Synthesis of a large library of macrocyclic peptides containing multiple and diverse N-alkylated residues.

abstract：:Comparative analysis of the complete genome sequences from a variety of poorly studied organisms aims at predicting ecological and behavioral properties of these organisms and helping in characterizing their habitats. This task requires finding appropriate descriptors that could be correlated with the core traits of e...

journal_title：Molecular bioSystems

authors： Galperin MY,Higdon R,Kolker E

更新日期：2010-04-01 00:00:00

abstract：:Recently circular RNA (circularRNA) has been discovered as an increasingly important type of long non-coding RNA (lncRNA), playing an important role in gene regulation, such as functioning as miRNA sponges. So it is very promising to identify circularRNA transcripts from de novo assembled transcripts obtained by high-...

journal_title：Molecular bioSystems

authors： Pan X,Xiong K

更新日期：2015-08-01 00:00:00

abstract：:We have investigated the thermodynamics of the interaction between the TATA-box-binding protein from Pyrococcus horikoshii (PhoTBP) and its target DNA (TATA-1). The interaction between PhoTBP and double-stranded DNA (dsDNA) is entropically favorable and enthalpically unfavorable. The thermodynamic parameters for TATA-...

journal_title：Molecular bioSystems

authors： Nagatoishi S,Tanaka Y,Kudou M,Tsumoto K

更新日期：2009-09-01 00:00:00

abstract：:Recently, more and more research has shown that microRNAs (miRNAs) play critical roles in the development and progression of various diseases, but it is not easy to predict potential human miRNA-disease associations from the vast amount of biological data. Computational methods for predicting potential disease-miRNA a...

journal_title：Molecular bioSystems

authors： Chen X,Liu MX,Yan GY

更新日期：2012-10-01 00:00:00

abstract：:At the intersection between artificial intelligence and statistics, supervised learning allows algorithms to automatically build predictive models from just observations of a system. During the last twenty years, supervised learning has been a tool of choice to analyze the always increasing and complexifying data gene...

journal_title：Molecular bioSystems

authors： Geurts P,Irrthum A,Wehenkel L

更新日期：2009-12-01 00:00:00

abstract：:The size and complexity of cellular systems make building predictive models an extremely difficult task. In principle dynamical time-course data can be used to elucidate the structure of the underlying molecular mechanisms, but a central and recurring problem is that many and very different models can be fitted to exp...

journal_title：Molecular bioSystems

authors： Erguler K,Stumpf MP

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Candida albicans, the most common fungal pathogen related to colonization and biofilm formation on the surfaces of indwelling medical devices, shows high resistance to the most commonly used antifungal drugs. In this study, an ion-pairing chromatography-porous graphitic carbon column coupled with a time-of-f...

journal_title：Molecular bioSystems

authors： Chen X,Wu H,Cao Y,Yao X,Zhao L,Wang T,Yang Y,Lv D,Chai Y,Cao Y,Zhu Z

更新日期：2014-01-01 00:00:00

abstract：:The protein kinase C (PKC) family of serine/threonine kinases is an attractive drug target for the treatment of cancer and other diseases. Diacylglycerol (DAG), phorbol esters and others act as ligands for the C1 domain of PKC isoforms. Inspection of the crystal structure of the PKCδ C1b subdomain in complex with phor...

journal_title：Molecular bioSystems

authors： Mamidi N,Gorai S,Mukherjee R,Manna D

更新日期：2012-04-01 00:00:00

abstract：:This paper describes a sensitive, non-destructive displacement assay, using a fluorescent peptide indicator, for real-time monitoring of the interactions between RNA and RNA binding proteins (RBPs). The developed fluorescent peptide indicators, each containing a mid-sequence fluorophore unit, allowed sensing of target...

journal_title：Molecular bioSystems

authors： Jeong HS,Choi SM,Kim HW,Park JW,Park HN,Park SM,Jang SK,Rhee YM,Kim BH

更新日期：2013-05-01 00:00:00

abstract：:Here, we used stopped-flow fluorescence techniques to conduct a comparative kinetic analysis of the conformational transitions in human apurinic/apyrimidinic endonuclease 1 (APE1) and in DNA containing an abasic site in the course of their interaction. Effects of monovalent (K(+)) and divalent (Mg(2+), Mn(2+), Ca(2+),...

journal_title：Molecular bioSystems

authors： Miroshnikova AD,Kuznetsova AA,Vorobjev YN,Kuznetsov NA,Fedorova OS

更新日期：2016-05-26 00:00:00

abstract：:Normalization of array data relies on the assumption that most genes are not altered, which means that the signals for different samples should be scaled to have similar median or average values. However, accumulating evidence suggests that gene expression could be widely up-regulated in cancers. Our previous results ...

journal_title：Molecular bioSystems

authors： Wu D,Kang J,Huang Y,Li X,Wang X,Huang D,Wang Y,Li B,Hao D,Gu Q,Tang N,Li K,Guo Z,Li X,Xu J,Wang D

更新日期：2014-06-01 00:00:00

abstract：:Identification of MHC binding peptides is essential for understanding the molecular mechanism of immune response. However, most of the prediction methods use motifs/profiles derived from experimental peptide binding data for specific MHC alleles, thus limiting their applicability only to those alleles for which such d...

journal_title：Molecular bioSystems

authors： Kumar N,Mohanty D

更新日期：2010-12-01 00:00:00

abstract：:Although angiotensin (Ang)II-induced Janus-activated kinase (JAK)2 phosphorylation was reported to be enhanced in failing human cardiomyocytes, the downstream balance between cardio-protective (signal transducer and activator of transcription-STAT3) and the pro-inflammatory (STAT2 and STAT5) response remains unexplore...

journal_title：Molecular bioSystems

authors： Cambi GE,Lucchese G,Djeokeng MM,Modesti A,Fiaschi T,Faggian G,Sani G,Modesti PA

更新日期：2012-09-01 00:00:00

abstract：:The significant increase in the demand for purified protein for crystallization and structural studies has made necessary the development of multi-sample methods for identifying solution conditions that affect protein stability and aggregation. Conditions that stabilize proteins can improve protein purification and cr...

journal_title：Molecular bioSystems

authors： Senisterra GA,Finerty PJ Jr

更新日期：2009-03-01 00:00:00

abstract：:J proteins are a diverse family of co-chaperones that cooperate with heat shock protein 70 (Hsp70) to coordinate protein quality control, especially in response to cellular stress. Current models suggest that individual J proteins might play roles in recruiting Hsp70s to specific functions, such as maintaining cell wa...

journal_title：Molecular bioSystems

authors： Gillies AT,Taylor R,Gestwicki JE

更新日期：2012-11-01 00:00:00

abstract：:Plant aquaporins belong to a large superfamily of conserved proteins called the major intrinsic proteins (MIPs). There is limited information about the diversity of MIPs and their water transport capacity in broccoli (Brassica oleracea) plants. In this study, the cDNAs of isoforms of Plasma Membrane Intrinsic Proteins...

journal_title：Molecular bioSystems

authors： Muries B,Faize M,Carvajal M,Martínez-Ballesta Mdel C

更新日期：2011-04-01 00:00:00

abstract：:Secretagogin is a hexa EF-hand Ca(2+)-binding protein expressed in neuroendocrine, pancreatic endocrine and retinal cells. The protein has been noted for its expression in specific neuronal subtypes in the support of hierarchical organizing principles in the mammalian brain. Secretagogin has previously been found to i...

journal_title：Molecular bioSystems

authors： Bauer MC,O'Connell DJ,Maj M,Wagner L,Cahill DJ,Linse S

更新日期：2011-07-01 00:00:00

abstract：:In the field of synthetic biology, recent genetic engineering efforts have enabled the construction of novel genetic circuits with diverse functionalities and unique activation mechanisms. Because of these advances, artificial genetic networks are becoming increasingly complex, and are demonstrating more robust behavi...

journal_title：Molecular bioSystems

authors： Sayut DJ,Kambam PK,Sun L

更新日期：2007-12-01 00:00:00

abstract：:Production of biofuels has been one of the promising efforts in biotechnology in the past few decades. The perspective of these efforts can be reduction of increasing demands for fossil fuels and consequently reducing environmental pollution. Nonetheless, most previous approaches did not succeed in obviating many big ...

journal_title：Molecular bioSystems

authors： Mohammadi R,Fallah-Mehrabadi J,Bidkhori G,Zahiri J,Javad Niroomand M,Masoudi-Nejad A

更新日期：2016-07-19 00:00:00

abstract：:Glycodendrimers, such as glycoclusters and glycopolymers, are known to be very useful molecules to probe carbohydrate-lectin interactions. Herein, new second generation glycopeptide dendrimers (G2a-f) presenting a L-lysine-based (Lys) tetraantennary scaffold, four external thiomannosyl residues and, in the case of com...

journal_title：Molecular bioSystems

authors： Euzen R,Reymond JL

更新日期：2011-02-01 00:00:00

abstract：:Conventional methods for detecting single nucleotide polymorphisms (SNPs), including direct DNA sequencing, pyrosequencing, and melting curve analysis, are to a great extent limited by their requirement for particular detection instruments. To overcome this limitation, we established a novel SNP detection technique ut...

journal_title：Molecular bioSystems

authors： Imai K,Ogai Y,Nishizawa D,Kasai S,Ikeda K,Koga H

更新日期：2007-08-01 00:00:00

abstract：:Cervical cancer is a clinical and pathological heterogeneity disease, which requires different types of treatments and leads to a variety of outcomes. In clinical practice, only some patients benefit from chemotherapy treatment. Identifying patients who will be responsive to chemotherapy could increase their survival ...

journal_title：Molecular bioSystems

authors： Hou Y,Yin M,Sun F,Zhang T,Zhou X,Li H,Zheng J,Chen X,Li C,Ning X,Lou G,Li K

更新日期：2014-08-01 00:00:00

abstract：:Glucocorticoids (GCs) have been proved to be an important pathogenic factor of some neuropsychiatric disorders. Usually, a classical injury model based on corticosterone-induced cytotoxicity of differentiated rat pheochromocytoma (PC12) cells was used to stimulate the state of GC damage of hippocampal neurons and inve...

journal_title：Molecular bioSystems

authors： Zhang H,Zheng H,Zhao G,Tang C,Lu S,Cheng B,Wu F,Wei J,Liang Y,Ruan J,Song H,Su Z

更新日期：2016-03-01 00:00:00

abstract：:RNA-binding proteins (RBPs) are key regulators of gene expression. Some long non-coding RNAs (lncRNAs) affect gene expression by interacting with RBPs. However, whether this influences the biological characteristics of lncRNAs in diseases still remains unknown. Here, we classify lncRNAs into two categories, using the ...

journal_title：Molecular bioSystems

authors： Zhang Q,Wei Y,Yan Z,Wu C,Chang Z,Zhu Y,Li K,Xu Y

更新日期：2017-06-01 00:00:00

abstract：:Renal cell carcinoma (RCC), the most common neoplasm affecting the adult kidney, is characterised by heterogeneity of histological subtypes, drug resistance, and absence of molecular markers. Two-dimensional difference gel electrophoresis (2-D DIGE) technology in combination with mass spectrometry (MS) was applied to ...

journal_title：Molecular bioSystems

authors： Raimondo F,Salemi C,Chinello C,Fumagalli D,Morosi L,Rocco F,Ferrero S,Perego R,Bianchi C,Sarto C,Pitto M,Brambilla P,Magni F

更新日期：2012-04-01 00:00:00

abstract：:The underlying reasons for the differences in the virulence of various types of Ebola virus (EBOV) remain unknown. Comparison of the percentage of disorder (PID) in nucleocapsid proteins VP30 and NP reveals high correlation between nucleocapsid PIDs and the case-fatality rates of EBOV. The higher disorder of these pro...

journal_title：Molecular bioSystems

authors： Goh GK,Dunker AK,Uversky VN

更新日期：2015-08-01 00:00:00

abstract：:A novel class of pH-sensitive PEG lipids bearing acid-cleavable acetal linkages and short PEG chains have been synthesised and used in ternary vector formulations. The cleavage pH was influenced by structural components including the terminal PEG moiety and spacer length. ...

journal_title：Molecular bioSystems

authors： Wong JB,Grosse S,Tabor AB,Hart SL,Hailes HC

更新日期：2008-06-01 00:00:00

abstract：:Chronic heart failure (CHF), as a progressive clinical syndrome, is characterized by failure of enough blood supply from the heart to meet the body's metabolic demands, and there is intense interest in identifying novel biomarkers that could make contributions to the diagnosis of CHF. Metabolomics, compared with curre...

journal_title：Molecular bioSystems

authors： Wang J,Li Z,Chen J,Zhao H,Luo L,Chen C,Xu X,Zhang W,Gao K,Li B,Zhang J,Wang W

更新日期：2013-11-01 00:00:00

abstract：:The induction of fungal metabolites by fungal co-cultures grown on solid media was explored using multi-well co-cultures in 2 cm diameter Petri dishes. Fungi were grown in 12-well plates to easily and rapidly obtain the large number of replicates necessary for employing metabolomic approaches. Fungal culture using suc...

journal_title：Molecular bioSystems

authors： Bertrand S,Azzollini A,Schumpp O,Bohni N,Schrenzel J,Monod M,Gindro K,Wolfender JL

更新日期：2014-07-29 00:00:00

abstract：:MicroRNAs are a predominant type of small non-coding RNAs approximately 21 nucleotides in length that play an essential role at the post-transcriptional level by either RNA degradation, translational repression or both through an RNA-induced silencing complex. Identification of these molecules can aid the dissecting o...

journal_title：Molecular bioSystems

authors： Yao Y,Ma C,Deng H,Liu Q,Zhang J,Yi M

更新日期：2016-10-20 00:00:00