Abstract:
BACKGROUND AND OBJECTIVES:Dysregulation of histone deacetylase expression and enzymatic activity is associated with a number of diseases. It has been reported that protein levels of histone deacetylase (HDAC)1 and HDAC5 increase during human pulmonary hypertension, and that the enzymatic activity of HDAC6 is induced in a chronic hypertensive animal model. This study investigated the protein expression profiles of class I and II a/b HDACs in three systemic hypertension models. SUBJECTS AND METHODS:We used three different hypertensive animal models: (i) Wistar-Kyoto rats (n=8) and spontaneously hypertensive rats (SHR; n=8), (ii) mice infused with saline or angiotensin II to induce hypertension, via osmotic mini-pump for 2 weeks, and (iii) mice that were allowed to drink L-NG-nitro-L-arginine methyl ester (L-NAME) to induce hypertension. RESULTS:SHR showed high systolic, diastolic, and mean blood pressures. Similar increases in systolic blood pressure were observed in angiotensin II or L-NAME-induced hypertensive mice. In SHR, class IIa HDAC (HDAC4, 5, and 7) and class IIb HDAC (HDAC6 and 10) protein expression were significantly increased. In addition, a HDAC3 protein expression was induced in SHR. However, in L-NAME mice, class IIa HDAC protein levels (HDAC4, 5, 7, and 9) were significantly reduced. HDAC8 protein levels were significantly reduced both in angiotensin II mice and in SHR. CONCLUSION:These results indicate that dysregulation of class I and class II HDAC protein is closely associated with chronic hypertension.
journal_name
Korean Circ Jjournal_title
Korean circulation journalauthors
Kee HJ,Kim GR,Lin MQ,Choi SY,Ryu Y,Jin L,Piao ZH,Jeong MHdoi
10.4070/kcj.2016.0266subject
Has Abstractpub_date
2017-05-01 00:00:00pages
392-400issue
3eissn
1738-5520issn
1738-5555journal_volume
47pub_type
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journal_title:Korean circulation journal
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doi:10.4070/kcj.2016.0237
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journal_title:Korean circulation journal
pub_type: 杂志文章,评审
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更新日期:2009-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
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journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2010.40.3.141
更新日期:2010-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-04-01 00:00:00