Abstract:
:Dynamic physical interactions between proteins underpin all key cellular processes and are a highly attractive area for the development of research tools and medicines. Protein-protein interactions frequently involve α-helical structures, but peptides matching the sequences of these structures usually do not fold correctly in isolation. Therefore, much research has focused on the creation of small peptides that adopt stable α-helical structures even in the absence of their intended protein targets. We show that short peptides alkylated with azobenzene crosslinkers can be used to photo-stimulate mitochondrial membrane depolarization and cytochrome c release in permeabilised cells, the initial events of the intrinsic apoptosis pathway.
journal_name
Mol Biosystjournal_title
Molecular bioSystemsauthors
Mart RJ,Errington RJ,Watkins CL,Chappell SC,Wiltshire M,Jones AT,Smith PJ,Allemann RKdoi
10.1039/c3mb70246dsubject
Has Abstractpub_date
2013-11-01 00:00:00pages
2597-603issue
11eissn
1742-206Xissn
1742-2051journal_volume
9pub_type
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