Cortical signatures of cognition and their relationship to Alzheimer's disease.

Abstract:

:Recent changes in diagnostic criteria for Alzheimer's disease (AD) state that biomarkers can enhance certainty in a diagnosis of AD. In the present study, we combined cognitive function and brain morphology, a potential imaging biomarker, to predict conversion from mild cognitive impairment to AD. We identified four biomarkers, or cortical signatures of cognition (CSC), from regressions of cortical thickness on neuropsychological factors representing memory, executive function/processing speed, language, and visuospatial function among participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Neuropsychological factor scores were created from a previously validated multidimensional factor structure of the neuropsychological battery in ADNI. Mean thickness of each CSC at the baseline study visit was used to evaluate risk of conversion to clinical AD among participants with mild cognitive impairment (MCI) and rate of decline on the Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) score. Of 307 MCI participants, 119 converted to AD. For all domain-specific CSC, a one standard deviation thinner cortical thickness was associated with an approximately 50% higher hazard of conversion and an increase of approximately 0.30 points annually on the CDR-SB. In combined models with a domain-specific CSC and neuropsychological factor score, both CSC and factor scores predicted conversion to AD and increasing clinical severity. The present study indicated that factor scores and CSCs for memory and language both significantly predicted risk of conversion to AD and accelerated deterioration in dementia severity. We conclude that predictive models are best when they utilize both neuropsychological measures and imaging biomarkers.

journal_name

Brain Imaging Behav

authors

Gross AL,Manly JJ,Pa J,Johnson JK,Park LQ,Mitchell MB,Melrose RJ,Inouye SK,McLaren DG,Alzheimer’s Disease Neuroimaging Initiative.

doi

10.1007/s11682-012-9180-5

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

584-98

issue

4

eissn

1931-7557

issn

1931-7565

journal_volume

6

pub_type

杂志文章
  • Altered regional homogeneity in pediatric bipolar disorder during manic and euthymic state: a resting-state fMRI study.

    abstract::Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission. Little is known about the abnormalities in PBD in resting state, especially comparing manic with euthymic state. Resting state brain activity measured by fM...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00117-4

    authors: Xiao Q,Cui D,Jiao Q,Zhong Y,Cao W,Lu G,Su L

    更新日期:2019-12-01 00:00:00

  • Parieto-frontal gyrification and working memory in healthy adults.

    abstract::Gyrification of the cortical mantle is a dynamic process that increases with cortical surface area and decreases with age. Increased gyrification is associated with higher scores on cognitive tasks in adults; however, the degree to which this relationship is independent of cortical surface area remains undefined. This...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-017-9696-9

    authors: Green S,Blackmon K,Thesen T,DuBois J,Wang X,Halgren E,Devinsky O

    更新日期:2018-04-01 00:00:00

  • Altered gray matter volume in primary insomnia patients: a DARTEL-VBM study.

    abstract::Previous neuroimaging studies have reported brain morphological alterations and the occurrence of mental disorders in primary insomnia (PI) patients. However, studies of the effect of disrupted sleep on brain structure have showed inconsistent results. In this study, DARTEL-VBM was used to evaluate the changes in gray...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9844-x

    authors: Li M,Yan J,Li S,Wang T,Wen H,Yin Y,Fu S,Zeng L,Tian J,Jiang G

    更新日期:2018-12-01 00:00:00

  • What can we learn from fMRI capture of visual hallucinations in Parkinson's disease?

    abstract::With disease progression, patients with Parkinson's disease (PD) may have chronic visual hallucinations (VH). The mechanisms behind this invalidating non-motor symptom remain largely unknown, namely because it is extremely difficult to capture hallucination events. This study aimed to describe the patterns of brain fu...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00185-6

    authors: Dujardin K,Roman D,Baille G,Pins D,Lefebvre S,Delmaire C,Defebvre L,Jardri R

    更新日期:2020-04-01 00:00:00

  • A preliminary study of the effects of working memory training on brain function.

    abstract::Working memory (WM) training improves WM ability in Attention-Deficit/Hyperactivity Disorder (ADHD), but its efficacy for non-cognitive ADHD impairments ADHD has been sharply debated. The purpose of this preliminary study was to characterize WM training-related changes in ADHD brain function and see if they were linke...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9416-2

    authors: Stevens MC,Gaynor A,Bessette KL,Pearlson GD

    更新日期:2016-06-01 00:00:00

  • Gut dysbiosis-influence on amygdala-based functional activity in patients with end stage renal disease: a preliminary study.

    abstract::Patients with end-stage renal disease (ESRD) are notably accompanied by cognitive disorder and anxiety or depressive symptom. We aimed to explore the linkages of the amygdala-based MR parameters, cognitive and mood performance, systematic inflammation and gut microbiota in ESRD. This prospective study enrolled 28 ESRD...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00223-3

    authors: Zheng LJ,Lin L,Zhong J,Zhang Z,Ye YB,Zhang XY,Wang YF,Zhang H,Liu Y,Lu GM,Gong D,Zhang LJ

    更新日期:2020-12-01 00:00:00

  • Relationship of negative urgency to cingulo-insular and cortico-striatal resting state functional connectivity in tobacco use.

    abstract::Negative urgency, defined as a tendency to act rashly under extreme negative emotion, is strongly associated with tobacco use. Despite the robust evidence linking negative urgency and tobacco use and accumulating evidence suggesting that localized, segregated brain regions such as the nucleus accumbens (NAcc), insula,...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00136-1

    authors: Um M,Hummer TA,Cyders MA

    更新日期:2020-10-01 00:00:00

  • Association cortex hypoperfusion in mild dementia with Lewy bodies: a potential indicator of cholinergic dysfunction?

    abstract::Dementia with Lewy bodies (DLB) is often associated with occipital hypometabolism or hypoperfusion, as well as deficits in cholinergic neurotransmission. In this study, 11 mild DLB, 16 mild AD and 16 age-matched controls underwent arterial spin-labeled perfusion MRI (ASL-pMRI) and neuropsychological testing. Patterns ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-010-9108-x

    authors: Fong TG,Inouye SK,Dai W,Press DZ,Alsop DC

    更新日期:2011-03-01 00:00:00

  • Assessment of the feasibility of a rehabilitation intervention program for breast cancer survivors with cognitive complaints.

    abstract::To assess the feasibility of a cognitive rehabilitation program in breast cancer survivors (BCS) with persistent post-treatment cognitive complaints. BCS with cognitive complaints, 18-months to 5-years post-treatment, were recruited for a once-weekly, five-week, group cognitive training intervention. Outcome measures ...

    journal_title:Brain imaging and behavior

    pub_type: 临床试验,杂志文章

    doi:10.1007/s11682-013-9237-0

    authors: Ercoli LM,Castellon SA,Hunter AM,Kwan L,Kahn-Mills BA,Cernin PA,Leuchter AF,Ganz PA

    更新日期:2013-12-01 00:00:00

  • Correction to: Age associated decline in the arcuate fasciculus and IQ.

    abstract::The author found a mistake in their published article. The sentence "The search region was limited within each side of the white matter." should read as "The search regions was limited within each side of the white matter at and above Z=0." ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s11682-019-00173-w

    authors: Ikuta T,Gollnick HM,Rutledge AN

    更新日期:2020-04-01 00:00:00

  • The relationship between microvasculature in white matter hyperintensities and cognitive function.

    abstract::White matter hyperintensities (WMHs) are associated with cognitive decline, but less is known about pathophysiology of cognitive decline in patients with WMHs. We investigated microvasculature and microstructure in WMHs using intravoxel incoherent motion (IVIM) and their associations with cognitive function. Thirty-tw...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9531-8

    authors: Sun J,Yu X,Jiaerken Y,Song R,Huang P,Wang C,Yuan L,Mao Y,Guo Y,Yu H,Zhang M

    更新日期:2017-04-01 00:00:00

  • Alcoholism and sexual dimorphism in the middle longitudinal fascicle: a pilot study.

    abstract::Alcoholism can lead to a complex mixture of cognitive and emotional deficits associated with abnormalities in fronto-cortico-striatal-limbic brain circuitries. Given the broad variety of neurobehavioral symptoms, one would also expect alterations of postrolandic neocortical systems. Thus, we used diffusion tensor imag...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9579-5

    authors: Seitz J,Sawyer KS,Papadimitriou G,Oscar-Berman M,Ng I,Kubicki A,Mouradian P,Ruiz SM,Kubicki M,Harris GJ,Makris N

    更新日期:2017-08-01 00:00:00

  • Positron emission tomography assessment of cerebral glucose metabolic rates in autism spectrum disorder and schizophrenia.

    abstract::Several models have been proposed to account for observed overlaps in clinical features and genetic predisposition between schizophrenia and autism spectrum disorder. This study assessed similarities and differences in topological patterns and vectors of glucose metabolism in both disorders in reference to these model...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-017-9721-z

    authors: Mitelman SA,Bralet MC,Mehmet Haznedar M,Hollander E,Shihabuddin L,Hazlett EA,Buchsbaum MS

    更新日期:2018-04-01 00:00:00

  • Common and distinct global functional connectivity density alterations in patients with bipolar disorder with and without auditory verbal hallucination during major depressive episodes.

    abstract::Although an increasing number of studies has explored the neural mechanisms of auditory verbal hallucination (AVH) using many modalities, including neuroimaging, neurotransmitters, and electroencephalography, the etiology of AVH remains unclear. In this study, we investigated the neuroimaging characteristics of AVH in...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00222-4

    authors: Qiu L,Ye J,Ji F,Li G,Li G,Ma X,Li R,Tian H,Wang L,Chen G,Xu Y,Wang W,Jiang D,Pan J,Zhuo C

    更新日期:2020-12-01 00:00:00

  • Gray & white matter tissue contrast differentiates Mild Cognitive Impairment converters from non-converters.

    abstract::The clinical relevance of gray/white matter contrast ratio (GWR) in mild cognitive impairment (MCI) remains unknown. This study examined baseline GWR and 3-year follow-up diagnostic status in MCI. Alzheimer's Disease Neuroimaging Initiative MCI participants with baseline 1.5 T MRI and 3-year follow-up clinical data we...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-014-9291-2

    authors: Jefferson AL,Gifford KA,Damon S,Chapman GW 4th,Liu D,Sparling J,Dobromyslin V,Salat D,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期:2015-06-01 00:00:00

  • Intrinsic network connectivity and own body perception in gender dysphoria.

    abstract::Gender dysphoria (GD) is characterized by incongruence between one's identity and gender assigned at birth. The biological mechanisms of GD are unclear. We investigated brain network connectivity patterns involved in own body perception in the context of self in GD. Twenty-seven female-to-male (FtM) individuals with G...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9578-6

    authors: Feusner JD,Lidström A,Moody TD,Dhejne C,Bookheimer SY,Savic I

    更新日期:2017-08-01 00:00:00

  • Fusion analysis of functional MRI data for classification of individuals based on patterns of activation.

    abstract::Classification of individuals based on patterns of brain activity observed in functional MRI contrasts may be helpful for diagnosis of neurological disorders. Prior work for classification based on these patterns have primarily focused on using a single contrast, which does not take advantage of complementary informat...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-014-9292-1

    authors: Ramezani M,Abolmaesumi P,Marble K,Trang H,Johnsrude I

    更新日期:2015-06-01 00:00:00

  • The short-term effect of liver transplantation on the low-frequency fluctuation of brain activity in cirrhotic patients with and without overt hepatic encephalopathy.

    abstract::Previous neuropsychological studies have demonstrated that liver transplantation (LT) is an effective method for improving the cognitive function of cirrhotic patients. However, the neural basis underlying the effects of LT is still unclear. Neuroimaging studies investigating changes in brain structures or functional ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9659-6

    authors: Zhang G,Cheng Y,Shen W,Liu B,Huang L,Xie S

    更新日期:2017-12-01 00:00:00

  • Acute social stress modulates coherence regional homogeneity.

    abstract::It is a generally accepted observation that individuals act differently under stress. Recent task-based neuroimaging studies have shown that individuals under stress favor the intuitive and fast system over the deliberative and reflective system. In the present study, using a within-subjects design in thirty young adu...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9898-9

    authors: Chang J,Yu R

    更新日期:2019-06-01 00:00:00

  • Headache frequency associates with brain microstructure changes in patients with migraine without aura.

    abstract::Neuroimaging studies have implicated abnormal brain microstructure in episodic migraine (EM), but whether the pattern is altered during migraine chronification is not well known. Fifty-six patients with migraine without aura, including 39 EM patients and 17 chronic migraine (CM) patients, and 35 healthy controls (HCs)...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00232-2

    authors: Yu Y,Zhao H,Dai L,Su Y,Wang X,Chen C,Shang Y,Ke J,Hu C

    更新日期:2021-02-01 00:00:00

  • KIBRA polymorphism modulates gray matter volume to influence cognitive ability in the elderly.

    abstract::Genetic variation in the kidney and brain expressed protein (KIBRA) rs17070145 gene has been linked to episodic memory and cognitive aging; yet, the neural mechanism underlying this association remains to be fully understood. Using the magnetic resonance imaging (MRI) technique, this study investigated the effect of K...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00047-1

    authors: Li R,Wan W,Li J

    更新日期:2020-10-01 00:00:00

  • Structural and functional neural correlates of self-reported attachment in healthy adults: evidence for an amygdalar involvement.

    abstract::The concept of attachment in long-term interpersonal relationships has been linked to relationship outcome and social-emotional health. To date, no relationship between the structural properties of the human amygdala and attachment in romantic relationships (measured through self-reported attachment related anxiety an...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9446-9

    authors: Rigon A,Duff MC,Voss MW

    更新日期:2016-12-01 00:00:00

  • Meta-analysis of the moral brain: patterns of neural engagement assessed using multilevel kernel density analysis.

    abstract::The neuroimaging literature in moral cognition has rapidly developed in the last decade with more than 200 publications on the topic. Neuroimaging based models generally agree that limbic regions work with medial prefrontal and temporal regions during moral processing to integrate emotional, social, and cognitive elem...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章,meta分析

    doi:10.1007/s11682-019-00035-5

    authors: Fede SJ,Kiehl KA

    更新日期:2020-04-01 00:00:00

  • The relationship between dorsal stream connections to the caudate and verbal fluency in Parkinson disease.

    abstract::Performance in verbal fluency tasks are widely used as a marker of cognitive impairment in Parkinson disease. However, the anatomical substrate of its impairment remains undetermined. Based on the dual-stream language model, we hypothesized cortical input to the subcortical circuitry would be a crucial determinant of ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-020-00407-2

    authors: Rodriguez-Porcel F,Wilmskoetter J,Cooper C,Taylor JA,Fridriksson J,Hickok G,Bonilha L

    更新日期:2020-10-12 00:00:00

  • Diffusion tensor imaging and magnetic resonance spectroscopy in traumatic brain injury: a review of recent literature.

    abstract::Concussion is the most common form of traumatic brain injury (TBI), but diagnosis remains controversial because the brain appears quite normal in conventional computed tomography and magnetic resonance imaging (MRI). These conventional tools are not sensitive enough to detect diffuse traumatic axonal injury, and canno...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章,评审

    doi:10.1007/s11682-013-9288-2

    authors: Xiong KL,Zhu YS,Zhang WG

    更新日期:2014-12-01 00:00:00

  • Cognitive fatigue is associated with reduced anterior internal capsule integrity in veterans with history of mild to moderate traumatic brain injury.

    abstract::No known studies have directly examined white matter microstructural correlates of cognitive fatigue post-TBI in a Veteran sample. We therefore investigated the relationship between cognitive fatigue and white matter integrity in Veterans with history of mild to moderate TBI (mmTBI). 59 Veterans (TBI = 34, Veteran Con...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9594-6

    authors: Clark AL,Delano-Wood L,Sorg SF,Werhane ML,Hanson KL,Schiehser DM

    更新日期:2017-10-01 00:00:00

  • Diffusion MRI as a complementary assessment to cognition, emotion, and motor dysfunction after sports-related concussion: a systematic review and critical appraisal of the literature.

    abstract::Sports-related concussion (SRC) is a complex and heterogeneous injury with psychological, cognitive and functional consequences. Advances in diffusion magnetic resonance imaging (dMRI) allow sensitive measurement of white matter pathology post-SRC and may provide insight into injury and recovery. We systematically rev...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章,评审

    doi:10.1007/s11682-020-00336-0

    authors: Hellewell SC,Welton T,Pearce AJ,Maller JJ,Grieve SM

    更新日期:2020-07-27 00:00:00

  • Schizophrenia-related abnormalities in the triple network: a meta-analysis of working memory studies.

    abstract::Previous meta-analyses found abnormal brain activations in schizophrenia patients compared with normal controls when performing working memory tasks. Although most studies focused on dysfunction of the working memory activation network in schizophrenia patients, deactivation abnormalities of the working memory in the ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00071-1

    authors: Wu D,Jiang T

    更新日期:2020-08-01 00:00:00

  • Association Study between Auditory P3a/P3b Event-Related Potentials and Thought Disorder in Schizophrenia.

    abstract::Thought disorder is considered as one of the core features of schizophrenia and several research groups previously reported an association between P300 (P3b) amplitude and thought disorder in schizophrenia. However, previous studies have not evaluated two P300 subcomponents (P3a and P3b) to investigate whether the rel...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-009-9069-0

    authors: Kirihara K,Araki T,Uetsuki M,Yamasue H,Hata A,Rogers MA,Iwanami A,Kasai K

    更新日期:2009-09-01 00:00:00

  • A multivariate pattern analysis of resting-state functional MRI data in Naïve and chronic betel quid chewers.

    abstract::Betel quid (BQ) is the fourth most commonly consumed psychoactive substance in the world. However, comprehensive functional magnetic resonance imaging (fMRI) studies exploring the neurophysiological mechanism of BQ addiction are lacking. Betel-quid-dependent (BQD) individuals (n = 24) and age-matched healthy controls ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-020-00322-6

    authors: Linli Z,Huang X,Liu Z,Guo S,Sariah A

    更新日期:2020-07-25 00:00:00