Abstract:
BACKGROUND AND OBJECTIVES:The redox system is an important anti-oxidative system composed of thioredoxin, thioredoxin reductase, and peroxiredoxin (PRx). The fine details of PRx expression and its protective effects in various cells in cardiovascular tissue under oxidative stress created by hydrogen peroxide have not been fully elucidated. SUBJECTS AND METHODS:Oxidative stress was induced by adding hydrogen peroxide at 0.25 mM for 2 hours to rat neonatal cardiomyocytes (rCMCs), rat vascular smooth muscle cells (rVSMCs), and human umbilical vein endothelial cells (HUVECs). Apoptosis was quantified by flow cytometry and the expression patterns of the six PRx isoforms were evaluated by western blotting in the three cell lines after hydrogen peroxide stimulation. Apoptosis and the cell survival signal pathway were evaluated by PRx1 gene delivery using lentiviral vector in hydrogen peroxide stimulated rCMCs versus green fluorescence protein gene delivery. RESULTS:Hydrogen peroxide induced 25% apoptosis in rCMCs. Furthermore, the PRx1 and 5 isoforms were found to be overexpressed in hydrogen peroxide treated rCMCs, and PRx1 overexpression by gene delivery was found to reduce hydrogen peroxide induced rCMCs apoptosis significantly. In addition, this effect was found to originate from cell survival pathway modification. CONCLUSION:Hydrogen peroxide induced significant oxidative stress in rCMCs, rVSMCs, and HUVECs, and PRx1 overexpression using a lentiviral vector system significantly reduced hydrogen peroxide induced rCMCs apoptosis by upregulation of cell survival signals and downregulation of apoptotic signals. These findings suggest that PRx1 could be used as a treatment strategy for myocardial salvage in conditions of oxidative stress.
journal_name
Korean Circ Jjournal_title
Korean circulation journalauthors
Park KJ,Kim YJ,Kim J,Kim SM,Lee SY,Bae JW,Hwang KK,Kim DW,Cho MCdoi
10.4070/kcj.2012.42.1.23subject
Has Abstractpub_date
2012-01-01 00:00:00pages
23-32issue
1eissn
1738-5520issn
1738-5555journal_volume
42pub_type
杂志文章abstract::A 63-year-old woman was diagnosed with ovarian cancer and peritoneal carcinomatosis. The day after paclitaxel was administered, an acute myocardial infarction occurred. Emergency coronary angiography revealed a filling defect in the left main coronary artery and total occlusion in the distal left anterior descending c...
journal_title:Korean circulation journal
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journal_title:Korean circulation journal
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journal_title:Korean circulation journal
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abstract:: ...
journal_title:Korean circulation journal
pub_type: 社论
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journal_title:Korean circulation journal
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journal_title:Korean circulation journal
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pub_type: 杂志文章
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journal_title:Korean circulation journal
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journal_title:Korean circulation journal
pub_type: 杂志文章
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journal_title:Korean circulation journal
pub_type: 杂志文章,评审
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journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2019.0074
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journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2011.41.10.603
更新日期:2011-10-01 00:00:00
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journal_title:Korean circulation journal
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Korean circulation journal
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journal_title:Korean circulation journal
pub_type: 杂志文章
doi:10.4070/kcj.2016.0203
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