Abstract:
:The pharmacological therapy for gastrointestinal (GI) diseases, such as inflammatory bowel diseases, continues to present challenges in targeting efficacy. The need for maximal local drug exposure at the inflamed regions of the GI tract has led research to focus on a disease-targeted drug delivery approach. Smart nanomaterials responsive to the reactive oxygen species (ROS) concentrated in the inflamed areas, can be formulated into nanoplatforms to selectively release the active compounds, avoiding unspecific drug delivery to healthy tissues and limiting systemic absorption. Recent developments of ROS-responsive nanoplatforms include combination with other materials to obtain multi-responsive systems and modifications/derivatization to increase the interactions with biological tissues, cell uptake and targeting. This review describes the applications of ROS-responsive nanosystems for on-demand drug delivery to the GI tract.
journal_name
Biopolymersjournal_title
Biopolymersauthors
Bertoni S,Machness A,Tiboni M,Bártolo R,Santos HAdoi
10.1002/bip.23336subject
Has Abstractpub_date
2020-01-01 00:00:00pages
e23336issue
1eissn
0006-3525issn
1097-0282journal_volume
111pub_type
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