Abstract:
BACKGROUND AND OBJECTIVES:The aims of this study were to establish a reliable model of chronic mitral regurgitation (MR) in rats and verify the pathophysiological features of this model by evaluating cardiac function using serial echocardiography and a pressure-volume analysis. MATERIALS AND METHODS:MR was created in 37 Sprague-Dawley rats by making a hole with a 23 gauge needle on the mitral leaflet through the left ventricular (LV) apex under the guidance of transesophageal echocardiography. RESULTS:Serial echocardiograms revealed that the LV began to dilate immediately after the MR operation and showed progressive dilation until the 14th week (LV end-systolic dimension at 14 weeks, 4.71±0.25 mm vs. 6.81±0.50 mm for sham vs. MR, p<0.01; LV end-diastolic dimension, 8.32±0.42 mm vs. 11.01±0.47 mm, p<0.01). The LV ejection fraction tended to increase immediately after the MR operation but started to decrease thereafter and showed a significant difference with the sham group from the 14th week (70.0±2.2% vs. 62.1±3.1% for sham vs. MR). In a pressure-volume analysis performed at the 14th week, the LV end-systolic pressure-volume relationship and +dp/dt decreased significantly in the MR group. A serial treadmill test revealed that exercise capacity remained in the normal range until the 14th week when it began to decrease (exercise duration, 406±45 seconds vs. 330±27 seconds, p<0.01). A pathological analysis showed no significance difference in interstitial fibrosis between the two groups. CONCLUSION:We established a small animal model of chronic MR and verified its pathophysiological features. This model may provide a useful tool for future research on MR and volume overload heart failure.
journal_name
Korean Circ Jjournal_title
Korean circulation journalauthors
Kim KH,Kim YJ,Lee SP,Kim HK,Seo JW,Sohn DW,Oh BH,Park YBdoi
10.4070/kcj.2011.41.10.603subject
Has Abstractpub_date
2011-10-01 00:00:00pages
603-11issue
10eissn
1738-5520issn
1738-5555journal_volume
41pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:The prognosis and natural history of bradycardia related to drugs such as beta-blockers and non-dihydropyridine calcium channel blockers are not well known. SUBJECTS AND METHODS:We retrospectively analyzed 38 consecutive patients (age 69+/-11, 21 women) with drug-related bradycardia (DRB) bet...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2009.39.9.367
更新日期:2009-09-01 00:00:00
abstract::Congestive heart failure is a major cause of morbidity and mortality as well as a major health care cost in the developed world. Despite the introduction of highly effective heart failure medical therapies and simple devices such as cardiac resynchronization therapy that reduce mortality, improve cardiac function and ...
journal_title:Korean circulation journal
pub_type: 杂志文章,评审
doi:10.4070/kcj.2019.0161
更新日期:2019-07-01 00:00:00
abstract::A 52-year-old woman with rheumatoid arthritis who had been treated with prednisone and hydroxychloroquine for >12 years presented with chest discomfort and a seizure. She was diagnosed with restrictive cardiomyopathy combined with sick sinus syndrome. A myocardial muscle biopsy was performed to identify the underlying...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2010.40.11.604
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Recent surgical results from total anomalous pulmonary venous return (TAPVR) are reported to have improved; however, mortality and morbidity are still high in the univentricles. This review was performed in order to demonstrate surgical results from TAPVR for recent years in a single institute...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2010.40.1.31
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Recently, Genoss drug-eluting stent (DES)™ stent comprising cobalt-chromium platform with an ultrathin strut thickness, sirolimus, and an abluminal biodegradable polymer was developed. Owing to the lack of substantial evidence for the safety and efficacy of this stent, we report 12-month resul...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2019.0258
更新日期:2020-04-01 00:00:00
abstract::Echocardiographic diagnosis of atrial myxoma may not always be straightforward, and the distinction between myxoma and thrombi is not easy, especially when we observe a mass after successful surgery. Our report describes a 72-year-old woman who presented with right upper limb hemiparesis and was subsequently diagnosed...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2016.46.6.875
更新日期:2016-11-01 00:00:00
abstract::Behçet's disease (BD) is a multisystem vascular inflammatory disease. BD can affect blood vessels of nearly all sizes and types. Arterial involvement is a rare but serious condition in the course of BD. Here, we report a case of stenosis at the iliac artery bifurcation which was treated with percutaneous balloon angio...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2014.44.5.351
更新日期:2014-09-01 00:00:00
abstract::Although its use in daily practice is not common, optical coherence tomography (OCT) is a powerful research tool in invasive cardiology. This report describes a hazy angiography image after percutaneous coronary intervention that has been assessed using OCT. Based on the results of the OCT, the patient underwent an el...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2013.43.1.44
更新日期:2013-01-01 00:00:00
abstract::For over 3 decades, it has been known that reentry circuits for ventricular tachycardia (VT) are not limited to the subendocardial myocardium. Rather, intramural or subepicardial substrates may also give rise to VT, particularly in those with non-ischemic cardiomyopathy. Percutaneous epicardial mapping and ablation ha...
journal_title:Korean circulation journal
pub_type: 杂志文章,评审
doi:10.4070/kcj.2018.0210
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The plasma concentration of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) is a st-rong prognostic indicator for patients with heart failure (HF) across all stages of the condition. Several clinical trials have de-monstrated convincingly that neurohormonal modulation on the renin angiot...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2011.41.2.61
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The prevalence of arthritis, which is often treated with celecoxib, is high in patients with coronary artery disease. Furthermore, celecoxib has been reported to reduce restenosis after coronary stenting by inhibiting expression of the proto-oncogene Akt. A concern is that celecoxib increases ...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2010.40.7.321
更新日期:2010-07-01 00:00:00
abstract::Unguarded tricuspid regurgitation (TR) due to a flail tricuspid leaflet is a rare condition of newborn cyanosis. A high perinatal mortality has been associated with this fatal condition. But, there are feasible surgical repairs to improve survival. We report the case of a male full-term neonate with intractable hypoxi...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2015.45.4.340
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:In clinical trials, hypertensive patients tend to have higher interleukin-18 (IL-18) concentrations than normotensive groups, but the relationship between IL-18 and left ventricular hypertrophy (LVH), which is a marker of end-organ damage, is not well studied. We aimed to investigate the relat...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2016.0351
更新日期:2017-03-01 00:00:00
abstract::Treatments of choice for cardiac implantable electronic device (CIED) infections are the removal of the entire CIED system, control of infection, and new device implantation. Occasionally, a complete CIED removal can not be performed for several reasons, such as very old age, severe comobidity, limited life expectancy...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2011.41.1.46
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Implantation of cardiac implantable electronic devices (CIED), including permanent pacemakers (PM), implantable cardioverter-defibrillators (ICD), and cardiac resynchronization therapy (CRT) devices, has increased significantly over the past several years. However, limited data exists regardin...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2018.0444
更新日期:2019-09-01 00:00:00
abstract::Without significant coronary artery stenosis, ischemic electrocardiographic change including ST segment elevation, segmental wall motion abnormality and elevated serum cardiac-specific markers (creatine kinase-MB, Troponin-T) may develop after central nervous system injuries such as subarachnoid, intracranial or subdu...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2012.42.3.216
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Atherosclerosis is characterized by a hypercoagulable state, during which coagulation and fibrinolytic factors are activated simultaneously. However, details regarding the thrombolytic pathway in this context remain unknown. Here we investigated how direct long-term inhibition of thrombin infl...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2020.0055
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Patients with acute myocardial infarction show varying degrees of collateral development. However, the relationships between angiogenic factors and degree of collaterals are not well known. SUBJECTS AND METHODS:Fifty-nine patients (mean age, 59±10 years) with ST-segment elevation myocardial i...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2012.42.7.464
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To assess the safety and efficacy of transcatheter closure of residual ductal flow after initial surgical ligation of the arterial duct. SUBJECTS AND METHODS:Between June 2005 and December 2009, transcatheter occlusion of residual postsurgical ductus arteriosus was performed in six children. ...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2011.41.11.654
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Stress-induced cardiomyopathy (SCM) is characterized by a transient left ventricular (LV) dysfunction due to emotional and physical stress. There are limited data about the clinical characteristics in Korean patients. We sought to clarify the clinical features and prognosis in patients with SC...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2010.40.6.277
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Left ventricular (LV) remodeling is a heterogeneous process, involving both infarcted and non-infarcted zones, which affects wall thickness and chamber size, shape and function. SUBJECTS AND METHODS:A total of 758 consecutive patients (62.8±12.0 years, 539 males) with acute myocardial infarct...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2011.41.3.124
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Udenafil, a new phosphodiesterase-5 inhibitor (PDE5i), has been used to treat erectile dysfunction. Given the proven benefit of PDE5i in pulmonary arterial hypertension (PAH), we evaluated serial hemodynamic changes after single udenafil administration to determine the appropriate therapeutic ...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2018.0281
更新日期:2019-04-01 00:00:00
abstract::We reported a patient with Buerger's disease who presented with critical limb ischemiawith prior recurrent occlusions after multiple surgical and endovascular treatments. Total occlusion of the whole native femoropopliteal and infrapopliteal arteries was observed. The femoropopliteal bypass graft, as well as a stent t...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2016.46.3.417
更新日期:2016-05-01 00:00:00
abstract::Left ventricular hypertrabeculation/noncompaction (LVHT) is an uncommon type of genetic cardiomyopathy characterized by trabeculations and recesses within the ventricular myocardium. LVHT is associated with diastolic or systolic dysfunction, thromboembolic complications, and arrhythmias, including atrial fibrillation,...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2012.42.10.705
更新日期:2012-10-01 00:00:00
abstract::Cardiac magnetic resonance (CMR) imaging provides accurate anatomic information and advanced soft contrast, making it the reference standard for assessing cardiac volumes and systolic function. In this review, we summarize the recent advances in CMR sequences. New technical development has widened the use of CMR imagi...
journal_title:Korean circulation journal
pub_type: 杂志文章,评审
doi:10.4070/kcj.2018.0246
更新日期:2019-02-01 00:00:00
abstract:: ...
journal_title:Korean circulation journal
pub_type: 社论
doi:10.4070/kcj.2018.0269
更新日期:2018-12-01 00:00:00
abstract::Traumatic thoracic aortic injury is typically fatal. However, recent improvements in pre-hospital care and diagnostic modalities have resulted in an increased number of patients with traumatic aortic injury arriving alive at the hospital. Also, the morbidity and mortality associated with endovascular repair are signif...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2012.42.5.341
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Clinical data for Korean patients with bicuspid aortic valve (BAV) that underwent aortic valve (AV) surgery are currently limited. METHODS:Data for 1,160 consecutive adult BAV patients who underwent AV surgery from 2000 to 2014 in 4 tertiary referral centers were retrospectively analyzed. A s...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2017.0124
更新日期:2018-01-01 00:00:00
abstract::The incidence of peri-stent graft infection (PGI) following thoracic endovascular aortic repair (TEVAR) is low, but the associated mortality rates are extremely high. The diagnosis of this complication can be difficult due to nonspecific symptoms. Here, we report a case of PGI combined with an aorto-esophageal fistula...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2012.42.5.366
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Adipokines have been suggested for their potential use in tracking the clinical progress in the subjects with metabolic syndrome (MS). To investigate the relationship between the serum levels of adipokines {adiponectin and retinol-binding protein 4 (RBP4)} and the serum level of uric acid in h...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2011.41.4.198
更新日期:2011-04-01 00:00:00