当前位置： SCI文献检索 > APPLIED MICROBIOLOGY AND BIOTECHNOLOGY期刊下所有文献 > Efficient production of polymalic acid from xylose mother liquor, an environmental waste from the xylitol industry, by a T-DNA-based mutant of Aureobasidium pullulans.

Efficient production of polymalic acid from xylose mother liquor, an environmental waste from the xylitol industry, by a T-DNA-based mutant of Aureobasidium pullulans.

Abstract：

:Polymalic acid (PMA) is a biodegradable polymer produced by the polyextremotolerant fungi Aureobasidium pullulans and has been shown to have potential applications in environmental fields. In this work, a high PMA yield mutant FJ-D2 was screened from T-DNA-based mutant libraries and showed a 12.9% increase in PMA titers, which was attributed to decreased the expression of a glycosyltransferase gene (celA), resulting in a 39.5% reduction in cellulose biosynthesis. Untreated waste xylose mother liquor (WXML), an environmental waste generated from the xylitol industry, can be directly used as an economical substrate for PMA production. Using batch-fermentation of FJ-D2, the PMA titer of 57.1 ± 0.02 g/L was produced in a 5-L fermentor, with the highest MA yield of 0.77 g/g mixed sugar. Furthermore, compared with ethylenediaminetetraacetic acid (EDTA), PMA had a comparable cadmium (Cd) removal efficiency (88.7% for EDTA versus 86.0% for PMA), which was not found in the monomer of L-malic acid (MA) monomers. These findings indicated that PMA was an environmentally friendly and biodegradable chelator for soil remediation. Moreover, our results provided an economically competitive process for PMA production from renewable environmental wastes.

journal_name

Appl Microbiol Biotechnol

journal_title

Applied microbiology and biotechnology

authors

Feng J,Li T,Zhang X,Chen J,Zhao T,Zou X

doi

10.1007/s00253-019-09974-x

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

6519-6527

issue

16

eissn

0175-7598

issn

1432-0614

pii

10.1007/s00253-019-09974-x

journal_volume

103

pub_type

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