Caged AG10: new tools for spatially predefined mitochondrial uncoupling.

abstract：:The main objectives of this work were to characterise a range of purified recombinant sterol 3β-glucosyltransferases and show that rational sampling of the diversity that exists within sterol 3β-glucosyltransferase sequence space can result in a range of enzyme selectivities. In our study the catalytically active doma...

journal_title：Molecular bioSystems

authors： Malik V,Zhang M,Dover LG,Northen JS,Flinn A,Perry JJ,Black GW

更新日期：2013-11-01 00:00:00

abstract：:Polyethylenimine (PEI, especially with M(w) of 25,000) has been known as an efficient gene carrier and a gold standard of gene transfection due to its high transfection efficiency (TE). However, high concomitant cytotoxicity limited the application of PEI. In this report, several cationic polymers derived from low mol...

journal_title：Molecular bioSystems

authors： Li S,Wang Y,Zhang J,Yang WH,Dai ZH,Zhu W,Yu XQ

更新日期：2011-04-01 00:00:00

abstract：:New approaches to improve the quality and efficiency of stem cell-derived neurons are important for both research and clinical arenas. Customized subsets of differentiated neurons can be used as model systems to understand the etiology of a variety of complex neurological diseases and disorders. These same neuronal ce...

journal_title：Molecular bioSystems

authors： Greco SJ,Rameshwar P

更新日期：2010-02-01 00:00:00

abstract：:Cervical cancer is initiated by infection with high-risk human papillomavirus (HPV). The viral E6 and E7 oncogenes are required for the initiation of cervical epithelial cell immortalization, but do not suffice to cause cervical cancer. Human oncogenes and tumor suppressor genes with altered activity in cervical carci...

journal_title：Molecular bioSystems

authors： Kravchenko-Balasha N,Klein S,Safrai M,Levitzki A

更新日期：2011-05-01 00:00:00

abstract：:There are clearly many different philosophies associated with adapting fragment screening into mainstream Drug Discovery Lead Generation strategies. Scientists at Astex, for instance, focus entirely on strategies involving use of X-ray crystallography and NMR. However, AstraZeneca uses a number of different fragment s...

journal_title：Molecular bioSystems

authors： Leach AR,Hann MM,Burrows JN,Griffen EJ

更新日期：2006-09-01 00:00:00

abstract：:Conversion of the predominantly α-helical cellular prion protein (PrP(C)) to the misfolded β-sheet enriched Scrapie form (PrP(Sc)) is a critical event in prion pathogenesis. However, the conformational triggers that lead to the isoform conversion (PrP(C) to PrP(Sc)) remain obscure, and conjectures about the role of un...

journal_title：Molecular bioSystems

authors： Menon S,Sengupta N

更新日期：2015-05-01 00:00:00

abstract：:Synthetic studies of lipid A and LPS partial structures have been performed to investigate the relationship between structures and functions of LPS. Recent studies have suggested several pathological implications of LPS from parasitic bacteria due to its influence on the host immune responses. To address this issue, w...

journal_title：Molecular bioSystems

authors： Fujimoto Y,Shimoyama A,Saeki A,Kitayama N,Kasamatsu C,Tsutsui H,Fukase K

更新日期：2013-05-01 00:00:00

abstract：:Although angiotensin (Ang)II-induced Janus-activated kinase (JAK)2 phosphorylation was reported to be enhanced in failing human cardiomyocytes, the downstream balance between cardio-protective (signal transducer and activator of transcription-STAT3) and the pro-inflammatory (STAT2 and STAT5) response remains unexplore...

journal_title：Molecular bioSystems

authors： Cambi GE,Lucchese G,Djeokeng MM,Modesti A,Fiaschi T,Faggian G,Sani G,Modesti PA

更新日期：2012-09-01 00:00:00

abstract：:Cells of the bacterium Myxococcus xanthus organize into two types of patterns depending on their nutritional status, i.e. in the presence of nutrients cells form spreading colonies and in the absence of nutrients cells form fruiting bodies. Formation of both patterns depends on directed cell movements, which, in turn,...

journal_title：Molecular bioSystems

authors： Leonardy S,Bulyha I,Søgaard-Andersen L

更新日期：2008-10-01 00:00:00

abstract：:Within systems biology there is an increasing interest in the stochastic behavior of genetic and biochemical reaction networks. An appropriate stochastic description is provided by the chemical master equation, which represents a continuous time Markov chain (CTMC). In this paper we consider the stochastic properties ...

journal_title：Molecular bioSystems

authors： Giampieri E,Remondini D,de Oliveira L,Castellani G,Lió P

更新日期：2011-10-01 00:00:00

abstract：:The pro-inflammatory cytokines interleukin 1 (IL-1) and 6 (IL-6) are crucially involved in the regulation of a multitude of physiological processes, in particular coordinating the immune response upon bacterial infection and tissue injury. Both interleukins induce complex signalling cascades and trigger the production...

journal_title：Molecular bioSystems

authors： Ryll A,Samaga R,Schaper F,Alexopoulos LG,Klamt S

更新日期：2011-12-01 00:00:00

abstract：:It is not surprising that a large number of diseases related to amyloid fibril depositions are formed in various organs. Therefore, it is necessary to understand the transformation of native proteins into amyloid fibrils in order to clarify which key elements of this process determine the pathway of protein misfolding...

journal_title：Molecular bioSystems

authors： Galzitskaya OV

更新日期：2015-08-01 00:00:00

abstract：:Understanding the complexity of cancer biology requires extensive information about the cancer proteome over the course of the disease. The recent advances in mass spectrometry-based proteomics technologies have led to the accumulation of an incredible amount of such proteomic information. This information allows us t...

journal_title：Molecular bioSystems

authors： Miah S,Banks CA,Adams MK,Florens L,Lukong KE,Washburn MP

更新日期：2016-12-20 00:00:00

abstract：:Sequence specific binding of DNA and RNA is of fundamental importance in the regulation of cellular gene expression. Because of their modular structure repeat domain proteins are particularly well suited for these processes and have been widely adopted throughout evolution. Detailed biochemical and structural data has...

journal_title：Molecular bioSystems

authors： Filipovska A,Rackham O

更新日期：2012-03-01 00:00:00

abstract：:Ligand-induced conditional protein splicing (CPS) using a split intein allows the covalent reconstitution of a protein from two polypeptide fragments. The small molecule rapamycin binds to the fused FKBP and FRB dimerizer domains and thereby induces folding of the split intein, which then removes itself in the trans-s...

journal_title：Molecular bioSystems

authors： Sonntag T,Mootz HD

更新日期：2011-06-01 00:00:00

abstract：:Plant aquaporins belong to a large superfamily of conserved proteins called the major intrinsic proteins (MIPs). There is limited information about the diversity of MIPs and their water transport capacity in broccoli (Brassica oleracea) plants. In this study, the cDNAs of isoforms of Plasma Membrane Intrinsic Proteins...

journal_title：Molecular bioSystems

authors： Muries B,Faize M,Carvajal M,Martínez-Ballesta Mdel C

更新日期：2011-04-01 00:00:00

abstract：:Recently, accumulating studies have indicated that microRNAs (miRNAs) play an important role in exploring the pathogenesis of various human diseases at the molecular level and may result in the design of specific tools for diagnosis, treatment evaluation and prevention. Experimental identification of disease-related m...

journal_title：Molecular bioSystems

authors： Sun D,Li A,Feng H,Wang M

更新日期：2016-06-21 00:00:00

abstract：:Fluorescent molecules that specifically target amyloid structures are highly desirable for amyloid research. Herein, we show a dimeric design of thioflavin T improves its binding affinity to Abeta amyloid by up to 70 fold, while not sacrificing the specificity and the "light-up" feature upon amyloid binding. ...

journal_title：Molecular bioSystems

authors： Qin L,Vastl J,Gao J

更新日期：2010-10-01 00:00:00

abstract：:When photoirradiated, an unnatural sialic acid analog can covalently capture the complex formed by ganglioside GM1 and cholera toxin subunit B. ...

journal_title：Molecular bioSystems

authors： Bond MR,Whitman CM,Kohler JJ

更新日期：2010-10-01 00:00:00

abstract：:Drug promiscuity is one of the key issues in current drug development. Many famous drugs have turned out to behave unexpectedly due to their propensity to bind to multiple targets. One of the primary reasons for this promiscuity is that drugs bind to multiple distinctive target environments, a feature that we call mul...

journal_title：Molecular bioSystems

authors： Park K,Lee S,Ahn HS,Kim D

更新日期：2009-08-01 00:00:00

abstract：:J proteins are a diverse family of co-chaperones that cooperate with heat shock protein 70 (Hsp70) to coordinate protein quality control, especially in response to cellular stress. Current models suggest that individual J proteins might play roles in recruiting Hsp70s to specific functions, such as maintaining cell wa...

journal_title：Molecular bioSystems

authors： Gillies AT,Taylor R,Gestwicki JE

更新日期：2012-11-01 00:00:00

abstract：:The effect of aging and development in male Wistar-derived rats on the profile of endogenous metabolites excreted in the urine was investigated using both (1)H NMR spectroscopy and HPLC-TOF MS using electrospray ionisation (ESI). The endogenous metabolites were profiled in samples collected from male rats every two we...

journal_title：Molecular bioSystems

authors： Williams RE,Lenz EM,Lowden JS,Rantalainen M,Wilson ID

更新日期：2005-07-01 00:00:00

abstract：:As a versatile pathogen Staphylococcus aureus can cause various disease patterns, which are influenced by strain specific virulence factor repertoires but also by S. aureus physiological adaptation capacity. Here, we present metabolomic descriptions of S. aureus central metabolic pathways and demonstrate the potential...

journal_title：Molecular bioSystems

authors： Liebeke M,Dörries K,Zühlke D,Bernhardt J,Fuchs S,Pané-Farré J,Engelmann S,Völker U,Bode R,Dandekar T,Lindequist U,Hecker M,Lalk M

更新日期：2011-04-01 00:00:00

abstract：:Classical Hodgkin lymphoma (cHL) is a malignancy with complex pathogenesis. The hallmark of the disease is the presence of large mononucleated Hodgkin and bi- or multinucleated Reed/Sternberg (H/RS) cells. The origin of HRS cells in cHL is controversial as these cells show the coexpression of markers of several lineag...

journal_title：Molecular bioSystems

authors： Vergara D,Simeone P,De Matteis S,Carloni S,Lanuti P,Marchisio M,Miscia S,Rizzello A,Napolitano R,Agostinelli C,Maffia M

更新日期：2016-01-01 00:00:00

abstract：:Cell penetrating peptides (CPPs), TATp, in particular, has been used widely for intracellular delivery of various agents ranging from small molecules to proteins, peptides, range of pharmaceutical nanocarriers and imaging agents. This review highlights the mechanisms of CPP-mediated delivery and summarizes numerous ex...

journal_title：Molecular bioSystems

authors： Sawant R,Torchilin V

更新日期：2010-04-01 00:00:00

abstract：:Mimicking receptor flexibility during receptor-ligand binding is a challenging task in computational drug design since it is associated with a large increase in the conformational search space. In the present study, we have devised an in silico design strategy incorporating receptor flexibility in virtual screening to...

journal_title：Molecular bioSystems

authors： Chakraborty S,Ramachandran B,Basu S

更新日期：2014-10-01 00:00:00

abstract：:Electrospray ionization mass spectrometry combined with high efficiency capillary liquid chromatography provides high sensitivity and broad dynamic range measurements for the characterization of biological macromolecules in complex matrices, and is an increasingly powerful analytical tool for systems biology research....

journal_title：Molecular bioSystems

authors： Smith RD,Tang K,Shen Y

更新日期：2006-05-01 00:00:00

abstract：:Diabetic retinopathy (DR) is a serious microvascular syndrome of diabetes, and is one of the most frequent causes of blindness in the world. It has three progressive stages with complex metabolic deregulations in the holistic system of Western medicine. Chinese medicine classifies DR into two different syndrome types;...

journal_title：Molecular bioSystems

authors： Li X,Luo X,Lu X,Duan J,Xu G

更新日期：2011-07-01 00:00:00

abstract：:Climatic change is an increasing challenge for agriculture that is driving the development of suitable crops in order to ensure supply for both human nutrition and animal feed. In this context, it is increasingly important to understand the biochemical responses of cells to environmental cues at the whole system level...

journal_title：Molecular bioSystems

authors： García-Flores M,Juárez-Colunga S,Montero-Vargas JM,López-Arciniega JA,Chagolla A,Tiessen A,Winkler R

更新日期：2012-06-01 00:00:00

abstract：:Hypoxia and inflammation have been identified as the hallmarks of colitis, intertwined with metabolism. Here, we report that halofuginone (HF), an antiparasitic drug, attenuates dextran sulfate sodium (DSS)-induced colitis in mice, as represented by attenuating the disease activity index, inhibiting colonic shortening...

journal_title：Molecular bioSystems

authors： Liu J,Xiao HT,Wang HS,Mu HX,Zhao L,Du J,Yang D,Wang D,Bian ZX,Lin SH

更新日期：2016-06-21 00:00:00