Coronary artery thrombosis associated with Paclitaxel in advanced ovarian cancer.

Abstract:

:A 63-year-old woman was diagnosed with ovarian cancer and peritoneal carcinomatosis. The day after paclitaxel was administered, an acute myocardial infarction occurred. Emergency coronary angiography revealed a filling defect in the left main coronary artery and total occlusion in the distal left anterior descending coronary artery, with no luminal irregularity or narrowing. Intravascular ultrasonography showed no significant plaque in the left main coronary artery. A thrombophilia work-up was negative, and the patient was treated with tirofiban, clopidogrel, and aspirin. The follow-up coronary angiogram showed that the occlusion of the distal obtuse marginal branch and distal left anterior descending artery had cleared. Paclitaxel has been associated with acute myocardial infarction. However, the pathogenesis of myocardial infarction associated with paclitaxel is not known. This case raises the possibility that paclitaxel can induce coronary artery thrombosis, resulting in myocardial infarction.

journal_name

Korean Circ J

authors

Park SH,Byon JS,Lee SW,Lee SJ,Jin DK,Shin WY

doi

10.4070/kcj.2009.39.3.124

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

124-7

issue

3

eissn

1738-5520

issn

1738-5555

journal_volume

39

pub_type

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