Effect of nucleobase change on cytosine deamination through DNA photo-cross-linking reaction via 3-cyanovinylcarbazole nucleoside.

abstract：:The mono-site mutations of the absolutely conserved residues, (464)LGR(466), in the α-helix 5 (h5) of HPV16 L1 completely disrupted the pentamer formation. The implication of this finding is the potential usage of a h5-like peptide as the reagent to interfere with the pentamer formation and stability as an anti-HPV re...

journal_title：Molecular bioSystems

authors： Jin S,Pan D,Zha X,Yu X,Wu Y,Liu Y,Yin F,Chen XS

更新日期：2014-04-01 00:00:00

abstract：:Rhein is a natural product purified from herbal plants such as Rheum palmatum, which has been shown to have anti-angiogenesis and anti-tumor metastasis properties. However, the biological effects of rhein on the behavior of breast cancers are not completely elucidated. To evaluate whether rhein might be useful in the ...

journal_title：Molecular bioSystems

authors： Huang HJ,Lin CC,Chou HC,Chen YW,Lin ST,Lin YC,Lin DY,Lyu KW,Chan HL

更新日期：2014-12-01 00:00:00

abstract：:The emergence of drug resistant strains of Mycobacterium Tuberculosis (Mtb) accentuates the urgent need for the development of novel antitubercular drugs. The major causes of drug resistance are genetic mutations, the influx-efflux transporter system, and the complex cell wall system of Mtb, which can function as perm...

journal_title：Molecular bioSystems

authors： Janardhan S,Ram Vivek M,Narahari Sastry G

更新日期：2016-10-18 00:00:00

abstract：:Protein methylation catalyzed by methyltransferases carries many important biological functions. Methylation and their regulatory enzymes are involved in a variety of human disease states, raising the possibility that abnormally methylated proteins can be disease markers and methyltransferases are potential therapeuti...

journal_title：Molecular bioSystems

authors： Shi SP,Xu HD,Wen PP,Qiu JD

更新日期：2015-10-01 00:00:00

abstract：:Unstable angina (UA) is one of the most dangerous types of coronary heart disease and has high mortality and morbidity rates worldwide. However, the diagnostic accuracy for UA is unsatisfactory in clinical practice. In this study, we investigated the application of plasma metabolomics in discovering potential biomarke...

journal_title：Molecular bioSystems

authors： Sun M,Gao X,Zhang D,Ke C,Hou Y,Fan L,Zhang R,Liu H,Li K,Yu B

更新日期：2013-12-01 00:00:00

abstract：:Normalization of high-throughput molecular expression profiles secures differential expression analysis between samples of different phenotypes or biological conditions, and facilitates comparison between experimental batches. While the same general principles apply to microRNA (miRNA) normalization, there is mounting...

journal_title：Molecular bioSystems

authors： Wang X,Gardiner EJ,Cairns MJ

更新日期：2015-05-01 00:00:00

abstract：:Infections caused by human parasites (HPs) affect the poorest 500 million people worldwide but chemotherapy has become expensive, toxic, and/or less effective due to drug resistance. On the other hand, many 3D structures in Protein Data Bank (PDB) remain without function annotation. We need theoretical models to quick...

journal_title：Molecular bioSystems

authors： González-Díaz H,Muíño L,Anadón AM,Romaris F,Prado-Prado FJ,Munteanu CR,Dorado J,Sierra AP,Mezo M,González-Warleta M,Gárate T,Ubeira FM

更新日期：2011-06-01 00:00:00

abstract：:Cellular heterogeneity and stochastic fluctuation play key roles in biological processes. Single molecule approaches have the key advantage of avoiding ensemble averaging, allowing the observation of transient intermediates and heterogeneity (both static and dynamic). Thus they have revolutionised the way many biologi...

journal_title：Molecular bioSystems

authors： Ying L

更新日期：2007-06-01 00:00:00

abstract：:Intrinsically disordered regions in proteins are known to evolve rapidly while maintaining their function. However, given their lack of structure and sequence conservation, the means through which they stay functional is not clear. Poor sequence conservation also hampers the classification of these regions into functi...

journal_title：Molecular bioSystems

authors： Moesa HA,Wakabayashi S,Nakai K,Patil A

更新日期：2012-10-30 00:00:00

abstract：:We report the successful application of selective excitation sculptured TOCSY NMR (SXS-TOCSY) to identify individual solution components from a heterogeneous system using selectively acquired (1)H NMR spin system patterns. SXS-TOCSY application is illustrated by detection of the simultaneous presence of poly-beta-(1,6...

journal_title：Molecular bioSystems

authors： Wagstaff JL,Sadovskaya I,Vinogradov E,Jabbouri S,Howard MJ

更新日期：2008-02-01 00:00:00

abstract：:MiRNAs are a fascinating kind of biomolecule due to their vital functions in gene regulation and potential value as biomarkers for serious diseases including cancers. Exploiting convenient and sensitive methods for miRNA expression assays is imperative. In this study, we employ an exonuclease (RecJf) and a nicking end...

journal_title：Molecular bioSystems

authors： Xu J,Han K,Liu D,Lin L,Miao P

更新日期：2016-11-15 00:00:00

abstract：:The interaction of spermine and its analogue, 1-naphthyl acetyl spermine with four double stranded DNA polynucleotides has been studied to understand the structural and thermodynamic basis of the binding. The efficacy and specificity of DNA binding of this analogue has not yet been revealed. The energetics of the inte...

journal_title：Molecular bioSystems

authors： Kabir A,Kumar GS

更新日期：2014-05-01 00:00:00

abstract：:The Library of Integrated Network-based Cellular Signatures (LINCS) L1000 big data provide gene expression profiles induced by over 10 000 compounds, shRNAs, and kinase inhibitors using the L1000 platform. We developed csNMF, a systematic compound signature discovery pipeline covering from raw L1000 data processing to...

journal_title：Molecular bioSystems

authors： Liu C,Su J,Yang F,Wei K,Ma J,Zhou X

更新日期：2015-03-01 00:00:00

abstract：:Proteomics is the study of proteins and their interactions within complex biological systems. While this field is often associated with mass spectrometry, it is more useful to consider proteomics in the context of an objective: to identify and understand the molecular basis of health and disease at the protein level i...

journal_title：Molecular bioSystems

authors： Bark SJ,Hook V

更新日期：2007-01-01 00:00:00

abstract：:Within systems biology there is an increasing interest in the stochastic behavior of genetic and biochemical reaction networks. An appropriate stochastic description is provided by the chemical master equation, which represents a continuous time Markov chain (CTMC). In this paper we consider the stochastic properties ...

journal_title：Molecular bioSystems

authors： Giampieri E,Remondini D,de Oliveira L,Castellani G,Lió P

更新日期：2011-10-01 00:00:00

abstract：:The study of mitochondria and mitochondrial Ca2+ signalling in localised regions is hampered by the lack of tools that can uncouple the mitochondrial membrane potential (DeltaPsi(m)) in a spatially predefined manner. Although there are a number of existing mitochondrial uncouplers, these compounds are necessarily memb...

journal_title：Molecular bioSystems

authors： Avlonitis N,Chalmers S,McDougall C,Stanton-Humphreys MN,Brown CT,McCarron JG,Conway SJ

更新日期：2009-05-01 00:00:00

abstract：:A growing number of diverse proteins are being identified that moonlight. Moonlighting proteins comprise an interesting subset of multifunctional proteins in which the two functions are found in a single polypeptide chain. They do not include proteins that are multifunctional due to gene fusions, families of homologou...

journal_title：Molecular bioSystems

authors： Jeffery CJ

更新日期：2009-04-01 00:00:00

abstract：:The protein kinase C (PKC) family of serine/threonine kinases is an attractive drug target for the treatment of cancer and other diseases. Diacylglycerol (DAG), phorbol esters and others act as ligands for the C1 domain of PKC isoforms. Inspection of the crystal structure of the PKCδ C1b subdomain in complex with phor...

journal_title：Molecular bioSystems

authors： Mamidi N,Gorai S,Mukherjee R,Manna D

更新日期：2012-04-01 00:00:00

abstract：:Genome sequencing technology has generated a vast amount of genomic and epigenomic data, and has provided us a great opportunity to study gene functions on a global scale from an epigenomic view. In the last decade, network-based studies, such as those based on PPI networks and co-expression networks, have shown good ...

journal_title：Molecular bioSystems

authors： Li W,Wang M,Sun J,Wang Y,Jiang R

更新日期：2017-10-24 00:00:00

abstract：:The epithelial to mesenchymal transition (EMT) is a cellular program associated with the organ morphogenesis but also with the disease progression. EMT in the cancer field fuels neoplastic progression promoting the resistance to cell death, the resistance to chemotherapy and the acquisition of stem cell properties. Co...

journal_title：Molecular bioSystems

authors： Vergara D,Simeone P,del Boccio P,Toto C,Pieragostino D,Tinelli A,Acierno R,Alberti S,Salzet M,Giannelli G,Sacchetta P,Maffia M

更新日期：2013-06-01 00:00:00

abstract：:Dynamic physical interactions between proteins underpin all key cellular processes and are a highly attractive area for the development of research tools and medicines. Protein-protein interactions frequently involve α-helical structures, but peptides matching the sequences of these structures usually do not fold corr...

journal_title：Molecular bioSystems

authors： Mart RJ,Errington RJ,Watkins CL,Chappell SC,Wiltshire M,Jones AT,Smith PJ,Allemann RK

更新日期：2013-11-01 00:00:00

abstract：:Calcium (Ca(2+)) is used as a signaling molecule to regulate many cellular processes. Calcium signaling generally involves transient elevations of the concentration of free Ca(2+) in the cytosol. More pronounced and sustained elevations of intracellular Ca(2+) concentrations are observed during apoptosis (programmed c...

journal_title：Molecular bioSystems

authors： Brnjic S,Olofsson MH,Havelka AM,Linder S

更新日期：2010-05-01 00:00:00

abstract：:Ca2+ transport across the sarco/endoplasmic reticulum (SR) plays an essential role in intracellular Ca2+ homeostasis, signalling, cell differentiation and muscle contractility. During SR Ca2+ uptake and release, proton fluxes are required to balance the charge deficit generated by the exchange of Ca2+ and other ions a...

journal_title：Molecular bioSystems

authors： Espinoza-Fonseca LM

更新日期：2017-03-28 00:00:00

abstract：:Protein-adsorptive properties are a key feature of membranes used for haemodialysis treatment. Protein adsorption is vital to the biocompatibility of a membrane material and influences membrane's performance. The object of the present study is to investigate membrane biocompatibility by correlating the adsorbed proteo...

journal_title：Molecular bioSystems

authors： Urbani A,Lupisella S,Sirolli V,Bucci S,Amoroso L,Pavone B,Pieroni L,Sacchetta P,Bonomini M

更新日期：2012-04-01 00:00:00

abstract：:Precise quantification of endogenous protein-protein interactions across live cells would be a major boon to biology. Such precise measurement is theoretically possible with fluorescence lifetime imaging microscopy (FLIM) but requires first properly addressing multiple biological, instrumental, statistical, and photop...

journal_title：Molecular bioSystems

authors： Walther KA,Papke B,Sinn MB,Michel K,Kinkhabwala A

更新日期：2011-02-01 00:00:00

abstract：:A metabolomic study was performed to investigate the biochemical profiles of livers from male and female zebrafish (Danio rerio), using a multiple platform approach, incorporating 1H NMR, GC/MS and LC/MS. The reproducibility and reliability of the three methods were validated prior to the assays. Major biomolecules de...

journal_title：Molecular bioSystems

authors： Ong ES,Chor CF,Zou L,Ong CN

更新日期：2009-03-01 00:00:00

abstract：:Genetic information in genomes is ordered, arranged in such a way that it constitutes a code, the so-called cis regulatory code. The regulatory machinery of the cell, termed trans-factors, decodes and expresses this information. In this way, genomes maintain a potential repertoire of genetic programs, parts of which a...

journal_title：Molecular bioSystems

authors： Rangel-Chavez C,Galan-Vasquez E,Martinez-Antonio A

更新日期：2017-03-28 00:00:00

abstract：:Chronic heart failure (CHF), as a progressive clinical syndrome, is characterized by failure of enough blood supply from the heart to meet the body's metabolic demands, and there is intense interest in identifying novel biomarkers that could make contributions to the diagnosis of CHF. Metabolomics, compared with curre...

journal_title：Molecular bioSystems

authors： Wang J,Li Z,Chen J,Zhao H,Luo L,Chen C,Xu X,Zhang W,Gao K,Li B,Zhang J,Wang W

更新日期：2013-11-01 00:00:00

abstract：:Estrogen positive breast cancer is a dreadful disease in women worldwide. The human estrogen receptor-α (ERα) pathway plays a critical role in estrogenic signaling and targeting ERα in breast cancer treatment. The key role of Lemur tyrosine kinase-3 (LMTK3) in regulation of ERα has been identified and it is found to b...

journal_title：Molecular bioSystems

authors： Anbarasu K,Jayanthi S

更新日期：2014-05-01 00:00:00

abstract：:A novel class of pH-sensitive PEG lipids bearing acid-cleavable acetal linkages and short PEG chains have been synthesised and used in ternary vector formulations. The cleavage pH was influenced by structural components including the terminal PEG moiety and spacer length. ...

journal_title：Molecular bioSystems

authors： Wong JB,Grosse S,Tabor AB,Hart SL,Hailes HC

更新日期：2008-06-01 00:00:00