The decline effect in cardiovascular medicine: is the effect of cardiovascular medicine and stent on cardiovascular events decline over the years?

Abstract:

:The term decline effect is referred to a diminution of scientifically discovered effects over time. Reasons for the decline effect are multifaceted and include publication bias, selective reporting, outcomes reporting bias, regression to the mean, scientific paradigm shift, overshadowing and habituation, among others. Such effects can be found in cardiovascular medicines through medications (e.g., aspirin, antithrombotics, proton pump inhibitor, beta-blockers, statins, estrogen/progestin, angiotensin converting enzyme inhibitor etc.), as well as with interventional devices (e.g., angioplasty, percutaneous coronary intervention, stents). The scientific community should understand the various dimensions of the decline effects, and effective steps should be undertaken to prevent or recognize such decline effects in cardiovascular medicines.

journal_name

Korean Circ J

authors

Lee MS,Flammer AJ,Lerman A

doi

10.4070/kcj.2013.43.7.443

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

443-52

issue

7

eissn

1738-5520

issn

1738-5555

journal_volume

43

pub_type

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