Role of mesenchymal stem cell therapy in Crohn's disease.

Abstract:

:Many trials of mesenchymal stem cells (MSCs) have been published in the past 5-6 y. MSCs inhibit T-cell alloreactivity in vitro by soluble factors and direct cell-to-cell contact. They are safe to infuse in humans with no acute toxicity and no ectopic tissue formation. Promising results of MSC infusion for graft-vs.-host disease and fistulizing Crohn's disease (CD) have been published. Treatment of CD requires a comprehensive treatment approach to maintain symptomatic control, improve health-related quality-of-life measures, and minimize complications from the disease. In this review, we will discuss the results of clinical trials using a novel treatment in the form of MSCs for treatment of CD and related complications. Success of these phase I, II, and III trials have set the stage for usage of this novel treatment for children with CD.

journal_name

Pediatr Res

journal_title

Pediatric research

authors

Dalal J,Gandy K,Domen J

doi

10.1038/pr.2011.56

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

445-51

issue

4 Pt 2

eissn

0031-3998

issn

1530-0447

pii

pr201156

journal_volume

71

pub_type

杂志文章,评审
  • Hyperoxia downregulates angiotensin-converting enzyme-2 in human fetal lung fibroblasts.

    abstract:BACKGROUND:Angiotensin (ANG) II is involved in experimental hyperoxia-induced lung fibrosis. Angiotensin-converting enzyme-2 (ACE-2) degrades ANG II and is thus protective, but is downregulated in adult human and experimental lung fibrosis. Hyperoxia is a known cause of chronic fibrotic lung disease in neonates, but th...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2015.27

    authors: Oarhe CI,Dang V,Dang M,Nguyen H,Gopallawa I,Gewolb IH,Uhal BD

    更新日期:2015-05-01 00:00:00

  • A case of transient renal tubular acidosis type 1,4 hybrid RTA: a study of the pathophysiologic characteristics of the acidification defect.

    abstract::The diagnosis of transient renal tubular acidosis was made in a 16 months old boy. Bicarbonate titration studies revealed that the acidification defect consisted of an association of proximal and distal tubular acidosis. The effect of experimentally induced potassium depletion revealed that hyperkalemia contributed to...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-197910000-00020

    authors: Donckerwolcke RA,Valk C,van Wijngaarden-Penterman MJ,van Stekelenburg GJ

    更新日期:1979-10-01 00:00:00

  • The effect of blue light exposure on the expression of circadian genes: bmal1 and cryptochrome 1 in peripheral blood mononuclear cells of jaundiced neonates.

    abstract::The purpose of this study was to investigate the effect of blue light phototherapy on the expression of circadian genes in peripheral blood mononuclear cells (PBMC) and plasma melatonin levels in neonates. Real-time reverse-transcriptase polymerase chain reaction (RT-PCR) was used to determine the expression of Bmal1 ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.pdr.0000183663.98446.05

    authors: Chen A,Du L,Xu Y,Chen L,Wu Y

    更新日期:2005-12-01 00:00:00

  • Role of glucagon-like peptide-2 deficiency in neonatal short-bowel syndrome using neonatal piglets.

    abstract:BACKGROUND:Short-bowel syndrome (SBS) is the most common cause of neonatal intestinal failure. Recovery requires intestinal adaptation, dependent on enteral nutrition (EN) and growth factors such as glucagon-like peptide-2 (GLP-2), which is secreted from L cells in the ileum. Neonatal SBS often results in loss of ileum...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2013.44

    authors: Hua Z,Turner JM,Sigalet DL,Wizzard PR,Nation PN,Mager DR,Ball RO,Pencharz PB,Wales PW

    更新日期:2013-06-01 00:00:00

  • Sleep state organization in premature infants of less than 35 weeks' gestational age.

    abstract::To assess sleep organization in premature infants of < 35 wk gestational age (w GA), we performed polygraphic recordings in 24 neurologically normal neonates (eight per group): artificially ventilated 27-30 and 31-34 w GA infants and nonventilated 31-34 w GA infants. Sleep states were defined by concordance of EEG and...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199311000-00013

    authors: Curzi-Dascalova L,Figueroa JM,Eiselt M,Christova E,Virassamy A,d'Allest AM,Guimarâes H,Gaultier C,Dehan M

    更新日期:1993-11-01 00:00:00

  • Effects of acute hypercapnia on maternal and fetal vasopressin and catecholamine release.

    abstract::Although fetal asphyxia, i.e. hypoxemia, acidosis, and hypercapnia, increases plasma arginine vasopressin (AVP) greater than 40-fold, hypoxemia and metabolic acidosis occurring independently cause only 5-fold and 2-fold increases, respectively. To determine the effects of hypercapnia on AVP release, we examined the ef...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199110000-00014

    authors: Faucher DJ,Laptook AR,Porter JC,Rosenfeld CR

    更新日期:1991-10-01 00:00:00

  • Role of pili in Haemophilus influenzae adherence to, and internalization by, respiratory cells.

    abstract::To determine the role of pili in mediating adherence of type b and nontypeable Haemophilus influenzae to several respiratory cell types, piliated bacteria, nonpiliated phase variants, and nonpiliated mutants possessing insertionally inactivated pilin genes were tested. Both piliated and nonpiliated strains adhered to ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199602000-00025

    authors: Gilsdorf JR,Tucci M,Marrs CF

    更新日期:1996-02-01 00:00:00

  • Neurobiology of hypoxic-ischemic injury in the developing brain.

    abstract::Hypoxic ischemia is a common cause of damage to the fetal and neonatal brain. Although systemic and cerebrovascular physiologic factors play an important role in the initial phases of hypoxic-ischemic injuries, the intrinsic vulnerability of specific cell types and systems in the developing brain may be more important...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审

    doi:10.1203/00006450-200106000-00003

    authors: Johnston MV,Trescher WH,Ishida A,Nakajima W

    更新日期:2001-06-01 00:00:00

  • Response of bifidobacterium species to growth promoters in human and cow milk.

    abstract::We used an in vitro assay to study and compare the growth-promotional activity of protein and nonprotein components in human milk (HM) and cow milk (CM) samples for infant strains of Bifidobacterium species. HM samples varied considerably in growth-promotion activity for Bifidobacterium bifidum var pennsylvanicus, Bif...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199102000-00021

    authors: Petschow BW,Talbott RD

    更新日期:1991-02-01 00:00:00

  • Caffeine administration modulates TGF-β signaling but does not attenuate blunted alveolarization in a hyperoxia-based mouse model of bronchopulmonary dysplasia.

    abstract:BACKGROUND:Caffeine is widely used to manage apnea of prematurity, and reduces the incidence of bronchopulmonary dysplasia (BPD). Deregulated transforming growth factor (TGF)-β signaling underlies arrested postnatal lung maturation in BPD. It is unclear whether caffeine impacts TGF-β signaling or postnatal lung develop...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2017.21

    authors: Rath P,Nardiello C,Surate Solaligue DE,Agius R,Mižíková I,Hühn S,Mayer K,Vadász I,Herold S,Runkel F,Seeger W,Morty RE

    更新日期:2017-05-01 00:00:00

  • Objective assessment of levels and patterns of physical activity in preschool children.

    abstract:BACKGROUND:The aim of this study was to examine in detail levels and patterns of physical activity in preschool children and the effects of gender and BMI on this activity. METHODS:Two hundred and fifty-three children aged 5 y participating in the Copenhagen Prospective Studies on Asthma in Childhood wore an accelerom...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2013.99

    authors: Brasholt M,Chawes B,Kreiner-Møller E,Vahlkvist S,Sinding M,Bisgaard H

    更新日期:2013-09-01 00:00:00

  • Human milk immunomodulatory proteins are related to development of infant body composition during the first year of lactation.

    abstract:BACKGROUND:To investigate relationships between infant body composition (BC) and human milk (HM) immunomodulatory proteins (IMPs) during the first 12 months of lactation. METHODS:BC of breastfeeding dyads (n = 20) was measured with ultrasound skinfolds (infants) and bioimpedance spectroscopy (infants/mothers) at 2, 5,...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-020-0961-z

    authors: Gridneva Z,Lai CT,Rea A,Tie WJ,Ward LC,Murray K,Hartmann PE,Geddes DT

    更新日期:2020-05-21 00:00:00

  • Histidine decarboxylase activity in fetal intrauterine growth-retarded rats.

    abstract::Fetal intrauterine growth retardation was induced in nine rats at 17 days' gestation by ligating the blood supply to one of the uterine horn. The 27 festuses from the uterine vessel ligated side were the intrauterine growth retarded fetuses (IUGR) and the 37 fetuses from the nonligated side were controls. The mean wei...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-197608000-00008

    authors: Kwong MS,Moore TC,Lemmi CA,Oh W,Thibeault DW

    更新日期:1976-08-01 00:00:00

  • Effects of ascorbic acid in alkaptonuria: alterations in benzoquinone acetic acid and an ontogenic effect in infancy.

    abstract::The effects of ascorbic acid on the excretion of homogentisic acid and its derivative benzoquinone acetic acid were studied in two adults and three infants. The administration of relatively large amounts of ascorbic acid to the adults was followed by a disappearance of benzoquinone acetic acid from the urine, whereas ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198908000-00015

    authors: Wolff JA,Barshop B,Nyhan WL,Leslie J,Seegmiller JE,Gruber H,Garst M,Winter S,Michals K,Matalon R

    更新日期:1989-08-01 00:00:00

  • Endogenous surfactant metabolism in newborn infants with and without respiratory failure.

    abstract::Studies using stable isotopically labeled glucose and palmitate as precursors of pulmonary surfactant synthesis have demonstrated slow surfactant turnover in premature infants with respiratory distress syndrome (RDS). However, only limited data about surfactant turnover are available for term infants. Because acetate ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/01.PDR.0000075084.56255.E0

    authors: Bohlin K,Merchak A,Spence K,Patterson BW,Hamvas A

    更新日期:2003-08-01 00:00:00

  • Fetal lung development in the diabetic pregnancy.

    abstract::It seems quite likely that the normal process of fetal lung biochemical maturation is delayed by maternal diabetes and that abnormalities in the pulmonary surfactant system are involved. The appearance of PG in amniotic fluid and possibly in fetal lung is impaired or at least delayed. The same is possibly true for DSP...

    journal_title:Pediatric research

    pub_type: 杂志文章,评审

    doi:10.1203/00006450-198503000-00001

    authors: Bourbon JR,Farrell PM

    更新日期:1985-03-01 00:00:00

  • Absorption of calcium, zinc, and iron from breast milk by five- to seven-month-old infants.

    abstract::Data are scarce regarding mineral bioavailability from human milk in older infants who may also be receiving solid foods (beikost). We measured the absorption of Ca, Zn, and Fe in 14 healthy, nonanemic 5-7-mo-old breast-fed infants whose mothers milk was extrinsically labeled with stable isotopes (44Ca, 70Zn, and 58Fe...

    journal_title:Pediatric research

    pub_type: 临床试验,杂志文章

    doi:10.1203/00006450-199703000-00014

    authors: Abrams SA,Wen J,Stuff JE

    更新日期:1997-03-01 00:00:00

  • Evaluation of insulin sensitivity in obese offspring of diabetic rats by hyperinsulinemic-euglycemic clamp technique.

    abstract::Young adult macrosomic offspring of streptozotocin-induced mildly hyperglycemic rats exhibit accelerated growth through the first 10 wk of age. At 10 wk, oral glucose loading resulted in elevated plasma insulin and glucose concentrations compared to controls. To assess the mechanism of the abnormal glucose tolerance i...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199107000-00008

    authors: Gelardi NL,Cha CJ,Oh W

    更新日期:1991-07-01 00:00:00

  • Surfactant protein A-producing cells in human fetal lung are good targets for recombinant adenovirus-mediated gene transfer.

    abstract::Local delivery of Escherichia coli beta-galactosidase gene (beta-gal) to surfactant protein-A (SP-A)-producing cells by a replication-defective recombinant adenovirus (AdCMV.beta-gal) was tested in human 8-12-wk-old fetal lung explants cultured in Waymouth's medium. In contrast to uninfected explants, direct addition ...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199607000-00024

    authors: Messina E,Muhlhauser J,Giuliano M,Pandolfi A,Morgese G,Procopio A

    更新日期:1996-07-01 00:00:00

  • Sensitization to cow's milk proteins during refeeding of guinea pigs recovering from polydeficient malnutrition.

    abstract::We have previously shown that milk sensitization aggravates intestinal dysfunction in the malnourished guinea pigs, suggesting that it may also impair the recovery from malnutrition. To test this hypothesis, the growing guinea pigs were malnourished by feeding only maize for 7 d and then were refed for 21 d with a bal...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199812000-00018

    authors: Darmon N,Abdoul E,Roucayrol AM,Blaton MA,Briend A,Desjeux JF,Heyman M

    更新日期:1998-12-01 00:00:00

  • Proportional assist ventilation decreases thoracoabdominal asynchrony and chest wall distortion in preterm infants.

    abstract::Thoracoabdominal asynchrony (TAA) and chest wall distortion (CWD) are commonly seen in preterm infants secondary to a highly compliant rib cage and poor compensation of distorting forces by inspiratory rib cage muscles. Continuous positive airway pressure (CPAP) reduces TAA and CWD by stenting the chest wall. We hypot...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-200102000-00008

    authors: Musante G,Schulze A,Gerhardt T,Everett R,Claure N,Schaller P,Bancalari E

    更新日期:2001-02-01 00:00:00

  • Application of high-resolution array comparative genomic hybridization in children with unknown syndromic microcephaly.

    abstract::BackroundMicrocephaly can either be isolated or it may coexist with other neurological entities and/or multiple congenital anomalies, known as syndromic microcephaly. Although many syndromic cases can be classified based on the characteristic phenotype, some others remain uncertain and require further investigation. T...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2017.65

    authors: Tsoutsou E,Tzetis M,Giannikou K,Braoudaki M,Mitrakos A,Amenta S,Selenti N,Kanavakis E,Zafeiriou D,Kitsiou-Tzeli S,Fryssira H

    更新日期:2017-08-01 00:00:00

  • Response to calcium of skinned gallbladder smooth muscle from newborn and adult guinea pigs.

    abstract::Guinea pig gallbladder smooth muscle contractility undergoes a period of postnatal maturation. Because tissues from adult animals contract more forcefully than tissues from newborn animals when stimulated with agonists that activate the contractile process through different mechanisms (receptor activation, membrane de...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199010000-00007

    authors: Lambert R,Ryan JP

    更新日期:1990-10-01 00:00:00

  • Surface cooling rapidly induces coordinated activity in the upper and lower airway muscles of the fetal lamb in utero.

    abstract::Stimulation of cutaneous thermoreceptors may be an important factor in the initiation of continuous breathing at birth. Maintenance of a patent airway is also important in the continuation of effective ventilation after birth, but whereas in the adult the principal pharyngeal dilator is the genioglossus muscle, in the...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198803000-00005

    authors: Johnston BM,Gunn TR,Gluckman PD

    更新日期:1988-03-01 00:00:00

  • Infant body composition relationship to maternal adipokines and fat mass: the PONCH study.

    abstract:BACKGROUND:Infant adiposity is linked to both high maternal fat mass (FM) and excessive gestational FM gain, whereas the association with maternal adipokines is less clear. The aim was to determine how levels of maternal leptin, the soluble leptin receptor (sOB-R), adiponectin, and FM during pregnancy were linked to in...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/s41390-020-01115-9

    authors: Andersson-Hall UK,Pivodic A,de Maré HK,Pernilla Svedin J,Carina Mallard E,Albertsson-Wikland KG,Holmäng AB

    更新日期:2020-09-14 00:00:00

  • Effect of pH and CO2 on in vitro susceptibility of Pseudomonas cepacia to beta-lactams.

    abstract::Inhibition of Pseudomonas cepacia (but not Pseudomonas aeruginosa) by beta-lactams was decreased in 5% CO2 in air compared with air alone. The effect of CO2 and pH (range, 6.0 to 8.0) on beta-lactam susceptibility, beta-lactamase expression, and outer membrane proteins was studied in isolates recovered from the sputum...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199403000-00003

    authors: Corkill JE,Deveney J,Pratt J,Shears P,Smyth A,Heaf D,Hart CA

    更新日期:1994-03-01 00:00:00

  • Physical properties of bedding that may increase risk of sudden infant death syndrome in prone-sleeping infants.

    abstract::Soft bedding has been shown in epidemiologic studies to increase the risk for sudden, unexpected death in prone-sleeping infants. We compared the physical properties of conventional bedding to bedding from two sources: 1) bedding that covered the airways of victims of sudden infant death syndrome (SIDS) lying prone an...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-199407001-00002

    authors: Kemp JS,Nelson VE,Thach BT

    更新日期:1994-07-01 00:00:00

  • Growth hormone stimulation testing in both short and normal statured children: use of an immunofunctional assay.

    abstract::Accurate interpretation of the results of GH stimulation tests is of pivotal importance not only in the evaluation of the etiology of growth retardation in children but also in the selection of the best candidates for GH therapy. We performed this study to test a novel immunofunctional GH ( IFGH) assay that makes use ...

    journal_title:Pediatric research

    pub_type: 评论,杂志文章

    doi:10.1203/00006450-200011000-00010

    authors: Mauras N,Walton P,Nicar M,Welch S,Rogol AD

    更新日期:2000-11-01 00:00:00

  • Humoral and cell-mediated immunity in growth hormone-deficient children: effect of therapy with human growth hormone.

    abstract::To delineate the role of growth hormone (GH) in the development and function of the immune system, immunological parameters including quantitative immunoglobulins, T and B lymphocytes, phytohemagglutinin lymphoproliferative response and delayed hypersensitivity skin tests were studied in nine GH-deficient children pri...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1203/00006450-198503000-00009

    authors: Abbassi V,Bellanti JA

    更新日期:1985-03-01 00:00:00

  • VEGF mRNA and protein concentrations in the developing human eye.

    abstract:BACKGROUND:Vascular endothelial growth factor (VEGF), a well-characterized regulator of angiogenesis, has been mechanistically implicated in retinal neovascularization and in the pathogenesis of retinopathy of prematurity. However, the ontogeny of VEGF expression in the human fetal retina is not well known. Because ret...

    journal_title:Pediatric research

    pub_type: 杂志文章

    doi:10.1038/pr.2015.15

    authors: Ma IT,McConaghy S,Namachivayam K,Halloran BA,Kurundkar AR,MohanKumar K,Maheshwari A,Ohls RK

    更新日期:2015-04-01 00:00:00