Nonlinear magnetic stereotaxis: three-dimensional, in vivo remote magnetic manipulation of a small object in canine brain.

Abstract:

:In a series of in vivo experiments on five adult canines, a small cylindrical permanent magnet (approximately 5-mm diameter x 5 mm long) was magnetically moved under fluoroscopic guidance from an occipital-lobe burr hole to a predetermined destination within the brain and then removed. On three of the animals, dorsal and temporal skull markers were used to establish a coordinate system against which the motions of the seed were referenced. These procedures were sufficiently accurate to permit the guided motion of the seed along nonlinear paths within the brain, including traversal of the midline through the corpus callosum. For removal, the seed could be steered either to a frontal lobe location for extraction through an auxiliary burr hole, or back to the same burr hole through which it had been inserted. This article discusses the way in which stereotactic motions were obtained, the performance limits of the instrumentation and the precision of motion achieved.

journal_name

Med Phys

journal_title

Medical physics

authors

Grady MS,Howard MA 3rd,Molloy JA,Ritter RC,Quate EG,Gillies GT

doi

10.1118/1.596520

subject

Has Abstract

pub_date

1990-05-01 00:00:00

pages

405-15

issue

3

eissn

0094-2405

issn

2473-4209

journal_volume

17

pub_type

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