Abstract:
:The Prospective comparison of Angiotensin Receptor-neprilysin inhibitor (ARNI) with Angiotensin converting enzyme inhibitor (ACEI) to Determine Impact on Global Mortality and morbidity in Heart Failure (HF) trial (PARADIGM-HF) showed that adding a neprilysin inhibitor (sacubitril) to a renin-angiotensin system blocker (and other standard therapy) reduced morbidity and mortality in ambulatory patients with chronic HF with reduced ejection fraction (HFrEF). In PARADIGM-HF, valsartan combined with sacubitril (a so-called ARNI) was superior to the current gold standard of an ACEI, specifically enalapril, reducing the risk of the primary composite outcome of cardiovascular (CV) death or first HF hospitalization by 20% and all-cause death by 16%. Following the results of PARADIGM-HF, sacubitril/valsartan was approved by American and European regulatory authorities for the treatment of HFrEF. The burden of HF in Asia is substantial, both due to the huge population of the region and as a result of increasing CV risk factors and disease. Both the prevalence and mortality associated with HF are high in Asia. In the following review, we discuss the development of sacubitril/valsartan, the prototype ARNI, and the available evidence for its efficacy and safety in Asian patients with HFrEF.
journal_name
Korean Circ Jjournal_title
Korean circulation journalauthors
Dewan P,Docherty KF,McMurray JJVdoi
10.4070/kcj.2019.0136subject
Has Abstractpub_date
2019-06-01 00:00:00pages
469-484issue
6eissn
1738-5520issn
1738-5555pii
49.469journal_volume
49pub_type
杂志文章,评审abstract:BACKGROUND AND OBJECTIVES:Kawasaki disease (KD) is an acute inflammatory process affecting the arterial walls that results in panvasculitis. Recent studies have shown that even after resolution of the disease, endothelial dysfunction persists and may progress to atherosclerosis. The pulse wave velocity (PWV) and the an...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2009.39.7.264
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Hyaluronic acid (HA) is highly biocompatible with cells and the extracellular matrix. In contrast to degradation products of a synthetic polymer, degradation products of HA do not acidify the local environment. The aim of this study was to fabricate an HA-coated paclitaxel (PTX)-eluting stent ...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2016.0203
更新日期:2017-01-01 00:00:00
abstract::Congestive heart failure is a major cause of morbidity and mortality as well as a major health care cost in the developed world. Despite the introduction of highly effective heart failure medical therapies and simple devices such as cardiac resynchronization therapy that reduce mortality, improve cardiac function and ...
journal_title:Korean circulation journal
pub_type: 杂志文章,评审
doi:10.4070/kcj.2019.0161
更新日期:2019-07-01 00:00:00
abstract::Heart transplantation (HTx) has become standard treatment for selected patients with end-stage heart failure. Improvements in immunosuppressant, donor procurement, surgical techniques, and post-HTx care have resulted in a substantial decrease in acute allograft rejection, which had previously significantly limited sur...
journal_title:Korean circulation journal
pub_type: 杂志文章,评审
doi:10.4070/kcj.2018.0189
更新日期:2018-07-01 00:00:00
abstract::Treatments of choice for cardiac implantable electronic device (CIED) infections are the removal of the entire CIED system, control of infection, and new device implantation. Occasionally, a complete CIED removal can not be performed for several reasons, such as very old age, severe comobidity, limited life expectancy...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2011.41.1.46
更新日期:2011-01-01 00:00:00
abstract::Drug-eluting stents (DES) are considered the treatment of choice for most patients with obstructive coronary artery disease when percutaneous intervention (PCI) is feasible. However, stent thrombosis seems to occur more frequently with DES and occasionally is associated with resistance to anti-platelet drugs. We have ...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2009.39.10.434
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Hypercholesterolemia is a key factor in the development of atherosclerosis. We sought to evaluate the relation between hypercholesterolemia and plaque composition in patients with coronary artery disease. SUBJECTS AND METHODS:Study subjects consisted of 323 patients (mean 61.5 years, 226 male...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2013.43.1.23
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:This study was intended to test how the inflammation at the Bacille Calmette-Guérin (BCG) inoculation site (BCGitis) can be a useful a diagnostic feature of Kawasaki disease (KD). SUBJECTS AND METHODS:All subjects were infants at the time of admission, and had received BCG vaccination during ...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2012.42.12.823
更新日期:2012-12-01 00:00:00
abstract::Herein, we present a case of a successful catheter ablation of ventricular tachycardia (VT) using a radial artery approach in a post-myocardial infarction patient, who had an implantable cardioverter-defibrillator and peripheral artery disease. Although the patient did not use antiarrhythmic drugs, the patient experie...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2012.42.9.632
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Although the use of heterogeneous overlapping drug-eluting stents (DES) is not uncommon in clinical practice, whether the implantation sequences of heterogeneous DES will influence the endothelialization or arterial responses differently remains unclear. MATERIALS AND METHODS:Twenty-one rabbi...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2012.42.6.397
更新日期:2012-06-01 00:00:00
abstract::A 77-year-old female patient underwent aortic valve replacement (AVR) with concomitant septal myectomy and tricuspid annuloplasty. Her symptoms did not improve after a successful operation. Echocardiogram demonstrated the presence of an iatrogenic ventricular septal defect (VSD). It was muscular in location and not th...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2014.44.1.45
更新日期:2014-01-01 00:00:00
abstract::Drug-eluting stents (DESs) are the treatment of choice for obstructive coronary artery disease when percutaneous intervention is feasible. However, late stent thrombosis seems to occur more frequently with DESs and is closely associated with the discontinuation of dual antiplatelet therapy. We report a case of very la...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2009.39.5.205
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Dysregulation of histone deacetylase expression and enzymatic activity is associated with a number of diseases. It has been reported that protein levels of histone deacetylase (HDAC)1 and HDAC5 increase during human pulmonary hypertension, and that the enzymatic activity of HDAC6 is induced in...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2016.0266
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Systemic inflammation has an important role in the initiation of atherosclerosis, which is associated with arterial stiffness (AS). Aortic flow propagation velocity (APV) is a new echocardiographic parameter of aortic stiffness. The relationship between systemic inflammation and AS has not yet...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2016.0400
更新日期:2017-07-01 00:00:00
abstract::A 52-year-old woman with rheumatoid arthritis who had been treated with prednisone and hydroxychloroquine for >12 years presented with chest discomfort and a seizure. She was diagnosed with restrictive cardiomyopathy combined with sick sinus syndrome. A myocardial muscle biopsy was performed to identify the underlying...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2010.40.11.604
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Since statins and angiotensin receptor blockers are a frequently prescribed combination in patients with atherosclerotic cardiovascular diseases, we tested the interactive effects of simvastatin and losartan on atherosclerosis in apolipoprotein E (apoE)(-/-) mice. MATERIALS AND METHODS:Apolip...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2012.42.8.543
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Vasospastic angina (VA) is a specific type of coronary artery disease and develops as a result of coronary artery spasm. Recently, a few studies have revealed that VA caused by coronary artery spasm is related to genetic traits. The objective of this study was to use the recently developed tec...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2011.41.7.385
更新日期:2011-07-01 00:00:00
abstract::We reported a patient with Buerger's disease who presented with critical limb ischemiawith prior recurrent occlusions after multiple surgical and endovascular treatments. Total occlusion of the whole native femoropopliteal and infrapopliteal arteries was observed. The femoropopliteal bypass graft, as well as a stent t...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2016.46.3.417
更新日期:2016-05-01 00:00:00
abstract::The incidence of peri-stent graft infection (PGI) following thoracic endovascular aortic repair (TEVAR) is low, but the associated mortality rates are extremely high. The diagnosis of this complication can be difficult due to nonspecific symptoms. Here, we report a case of PGI combined with an aorto-esophageal fistula...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2012.42.5.366
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Udenafil, a new phosphodiesterase-5 inhibitor (PDE5i), has been used to treat erectile dysfunction. Given the proven benefit of PDE5i in pulmonary arterial hypertension (PAH), we evaluated serial hemodynamic changes after single udenafil administration to determine the appropriate therapeutic ...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2018.0281
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Pentraxin 3 (PTX3) was shown to be elevated in the acute phase of acute myocardial infarction (AMI) and to have prognostic significance in AMI patients. The aim of this study was to estimate whether the value of PTX3 could be used as a prognostic biomarker, with the global registry of acute co...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2010.40.8.370
更新日期:2010-08-01 00:00:00
abstract::Left atrial intramural hematoma is a very rare complication of radiofrequency ablation procedures. A patient with tachyarrhythmia underwent radiofrequency catheter ablation. Echocardiography performed the following morning showed a large mass in the left atrium, suggestive of intramural hematoma formation. The patient...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2016.46.4.580
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Clinical data for Korean patients with bicuspid aortic valve (BAV) that underwent aortic valve (AV) surgery are currently limited. METHODS:Data for 1,160 consecutive adult BAV patients who underwent AV surgery from 2000 to 2014 in 4 tertiary referral centers were retrospectively analyzed. A s...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2017.0124
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Several recent studies have shown that there is an inverse relationship between plasma B-type natriuretic peptide (BNP) and body mass index (BMI) in subjects with and without heart failure. Obesity frequently coexists with diabetes, so it is important to consider the relationship between diabe...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2009.39.12.538
更新日期:2009-12-01 00:00:00
abstract::Platelet aggregation is not only an essential part of hemostasis, but also initiates acute coronary syndrome or ischemic stroke. The precise understanding of the activation mechanism of platelet aggregation is fundamental for the development of more effective agents against platelet aggregation. Adenosine diphosphate,...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2012.42.5.295
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Implantation of cardiac implantable electronic devices (CIED), including permanent pacemakers (PM), implantable cardioverter-defibrillators (ICD), and cardiac resynchronization therapy (CRT) devices, has increased significantly over the past several years. However, limited data exists regardin...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2018.0444
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Coronary artery disease (CAD) is a major cause of heart failure associated with left ventricular systolic dysfunction (LVSD). The prognosis of LVSD is significantly influenced by the etiology of heart failure and therefore, differentiation of significant CAD from other etiologies is important....
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2010.40.12.665
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Glutaraldehyde (GA) has been used as a representative method of tissue preservation in cardiovascular surgery. However, GA has showed limited durability including calcification, mechanical failure and toxicity. To overcome those unsolved problems, we analyzed the crosslinking differences of pr...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2012.42.3.154
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Intermediate coronary lesion that can be under- or over-estimated by visual estimation frequently results in stenting of functionally nonsignificant lesions or deferral of percutaneous coronary intervention (PCI) of significant lesions inappropriately. We evaluated current status of PCI for in...
journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2019.0074
更新日期:2019-11-01 00:00:00
abstract::Humans have pre-formed collateral vessels that enlarge with ischemia. In addition, new vessels can be formed within ischemic zones from pre-formed endocardial arcades of vessels providing rich collateral flow. Collateral flow under resting conditions (if >25% of normal) is enough to maintain myocardial viability, but ...
journal_title:Korean circulation journal
pub_type: 杂志文章,评审
doi:10.4070/kcj.2015.45.5.351
更新日期:2015-09-01 00:00:00