Abstract：
:Pharmacotherapy for gastroesophageal reflux (GER) in neonates, aimed at interfering with this physiologic process and potentially reducing the negative sequelae that providers often attribute to GER, consists primarily of drugs that increase the viscosity of feeds, reduce stomach acidity, or improve gut motility. Medications used to treat clinical signs thought to be from GER, such as apnea, bradycardia, or feeding intolerance, are among the most commonly prescribed medications in neonatal intensive care units in the United States, despite the lack of evidence of safety and efficacy in this population.
journal_name
Clin Perinatoljournal_title
Clinics in perinatologyauthors
Malcolm WF,Cotten CMdoi
10.1016/j.clp.2011.12.015subject
Has Abstractpub_date
2012-03-01 00:00:00pages
99-109issue
1eissn
0095-5108issn
1557-9840pii
S0095-5108(11)00142-4journal_volume
39pub_type
杂志文章,评审abstract：:As a standard of care for preterm/term newborns effective pain management may improve their clinical and neurodevelopmental outcomes. Neonatal pain is assessed using context-specific, validated, and objective pain methods, despite the limitations of currently available tools. Therapeutic approaches reducing invasive p...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2014.08.010
更新日期：2014-12-01 00:00:00
abstract：:The care of extremely premature infants involves a number of complex clinical and ethical issues. The ethical and scientific quality of decisions made in the care of these infants has profound long-term consequences for these infants and their families. In circumstances when it is unclear whether intensive care should...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/s0095-5108(03)00028-9
更新日期：2003-06-01 00:00:00
abstract：:For more than 100 years, three principles have guided the treatment of neonatal asphyxia: maintain body heat, free air passages of obstructions, and stimulate respiration by supplying air to the lungs for oxygenation of the blood. This article addresses the question of which gas, air or 100% oxygen, is best supplied t...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2005.11.003
更新日期：2006-03-01 00:00:00
abstract：:This article discusses the management of short bowel syndrome during the neonatal period. It includes information regarding etiology and pathophysiology and parenteral and enteral nutrition therapy. Finally, a discussion of the role of intestinal transplantation in the treatment of short bowel syndrome is included. ...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1996-06-01 00:00:00
abstract：:Discussed in this article are the effects of pregnancy-induced hypertension on the renin-angiotensin-aldosterone system; the possible role of prostanoids, deoxycorticosterone, and deoxycorticosterone sulfate in blood pressure control; and the effect of pregnancy-induced hypertension upon the endocrinology of the mater...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1983-10-01 00:00:00
abstract：:Ischemic perinatal stroke (IPS) occurs in 1 of 2300 to 5000 live births. It is an under-recognized cause of significant long-term disabilities, including hemiplegic cerebral palsy, epilepsy, cognitive delays, and behavioral impairments. The pathophysiology is complex and multifactorial, involving maternal, fetal, plac...
journal_title：Clinics in perinatology
pub_type： 杂志文章
doi：10.1016/j.clp.2008.09.008
更新日期：2009-03-01 00:00:00
abstract：:Many aspects of the forward propulsion of enteral nutrients are not fully mature in the preterm and term neonate. Because the regulation of motor activity in the gastrointestinal tract is complex and multifaceted, many levels of regulation of this activity are immature in the preterm infant; however, as neonatologists...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1996-06-01 00:00:00
abstract：:Immunotherapy was a common method of treating infectious diseases in the preantibiotic era. Serotherapy was a popular approach to serious infections and employed hyperimmune globulins harvested from various large animals. Such antisera needed to be administered early in the course of the disease and unfortunately was ...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1991-06-01 00:00:00
abstract：:Diabetic pregnancies involve complex alterations in maternal-placental and fetal compartments. This article discusses the unique features of diabetic pregnancies as they pertain to the maternal changes that must occur to accommodate the fetus. ...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1983-10-01 00:00:00
abstract：:Our current ability to predict neurologic outcome based on intrapartum information is very limited. Adding information on neurologic state during the first days of life adds powerfully to the ability to predict long-term outcome. Further enhancement of predictive abilities will require putting together into single stu...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1989-12-01 00:00:00
abstract：:This article reviews key recent findings in the field of human cortical development. This development is divided into three major time-dependent phases: neural proliferation of inhibitory and excitatory neurons in spatially distinct regions, migration through multiple cellular boundaries, and maturation through morpho...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2009.06.008
更新日期：2009-09-01 00:00:00
abstract：:Congenital lobar emphysema is an uncommon but potentially life-threatening cause of respiratory distress in the newborn. The clinical picture and radiologic findings are diagnostic. Lobectomy in the distressed neonate is curative. In infants with onset of symptoms between one and four months of age surgery may not be ...
journal_title：Clinics in perinatology
pub_type： 杂志文章
doi：
更新日期：1978-03-01 00:00:00
abstract：:Phototherapy is now the preferred method of treatment for neonatal hyperbilirubinemia by virtue of its noninvasive nature and its relative freedom from major complications. It is also convenient, easy to use, and inexpensive in terms of personnel, equipment, and disposals. Long-term experience with phototherapy has de...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1991-09-01 00:00:00
abstract：:The final common pathway to death in all of us is an arrhythmia, yet we still know far too little about the contribution of conduction abnormalities and arrhythmias to the compromised states of the human fetus. At no other time in the human life cycle is the human being at more risk of unexplained and unexpected death...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2007.10.002
更新日期：2007-12-01 00:00:00
abstract：:Because of the high frequency, serious sequelae, and complex and costly management, neonatal jaundice is a good candidate for preventive treatment. In this respect the clinical problem of neonatal jaundice has many similarities with the problem of hemorrhagic disease of the newborn. Both conditions are transient pecul...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1990-06-01 00:00:00
abstract：:It is estimated that 4 million children die each year of vaccine-preventable diseases and another 4 million are permanently disabled. Although vaccination is the most cost-effective health method, there is a discrepancy between our level of knowledge and practices applied. Vaccination of pregnant women provides the mo...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1994-09-01 00:00:00
abstract：:The past 15 years has seen the resurgence of an interest in biomedical ethics and an awareness of the importance of teaching this discipline in medical curricula at varying levels. Physicians and philosophers can work together to achieve an integration of clinical case material and philosophical theory, in order to te...
journal_title：Clinics in perinatology
pub_type： 杂志文章
doi：
更新日期：1987-06-01 00:00:00
abstract：:Current methods of intrapartum surveillance have made little impact on fetal mortality and morbidity while leading to increased caesarean section rates. Near-infrared spectroscopy is a powerful new technique that can continuously measure changes in fetal cerebral oxygenation and hemodynamics during labor. Data are pre...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1997-09-01 00:00:00
abstract：:We have learned from prenatal diagnosis that there is a wide spectrum of clinical severity for fetuses that have a lung mass. Accurate prognostic information is necessary for providing appropriate management and parental counseling. If an associated life-threatening anomaly is present or if the mother is ill with the ...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/s0095-5108(03)00047-2
更新日期：2003-09-01 00:00:00
abstract：:The epitome of FAS and ARBD has been documented substantially in the medical literature. There appears to be little question that alcohol is a teratogen. The precise nature for the mechanism of causing congenital defects, whether it be direct or indirect, is still unknown. There is no unequivocal information that can ...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1991-03-01 00:00:00
abstract：:The nutritional support of gastrointestinal growth and function is an important consideration in the clinical care of neonatal infants. In most health infants, the provision of either breast milk or formula seems to support normal intestinal mucosal growth, but the most significant advantages of breast milk may be for...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/s0095-5108(03)00065-4
更新日期：2002-03-01 00:00:00
abstract：:Severe combined immunodeficiency (SCID) encompasses a group of genetic defects. T cell development is universally affected and has alteration of B and/or NK cells. We present the case of a 5-day-old boy with combined heterozygous frame shift (c.256_257del, p.(Lys86Valfs*33)) and missense (c.1186C>T, p.(Arg396Cys)) var...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2019.09.004
更新日期：2020-03-01 00:00:00
abstract：:Ultrasonography has increasingly become essential in the practice of obstetrics and gynecology. Its antenatal use is well described in the literature and is a continuing subject of study. However, the use of ultrasonography in the labor and delivery suite has not been the subject of many articles. The purpose of this ...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1996-03-01 00:00:00
abstract：:This article examines the role of biologic and environmental factors in determining the long-term outcomes of extremely low-birth weight infants. Research focusing on follow-up to at least 4 years of age is reviewed. Methodologic issues related to sampling, the use of control groups, and diagnostic criteria are also d...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/s0095-5108(05)70031-2
更新日期：2000-06-01 00:00:00
abstract：:There is now clear evidence that dietary supplementation of omega-3 fatty acid is essential for normal eye and brain development. Corn oil-based diets induce omega-3 deficiency in preterm infants, affecting retinal responses to light, cortical visual evoked potentials, and behavioral measures of visual acuity. Preterm...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1995-03-01 00:00:00
abstract：:New knowledge has accumulated in recent years making it prudent to ask questions regarding current oxygenation policies and guidelines. Because new-born resuscitation affects so many individuals, and because resuscitation procedures may have dramatic consequences on infant and child health, intensified discussion and ...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2004.04.021
更新日期：2004-09-01 00:00:00
abstract：:A review of the English literature reveals considerable disagreement regarding the cardiovascular hemodynamics of preeclampsia as measured by both noninvasive and invasive techniques. In the untreated patient, most of the data suggest the presence of low CO, low PCWP, and elevated SVR as compared to normotensive pregn...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1991-12-01 00:00:00
abstract：:The photoplethysmogram (PPG) is a noninvasive circulatory signal related to the pulsatile volume in tissue and is displayed by many pulse oximeters. The PPG is similar in appearance to the invasive arterial waveform, but is noninvasive and ubiquitous in hospitals. There is increasing interest in seeking circulatory in...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2012.06.012
更新日期：2012-09-01 00:00:00
abstract：:The role of infection in the pathogenesis of preterm labor and delivery, and the specific mechanisms through which this association is demonstrated are presented. Cellular and biochemical changes that initiate parturition in the setting of infection are discussed, particularly prostaglandins and cytokines. ...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1995-06-01 00:00:00
abstract：:Familial hypothyroidism results from both thyroidal and extrathyroidal dysfunction. Specific intrathyroidal abnormalities in thyroid hormone synthesis causing goitrous hypothyroidism are iodide trap defect, organification defect, "coupling" defect, iodoprotein defect, and dehalogenase defect. The diagnostic studies fo...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1976-03-01 00:00:00
