The decline effect in cardiovascular medicine: is the effect of cardiovascular medicine and stent on cardiovascular events decline over the years?


:The term decline effect is referred to a diminution of scientifically discovered effects over time. Reasons for the decline effect are multifaceted and include publication bias, selective reporting, outcomes reporting bias, regression to the mean, scientific paradigm shift, overshadowing and habituation, among others. Such effects can be found in cardiovascular medicines through medications (e.g., aspirin, antithrombotics, proton pump inhibitor, beta-blockers, statins, estrogen/progestin, angiotensin converting enzyme inhibitor etc.), as well as with interventional devices (e.g., angioplasty, percutaneous coronary intervention, stents). The scientific community should understand the various dimensions of the decline effects, and effective steps should be undertaken to prevent or recognize such decline effects in cardiovascular medicines.


Korean Circ J


Lee MS,Flammer AJ,Lerman A




Has Abstract


2013-07-01 00:00:00












  • Morbidity and Mortality of Very Low Birth Weight Infants with Congenital Heart Disease.

    abstract:BACKGROUND AND OBJECTIVES:This study aimed to provide morbidity and mortality information on very low birth weight (VLBW) infants with congenital heart disease (CHD-VLBWs). METHODS:The study used a 10-year cohort of VLBW infants from a single institution. CHD was classified according to International Classification of...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Song WS,Kim CY,Lee BS,Kim EAR,Kim KS,Jung E

    更新日期:2020-12-01 00:00:00

  • Subarachnoid Hemorrhage Misdiagnosed as an Acute ST Elevation Myocardial Infarction.

    abstract::Without significant coronary artery stenosis, ischemic electrocardiographic change including ST segment elevation, segmental wall motion abnormality and elevated serum cardiac-specific markers (creatine kinase-MB, Troponin-T) may develop after central nervous system injuries such as subarachnoid, intracranial or subdu...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Heo WJ,Kang JH,Jeong WS,Jeong MY,Lee SH,Seo JY,Jo SW

    更新日期:2012-03-01 00:00:00

  • The Control of Drug Release and Vascular Endothelialization after Hyaluronic Acid-Coated Paclitaxel Multi-Layer Coating Stent Implantation in Porcine Coronary Restenosis Model.

    abstract:BACKGROUND AND OBJECTIVES:Hyaluronic acid (HA) is highly biocompatible with cells and the extracellular matrix. In contrast to degradation products of a synthetic polymer, degradation products of HA do not acidify the local environment. The aim of this study was to fabricate an HA-coated paclitaxel (PTX)-eluting stent ...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Bae IH,Jeong MH,Kim JH,Park YH,Lim KS,Park DS,Shim JW,Kim JH,Ahn Y,Hong YJ,Sim DS

    更新日期:2017-01-01 00:00:00

  • Pericardial approach for cardiac therapies: old practice with new ideas.

    abstract::Treatment of cardiac disease via the epicardium fell under the domain of cardiac surgery due to the need for an open thoracotomy. Since an open thoracotomy is invasive in nature and has the potential for complications, a minimally invasive and percutaneous approach would be more attractive for suitable patients. The r...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Han S,Hwang C

    更新日期:2010-10-01 00:00:00

  • Morphologic Characteristics and Relating Factors to the Need of Technical Modification in Transcatheter Closure of Large Atrial Septal Defect (>/=25 mm).

    abstract:BACKGROUND AND OBJECTIVES:The rigid coupling between the delivery wire and the right atrial disk has been occasionally encountered during transcatheter closure of atrial septal defect (ASD). Therefore the device frequently makes a perpendicular angle, and the leading edge of left atrial disk slips through the defect an...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Park SJ,Kim NK,Kim JO,Yoo BW,Choi JY,Sul JH

    更新日期:2010-04-01 00:00:00

  • Isoproterenol Enhances Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis in Human Embryonic Kidney Cells through Death Receptor 5 up-Regulation.

    abstract:BACKGROUND AND OBJECTIVES:Chronic impairment of β-adrenergic receptor signaling increases cardiac apoptosis, hypertrophy and fibrosis. The aim of this study was to investigate whether isoproterenol (ISO), an agonist of the adrenergic receptor, can enhance tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Eom YW,Jung HY,Oh JE,Lee JW,Ahn MS,Youn YJ,Ahn SG,Kim JY,Lee SH,Yoon J,Yoo BS

    更新日期:2016-01-01 00:00:00

  • Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting for the Treatment of Left Main Coronary Artery Disease.

    abstract::Severe stenosis of the left main coronary artery (LMCA) generally occurs as a result of atherosclerosis and compromises the blood supply to a wide area of myocardium, thereby increasing the risk of serious adverse cardiac events. Current revascularization strategies for patients with significant LMCA disease include c...

    journal_title:Korean circulation journal

    pub_type: 杂志文章,评审


    authors: Cho SC,Park DW,Park SJ

    更新日期:2019-05-01 00:00:00

  • Acute Pulmonary Embolism: Focus on the Clinical Picture.

    abstract::Acute pulmonary embolism (APE) is characterized by numerous clinical manifestations which are the result of a complex interplay between different organs; the symptoms are therefore various and part of a complex clinical picture. For this reason, it may not be easy to make an immediate diagnosis. This is a comprehensiv...

    journal_title:Korean circulation journal

    pub_type: 杂志文章,评审


    authors: Morrone D,Morrone V

    更新日期:2018-05-01 00:00:00

  • Serial plasma levels of angiogenic factors in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.

    abstract:BACKGROUND AND OBJECTIVES:Patients with acute myocardial infarction show varying degrees of collateral development. However, the relationships between angiogenic factors and degree of collaterals are not well known. SUBJECTS AND METHODS:Fifty-nine patients (mean age, 59±10 years) with ST-segment elevation myocardial i...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Kim BH,Ko YG,Her AY,Kim JS,Hwang KC,Shin DH,Kim BK,Choi D,Ha JW,Hong MK,Jang Y

    更新日期:2012-07-01 00:00:00

  • Relationship between Waist Circumference and Cardiovascular Risk Factors in Adolescents: Analysis of the Korea National Health and Nutrition Examination Survey Data.

    abstract:BACKGROUND AND OBJECTIVES:High waist circumference (WC) is associated with increased cardiovascular risk (CVR) in adulthood. We investigated this association in adolescents. METHODS:We performed a cross-sectional analysis of data for 10-18-year-olds included in the Korea National Health and Nutrition Examination Surve...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Lee JS,Song YH

    更新日期:2020-08-01 00:00:00

  • Takayasu's Disease in a Patient with Ulcerative Colitis.

    abstract::A 35-year-old Korean man with a 10-year history of ulcerative colitis (UC) presented with pain and swelling of the right neck. The patient was diagnosed with Takayasu's arteritis (TA) and had human leukocyte antigen (HLA) B-52, which is frequently found in patients having both UC and Takayasu's disease concurrently on...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Chae MJ,Yu CW,Lee SY,Jang DH,Hyun JY,Jeong SJ,Kim MH

    更新日期:2013-02-01 00:00:00

  • Retrograde distal superficial femoral artery approach in the supine position for chronic superficial femoral artery occlusion.

    abstract::Subintimal angioplasty is an effective method for the treatment of long superficial femoral artery (SFA) occlusions. One of the major limiting factors for the success of this procedure is the failure to re-enter the true lumen. The recently introduced luminal re-entry devices provide a high technical success rate, but...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Shin S,Kim S,Ko YG,Hong MK,Jang Y,Choi D

    更新日期:2014-05-01 00:00:00

  • Conservative Management of Left Atrial Intramural Hematoma after Catheter Ablation.

    abstract::Left atrial intramural hematoma is a very rare complication of radiofrequency ablation procedures. A patient with tachyarrhythmia underwent radiofrequency catheter ablation. Echocardiography performed the following morning showed a large mass in the left atrium, suggestive of intramural hematoma formation. The patient...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Moradi B,Oraii S,Roshanali F,Ghorbanisharif A,Mikaeili J,Tahraei M

    更新日期:2016-07-01 00:00:00

  • A case of left ventricular noncompaction accompanying fasciculo-ventricular accessory pathway and atrial flutter.

    abstract::Left ventricular hypertrabeculation/noncompaction (LVHT) is an uncommon type of genetic cardiomyopathy characterized by trabeculations and recesses within the ventricular myocardium. LVHT is associated with diastolic or systolic dysfunction, thromboembolic complications, and arrhythmias, including atrial fibrillation,...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Yim SM,Jang SW,Chun HJ,Kim SJ,Choi KY,Kwon BJ,Kim DB,Cho EJ,Lee MY,Rho TH,Kim JH

    更新日期:2012-10-01 00:00:00

  • Role of Soluble ST2 as a Marker for Rejection after Heart Transplant.

    abstract:BACKGROUND AND OBJECTIVES:Endomyocardial biopsy is obligatory during the first year after heart transplant (HTx) for the surveillance of acute rejection. Previous attempts using cardiac biomarkers for the detection of rejection failed to show enough evidence to substitute endomyocardial biopsy. Therefore, this study so...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Lee GY,Choi JO,Ju ES,Lee YJ,Jeon ES

    更新日期:2016-11-01 00:00:00

  • Prevalence of Masked Hypertension: a Population-Based Survey in a Large City by Using 24-Hour Ambulatory Blood Pressure Monitoring.

    abstract:BACKGROUND AND OBJECTIVES:We estimated the prevalence of hypertension and hypertension subtypes in a large semi-urban city in Korea, using 24-hour ambulatory blood pressure monitoring (ABPM) in a randomly selected sample population. SUBJECTS AND METHODS:A random sample (aged 20-65 years) from a city with an adult popu...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Rhee MY,Kim SW,Choi EH,Kim JH,Nah DY,Shin SJ,Gu N

    更新日期:2016-09-01 00:00:00

  • Stroke and bleeding risk in atrial fibrillation.

    abstract::Non-valvular atrial fibrillation (AF) is the most common cardiac arrhythmia in the clinical setting. AF increases both the risk and severity of strokes, and is associated with substantial morbidity and mortality. Despite the clear net clinical benefit of oral anticoagulants (OACs) in patients with AF at risk for strok...

    journal_title:Korean circulation journal

    pub_type: 杂志文章,评审


    authors: Senoo K,Lane D,Lip GY

    更新日期:2014-09-01 00:00:00

  • Current Drug Therapy in Chronic Heart Failure: the New Guidelines of the European Society of Cardiology (ESC).

    abstract::Congestive heart failure (HF) is a morbidity that is increasing worldwide due to the aging population and improvement in (acute) care for patients with cardiovascular diseases. The prognosis for patients with HF is very poor without treatment. Furthermore, (repeated) hospitalizations for cardiac decompensation cause a...

    journal_title:Korean circulation journal

    pub_type: 杂志文章,评审


    authors: Berliner D,Bauersachs J

    更新日期:2017-09-01 00:00:00

  • Potential inherited causes of recurrent prosthetic mitral valve thrombosis in a pregnant patient suffering from recurrent miscarriage.

    abstract::An effective anticoagulation is critical in pregnant patients with prosthetic heart valves. Inherited disorders may interfere with the coagulation cascade and may be associated with obstetrical complications as well as with prosthetic valve-derived complications. The patient in the present case had a history of recurr...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Kalcik M,Gursoy MO,Karakoyun S,Yesin M,Astarcioglu MA,Ozkan M

    更新日期:2014-07-01 00:00:00

  • Expression of Class I and Class II a/b Histone Deacetylase is Dysregulated in Hypertensive Animal Models.

    abstract:BACKGROUND AND OBJECTIVES:Dysregulation of histone deacetylase expression and enzymatic activity is associated with a number of diseases. It has been reported that protein levels of histone deacetylase (HDAC)1 and HDAC5 increase during human pulmonary hypertension, and that the enzymatic activity of HDAC6 is induced in...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Kee HJ,Kim GR,Lin MQ,Choi SY,Ryu Y,Jin L,Piao ZH,Jeong MH

    更新日期:2017-05-01 00:00:00

  • Comparison of Prolonged Atrial Electromechanical Delays with Different Definitions in the Discrimination of Patients with Non-Valvular Paroxysmal Atrial Fibrillation.

    abstract:BACKGROUND AND OBJECTIVES:Previous studies have evaluated atrial electromechanical delays (AEMDs) with a number of different definitions to discriminate patients with paroxysmal atrial fibrillation (PAF) from controls without PAF. However, their discriminative values for PAF have not previously been directly compared. ...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Lee DH,Choi SY,Park JS,Seo JM,Choi JH,Cho YR,Park K,Kim MH,Kim YD

    更新日期:2015-11-01 00:00:00

  • Clinical Characteristics of Korean Patients with Bicuspid Aortic Valve Who Underwent Aortic Valve Surgery.

    abstract:BACKGROUND AND OBJECTIVES:Clinical data for Korean patients with bicuspid aortic valve (BAV) that underwent aortic valve (AV) surgery are currently limited. METHODS:Data for 1,160 consecutive adult BAV patients who underwent AV surgery from 2000 to 2014 in 4 tertiary referral centers were retrospectively analyzed. A s...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Sun BJ,Jin X,Song JK,Lee S,Lee JH,Park JB,Lee SP,Kim DH,Park SJ,Kim YJ,Cho GY,Song JM,Kang DH,Sohn DW

    更新日期:2018-01-01 00:00:00

  • Transcatheter closure of a residual patent ductus arteriosus after surgical ligation in children.

    abstract:BACKGROUND AND OBJECTIVES:To assess the safety and efficacy of transcatheter closure of residual ductal flow after initial surgical ligation of the arterial duct. SUBJECTS AND METHODS:Between June 2005 and December 2009, transcatheter occlusion of residual postsurgical ductus arteriosus was performed in six children. ...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Baspinar O,Kilinc M,Kervancioglu M,Irdem A

    更新日期:2011-11-01 00:00:00

  • Incidence and Risk Factors for Atrial Fibrillation in Korea: the National Health Insurance Service Database (2002-2010).

    abstract:BACKGROUND AND OBJECTIVES:Atrial fibrillation (AF) is a common arrhythmia that is known as an important independent risk factor for stroke. However, limited information is available on AF in Korea. This study evaluated the incidence of AF, its associated co-morbidities and risk factors for AF in Korea. SUBJECTS AND ME...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Son MK,Lim NK,Cho MC,Park HY

    更新日期:2016-07-01 00:00:00

  • Congenital Absence of Superior Vena Cava with no Manifestation of Superior Vena Cava Syndrome.

    abstract::Total absence of superior vena cava (SVC) is a very rare anomaly, and the patient usually suffers from SVC syndrome or conduction disturbances. We report an asymptomatic 27 year-old male, with complete absence of SVC. Transthoracic echocardiography and computed tomography demonstrated the absence of SVC and other cong...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Park CS,Kim JJ,Park JJ

    更新日期:2016-09-01 00:00:00

  • Anomalous separate origin of left anterior descending coronary artery: presented as acute anterior myocardial infarction.

    abstract::Coronary artery anomalies are rare presentations in primary percutaneous coronary interventions of acute myocardial infarction. Herein, we report the case of a 59-year-old man with acute anterior myocardial infarction who had anomalous separate origin of left anterior descending artery (LAD) and left circumflex artery...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Hong MY,Shin DH,Kwon JH,Chang WS,Choi KU,Song YA,Oh KH,Lee JH

    更新日期:2013-06-01 00:00:00

  • Acute Hemodynamic Changes after Single Administration of Udenafil in Pulmonary Arterial Hypertension: a Phase IIa Study.

    abstract:BACKGROUND AND OBJECTIVES:Udenafil, a new phosphodiesterase-5 inhibitor (PDE5i), has been used to treat erectile dysfunction. Given the proven benefit of PDE5i in pulmonary arterial hypertension (PAH), we evaluated serial hemodynamic changes after single udenafil administration to determine the appropriate therapeutic ...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Chang SA,Kim HK,Chang HJ,Kim DK

    更新日期:2019-04-01 00:00:00

  • Small left atrial size complicating percutaneous transcatheter device closure of secundum atrial septal defect with conventional approach.

    abstract:BACKGROUND AND OBJECTIVES:Transcatheter device closure becomes the first option for treating secundum atrial septal defect (ASD), but the conventional method is sometimes unsuccessful even when the defect size indicates the closure to be feasible. To increase the success rate, modified methods have been introduced and ...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Ko HK,Kang SY,Yu JJ,Ko JK,Kim YH

    更新日期:2015-05-01 00:00:00

  • Prognosis and natural history of drug-related bradycardia.

    abstract:BACKGROUND AND OBJECTIVES:The prognosis and natural history of bradycardia related to drugs such as beta-blockers and non-dihydropyridine calcium channel blockers are not well known. SUBJECTS AND METHODS:We retrospectively analyzed 38 consecutive patients (age 69+/-11, 21 women) with drug-related bradycardia (DRB) bet...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Lee JH,Ryu HM,Bae MH,Kwon YS,Lee JH,Park Y,Heo JH,Lee YS,Yang DH,Park HS,Cho Y,Chae SC,Kim YN,Jun JE,Park WH

    更新日期:2009-09-01 00:00:00

  • Recurrent very late stent thrombosis in a systemic lupus erythematous patient.

    abstract::Coronary artery disease is the most important cause of mortality in patients with systemic lupus erythematous (SLE). After stenting for coronary artery disease in SLE patients similar to non-SLE patients, the risk of stent thrombosis is always present. Although there are reports of stent thrombosis in SLE patients, ve...

    journal_title:Korean circulation journal

    pub_type: 杂志文章


    authors: Lee DY,Park JP,Ko SJ,Lee SE,Jhon SH,Lim JH,Rhew JY

    更新日期:2012-02-01 00:00:00