Abstract:
BACKGROUND AND OBJECTIVES:The plasma concentration of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) is a st-rong prognostic indicator for patients with heart failure (HF) across all stages of the condition. Several clinical trials have de-monstrated convincingly that neurohormonal modulation on the renin angiotensin system (RAS) decreases plasma NT-pro-BNP level and results in favorable outcomes. But there are still limited comparative data on the neuro-hormonal modulatory effects of two RAS inhibitors: angiotensin converting enzyme inhibitor and angiotensin receptor blocker. SUBJECTS AND METHODS:This study was a prospective, multi-center, randomized, open-label, controlled, and non-inferiority study involving 445 patients with left ventricular ejection fraction (LVEF) less than 45%. Patients were assigned to receive either valsartan (target dose of 160 mg bid) or enalapril (target dose of 10 mg bid) for 12 months. We compared plasma NT-pro-BNP, high sensitive C-reactive protein (hs-CRP) level and echocardiographic parameters before and after treatment with valsartan or enalapril. RESULTS:The NT-pro-BNP and hs-CRP levels were significantly decreased after 12 months of treatment with valsartan and enalapril. The percentage change was similar between both groups. LVEF improved and left ventricular internal dimensions were decreased in both groups, and there were no significant differences between two groups. CONCLUSION:Valsartan is as effective on improving plasma NT-pro-BNP level as enalapril in patients with stable chronic HF.
journal_name
Korean Circ Jjournal_title
Korean circulation journalauthors
Lee YS,Kim KS,Lee JB,Ryu JK,Choi JY,Kim BK,Chang SG,Hur SH,Lee BR,Jung BC,Hong GR,Kim BS,Park TH,Kim YD,Kim TI,Kim DSdoi
10.4070/kcj.2011.41.2.61subject
Has Abstractpub_date
2011-02-01 00:00:00pages
61-7issue
2eissn
1738-5520issn
1738-5555journal_volume
41pub_type
杂志文章abstract::A 29-year-old man was referred to the emergency department with a complaint of abdominal pain and dizziness. He had experienced two previous syncopal episodes. His family history revealed that his mother and his two uncles had received permanent pacemaker implantation. His initial heart rate was 49 beats per minute. T...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2011.41.5.276
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The prevalence of arthritis, which is often treated with celecoxib, is high in patients with coronary artery disease. Furthermore, celecoxib has been reported to reduce restenosis after coronary stenting by inhibiting expression of the proto-oncogene Akt. A concern is that celecoxib increases ...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2010.40.7.321
更新日期:2010-07-01 00:00:00
abstract::A 65 year-old female with a history of xerostomia and xerophthalmia was presented with dyspnea on exertion (New York Heart Association class III). Echocardiography and cardiac catheterization demonstrated severe pulmonary hypertension (PH). Laboratory examinations showed positive anti-nuclear and anti-Ro/SS-A antibodi...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2013.43.7.504
更新日期:2013-07-01 00:00:00
abstract::Revascularization of severe left main and multivessel coronary artery disease has been shown to improve survival in both stable ischemic heart disease and acute coronary syndrome. While revascularization with coronary artery bypass surgery for these disease entities carries class I recommendation in most current guide...
journal_title:Korean circulation journal
pub_type: 杂志文章,评审
doi:10.4070/kcj.2018.0078
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Implantation of cardiac implantable electronic devices (CIED), including permanent pacemakers (PM), implantable cardioverter-defibrillators (ICD), and cardiac resynchronization therapy (CRT) devices, has increased significantly over the past several years. However, limited data exists regardin...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2018.0444
更新日期:2019-09-01 00:00:00
abstract::An effective anticoagulation is critical in pregnant patients with prosthetic heart valves. Inherited disorders may interfere with the coagulation cascade and may be associated with obstetrical complications as well as with prosthetic valve-derived complications. The patient in the present case had a history of recurr...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2014.44.4.268
更新日期:2014-07-01 00:00:00
abstract::Spontaneous isolated superior mesenteric artery dissection (SISMAD) is an uncommon but potentially catastrophic pathology. Multiple classification schemes have been proposed for this occurrence. Although no consensus has emerged regarding which classification should be used, Li's classification scheme is more precise ...
journal_title:Korean circulation journal
pub_type: 杂志文章,评审
doi:10.4070/kcj.2016.0237
更新日期:2017-07-01 00:00:00
abstract::The term decline effect is referred to a diminution of scientifically discovered effects over time. Reasons for the decline effect are multifaceted and include publication bias, selective reporting, outcomes reporting bias, regression to the mean, scientific paradigm shift, overshadowing and habituation, among others....
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2013.43.7.443
更新日期:2013-07-01 00:00:00
abstract::It has been estimated that coronary chronic total occlusion (CTO) is encountered in 15 to 20% patients referred for coronary angiography (CAG). The success of percutaneous coronary intervention (PCI) of CTO can be attributed to the vast array of hardware that has now become available and also to the vastly enhanced op...
journal_title:Korean circulation journal
pub_type: 杂志文章,评审
doi:10.4070/kcj.2017.0345
更新日期:2018-04-01 00:00:00
abstract::Unguarded tricuspid regurgitation (TR) due to a flail tricuspid leaflet is a rare condition of newborn cyanosis. A high perinatal mortality has been associated with this fatal condition. But, there are feasible surgical repairs to improve survival. We report the case of a male full-term neonate with intractable hypoxi...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2015.45.4.340
更新日期:2015-07-01 00:00:00
abstract::Treatments of choice for cardiac implantable electronic device (CIED) infections are the removal of the entire CIED system, control of infection, and new device implantation. Occasionally, a complete CIED removal can not be performed for several reasons, such as very old age, severe comobidity, limited life expectancy...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2011.41.1.46
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Impaired recovery from left ventricular (LV) dysfunction is a major prognostic factor after myocardial infarction (MI). Because P2Y₁₂ receptor blockade inhibits myocardial injury, ticagrelor with off-target properties may have myocardial protection over clopidogrel. In animal models, ticagrelo...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2018.0415
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:There is a paucity of data regarding the benefit of clopidogrel monotherapy after dual antiplatelet therapy (DAPT) in patients treated with drug-eluting stents (DES). This study compared outcome between clopidogrel versus aspirin as monotherapy after DES for acute myocardial infarction (MI). ...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2019.0166
更新日期:2020-02-01 00:00:00
abstract::Drug-eluting stents (DES) are considered the treatment of choice for most patients with obstructive coronary artery disease when percutaneous intervention (PCI) is feasible. However, stent thrombosis seems to occur more frequently with DES and occasionally is associated with resistance to anti-platelet drugs. We have ...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2009.39.10.434
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Transcatheter device closure becomes the first option for treating secundum atrial septal defect (ASD), but the conventional method is sometimes unsuccessful even when the defect size indicates the closure to be feasible. To increase the success rate, modified methods have been introduced and ...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2015.45.3.216
更新日期:2015-05-01 00:00:00
abstract::Stent fracture is likely to be caused due to mechanical stress at the hinge point or kinking movement at the point of aneurysm formation with stent malapposition. To our knowledge, this is the first published report of stent fracture at the proximal shaft of the left main stem in a patient with acute myocardial infarc...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2011.41.12.763
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We estimated the prevalence of hypertension and hypertension subtypes in a large semi-urban city in Korea, using 24-hour ambulatory blood pressure monitoring (ABPM) in a randomly selected sample population. SUBJECTS AND METHODS:A random sample (aged 20-65 years) from a city with an adult popu...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2016.46.5.681
更新日期:2016-09-01 00:00:00
abstract::A 77-year-old female patient underwent aortic valve replacement (AVR) with concomitant septal myectomy and tricuspid annuloplasty. Her symptoms did not improve after a successful operation. Echocardiogram demonstrated the presence of an iatrogenic ventricular septal defect (VSD). It was muscular in location and not th...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2014.44.1.45
更新日期:2014-01-01 00:00:00
abstract::Left atrial intramural hematoma is a very rare complication of radiofrequency ablation procedures. A patient with tachyarrhythmia underwent radiofrequency catheter ablation. Echocardiography performed the following morning showed a large mass in the left atrium, suggestive of intramural hematoma formation. The patient...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2016.46.4.580
更新日期:2016-07-01 00:00:00
abstract::Atrial fibrillation (AF) is the most common arrhythmia and is associated with increased cardiovascular morbidity and mortality. The anti-arrhythmic effect of statins on AF prevention appears to be highly significant in most clinical studies. However, some discrepancies do exist among different clinical studies. Differ...
journal_title:Korean circulation journal
pub_type: 杂志文章,评审
doi:10.4070/kcj.2014.44.4.205
更新日期:2014-07-01 00:00:00
abstract::Coronary artery anomalies are rare presentations in primary percutaneous coronary interventions of acute myocardial infarction. Herein, we report the case of a 59-year-old man with acute anterior myocardial infarction who had anomalous separate origin of left anterior descending artery (LAD) and left circumflex artery...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2013.43.6.408
更新日期:2013-06-01 00:00:00
abstract::We describe a case of chronic total occlusion of the right coronary artery ostium 5 months after a repeated Bentall procedure in a patient with Behçet's disease. In this patient, an antegrade approach to delivering the guidewire during percutaneous coronary intervention was not successful. Coronary angiography reveale...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2013.43.4.277
更新日期:2013-04-01 00:00:00
abstract::Ergonovine provocation test is known to be very sensitive for diagnosing variant angina. The patient described in this study initially presented with atypical chest pain and underwent coronary angiography and ergonovine provocation tests, which were negative. The patient was subsequently prescribed a proton pump inhib...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2013.43.3.199
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Bicaval heart transplantation (HTx) may promote parasympathetic reinnervation. However, the prevalence and timing of reinnervation have not been fully investigated. Heart rate variability (HRV) and direct vagal stimulation were used to evaluate the presence of parasympathetic reinnervation aft...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2016.46.2.197
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Chronic impairment of β-adrenergic receptor signaling increases cardiac apoptosis, hypertrophy and fibrosis. The aim of this study was to investigate whether isoproterenol (ISO), an agonist of the adrenergic receptor, can enhance tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2016.46.1.93
更新日期:2016-01-01 00:00:00
abstract::We report a case of a 19-year-old female with an elevated plasma B-type natriuretic peptide (BNP) level, but without evidence of heart failure (HF). She presented with non-specific chest pain and a high level of the B-type natriuretic peptide, despite having unremarkable findings on physical examination, laboratory an...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2010.40.3.141
更新日期:2010-03-01 00:00:00
abstract::A 63-year-old woman was diagnosed with ovarian cancer and peritoneal carcinomatosis. The day after paclitaxel was administered, an acute myocardial infarction occurred. Emergency coronary angiography revealed a filling defect in the left main coronary artery and total occlusion in the distal left anterior descending c...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2009.39.3.124
更新日期:2009-03-01 00:00:00
abstract::QT prolongation is a serious adverse drug effect, which is associated with an increased risk of Torsade de pointes and sudden death. Many drugs, including both cardiac and non-cardiac drugs, have been reported to cause prolongation of QT interval. Although meperidine has not been considered proarrhythmic, we present a...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2011.41.6.342
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Systemic inflammation has an important role in the initiation of atherosclerosis, which is associated with arterial stiffness (AS). Aortic flow propagation velocity (APV) is a new echocardiographic parameter of aortic stiffness. The relationship between systemic inflammation and AS has not yet...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2016.0400
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Glutaraldehyde (GA) has been used as a representative method of tissue preservation in cardiovascular surgery. However, GA has showed limited durability including calcification, mechanical failure and toxicity. To overcome those unsolved problems, we analyzed the crosslinking differences of pr...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2012.42.3.154
更新日期:2012-03-01 00:00:00