Abstract:
BACKGROUND AND OBJECTIVES:Undiagnosed diabetes mellitus (DM) or impaired glucose tolerance (IGT) is not uncommon in patients with coronary atherosclerosis and is known to be associated with abnormal scores for atherosclerosis surrogates. We sought to determine the prevalence of undiagnosed DM or IGT, and the association between insulin resistance (IR) and atherosclerosis surrogates in patients with coronary atherosclerosis. SUBJECTS AND METHODS:The study population consisted of 187 consecutive patients with angiographically proven coronary atherosclerosis (mean: 61 years old, 94 males). We measured carotid intima-media thickness (IMT) and flow mediated brachial artery dilatation (FMD). We also did oral glucose tolerance tests (OGTT), quantitative insulin-sensitivity check indexes (QUICKI) and homeostasis model assessment-IR (HOMA-IR). RESULTS:Abnormal OGTT was found in 164 patients (87.7%), even though there were only 63 known cases of DM (33.7%). There were 58 patients (31%) with newly diagnosed IGT and 43 patients (23%) with newly diagnosed DM. There were 71 patients (38%) who had IR (defined as measured HOMA-R >/=3.0). HOMA-IR showed a positive correlation with body mass index (BMI) (r=0.275, p<0.001) and triglycerides (r=0.2, p=0.01), whereas QUICKI had a negative correlation with BMI (r=-0.26, p<0.001), total cholesterol (r=-0.15, p=0.04), triglycerides (r=-0.21, p=0.004) and low-density lipoprotein-cholesterol (LDL-C) (r=-0.17, p=0.02). HOMA-IR and QUICKI were not significantly correlated with IMT or FMD. CONCLUSION:This study suggests that there is a high incidence of undiagnosed DM and IGT, but atherosclerosis surrogates are not associated with IR in patients with coronary atherosclerosis.
journal_name
Korean Circ Jjournal_title
Korean circulation journalauthors
Park HW,Kown TG,Kim KY,Bae JHdoi
10.4070/kcj.2010.40.2.62subject
Has Abstractpub_date
2010-02-01 00:00:00pages
62-7issue
2eissn
1738-5520issn
1738-5555journal_volume
40pub_type
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journal_title:Korean circulation journal
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doi:10.4070/kcj.2010.40.7.321
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journal_title:Korean circulation journal
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abstract::There have been great advances in ventricular assist device (VAD) treatment for pediatric patients with advanced heart failure. VAD support provides more time for the patient in the heart transplant waiting list. Augmented cardiac output improves heart failure symptoms, end-organ function, and general condition, and c...
journal_title:Korean circulation journal
pub_type: 杂志文章,评审
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journal_title:Korean circulation journal
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journal_title:Korean circulation journal
pub_type: 杂志文章,评审
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journal_title:Korean circulation journal
pub_type: 杂志文章
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journal_title:Korean circulation journal
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doi:10.4070/kcj.2009.39.6.243
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journal_title:Korean circulation journal
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journal_title:Korean circulation journal
pub_type: 杂志文章,评审
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journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2013.43.7.504
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doi:10.4070/kcj.2011.41.1.46
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pub_type: 杂志文章
doi:10.4070/kcj.2012.42.3.154
更新日期:2012-03-01 00:00:00
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journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2016.0079
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journal_title:Korean circulation journal
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journal_title:Korean circulation journal
pub_type: 杂志文章
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journal_title:Korean circulation journal
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journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2011.41.12.763
更新日期:2011-12-01 00:00:00
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journal_title:Korean circulation journal
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pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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journal_title:Korean circulation journal
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.4070/kcj.2012.42.7.464
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