Abstract:
:Betel quid (BQ) is the fourth most commonly consumed psychoactive substance in the world. However, comprehensive functional magnetic resonance imaging (fMRI) studies exploring the neurophysiological mechanism of BQ addiction are lacking. Betel-quid-dependent (BQD) individuals (n = 24) and age-matched healthy controls (HC) (n = 26) underwent fMRI before and after chewing BQ. Multivariate pattern analysis (MVPA) was used to explore the acute effects of BQ-chewing in both groups. A cross-sectional comparison was conducted to explore the chronic effects of BQ-chewing. Regression analysis was used to investigate the relationship between altered circuits of BQD individuals and the severity of BQ addiction. MVPA achieved classification accuracies of up to 90% in both groups for acute BQ-chewing. Suppression of the default-mode network was the most prominent feature. BQD showed more extensive and intensive within- and between-network dysconnectivity of the default, frontal-parietal, and occipital regions associated with high-order brain functions such as self-awareness, inhibitory control, and decision-making. In contrast, the chronic effects of BQ on the brain function were mild, but impaired circuits were predominately located in the default and frontal-parietal networks which might be associated with compulsive drug use. Simultaneously quantifying the effects of both chronic and acute BQ exposure provides a possible neuroimaging-based BQ addiction foci. Results from this study may help us understand the neural mechanisms involved in BQ-chewing and BQ dependence.
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Linli Z,Huang X,Liu Z,Guo S,Sariah Adoi
10.1007/s11682-020-00322-6subject
Has Abstractpub_date
2020-07-25 00:00:00eissn
1931-7557issn
1931-7565pii
10.1007/s11682-020-00322-6pub_type
杂志文章abstract::Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS) in the long-term. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we condu...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9638-y
更新日期:2017-10-01 00:00:00
abstract::Working memory (WM) training improves WM ability in Attention-Deficit/Hyperactivity Disorder (ADHD), but its efficacy for non-cognitive ADHD impairments ADHD has been sharply debated. The purpose of this preliminary study was to characterize WM training-related changes in ADHD brain function and see if they were linke...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-015-9416-2
更新日期:2016-06-01 00:00:00
abstract::The ability to suppress responses that are inappropriate, as well as the mechanisms monitoring the accuracy of actions in order to compensate for errors, is central to human behavior. Neural alterations that prevent stopping an inaccurate response, combined with a decreased ability of error monitoring, are considered ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9654-y
更新日期:2017-12-01 00:00:00
abstract::The association between gray matter (GM) density and neurophysiologic changes is still unclear in amyotrophic lateral sclerosis (ALS). We evaluated the relationship between GM density and motor system integrity combining voxel-based morphometry (VBM) and transcranial magnetic stimulation (TMS) in ALS. We included 17 A...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9841-0
更新日期:2018-12-01 00:00:00
abstract::Autism spectrum disorder (ASD) is a neurodevelopmental disorder with prominent impairments in sociocommunicative abilities, which have been linked to anomalous brain network organization. Despite ample evidence of atypical long-distance connectivity, the literature on local connectivity remains small and divergent. We...
journal_title:Brain imaging and behavior
pub_type: 杂志文章,多中心研究
doi:10.1007/s11682-017-9678-y
更新日期:2018-02-01 00:00:00
abstract::Neuroticism and extraversion are proposed personality dimensions for individual emotion processing. Neuroticism is correlated with depression and anxiety disorders, implicating a common neurobiological basis. Extraversion is rather inversely correlated with anxiety and depression. We examined neural correlates of pers...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-011-9114-7
更新日期:2011-06-01 00:00:00
abstract::Nicotine addiction is characterized as a neural circuit dysfunction, particularly with regard to the alterations in central reward pathways. The insula, a cortical region that is thought to play a central role in this reward circuitry, has been implicated in the maintenance of nicotine addiction. However, it remains l...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-020-00389-1
更新日期:2020-09-24 00:00:00
abstract::In conventional resting-state functional MRI (R-fMRI) analysis, functional connectivity is assumed to be temporally stationary, overlooking neural activities or interactions that may happen within the scan duration. Dynamic changes of neural interactions can be reflected by variations of topology and correlation stren...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-015-9408-2
更新日期:2016-06-01 00:00:00
abstract::Gyrification of the cortical mantle is a dynamic process that increases with cortical surface area and decreases with age. Increased gyrification is associated with higher scores on cognitive tasks in adults; however, the degree to which this relationship is independent of cortical surface area remains undefined. This...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-017-9696-9
更新日期:2018-04-01 00:00:00
abstract::Several behavioral and neuroimaging markers could be used to predict eventual antidepressant medication (ADM) outcomes in patients with major depressive disorder (MDD). However, these predictors are either subjective or complex, which has limited their clinical use. Thus, we aimed to identify an objective and easy-to-...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9845-9
更新日期:2018-12-01 00:00:00
abstract::Negative urgency, defined as a tendency to act rashly under extreme negative emotion, is strongly associated with tobacco use. Despite the robust evidence linking negative urgency and tobacco use and accumulating evidence suggesting that localized, segregated brain regions such as the nucleus accumbens (NAcc), insula,...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00136-1
更新日期:2020-10-01 00:00:00
abstract::Chronic Traumatic Encephalopathy (CTE) is a neurodegenerative disease thought to be caused, at least in part, by repetitive brain trauma, including concussive and subconcussive injuries. It is thought to result in executive dysfunction, memory impairment, depression and suicidality, apathy, poor impulse control, and e...
journal_title:Brain imaging and behavior
pub_type: 杂志文章,评审
doi:10.1007/s11682-012-9164-5
更新日期:2012-06-01 00:00:00
abstract::The present study evaluates the integrity of uncinate fasciculus (UF) and the association between UF microstructure and verbal episodic memory (as one of the cognitive functions linked to UF) in non-demented patients with amyotrophic lateral sclerosis (ALS) using diffusion tensor imaging (DTI). We studied 21 patients ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-013-9271-y
更新日期:2014-12-01 00:00:00
abstract::Feeling of presence (FOP) refers to the vivid sensation of a person's presence near oneself and is common in Dementia with Lewy Bodies (DLB). Based on previous observations on epileptic subjects, we hypothesized that DLB subjects with FOP would harbour 18F-fluorodeoxyglucose PET hypometabolism in left parietal areas. ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9997-7
更新日期:2020-08-01 00:00:00
abstract::In patients with premotor Huntington's disease (pmHD), literature has reported decreases in caudate volume. However, the regional vulnerability of the caudate nucleus to pmHD remains to be clarified. We aimed to determine whether regional structural damage of the caudate nucleus was present in pmHD and was correlated ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9616-4
更新日期:2017-10-01 00:00:00
abstract::Diffusion tensor imaging (DTI) has demonstrated its utility in detecting microscopic post-concussion cerebral white matter structural changes, which are not routinely evident on conventional neuroimaging modalities. In this study, we compared 10 adolescents with sports concussion (SC) to 12 orthopedically-injured (OI)...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-017-9752-5
更新日期:2018-08-01 00:00:00
abstract::Alcoholism can lead to a complex mixture of cognitive and emotional deficits associated with abnormalities in fronto-cortico-striatal-limbic brain circuitries. Given the broad variety of neurobehavioral symptoms, one would also expect alterations of postrolandic neocortical systems. Thus, we used diffusion tensor imag...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9579-5
更新日期:2017-08-01 00:00:00
abstract::Previous neuropsychological studies have demonstrated that liver transplantation (LT) is an effective method for improving the cognitive function of cirrhotic patients. However, the neural basis underlying the effects of LT is still unclear. Neuroimaging studies investigating changes in brain structures or functional ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9659-6
更新日期:2017-12-01 00:00:00
abstract::Different family composition and size inevitably make only-children different from non-only-children. Previous studies have focused on the differences in behaviors, such as cognitive function and personality traits, between the only-child and the non-only-child. However, there are few studies that have focused on the ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9530-9
更新日期:2017-04-01 00:00:00
abstract::Copy number variants at the chromosomal locus 16p11.2 contribute to neurodevelopmental disorders such as autism spectrum disorders, epilepsy, schizophrenia, and language and articulation disorders. Here, we provide detailed findings on the disrupted structural brain connectivity in 16p11.2 deletion syndrome (patients:...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9859-3
更新日期:2019-04-01 00:00:00
abstract::Traumatic brain injury results in a metabolic cascade of changes that occur at the molecular level, invisible to conventional imaging methods such as computed tomography or magnetic resonance imaging. Non-invasive metabolic imaging tools such as single photon emission computed tomography (SPECT), positron emission tom...
journal_title:Brain imaging and behavior
pub_type: 杂志文章,评审
doi:10.1007/s11682-012-9181-4
更新日期:2012-06-01 00:00:00
abstract::The clinical relevance of gray/white matter contrast ratio (GWR) in mild cognitive impairment (MCI) remains unknown. This study examined baseline GWR and 3-year follow-up diagnostic status in MCI. Alzheimer's Disease Neuroimaging Initiative MCI participants with baseline 1.5 T MRI and 3-year follow-up clinical data we...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-014-9291-2
更新日期:2015-06-01 00:00:00
abstract::Concussion is the most common form of traumatic brain injury (TBI), but diagnosis remains controversial because the brain appears quite normal in conventional computed tomography and magnetic resonance imaging (MRI). These conventional tools are not sensitive enough to detect diffuse traumatic axonal injury, and canno...
journal_title:Brain imaging and behavior
pub_type: 杂志文章,评审
doi:10.1007/s11682-013-9288-2
更新日期:2014-12-01 00:00:00
abstract::Restless legs syndrome (RLS) is common in the end-stage renal disease (ESRD) population; however, their interrelationship remains largely unclear. In the current study, we aimed to investigate the brain structure variation in ESRD patients with RLS (ERSD-RLS) and its potential relation with the severity of RLS. Diffus...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9968-z
更新日期:2020-02-01 00:00:00
abstract::Patients with Crohn's disease (CD) are shown to have abnormal changes in brain structures. This study aimed to further investigate whether these patients have abnormal brain activities and network connectivity. Sixty patients with CD and 40 healthy controls (HCs) underwent resting-state functional magnetic resonance i...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9850-z
更新日期:2018-12-01 00:00:00
abstract::Cognitive flexibility, a core dimension of executive functions, refers to one's ability to switch between multiple tasks and sets in a quick and flexible manner. However, whether objective neuroimaging can be used to quantitatively predict cognitive flexibility at the individual level remains largely unexplored. High-...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9905-1
更新日期:2019-06-01 00:00:00
abstract::No known studies have directly examined white matter microstructural correlates of cognitive fatigue post-TBI in a Veteran sample. We therefore investigated the relationship between cognitive fatigue and white matter integrity in Veterans with history of mild to moderate TBI (mmTBI). 59 Veterans (TBI = 34, Veteran Con...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9594-6
更新日期:2017-10-01 00:00:00
abstract::Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission. Little is known about the abnormalities in PBD in resting state, especially comparing manic with euthymic state. Resting state brain activity measured by fM...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00117-4
更新日期:2019-12-01 00:00:00
abstract::Neuroimaging studies have implicated abnormal brain microstructure in episodic migraine (EM), but whether the pattern is altered during migraine chronification is not well known. Fifty-six patients with migraine without aura, including 39 EM patients and 17 chronic migraine (CM) patients, and 35 healthy controls (HCs)...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00232-2
更新日期:2021-02-01 00:00:00
abstract::Exercise improves both physical and mental health and increases neurogenesis in the dendate gyrus (DG) of the hippocampus. The aim of this study was to examine whether exercising, as compared to no change in regular physical activity, would impact on hippocampal volume, and in particular the core hippocampal structure...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00088-6
更新日期:2020-10-01 00:00:00