QT Prolongation and Life Threatening Ventricular Tachycardia in a Patient Injected With Intravenous Meperidine (Demerol®).

Abstract:

:QT prolongation is a serious adverse drug effect, which is associated with an increased risk of Torsade de pointes and sudden death. Many drugs, including both cardiac and non-cardiac drugs, have been reported to cause prolongation of QT interval. Although meperidine has not been considered proarrhythmic, we present a unique case of a 16-year-old boy without an underlying cardiac disease, who developed polymorphic ventricular tachycardia, ventricular fibrillation and QT prolongation after an intravenous meperidine injection. He had no mutation in long QT syndrome genes (KCNQ1, KCNH2, and SCN5A), but single nucleotide polymorphisms were reported, including H558R in SCNA5A and K897T in KCNH2.

journal_name

Korean Circ J

authors

Song MK,Bae EJ,Baek JS,Kwon BS,Kim GB,Noh CI,Choi JY,Park SS

doi

10.4070/kcj.2011.41.6.342

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

342-5

issue

6

eissn

1738-5520

issn

1738-5555

journal_volume

41

pub_type

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