Proteomic analysis in clear cell renal cell carcinoma: identification of differentially expressed protein by 2-D DIGE.

abstract：:Calcium homeostasis is a key factor in the regulation of cardiac excitation-contraction coupling. Calcium dynamics in cardiomyocytes is governed by ATP which depends on insulin dependent glucose concentration, via the glucose transporter type 4 (GLUT4) transporter. It would therefore be interesting to see how calcium ...

journal_title：Molecular bioSystems

authors： Das PN,Kumar A,Bairagi N,Chatterjee S

更新日期：2017-09-26 00:00:00

abstract：:Upon entering biological systems, such as the blood stream, nanoparticles form molecular complexes with the proteins encountered called protein coronas, which shield the surface of the exogenous nanoparticle. The most abundant blood proteins, such as albumin, initially occupy the surface of the nanoparticle. Owing to ...

journal_title：Molecular bioSystems

authors： Ramezani F,Rafii-Tabar H

更新日期：2015-02-01 00:00:00

abstract：:Climatic change is an increasing challenge for agriculture that is driving the development of suitable crops in order to ensure supply for both human nutrition and animal feed. In this context, it is increasingly important to understand the biochemical responses of cells to environmental cues at the whole system level...

journal_title：Molecular bioSystems

authors： García-Flores M,Juárez-Colunga S,Montero-Vargas JM,López-Arciniega JA,Chagolla A,Tiessen A,Winkler R

更新日期：2012-06-01 00:00:00

abstract：:A metabolomic study was performed to investigate the biochemical profiles of livers from male and female zebrafish (Danio rerio), using a multiple platform approach, incorporating 1H NMR, GC/MS and LC/MS. The reproducibility and reliability of the three methods were validated prior to the assays. Major biomolecules de...

journal_title：Molecular bioSystems

authors： Ong ES,Chor CF,Zou L,Ong CN

更新日期：2009-03-01 00:00:00

abstract：:Analysis of complex formation between amyloid-β fragments using surface plasmon resonance biosensing and electrospray mass spectrometry reveals that region 11-14 mediates zinc-induced dimerization of amyloid-β and may serve as a potential drug target for preventing development and progression of Alzheimer's disease. ...

journal_title：Molecular bioSystems

authors： Kozin SA,Mezentsev YV,Kulikova AA,Indeykina MI,Golovin AV,Ivanov AS,Tsvetkov PO,Makarov AA

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Candida albicans, the most common fungal pathogen related to colonization and biofilm formation on the surfaces of indwelling medical devices, shows high resistance to the most commonly used antifungal drugs. In this study, an ion-pairing chromatography-porous graphitic carbon column coupled with a time-of-f...

journal_title：Molecular bioSystems

authors： Chen X,Wu H,Cao Y,Yao X,Zhao L,Wang T,Yang Y,Lv D,Chai Y,Cao Y,Zhu Z

更新日期：2014-01-01 00:00:00

abstract：:Protein-protein interactions are important for the majority of biological processes. A significant number of computational methods have been developed to predict protein-protein interactions using protein sequence, structural and genomic data. Vast experimental data is publicly available on the Internet, but it is sca...

journal_title：Molecular bioSystems

authors： Saha I,Zubek J,Klingström T,Forsberg S,Wikander J,Kierczak M,Maulik U,Plewczynski D

更新日期：2014-04-01 00:00:00

abstract：:The crystal structure of the versatile CYP109B1 enzyme from Bacillus subtilis has been solved at 1.8 Å resolution. This is the first structure of an enzyme from this CYP family, whose members are prevalent across diverse species of bacteria. In the crystal structure the enzyme has an open conformation with an access c...

journal_title：Molecular bioSystems

authors： Zhang A,Zhang T,Hall EA,Hutchinson S,Cryle MJ,Wong LL,Zhou W,Bell SG

更新日期：2015-03-01 00:00:00

abstract：:The identification of genetic markers (e.g. genes, pathways and subnetworks) for cancer has been one of the most challenging research areas in recent years. A subset of these studies attempt to analyze genome-wide expression profiles to identify markers with high reliability and reusability across independent whole-tr...

journal_title：Molecular bioSystems

authors： Farahmand S,Goliaei S,Ansari-Pour N,Razaghi-Moghadam Z

更新日期：2016-03-01 00:00:00

abstract：:In the present study, we focused on the expression and biological functions of TMEM45B in pancreatic cancer tissues and cell lines. Real-time PCR and Western blotting were used to examine the expression levels of TMEM45B in pancreatic cancer tissues and cell lines. The functions of TMEM45B were evaluated using CCK-8, ...

journal_title：Molecular bioSystems

authors： Zhao LC,Shen BY,Deng XX,Chen H,Zhu ZG,Peng CH

更新日期：2016-05-24 00:00:00

abstract：:The main objectives of this work were to characterise a range of purified recombinant sterol 3β-glucosyltransferases and show that rational sampling of the diversity that exists within sterol 3β-glucosyltransferase sequence space can result in a range of enzyme selectivities. In our study the catalytically active doma...

journal_title：Molecular bioSystems

authors： Malik V,Zhang M,Dover LG,Northen JS,Flinn A,Perry JJ,Black GW

更新日期：2013-11-01 00:00:00

abstract：:Complex signalling systems have evolved in multicellular organisms to enable cell-to-cell communication during growth and development. In plants, cell communication via the extracellular matrix (apoplast) controls many processes vital for plant survival. Secretion of ATP into the extracellular matrix is now recognised...

journal_title：Molecular bioSystems

authors： Chivasa S,Slabas AR

更新日期：2012-02-01 00:00:00

abstract：:New approaches to improve the quality and efficiency of stem cell-derived neurons are important for both research and clinical arenas. Customized subsets of differentiated neurons can be used as model systems to understand the etiology of a variety of complex neurological diseases and disorders. These same neuronal ce...

journal_title：Molecular bioSystems

authors： Greco SJ,Rameshwar P

更新日期：2010-02-01 00:00:00

abstract：:Protein methylation catalyzed by methyltransferases carries many important biological functions. Methylation and their regulatory enzymes are involved in a variety of human disease states, raising the possibility that abnormally methylated proteins can be disease markers and methyltransferases are potential therapeuti...

journal_title：Molecular bioSystems

authors： Shi SP,Xu HD,Wen PP,Qiu JD

更新日期：2015-10-01 00:00:00

abstract：:The Library of Integrated Network-based Cellular Signatures (LINCS) L1000 big data provide gene expression profiles induced by over 10 000 compounds, shRNAs, and kinase inhibitors using the L1000 platform. We developed csNMF, a systematic compound signature discovery pipeline covering from raw L1000 data processing to...

journal_title：Molecular bioSystems

authors： Liu C,Su J,Yang F,Wei K,Ma J,Zhou X

更新日期：2015-03-01 00:00:00

abstract：:Individuals infected with the human immunodeficiency virus (HIV) often suffer from concomitant metabolic complications. Treatment with antiretroviral therapy has also been shown to alter the metabolism of patients. Although chemometric analysis of nuclear magnetic resonance (NMR) spectra of human sera can distinguish ...

journal_title：Molecular bioSystems

authors： McKnight TR,Yoshihara HA,Sitole LJ,Martin JN,Steffens F,Meyer D

更新日期：2014-11-01 00:00:00

abstract：:Diabetic retinopathy (DR) is a serious microvascular syndrome of diabetes, and is one of the most frequent causes of blindness in the world. It has three progressive stages with complex metabolic deregulations in the holistic system of Western medicine. Chinese medicine classifies DR into two different syndrome types;...

journal_title：Molecular bioSystems

authors： Li X,Luo X,Lu X,Duan J,Xu G

更新日期：2011-07-01 00:00:00

abstract：:J proteins are a diverse family of co-chaperones that cooperate with heat shock protein 70 (Hsp70) to coordinate protein quality control, especially in response to cellular stress. Current models suggest that individual J proteins might play roles in recruiting Hsp70s to specific functions, such as maintaining cell wa...

journal_title：Molecular bioSystems

authors： Gillies AT,Taylor R,Gestwicki JE

更新日期：2012-11-01 00:00:00

abstract：:The adaptation of the cellular network to functional changes, timing and patterning of gene expression is regulated by binding of transcription factors to gene regulatory elements, which in turn depends on co-occurring histone modifications. These two layers influence each other, enabling a further level of regulatory...

journal_title：Molecular bioSystems

authors： Schueler M,Zhang Q,Schlesinger J,Tönjes M,Sperling SR

更新日期：2012-02-01 00:00:00

abstract：:The effect of aging and development in male Wistar-derived rats on the profile of endogenous metabolites excreted in the urine was investigated using both (1)H NMR spectroscopy and HPLC-TOF MS using electrospray ionisation (ESI). The endogenous metabolites were profiled in samples collected from male rats every two we...

journal_title：Molecular bioSystems

authors： Williams RE,Lenz EM,Lowden JS,Rantalainen M,Wilson ID

更新日期：2005-07-01 00:00:00

abstract：:Synthetic studies of lipid A and LPS partial structures have been performed to investigate the relationship between structures and functions of LPS. Recent studies have suggested several pathological implications of LPS from parasitic bacteria due to its influence on the host immune responses. To address this issue, w...

journal_title：Molecular bioSystems

authors： Fujimoto Y,Shimoyama A,Saeki A,Kitayama N,Kasamatsu C,Tsutsui H,Fukase K

更新日期：2013-05-01 00:00:00

abstract：:The molecular segmentation clock is a complex regulatory network that governs the periodic somite segmentation in vertebrate embryos. Underlying the rhythm of the segmentation clock is a single-cell level pace-making circuit, where inevitable molecular noise and time delay impose normal operating constraints to the pa...

journal_title：Molecular bioSystems

authors： Song H,Yuan Z,Zhou T

更新日期：2013-06-01 00:00:00

abstract：:Genome sequencing technology has generated a vast amount of genomic and epigenomic data, and has provided us a great opportunity to study gene functions on a global scale from an epigenomic view. In the last decade, network-based studies, such as those based on PPI networks and co-expression networks, have shown good ...

journal_title：Molecular bioSystems

authors： Li W,Wang M,Sun J,Wang Y,Jiang R

更新日期：2017-10-24 00:00:00

abstract：:Affinity probes are useful tools for determining molecular targets and elucidating mechanism of action for novel, bioactive compounds. In the case of covalent inhibitors, activity based probes are particularly valuable for ensuring acceptable selectivity margins. However, there is a variety of bioorthogonal chemistry ...

journal_title：Molecular bioSystems

authors： Paresi CJ,Liu Q,Li YM

更新日期：2016-05-01 00:00:00

abstract：:The complex web of interactions between the host immune system and the pathogen determines the outcome of any infection. A computational model of this interaction network, which encodes complex interplay among host and bacterial components, forms a useful basis for improving the understanding of pathogenesis, in filli...

journal_title：Molecular bioSystems

authors： Raman K,Bhat AG,Chandra N

更新日期：2010-03-01 00:00:00

abstract：:A genome-wide screen of a yeast non-essential gene-deletion library was used to identify sick phenotypes due to oxygen deprivation. The screen provided a manageable list of 384 potentially novel as well as known oxygen responding (anoxia-survival) genes. The gene-deletion mutants were further assayed for sensitivity t...

journal_title：Molecular bioSystems

authors： Samanfar B,Omidi K,Hooshyar M,Laliberte B,Alamgir M,Seal AJ,Ahmed-Muhsin E,Viteri DF,Said K,Chalabian F,Golshani A,Wainer G,Burnside D,Shostak K,Bugno M,Willmore WG,Smith ML,Golshani A

更新日期：2013-06-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) consist of a class of proteins required for normal tissue function. Their over expression is associated with many disease states and hence the interest in MMPs as drug targets. Almost all MMP inhibitors have been reported to fail in clinical trials due to lack of specificity. Zinc in t...

journal_title：Molecular bioSystems

authors： Singh T,Adekoya OA,Jayaram B

更新日期：2015-04-01 00:00:00

abstract：:Integrative pharmacology has been used to identify the key active constituents (KACs) of Buchang Naoxintong capsules (BNCs), a traditional Chinese medical preparation; this approach involves the evaluation of the content profiles and drug-like properties of the BNC constituents and development of an ingredient-target ...

journal_title：Molecular bioSystems

authors： Haiyu X,Yang S,Yanqiong Z,Qiang J,Defeng L,Yi Z,Feng L,Hongjun Y

更新日期：2016-01-01 00:00:00

abstract：:In the post-genome era, one of the most important and challenging tasks is to identify the subcellular localizations of protein complexes, and further elucidate their functions in human health with applications to understand disease mechanisms, diagnosis and therapy. Although various experimental approaches have been ...

journal_title：Molecular bioSystems

authors： Li ZC,Lai YH,Chen LL,Chen C,Xie Y,Dai Z,Zou XY

更新日期：2013-04-05 00:00:00

abstract：:Enediyne natural product biosynthesis is characterized by a convergence of multiple pathways, generating unique peripheral moieties that are appended onto the distinctive enediyne core. Kedarcidin (KED) possesses two unique peripheral moieties, a (R)-2-aza-3-chloro-β-tyrosine and an iso-propoxy-bearing 2-naphthonate m...

journal_title：Molecular bioSystems

authors： Lohman JR,Huang SX,Horsman GP,Dilfer PE,Huang T,Chen Y,Wendt-Pienkowski E,Shen B

更新日期：2013-03-01 00:00:00