当前位置： SCI文献检索 > Korean Circulation Journal期刊下所有文献 > Impact of heterogeneous overlapping drug-eluting stents on the arterial responses of rabbit iliac arteries: a comparison with overlapping bare metal stents.

Impact of heterogeneous overlapping drug-eluting stents on the arterial responses of rabbit iliac arteries: a comparison with overlapping bare metal stents.

Abstract：

BACKGROUND AND OBJECTIVES:Although the use of heterogeneous overlapping drug-eluting stents (DES) is not uncommon in clinical practice, whether the implantation sequences of heterogeneous DES will influence the endothelialization or arterial responses differently remains unclear. MATERIALS AND METHODS:Twenty-one rabbits were randomized to receive overlapping stents in the iliac artery for 3 months {distal sirolimus-eluting stent (SES, Cypher™)+proximal paclitaxel-eluting stent (PES, Taxus™) (C+T, n=7), distal Taxus+proximal Cypher (T+C, n=7) and bare metal stent (BMS)+BMS (B+B, n=7)}. Endothelial function was evaluated by the acetylcholine provocation test during follow-up angiography. Histopathological changes in proximal, overlapped, and distal stented segments were evaluated. RESULTS:Although the overall angiographic outcomes were comparable, late loss (mm) in the distal stented segment was higher in the B+B (0.39±0.07) and C+T (0.40±0.20) than that in the T+C (0.06±0.02) group (p<0.001). The incidence of acetylcholine-induced spasm was higher in the DES groups compared with BMS, regardless of the implantation sequences (85.7% in C+T vs. 14.3% in B+B vs. 71.4% in T+C, p=0.017). Notably, only the distal Cypher implantation group (C+T) had three cases of stent fracture. A histopathological analysis showed that despite similar arterial injury scores, Taxus and Cypher stents had higher inflammatory reactions at the overlapped and distal segments compared with those of BMS. CONCLUSION:Despite similar arterial injury, higher inflammatory reactions were observed in overlapping DES segments regardless of the implantation sequence compared with that of BMS. Moreover, DES was associated with impaired endothelial function on the adjacent non-stented segments.

journal_name

Korean Circ J

journal_title

Korean circulation journal

authors

Rha SW,Chen KY,Oh DJ,Li YJ,Jin Z,Poddar KL,Ramasamy S,Minami Y,Elnagar A,Choi BG,Hong SP,Cheon BW,Moon SK,Im SI,Kim SW,Na JO,Choi CU,Lim HE,Kim JW,Kim EJ,Han SW,Park CG,Seo HS,Kim JH,Hong YJ,Jeong MH

doi

10.4070/kcj.2012.42.6.397

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

397-405

issue

eissn

1738-5520

issn

1738-5555

journal_volume

pub_type

杂志文章

在线工具

Impact of heterogeneous overlapping drug-eluting stents on the arterial responses of rabbit iliac arteries: a comparison with overlapping bare metal stents.