Abstract:
BACKGROUND AND OBJECTIVES:Vasospastic angina (VA) is a specific type of coronary artery disease and develops as a result of coronary artery spasm. Recently, a few studies have revealed that VA caused by coronary artery spasm is related to genetic traits. The objective of this study was to use the recently developed technique of array comparative genomic hybridization (CGH) to screen the genetic aberrations of VA. SUBJECTS AND METHODS:To identify candidate genes that might be causally involved in the pathogenesis of VA, genomic deoxyribonucleic acids were extracted from whole blood of 28 patients with VA who presented at Department of Cardiology at Seoul St. Mary's Hospital, Seoul, Korea. The copy number profiles of these patients was then analyzed using array CGH and reverse transcriptase (RT) quantitative polymerase chain reaction (PCR). RESULTS:Array CGH revealed gains in 31 different regions, with losses in the 4q35.2, 7q22.1, 10q26.3, 15q11.2, 16p13.11, 17p11.2 and 19q13.3 regions (more than 32% aberration in these regions). Several loci were found to be frequently including gains of 5p and 11q (50% of samples). The most common losses were found in 7q (54% of samples). Copy number aberrations in chromosomal regions were detected and corresponding genes were confirmed by RT quantitative PCR. The fold change levels were highest in the CTDP1 (18q23), HDAC10 (22q13.33), KCNQ1 (11p15.5-p15.4), NINJ2 (12p13.33), NOTCH2 (1p12-p11.2), PCSK6 (15q26.3), SDHA (5p15.33), and MUC17 (7q22.1) genes. CONCLUSION:Many candidate chromosomal regions that might be related to the pathogenesis of VA were detected by array CGH and should be systematically investigated to establish the causative and specific genes for VA.
journal_name
Korean Circ Jjournal_title
Korean circulation journalauthors
Seo SM,Koh YS,Jung HO,Choi JS,Kim PJ,Baek SH,Youn HJ,Lee KH,Seung KBdoi
10.4070/kcj.2011.41.7.385subject
Has Abstractpub_date
2011-07-01 00:00:00pages
385-93issue
7eissn
1738-5520issn
1738-5555journal_volume
41pub_type
杂志文章abstract::The term decline effect is referred to a diminution of scientifically discovered effects over time. Reasons for the decline effect are multifaceted and include publication bias, selective reporting, outcomes reporting bias, regression to the mean, scientific paradigm shift, overshadowing and habituation, among others....
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.4070/kcj.2014.44.1.45
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pub_type: 杂志文章
doi:10.4070/kcj.2009.39.3.124
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pub_type: 杂志文章
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journal_title:Korean circulation journal
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pub_type: 杂志文章,评审
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