Abstract：
BACKGROUND:In first-episode psychosis (FEP), symptoms of anxiety and depression are common. We examined whether cognitive performance is associated with these clinical measures in FEP during a one-year follow-up. METHODS:Young adults with non-affective FEP (n = 52) were assessed two months after their first psychiatric contact for psychosis. Matched controls (n = 62) were administered a baseline assessment. 32 FEP subjects and 44 controls were assessed again at a one-year follow-up. In both assessments, a broad neuropsychological test battery was administered. Clinical evaluation was done with the Brief Psychiatric Rating Scale. Cross-sectional correlations were calculated at both time points. Cognitive test scores were used as independent variables in regression models, predicting both baseline and follow-up symptom levels. RESULTS:At baseline, better performance especially in verbal memory and executive functioning was associated with elevated anxiety symptoms in FEP. In addition, better performance especially in verbal working memory was associated with depression. A year later, better cognitive performance was no longer associated with affective symptoms. LIMITATIONS:Small sample sizes are a limitation. CONCLUSIONS:In the FEP group, higher cognitive performance associated with affective symptoms. Right after getting severely ill, anxiety and depression may be a part of normal adaptive reactions to the situation and markers of an intact cognitive performance. This association seems to cease during the year following the FEP.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Lindgren M,Birling H,Kieseppä T,Tuulio-Henriksson Adoi
10.1016/j.jad.2019.11.161subject
Has Abstractpub_date
2020-02-15 00:00:00pages
221-227eissn
0165-0327issn
1573-2517pii
S0165-0327(19)31188-7journal_volume
263pub_type
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