Control of bacterial biofilms with marine alkaloid derivatives.

abstract：:Biochemical modifications to mRNA, especially N6-methyladenosine (m6A) and 5-methylcytosine (m5C), have been recently shown to be associated with crucial biological functions. Despite the intriguing advancements, little is known so far about the dynamic landscape of RNA methylome across different cell types and how th...

journal_title：Molecular bioSystems

authors： Liu L,Zhang SW,Zhang YC,Liu H,Zhang L,Chen R,Huang Y,Meng J

更新日期：2015-01-01 00:00:00

abstract：:The recognition and association between the Ca2+/calmodulin-activated protein kinase II-α (CaMKIIα) and the multi-PDZ domain protein 1 (MUPP1) plays an important role in the sperm acrosome reaction and human fertilization. Previously, we have demonstrated that the MUPP1 PDZ11 domain is the primary binding partner of t...

journal_title：Molecular bioSystems

authors： Zhang YL,Han ZF

更新日期：2017-09-26 00:00:00

abstract：:Microtubules (mt) are highly dynamic polymers composed of alpha- and beta-tubulin monomers that are present in all dividing and non-dividing cells. A broad variety of natural products exists that are known to interfere with the microtubule network, by either stabilizing or de-stabilizing these rope-like polymers. Amon...

journal_title：Molecular bioSystems

authors： Eirich J,Burkhart JL,Ullrich A,Rudolf GC,Vollmar A,Zahler S,Kazmaier U,Sieber SA

更新日期：2012-08-01 00:00:00

abstract：:Fabry disease (FD) is an X-linked lysosomal storage disorder caused by a deficiency of the lysosomal hydrolase α-galactosidase A (α-GalA) that leads to the intra-lysosomal accumulation of globotriaosylceramide (Gb3) in various organ systems. As a consequence, a multisystems disorder develops, culminating in stroke, pr...

journal_title：Molecular bioSystems

authors： Matafora V,Cuccurullo M,Beneduci A,Petrazzuolo O,Simeone A,Anastasio P,Mignani R,Feriozzi S,Pisani A,Comotti C,Bachi A,Capasso G

更新日期：2015-06-01 00:00:00

abstract：:At the intersection between artificial intelligence and statistics, supervised learning allows algorithms to automatically build predictive models from just observations of a system. During the last twenty years, supervised learning has been a tool of choice to analyze the always increasing and complexifying data gene...

journal_title：Molecular bioSystems

authors： Geurts P,Irrthum A,Wehenkel L

更新日期：2009-12-01 00:00:00

abstract：:Are protein functions continuous or discretized? Proteomics investigations are starting to address this non-trivial awesome question focusing upon determining the nature of biological molecular relationships. In the following editorial we present a number of experimental studies published in this themed Proteomics Iss...

journal_title：Molecular bioSystems

authors： Urbani A,Castagnola M,Fasano M,Bini L,Modesti A,Timperio AM,Roncada P

更新日期：2013-06-01 00:00:00

abstract：:The identification of a suitable non-fluorescent molecule that can be oxidized by G-quadruplexes into a fluorescent product will be important for several fields such as bioanalyte sensing and cancer therapeutic discovery. Herein, we demonstrate that 2',7'-dichlorodihydrofluorescein diacetate is a superior reducing sub...

journal_title：Molecular bioSystems

authors： Nakayama S,Sintim HO

更新日期：2010-01-01 00:00:00

abstract：:Biotin is an enzyme cofactor indispensable to metabolic fixation of carbon dioxide in all three domains of life. Although the catalytic and physiological roles of biotin have been well characterized, the biosynthesis of biotin remains to be fully elucidated. Studies in microbes suggest a two-stage biosynthetic pathway...

journal_title：Molecular bioSystems

authors： Lin S,Cronan JE

更新日期：2011-06-01 00:00:00

abstract：:In actively proliferating cells, such as the cells of the developing embryo, DNA repair is crucial for preventing the accumulation of mutations and synchronizing cell division. Sea urchin embryo growth was analyzed and extracts were prepared. The relative activity of DNA polymerase, apurinic/apyrimidinic (AP) endonucl...

journal_title：Molecular bioSystems

authors： Torgasheva NA,Menzorova NI,Sibirtsev YT,Rasskazov VA,Zharkov DO,Nevinsky GA

更新日期：2016-06-21 00:00:00

abstract：:Large combinatorial libraries of macrocyclic peptides are a useful source of bioactive compounds. However, peptides are not generally cell permeable, so there is great interest in the development of methods to create large libraries of modified peptides. In particular, N-alkylation of peptides is known to improve thei...

journal_title：Molecular bioSystems

authors： Morimoto J,Kodadek T

更新日期：2015-10-01 00:00:00

abstract：:Information on extracellular signals and conditions is often transduced by biological systems using cascades of protein phosphorylation that affect the activity of enzymes, the localization of proteins and gene expression. A model to study signal transduction is the response of the yeast Saccharomyces cerevisiae to os...

journal_title：Molecular bioSystems

authors： Soufi B,Kelstrup CD,Stoehr G,Fröhlich F,Walther TC,Olsen JV

更新日期：2009-11-01 00:00:00

abstract：:Here, we used stopped-flow fluorescence techniques to conduct a comparative kinetic analysis of the conformational transitions in human apurinic/apyrimidinic endonuclease 1 (APE1) and in DNA containing an abasic site in the course of their interaction. Effects of monovalent (K(+)) and divalent (Mg(2+), Mn(2+), Ca(2+),...

journal_title：Molecular bioSystems

authors： Miroshnikova AD,Kuznetsova AA,Vorobjev YN,Kuznetsov NA,Fedorova OS

更新日期：2016-05-26 00:00:00

abstract：:As a versatile pathogen Staphylococcus aureus can cause various disease patterns, which are influenced by strain specific virulence factor repertoires but also by S. aureus physiological adaptation capacity. Here, we present metabolomic descriptions of S. aureus central metabolic pathways and demonstrate the potential...

journal_title：Molecular bioSystems

authors： Liebeke M,Dörries K,Zühlke D,Bernhardt J,Fuchs S,Pané-Farré J,Engelmann S,Völker U,Bode R,Dandekar T,Lindequist U,Hecker M,Lalk M

更新日期：2011-04-01 00:00:00

abstract：:In this review we bring together recent results from our group focused towards the development of biosensors from single conically-shaped artificial nanopores. The nanopores, used in the work presented here, were prepared using the track-etch process. The fabrication of track-etched conical nanopores has been optimize...

journal_title：Molecular bioSystems

authors： Sexton LT,Horne LP,Martin CR

更新日期：2007-10-01 00:00:00

abstract：:Infections caused by human parasites (HPs) affect the poorest 500 million people worldwide but chemotherapy has become expensive, toxic, and/or less effective due to drug resistance. On the other hand, many 3D structures in Protein Data Bank (PDB) remain without function annotation. We need theoretical models to quick...

journal_title：Molecular bioSystems

authors： González-Díaz H,Muíño L,Anadón AM,Romaris F,Prado-Prado FJ,Munteanu CR,Dorado J,Sierra AP,Mezo M,González-Warleta M,Gárate T,Ubeira FM

更新日期：2011-06-01 00:00:00

abstract：:The effect of the glutathione transferase P1-1 (GSTP1-1) targeting has been investigated in both sensitive (U-2OS) and cisplatin-resistant (U-2OS/CDDP4 μg) human osteosarcoma cell lines. Despite the different enzyme's content, inhibition of GSTP1-1 by 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) causes the...

journal_title：Molecular bioSystems

authors： Sau A,Filomeni G,Pezzola S,D'Aguanno S,Tregno FP,Urbani A,Serra M,Pasello M,Picci P,Federici G,Caccuri AM

更新日期：2012-04-01 00:00:00

abstract：:The glutamate γ-carboxylation plays a pivotal part in a number of important human diseases. However, traditional protein γ-carboxylation site detection by experimental approaches are often laborious and time-consuming. In this study, we initiated an attempt for the computational prediction of protein γ-carboxylation s...

journal_title：Molecular bioSystems

authors： Zhang N,Li BQ,Gao S,Ruan JS,Cai YD

更新日期：2012-11-01 00:00:00

abstract：:In the post-genome era, one of the most important and challenging tasks is to identify the subcellular localizations of protein complexes, and further elucidate their functions in human health with applications to understand disease mechanisms, diagnosis and therapy. Although various experimental approaches have been ...

journal_title：Molecular bioSystems

authors： Li ZC,Lai YH,Chen LL,Chen C,Xie Y,Dai Z,Zou XY

更新日期：2013-04-05 00:00:00

abstract：:Small molecule modulators are critical for dissecting and understanding signaling pathways at the molecular level. Interleukin 6 (IL-6) is a cytokine that signals via the JAK-STAT pathway and is implicated in cancer and inflammation. To identify modulators of this pathway, we screened a chemical collection against an ...

journal_title：Molecular bioSystems

authors： Johnson RL,Huang R,Jadhav A,Southall N,Wichterman J,MacArthur R,Xia M,Bi K,Printen J,Austin CP,Inglese J

更新日期：2009-09-01 00:00:00

abstract：:When photoirradiated, an unnatural sialic acid analog can covalently capture the complex formed by ganglioside GM1 and cholera toxin subunit B. ...

journal_title：Molecular bioSystems

authors： Bond MR,Whitman CM,Kohler JJ

更新日期：2010-10-01 00:00:00

abstract：:Individuals infected with the human immunodeficiency virus (HIV) often suffer from concomitant metabolic complications. Treatment with antiretroviral therapy has also been shown to alter the metabolism of patients. Although chemometric analysis of nuclear magnetic resonance (NMR) spectra of human sera can distinguish ...

journal_title：Molecular bioSystems

authors： McKnight TR,Yoshihara HA,Sitole LJ,Martin JN,Steffens F,Meyer D

更新日期：2014-11-01 00:00:00

abstract：:Protein-protein interactions play an essential role in the regulation of various cellular processes. Understanding the recognition mechanism of protein-protein complexes is a challenging task in molecular and computational biology. In this work, we have developed an energy based approach for identifying the binding si...

journal_title：Molecular bioSystems

authors： Gromiha MM,Yokota K,Fukui K

更新日期：2009-12-01 00:00:00

abstract：:The zebrafish Danio rerio is a model vertebrate organism for understanding biological mechanisms. Recent studies have explored using zebrafish as a model for lipid-related diseases, for in vivo fish bioassays, and for embryonic toxicity experiments. Mass spectrometry (MS) and MS imaging are established tools for lipid...

journal_title：Molecular bioSystems

authors： Pirro V,Guffey SC,Sepúlveda MS,Mahapatra CT,Ferreira CR,Jarmusch AK,Cooks RG

更新日期：2016-06-01 00:00:00

abstract：:Renal cell carcinoma (RCC), the most common neoplasm affecting the adult kidney, is characterised by heterogeneity of histological subtypes, drug resistance, and absence of molecular markers. Two-dimensional difference gel electrophoresis (2-D DIGE) technology in combination with mass spectrometry (MS) was applied to ...

journal_title：Molecular bioSystems

authors： Raimondo F,Salemi C,Chinello C,Fumagalli D,Morosi L,Rocco F,Ferrero S,Perego R,Bianchi C,Sarto C,Pitto M,Brambilla P,Magni F

更新日期：2012-04-01 00:00:00

abstract：:Rhein is a natural product purified from herbal plants such as Rheum palmatum, which has been shown to have anti-angiogenesis and anti-tumor metastasis properties. However, the biological effects of rhein on the behavior of breast cancers are not completely elucidated. To evaluate whether rhein might be useful in the ...

journal_title：Molecular bioSystems

authors： Huang HJ,Lin CC,Chou HC,Chen YW,Lin ST,Lin YC,Lin DY,Lyu KW,Chan HL

更新日期：2014-12-01 00:00:00

abstract：:Single molecule observation of fluorescence resonance energy transfer can be used to provide insight into the structure and dynamics of proteins. Using a straightforward triple-colour labelling strategy, we present a measurement and analysis scheme that can simultaneously study multiple regions within single intrinsic...

journal_title：Molecular bioSystems

authors： Milles S,Koehler C,Gambin Y,Deniz AA,Lemke EA

更新日期：2012-10-01 00:00:00

abstract：:The human corticotropin-releasing factor receptor type 1 (CRF1R) is a class B G-protein-coupled receptor (GPCR), which mediates the response to stress and has been considered as a drug target for depression and anxiety. Based on the CRF1R-antagonist crystal structure, we study the binding mechanism of two distinct ant...

journal_title：Molecular bioSystems

authors： Xu J,Wang Z,Liu P,Li D,Lin J

更新日期：2015-07-01 00:00:00

abstract：:With the advent of new cancer therapies in the last few years, the goals of reducing disease burden and improving quality of life are frequently achieved. Yet despite the advances seen with numerous monotherapies, a multimodality approach that targets different aspects of tumor biology may yield the greatest clinical ...

journal_title：Molecular bioSystems

authors： Kamrava M,Bernstein MB,Camphausen K,Hodge JW

更新日期：2009-11-01 00:00:00

abstract：:Major progress in the study of RNase P has resulted from crystallography of bacterial catalytic subunits and the discovery of catalytic activity in eukaryotes. Several new substrates have also been identified, primarily in bacteria but also in yeast. Our current world should be called the "RNA-protein world" rather th...

journal_title：Molecular bioSystems

authors： Altman S

更新日期：2007-09-01 00:00:00

abstract：:Secretagogin is a hexa EF-hand Ca(2+)-binding protein expressed in neuroendocrine, pancreatic endocrine and retinal cells. The protein has been noted for its expression in specific neuronal subtypes in the support of hierarchical organizing principles in the mammalian brain. Secretagogin has previously been found to i...

journal_title：Molecular bioSystems

authors： Bauer MC,O'Connell DJ,Maj M,Wagner L,Cahill DJ,Linse S

更新日期：2011-07-01 00:00:00