Abstract:
:Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides lysine for protein synthesis and both lysine and meso-diaminopimelate for construction of the bacterial peptidoglycan cell wall. In this Highlight article we review recent advances in the validation of antibiotic targets, studies of the enzymes of the lysine biosynthetic pathway and development of inhibitors of these enzymes.
journal_name
Mol Biosystjournal_title
Molecular bioSystemsauthors
Hutton CA,Perugini MA,Gerrard JAdoi
10.1039/b705624asubject
Has Abstractpub_date
2007-07-01 00:00:00pages
458-65issue
7eissn
1742-206Xissn
1742-2051journal_volume
3pub_type
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