Abstract:
:The community working on model organisms is growing steadily and the number of model organisms for which proteome data are being generated is continuously increasing. To standardize efforts and to make optimal use of proteomics data acquired from model organisms, a new Human Proteome Organisation (HUPO) initiative on model organism proteomes (iMOP) was approved at the HUPO Ninth Annual World Congress in Sydney, 2010. iMOP will seek to stimulate scientific exchange and disseminate HUPO best practices. The needs of model organism researchers for central databases will be better represented, catalyzing the integration of proteomics and organism-specific databases. Full details of iMOP activities, members, tools and resources can be found at our website http://www.imop.uzh.ch/ and new members are invited to join us.
journal_name
Proteomicsjournal_title
Proteomicsauthors
Jones AM,Aebersold R,Ahrens CH,Apweiler R,Baerenfaller K,Baker M,Bendixen E,Briggs S,Brownridge P,Brunner E,Daube M,Deutsch EW,Grossniklaus U,Heazlewood J,Hengartner MO,Hermjakob H,Jovanovic M,Lawless C,Lochnit G,Madoi
10.1002/pmic.201290014subject
Has Abstractpub_date
2012-02-01 00:00:00pages
340-5issue
3eissn
1615-9853issn
1615-9861journal_volume
12pub_type
杂志文章相关文献
PROTEOMICS文献大全abstract::Data-independent acquisition (DIA) offers several advantages over data-dependent acquisition (DDA) schemes for characterizing complex protein digests analyzed by LC-MS/MS. In contrast to the sequential detection, selection, and analysis of individual ions during DDA, DIA systematically parallelizes the fragmentation o...
journal_title:Proteomics
pub_type: 杂志文章,评审
doi:10.1002/pmic.201400323
更新日期:2015-03-01 00:00:00
abstract::Sandwich ELISA microarrays have great potential for validating disease biomarkers. Each ELISA relies on robust-affinity reagents that retain activity when immobilized on a solid surface or when labeled for detection. Single-chain antibodies (scFv) are affinity reagents that have greater potential for high-throughput p...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200701036
更新日期:2008-06-01 00:00:00
abstract::Quantitative acetyl-proteomics, a newly identified post-translational modification, is known to regulate transcriptional activity in different organisms. Neurospora crassa is a model ascomycete fungus maintained for biochemistry and molecular biology research; however, extensive studies of the functions of its acylati...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.202000212
更新日期:2021-01-24 00:00:00
abstract::Proteomics assays hold great promise for unraveling molecular events that underlie human diseases. Effective analysis of clinical samples is essential, but this task is considerably complicated by tissue heterogeneity. Laser capture microdissection (LCM) can be used to selectively isolate target cells from their nativ...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200600293
更新日期:2007-01-01 00:00:00
abstract::The pilot phase of the Human Brain Proteome Project as a part of the Human Proteome Organisation has just been started. In two pilot studies, 18 different laboratories are analyzing mouse brains of three age stages and human brain autopsy versus biopsy material, respectively. The overall aim is to elucidate the portfo...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200400867
更新日期:2004-08-01 00:00:00
abstract::The Asia Oceania Human Proteome Organisation (AOHUPO) has embarked on a Membrane Proteomics Initiative with goals of systematic comparison of strategies for analysis of membrane proteomes and discovery of membrane proteins. This multilaboratory project is based on the analysis of a subcellular fraction from mouse live...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201000126
更新日期:2010-11-01 00:00:00
abstract::SDS interferes with both bottom-up and top-down MS analysis, requiring removal prior to detection. Filter-aided sample preparation (FASP) is favored for bottom-up proteomics (BUP) while acetone precipitation is popular for top-down proteomics (TDP). We recently demonstrated acetone precipitation in a membrane filter c...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201700025
更新日期:2018-05-01 00:00:00
abstract::Scanning MS by MALDI MS imaging (MALDI-MSI) creates large volumetric global datasets that describe the location and identity of ions registered at each sampling location. While thousands of ion peaks are recorded in a typical whole-tissue analysis, only a fraction of these measured molecules are purposefully scrutiniz...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201300431
更新日期:2014-04-01 00:00:00
abstract::Since the proposal of the signal hypothesis on protein subcellular sorting, a number of computational analyses have been performed in this field. A typical example is the development of prediction algorithms for the subcellular localization sites of input protein sequences. In this review, we mainly focus on the biolo...
journal_title:Proteomics
pub_type: 杂志文章,评审
doi:10.1002/pmic.201000274
更新日期:2010-11-01 00:00:00
abstract::In-gel peptide digestion has become a widely used technique for characterizing proteins resolved by two-dimensional gel electrophoresis. Peptides generated from gel pieces are frequently contaminated with detergent and salts. Prior to matrix-assisted laser desorption/ionization-time of flight mass spectrometry analysi...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/1615-9861(200202)2:2<145::aid-prot145>3.0.
更新日期:2002-02-01 00:00:00
abstract::Colorectal cancer risk is increased when dietary folate intake is low, with or without a deficiency in methylenetetrahydrofolate reductase (MTHFR). We have observed that intestinal tumors are induced in mice fed low-folate diets, and that tumor incidence is increased when these mice also have MTHFR deficiency. This st...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201400280
更新日期:2014-11-01 00:00:00
abstract::Four rhoptry proteins (ROP) of Toxoplasma gondii previously identified with mAb have been affinity purified and analyzed by MS; the data obtained allowed the genomic sequences to be assigned to these proteins. As previously suggested for some of them by antibody crossreactivity, these proteins were shown to belong to ...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200600187
更新日期:2006-11-01 00:00:00
abstract::Reporter ion-based methods are among the major techniques to quantify peptides and proteins. Two main labels, tandem mass tag (TMT) and iTRAQ, are widely used by the proteomics community. They are, however, often applied as out-of-the-box methods, without thorough quality control. Thus, due to undiscovered limitations...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201000711
更新日期:2011-03-01 00:00:00
abstract::The recent development in immune checkpoint inhibitors and chimeric antigen receptor (CAR) T-cells in the treatment of cancer has not only demonstrated the potency of utilizing T-cell reactivity for cancer therapy, but has also highlighted the need for developing new approaches to discover targets suitable for such no...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201700465
更新日期:2018-06-01 00:00:00
abstract::SugarQb (www.imba.oeaw.ac.at/sugarqb) is a freely available collection of computational tools for the automated identification of intact glycopeptides from high-resolution HCD MS/MS datasets in the Proteome Discoverer environment. We report the migration of SugarQb to the latest and free version of Proteome Discoverer...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201700436
更新日期:2018-07-01 00:00:00
abstract::Identification and analysis of types of biological protein-protein interactions and their interfaces to predict obligate and non-obligate complexes is a problem that has drawn the attention of the research community in the past few years. In this paper, we propose a prediction approach to predict these two types of co...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201100186
更新日期:2011-10-01 00:00:00
abstract::Calcineurin is a heterodimeric serine/threonine protein phosphatase, important for many cellular processes such as T-cell regulation, cardiac hypertrophy and kidney development. We previously reported the characterization of Caenorhabditis elegans calcineurin mutants as providing a simple but excellent genetic model s...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200500315
更新日期:2006-02-01 00:00:00
abstract::Gliadins and glutenins are the main protein fractions present in wheat gluten. They are responsible for technological and nutritional quality of wheat based products. In particular, glutenins are mainly responsible for dough visco-elastic properties, whereas gliadins confer extensibility to dough and are the most impo...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200500236
更新日期:2006-03-01 00:00:00
abstract::A monolithic enzymatic microreactor was prepared in a fused-silica capillary by in situ polymerization of acrylamide, glycidyl methacrylate (GMA) and ethylene dimethacrylate (EDMA) in the presence of a binary porogenic mixture of dodecanol and cyclohexanol, followed by ammonia solution treatment, glutaraldehyde activa...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200500234
更新日期:2006-01-01 00:00:00
abstract::The CpG motif of bacterial DNA (CpG-DNA) is a potent immunostimulating agent whose mechanism of action is not yet clear. Here, we used both DNA microarray and proteomic approaches to investigate the effects of oligodeoxynucleotides containing the CpG motif (CpG-ODN) on gene transcription and protein expression profile...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200401144
更新日期:2005-03-01 00:00:00
abstract::Imbalance in protein homeostasis in specific subcellular organelles is alleviated through organelle-specific stress response pathways. As a canonical example of stress activated pathway, accumulation of misfolded proteins in ER activates unfolded protein response (UPR) in almost all eukaryotic organisms. However, very...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201300449
更新日期:2014-08-01 00:00:00
abstract::The thermophilic bacterium Bacillus stearothermophilus P1 is unique in its ability to thrive in extreme environments such as high temperatures or high pH conditions. The study of cold shock response is very interesting and interpreted as a shock response to express the genes involved in synthesis of specific proteins....
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/1615-9861(200209)2:9<1316::AID-PROT1316>3.
更新日期:2002-09-01 00:00:00
abstract::Toxic oil syndrome (TOS) is a disease that appeared in Spain in 1981. It affected more than 20 000 people and produced over 300 deaths in the first 2 years. In this paper, a prospective study on the differences in gene expression in sera between a control versus a TOS-affected population, both originally exposed to th...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200300630
更新日期:2004-02-01 00:00:00
abstract::Human embryonic stem cells (hESCs) have received considerable attention due to their therapeutic potential and usefulness in understanding early development and cell fate commitment. In order to appreciate the unique properties of these pluripotent, self-renewing cells, we have performed an in-depth multidimensional f...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201400132
更新日期:2015-01-01 00:00:00
abstract::The skin provides protection against environmental stress. However, intrinsic and extrinsic aging causes significant alteration to skin structure and components, which subsequently impairs molecular characteristics and biochemical processes. Here, we have conducted an immunohistological investigation and established t...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201600141
更新日期:2016-10-01 00:00:00
abstract::Liquid Chromatography coupled to tandem mass spectrometry (nanoLC-MS/MS) is a powerful analytical technique for the identification and mass analysis of complex protein mixtures. Here, we present a combination of methods developed for the extensive/deep proteomic analysis of purified ribosome/mRNA particles assembled i...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201400628
更新日期:2015-07-01 00:00:00
abstract::Human plasma is the most clinically valuable specimen, containing not only a dynamic concentration range of protein components, but also several groups of high-abundance proteins that seriously interfere with the detection of low-abundance potential biomarker proteins. To establish a high-throughput method for efficie...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.200401310
更新日期:2005-08-01 00:00:00
abstract::O-GlcNAcylation is a dynamic PTM of nuclear and cytoplasmic proteins, regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase, which catalyze the addition and removal of O-GlcNAc, respectively. This modification is associated with glucose metabolism, which plays important roles in many diseases including cancer. Altho...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201200126
更新日期:2013-07-01 00:00:00
abstract::Phosphoproteomics can be defined as the comprehensive study of protein phosphorylation by identification of the phosphoproteins, exact mapping of the phosphorylation sites, quantification of phosphorylation, and eventually, revealing their biological function. Its place in today's research is vitally important to addr...
journal_title:Proteomics
pub_type: 杂志文章,评审
doi:10.1002/pmic.200600232
更新日期:2006-10-01 00:00:00
abstract::Long-term storage of protein samples for transportation is a challenge in the field of mass spectrometric analysis because the low temperature condition is not easy to be maintained. Here we introduce a simple method to preserve proteins at room temperature for at least one month. In this method, the protein sample is...
journal_title:Proteomics
pub_type: 杂志文章
doi:10.1002/pmic.201700336
更新日期:2018-07-01 00:00:00