BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells.


:Dynamic physical interactions between proteins underpin all key cellular processes and are a highly attractive area for the development of research tools and medicines. Protein-protein interactions frequently involve α-helical structures, but peptides matching the sequences of these structures usually do not fold correctly in isolation. Therefore, much research has focused on the creation of small peptides that adopt stable α-helical structures even in the absence of their intended protein targets. We show that short peptides alkylated with azobenzene crosslinkers can be used to photo-stimulate mitochondrial membrane depolarization and cytochrome c release in permeabilised cells, the initial events of the intrinsic apoptosis pathway.


Mol Biosyst


Molecular bioSystems


Mart RJ,Errington RJ,Watkins CL,Chappell SC,Wiltshire M,Jones AT,Smith PJ,Allemann RK




Has Abstract


2013-11-01 00:00:00












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    authors: Kravchenko-Balasha N,Klein S,Safrai M,Levitzki A

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    authors: Liu L,Zhang SW,Zhang YC,Liu H,Zhang L,Chen R,Huang Y,Meng J

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    authors: Jiang P,Dai W,Yan S,Chen Z,Xu R,Ding J,Xiang L,Wang S,Liu R,Zhang W

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    authors: Liu Y,Platchek M,Kement B,Bee WT,Truong M,Zeng X,Hung S,Lin H,Morrow D,Kallal LA,Xie Q,Agarwal P,Pope AJ,Wu Z

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    authors: Menon S,Sengupta N

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    authors: Valeyev NV,Heslop-Harrison P,Postlethwaite I,Gizatullina AN,Kotov NV,Bates DG

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    authors: Sano M,Kato Y,Taira K

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    authors: Mamidi N,Gorai S,Mukherjee R,Manna D

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    authors: Hagen DR,Tidor B

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    authors: Jin S,Pan D,Zha X,Yu X,Wu Y,Liu Y,Yin F,Chen XS

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    authors: Muries B,Faize M,Carvajal M,Martínez-Ballesta Mdel C

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    authors: Janardhan S,Ram Vivek M,Narahari Sastry G

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    authors: Shyti R,Kohler I,Schoenmaker B,Derks RJ,Ferrari MD,Tolner EA,Mayboroda OA,van den Maagdenberg AM

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    abstract::Structural insight into DNA quadruplex structures formed by oligodeoxyribonucleotides 3'TG5'-5'GGGT3' (QS55) and 5'TG3'-3'GGGT5' (QS33) is presented. NMR analysis reveals that QS33 forms a parallel-like four-fold symmetric quadruplex, while QS55 possesses a two-fold symmetry and is characterized by a tetrameric antipa...

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    authors: Galeone A,Mayol L,Virgilio A,Virno A,Randazzo A

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  • A novel SNP detection technique utilizing a multiple primer extension (MPEX) on a phospholipid polymer-coated surface.

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    authors: Imai K,Ogai Y,Nishizawa D,Kasai S,Ikeda K,Koga H

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    authors: Tanaka Y,Bond MR,Kohler JJ

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  • Studies of N(9)-arenthenyl purines as novel DFG-in and DFG-out dual Src/Abl inhibitors using 3D-QSAR, docking and molecular dynamics simulations.

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    journal_title:Molecular bioSystems

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    authors: Ma S,Zeng G,Fang D,Wang J,Wu W,Xie W,Tan S,Zheng K

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    abstract::Many Gram-negative bacterial pathogens use type III secretion systems (TTSSs) for subverting the normal cellular functions of their target eukaryotic cells. The type III secretion apparatus (TTSA) functions like a syringe to inject proteins through an external needle and into a target cell's membrane and cytosol. The ...

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    authors: Wang Y,Zhang L,Picking WL,Picking WD,De Guzman RN

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    abstract::As a versatile pathogen Staphylococcus aureus can cause various disease patterns, which are influenced by strain specific virulence factor repertoires but also by S. aureus physiological adaptation capacity. Here, we present metabolomic descriptions of S. aureus central metabolic pathways and demonstrate the potential...

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    authors: Liebeke M,Dörries K,Zühlke D,Bernhardt J,Fuchs S,Pané-Farré J,Engelmann S,Völker U,Bode R,Dandekar T,Lindequist U,Hecker M,Lalk M

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    abstract::In the present study, we focused on the expression and biological functions of TMEM45B in pancreatic cancer tissues and cell lines. Real-time PCR and Western blotting were used to examine the expression levels of TMEM45B in pancreatic cancer tissues and cell lines. The functions of TMEM45B were evaluated using CCK-8, ...

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    pub_type: 杂志文章


    authors: Zhao LC,Shen BY,Deng XX,Chen H,Zhu ZG,Peng CH

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    pub_type: 杂志文章


    authors: Huang Z,Shao W,Gu J,Hu X,Shi Y,Xu W,Huang C,Lin D

    更新日期:2015-07-01 00:00:00

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    journal_title:Molecular bioSystems

    pub_type: 杂志文章,评审


    authors: Sopko R,Andrews BJ

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    abstract::Identification of MHC binding peptides is essential for understanding the molecular mechanism of immune response. However, most of the prediction methods use motifs/profiles derived from experimental peptide binding data for specific MHC alleles, thus limiting their applicability only to those alleles for which such d...

    journal_title:Molecular bioSystems

    pub_type: 杂志文章


    authors: Kumar N,Mohanty D

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    abstract::The essential idea of regenerative medicine is to fix or replace tissues or organs with alive and patient-specific implants. Pluripotent stem cells are able to indefinitely self-renew and differentiate into all cell types of the body which makes them a potent substantial player in regenerative medicine. The easily acc...

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    pub_type: 杂志文章,评审


    authors: Baranek M,Belter A,Naskręt-Barciszewska MZ,Stobiecki M,Markiewicz WT,Barciszewski J

    更新日期:2017-01-31 00:00:00