacteria due to its influence on the host immune responses. To address this issue, w...

journal_title：Molecular bioSystems

authors： Fujimoto Y,Shimoyama A,Saeki A,Kitayama N,Kasamatsu C,Tsutsui H,Fukase K

更新日期：2013-05-01 00:00:00

abstract：:Thyroid carcinoma is a common endocrine malignancy worldwide, accounting for approximately 1% of all diagnosed cancers and about 91.5% of the malignancies of head and neck. However, differentiating malignant thyroid nodules from benign ones remains a diagnostic challenge. Thus, novel molecular markers that enable non-...

journal_title：Molecular bioSystems

authors： Yao Z,Yin P,Su D,Peng Z,Zhou L,Ma L,Guo W,Ma L,Xu G,Shi J,Jiao B

更新日期：2011-09-01 00:00:00

abstract：:Nitronyl nitroxides are capable of preventing cells, tissues, and organs from radical-induced damage through scavenging NO˙, ˙O(2)(-) and ˙OH. In order to explore the conversions of nitronyl nitroxides in biological systems with and without NO˙, HPLC-MS aided PC12 cell systems were developed, and the conversions of 2-...

journal_title：Molecular bioSystems

authors： Wang Y,Jiang X,Liu J,Zhao M,Kang G,Wu J,Peng L,Peng S

更新日期：2011-05-01 00:00:00

abstract：:Calcium homeostasis is a key factor in the regulation of cardiac excitation-contraction coupling. Calcium dynamics in cardiomyocytes is governed by ATP which depends on insulin dependent glucose concentration, via the glucose transporter type 4 (GLUT4) transporter. It would therefore be interesting to see how calcium ...

journal_title：Molecular bioSystems

authors： Das PN,Kumar A,Bairagi N,Chatterjee S

更新日期：2017-09-26 00:00:00

abstract：:Matrix metalloproteinases (MMPs) consist of a class of proteins required for normal tissue function. Their over expression is associated with many disease states and hence the interest in MMPs as drug targets. Almost all MMP inhibitors have been reported to fail in clinical trials due to lack of specificity. Zinc in t...

journal_title：Molecular bioSystems

authors： Singh T,Adekoya OA,Jayaram B

更新日期：2015-04-01 00:00:00

abstract：:Bacterial biofilms are defined as a community of surface-attached bacteria that are protected by an extracellular matrix of biomolecules. We have recently reported the synthesis of a small molecule, denoted TAGE, based on the natural product bromoageliferin and demonstrated that TAGE has anti-biofilm activity against ...

journal_title：Molecular bioSystems

authors： Huigens RW 3rd,Ma L,Gambino C,Moeller PD,Basso A,Cavanagh J,Wozniak DJ,Melander C

更新日期：2008-06-01 00:00:00

abstract：:4-Hydroxyderricin is a heat labile bioactive chalcone isolated from the plant Angelica keiskei. It received attention due to its antibiotic potency against several strains of bacteria including pathogens such as Staphylococcus aureus. Despite these promising pharmacological properties, the exact mode of action or the ...

journal_title：Molecular bioSystems

authors： Battenberg OA,Yang Y,Verhelst SH,Sieber SA

更新日期：2013-03-01 00:00:00