A case of chloroquine-induced cardiomyopathy that presented as sick sinus syndrome.

Abstract:

:A 52-year-old woman with rheumatoid arthritis who had been treated with prednisone and hydroxychloroquine for >12 years presented with chest discomfort and a seizure. She was diagnosed with restrictive cardiomyopathy combined with sick sinus syndrome. A myocardial muscle biopsy was performed to identify the underlying cardiomyopathy, which showed marked muscle fiber hypertrophy, fiber dropout, slightly increased interstitial fibrous connective tissue, and extensive cytoplasmic vacuolization of the myocytes under light microscopy. Electron microscopy of the myocytes demonstrated dense, myeloid, and curvilinear bodies. The diagnosis of hydroxychloroquine-induced cardiomyopathy was made based on the clinical, hemodynamic, and pathologic findings. This is the first case report describing chloroquine-induced cardiomyopathy involving the heart conduction system.

journal_name

Korean Circ J

authors

Lee JH,Chung WB,Kang JH,Kim HW,Kim JJ,Kim JH,Hwang HJ,Lee JB,Chung JW,Kim HL,Choi YS,Park CS,Youn HJ,Lee MY

doi

10.4070/kcj.2010.40.11.604

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

604-8

issue

11

eissn

1738-5520

issn

1738-5555

journal_volume

40

pub_type

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