Potential inherited causes of recurrent prosthetic mitral valve thrombosis in a pregnant patient suffering from recurrent miscarriage.

Abstract:

:An effective anticoagulation is critical in pregnant patients with prosthetic heart valves. Inherited disorders may interfere with the coagulation cascade and may be associated with obstetrical complications as well as with prosthetic valve-derived complications. The patient in the present case had a history of recurrent prosthetic heart valve thrombosis (PHVT) despite an effective anticoagulation. She underwent a thrombolysis with low-dose prolonged infusion of tissue-type plasminogen activator for the management of her recurrrent prosthetic valve thrombosis. The genetic testing showed homozygous mutations of methylenetetrahydrofolate reductase (MTHFR) A 1298 C and heterozygous mutations of β-fibrinogen 455 G-A. Inherited disorders such as MTHFR A 1298 C and fibrinogen 455G/A polymorphisms may be involved in the pathogenesis of recurrent PHVT and/or pregnancy loss.

journal_name

Korean Circ J

authors

Kalcik M,Gursoy MO,Karakoyun S,Yesin M,Astarcioglu MA,Ozkan M

doi

10.4070/kcj.2014.44.4.268

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

268-70

issue

4

eissn

1738-5520

issn

1738-5555

journal_volume

44

pub_type

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