Abstract:
:Are protein functions continuous or discretized? Proteomics investigations are starting to address this non-trivial awesome question focusing upon determining the nature of biological molecular relationships. In the following editorial we present a number of experimental studies published in this themed Proteomics Issue demonstrating the development of a new analogical vision for the interpretation of genotype-phenotype relationships. New metrics and languages are evolving, which may complement the insufficiency based on a binary digital interpretation of biological phenomena, providing new tools for the interpretation of large scale-experimental studies.
journal_name
Mol Biosystjournal_title
Molecular bioSystemsauthors
Urbani A,Castagnola M,Fasano M,Bini L,Modesti A,Timperio AM,Roncada Pdoi
10.1039/c3mb90013dsubject
Has Abstractpub_date
2013-06-01 00:00:00pages
1062-3issue
6eissn
1742-206Xissn
1742-2051journal_volume
9pub_type
社论abstract::A recent model proposing that a barrier is raised against tumor evolution in pre-cancer tissues is investigated. For that we quantify expression alterations in genome maintenance pathways: DNA damage response, death pathways and cell cycle and also differentially expressed genes in transcriptomes of pre-cancerous and ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
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abstract::Celastrol, isolated from the traditional Chinese medicinal herb Tripterygium wilfordii Hook. f. (Thunder God's Vine), has been used to treat cancer, chronic inflammatory, autoimmune and other human diseases. However, to date, the protein targets and the mechanism of action of celastrol have remained elusive. In this s...
journal_title:Molecular bioSystems
pub_type: 杂志文章
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abstract::A lipase substrate microarray was obtained by printing aliphatic C2-C12 monoesters of (5R)- and (5S)-3-(5,6-dihydroxyhexyloxy)benzaldehyde by reductive alkylation on amine-functionalized glass slides coated with bovine serum albumin and a short PEG linker. The microarray features 12 substrates and their 66 possible bi...
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journal_title:Molecular bioSystems
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journal_title:Molecular bioSystems
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journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
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journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
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journal_title:Molecular bioSystems
pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c5mb00071h
更新日期:2015-06-01 00:00:00
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journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c5mb00415b
更新日期:2016-01-01 00:00:00
abstract::Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides lysine for protein synthesis and both lysine and meso-diaminopimelate for construction of the bacterial peptidoglycan cell wall. In this Highlight article we review recent advances in the valida...
journal_title:Molecular bioSystems
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journal_title:Molecular bioSystems
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journal_title:Molecular bioSystems
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journal_title:Molecular bioSystems
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journal_title:Molecular bioSystems
pub_type: 杂志文章
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journal_title:Molecular bioSystems
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journal_title:Molecular bioSystems
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journal_title:Molecular bioSystems
pub_type: 杂志文章
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journal_title:Molecular bioSystems
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journal_title:Molecular bioSystems
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journal_title:Molecular bioSystems
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